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Volumn 44, Issue 2, 2004, Pages 115-119

Role of Stereoselective Assays in Bioequivalence Studies of Racemic Drugs: Have We Reached a Consensus?

Author keywords

Bioequivalence; Chiral; Pharmacokinetics; Racemate; Stereoselectivity

Indexed keywords

DRUG; RACEMIC DRUG; UNCLASSIFIED DRUG;

EID: 1642494655     PISSN: 00912700     EISSN: None     Source Type: Journal    
DOI: 10.1177/0091270003262098     Document Type: Review
Times cited : (11)

References (50)
  • 1
    • 0026769510 scopus 로고
    • Chiral separation by high performance liquid chromatography: I. Review on indirect separation of enantiomers as diastereomeric derivatives using ultraviolet, fluorescence and electrochemical detection
    • Srinivas NR, Igwemezie LN: Chiral separation by high performance liquid chromatography: I. Review on indirect separation of enantiomers as diastereomeric derivatives using ultraviolet, fluorescence and electrochemical detection. Biomed Chromatogr 1992;6:163.
    • (1992) Biomed Chromatogr , vol.6 , pp. 163
    • Srinivas, N.R.1    Igwemezie, L.N.2
  • 2
    • 0028894156 scopus 로고
    • Gas chromatographic determination of enantiomers as diastereomers following pre-column derivatization and applications to pharmacokinetic studies: A review
    • Srinivas NR, Shyu WC, Barbhaiya RH: Gas chromatographic determination of enantiomers as diastereomers following pre-column derivatization and applications to pharmacokinetic studies: a review. Biomed Chromotogr 1995;9:1.
    • (1995) Biomed Chromotogr , vol.9 , pp. 1
    • Srinivas, N.R.1    Shyu, W.C.2    Barbhaiya, R.H.3
  • 3
    • 0035061554 scopus 로고    scopus 로고
    • Chiral derivatization reagents for drug enantioseparation by high-performance liquid chromatography based upon pre-column derivatization and formation of diastereomers: Enantioselectivity and related structure
    • Sun XX, Sun LZ, Aboul-Enein HY: Chiral derivatization reagents for drug enantioseparation by high-performance liquid chromatography based upon pre-column derivatization and formation of diastereomers: enantioselectivity and related structure. Biomed Chromatogr 2001;15(2):116-132.
    • (2001) Biomed Chromatogr , vol.15 , Issue.2 , pp. 116-132
    • Sun, X.X.1    Sun, L.Z.2    Aboul-Enein, H.Y.3
  • 4
    • 0031798996 scopus 로고    scopus 로고
    • Recent applications of polysaccharide-type chiral stationary phases for the enantioselective analysis of chiral drugs with one and two stereogenic centers
    • Aboul-Enein HY: Recent applications of polysaccharide-type chiral stationary phases for the enantioselective analysis of chiral drugs with one and two stereogenic centers. Biomed Chromatogr 1998;12:116-119.
    • (1998) Biomed Chromatogr , vol.12 , pp. 116-119
    • Aboul-Enein, H.Y.1
  • 5
    • 0035847233 scopus 로고    scopus 로고
    • Chiral separations using the macrocyclic antibiotics: A review
    • Ward TJ, Francis AB III: Chiral separations using the macrocyclic antibiotics: a review. J Chromatogr A 2001;906:73-89.
    • (2001) J Chromatogr A , vol.906 , pp. 73-89
    • Ward, T.J.1    Francis III, A.B.2
  • 6
    • 0036130597 scopus 로고    scopus 로고
    • Role of chiral chromatography in therapeutic drug monitoring and in clinical and forensic toxicology
    • Williams ML, Wainer IW: Role of chiral chromatography in therapeutic drug monitoring and in clinical and forensic toxicology. Ther Drug Monitor 2002;24:290-296.
    • (2002) Ther Drug Monitor , vol.24 , pp. 290-296
    • Williams, M.L.1    Wainer, I.W.2
  • 7
    • 0035847212 scopus 로고    scopus 로고
    • High-performance liquid chromatographic enantioseparation of drugs containing multiple chiral centers on polysaccharide-type chiral stationary phases
    • Aboul-Enein HY: High-performance liquid chromatographic enantioseparation of drugs containing multiple chiral centers on polysaccharide-type chiral stationary phases. J Chromatogr A 2001;906:185-193.
    • (2001) J Chromatogr A , vol.906 , pp. 185-193
    • Aboul-Enein, H.Y.1
  • 8
    • 0035847236 scopus 로고    scopus 로고
    • Reviewing mobile phases used on Chiralcel OD through an application of data mining tools to CHIRBASE database
    • Piras P, Roussel C, Pierrot-Saunders J: Reviewing mobile phases used on Chiralcel OD through an application of data mining tools to CHIRBASE database. J Chromotogr A 2001;906:443-458.
    • (2001) J Chromotogr A , vol.906 , pp. 443-458
    • Piras, P.1    Roussel, C.2    Pierrot-Saunders, J.3
  • 9
    • 0033385302 scopus 로고    scopus 로고
    • Application of thin-layer chromatography in enantiomeric chiral analysis: An overview
    • Aboul-Enein HY, El-Awady MI, Heard CM, Nicholls PJ: Application of thin-layer chromatography in enantiomeric chiral analysis: an overview. Biomed Chromatogr 1999;13:531-537.
    • (1999) Biomed Chromatogr , vol.13 , pp. 531-537
    • Aboul-Enein, H.Y.1    El-Awady, M.I.2    Heard, C.M.3    Nicholls, P.J.4
  • 10
    • 0035824257 scopus 로고    scopus 로고
    • Separation of enantiomers of ibuprofen on chiral stationary phases by packed column supercritical fluid chromatography
    • Johannsen M: Separation of enantiomers of ibuprofen on chiral stationary phases by packed column supercritical fluid chromatography. J Chromatogr A 2001;937:135-138.
    • (2001) J Chromatogr A , vol.937 , pp. 135-138
    • Johannsen, M.1
  • 11
    • 0034048114 scopus 로고    scopus 로고
    • Enantioselective supercritical fluid chromatography using ristocetin A chiral stationary phases
    • Svensson LA, Owens PK: Enantioselective supercritical fluid chromatography using ristocetin A chiral stationary phases. Analyst 2000;125:1037-1039.
    • (2000) Analyst , vol.125 , pp. 1037-1039
    • Svensson, L.A.1    Owens, P.K.2
  • 12
    • 0034282506 scopus 로고    scopus 로고
    • Comparison of packed-column supercritical fluid chromatography-tandem mass spectrometry for bioanalytical determination of (R)-and (S)-ketoprofen in human plasma following automated 96-well solid-phase extraction
    • Hoke SH, Pinkston JD, Bailey RE, Tanguay SL, Eichold TH: Comparison of packed-column supercritical fluid chromatography-tandem mass spectrometry for bioanalytical determination of (R)-and (S)-ketoprofen in human plasma following automated 96-well solid-phase extraction. Anal Chem 2000;72:4235-4241.
    • (2000) Anal Chem , vol.72 , pp. 4235-4241
    • Hoke, S.H.1    Pinkston, J.D.2    Bailey, R.E.3    Tanguay, S.L.4    Eichold, T.H.5
  • 13
    • 0028520084 scopus 로고
    • Sub- and supercritical fluid chromatography on packed columns: A versatile tool for the enantioselective separation of basic and acidic drugs
    • Kot A, Sandra P, Venema A: Sub- and supercritical fluid chromatography on packed columns: a versatile tool for the enantioselective separation of basic and acidic drugs. J Chromatogr Sci 1994;32:439-448.
    • (1994) J Chromatogr Sci , vol.32 , pp. 439-448
    • Kot, A.1    Sandra, P.2    Venema, A.3
  • 14
    • 0037135005 scopus 로고    scopus 로고
    • Liquid-phase microextraction combined with capillary electrophoresis, a promising tool for the determination of chiral drugs in biological matrices
    • Andersen S, Halvorsen TG, Pedersen-Bjergaard S, Rasmussen KE: Liquid-phase microextraction combined with capillary electrophoresis, a promising tool for the determination of chiral drugs in biological matrices. J Chromatogr A 2002;963:303-312.
    • (2002) J Chromatogr A , vol.963 , pp. 303-312
    • Andersen, S.1    Halvorsen, T.G.2    Pedersen-Bjergaard, S.3    Rasmussen, K.E.4
  • 15
    • 0034790295 scopus 로고    scopus 로고
    • Separation of basic drugs enantiomers by capillary electrophoresis using ovoglycoprotein as a chiral selector: Comparison of chiral resolution ability of ovoglycoprotein and completely deglycosylated ovoglycoprotein
    • Matsunga H, Haginaka J: Separation of basic drugs enantiomers by capillary electrophoresis using ovoglycoprotein as a chiral selector: comparison of chiral resolution ability of ovoglycoprotein and completely deglycosylated ovoglycoprotein. Electrophoresis 2001;22:3252-3256.
    • (2001) Electrophoresis , vol.22 , pp. 3252-3256
    • Matsunga, H.1    Haginaka, J.2
  • 16
    • 0032749158 scopus 로고    scopus 로고
    • FDA policy and regulation of stereoisomers: Paradigm shift and the future of safer, more effective drugs
    • Strong M: FDA policy and regulation of stereoisomers: paradigm shift and the future of safer, more effective drugs. Food Drug Law J 1999;54:463-487.
    • (1999) Food Drug Law J , vol.54 , pp. 463-487
    • Strong, M.1
  • 17
    • 0023639698 scopus 로고
    • Bias in pharmacokinetics and clinical pharmacology
    • Ariens EJ, Wuis EW: Bias in pharmacokinetics and clinical pharmacology. Clin Pharmacol Ther 1987;42:361.
    • (1987) Clin Pharmacol Ther , vol.42 , pp. 361
    • Ariens, E.J.1    Wuis, E.W.2
  • 18
    • 0026484986 scopus 로고
    • The importance of stereochemistry in drug action and disposition
    • Caldwell J: The importance of stereochemistry in drug action and disposition. J Clin Pharmacol 1992;32:925-929.
    • (1992) J Clin Pharmacol , vol.32 , pp. 925-929
    • Caldwell, J.1
  • 19
    • 0028019730 scopus 로고
    • Chirality in new drug development: Clinical pharmacokinetic considerations
    • Nation RL: Chirality in new drug development: clinical pharmacokinetic considerations. Clin Pharmacokin 1994;27:249-255.
    • (1994) Clin Pharmacokin , vol.27 , pp. 249-255
    • Nation, R.L.1
  • 20
    • 0034820056 scopus 로고    scopus 로고
    • Enantiomeric drug development: Issues, considerations, and regulatory requirements. Invited Min-Review
    • Srinivas NR, Barbhaiya RH, Midha KK: Enantiomeric drug development: issues, considerations, and regulatory requirements. Invited Min-Review. J Pharm Sci 2001;90(9):1205-1215.
    • (2001) J Pharm Sci , vol.90 , Issue.9 , pp. 1205-1215
    • Srinivas, N.R.1    Barbhaiya, R.H.2    Midha, K.K.3
  • 21
    • 0026445535 scopus 로고
    • Stereochemistry and bioequivalence
    • Jamali F: Stereochemistry and bioequivalence. J Clin Pharmacol 1992;32:930-934.
    • (1992) J Clin Pharmacol , vol.32 , pp. 930-934
    • Jamali, F.1
  • 22
    • 0026492324 scopus 로고
    • From controversy to resolution: Bioequivalency of racemic drugs-a symposium on the dynamics, kinetics, bioequivalency, and analytical aspects of stereochemistry
    • Wechter WJ: From controversy to resolution: bioequivalency of racemic drugs-a symposium on the dynamics, kinetics, bioequivalency, and analytical aspects of stereochemistry. J Clin Pharmacol 1992;32:915-916.
    • (1992) J Clin Pharmacol , vol.32 , pp. 915-916
    • Wechter, W.J.1
  • 24
    • 0026683718 scopus 로고
    • Enantioselective versus non-enantioselective assays in comparative bioavailability studies with racemic drugs
    • Hooper WD, Dickinson RG, Gal J: Enantioselective versus non-enantioselective assays in comparative bioavailability studies with racemic drugs. Biopharm Drug Disp 1992;13:383-387.
    • (1992) Biopharm Drug Disp , vol.13 , pp. 383-387
    • Hooper, W.D.1    Dickinson, R.G.2    Gal, J.3
  • 25
    • 0026773812 scopus 로고
    • Enantioselective versus non-enantioselective assays in comparative bioavailability studies for racemic drugs
    • Jamali F: Enantioselective versus non-enantioselective assays in comparative bioavailability studies for racemic drugs. Biopharm Drug Disp 1992;13:385.
    • (1992) Biopharm Drug Disp , vol.13 , pp. 385
    • Jamali, F.1
  • 26
    • 0030018387 scopus 로고    scopus 로고
    • Enantioselective assays in comparative bioavailability studies of racemic drug formulations: Nice to know or need to know
    • Karim A: Enantioselective assays in comparative bioavailability studies of racemic drug formulations: nice to know or need to know. J Clin Pharmacol 1996;36:490-499.
    • (1996) J Clin Pharmacol , vol.36 , pp. 490-499
    • Karim, A.1
  • 27
    • 0030851895 scopus 로고    scopus 로고
    • Bioequivalence of chiral drugs: Stereospecific versus non-stereospecific methods
    • Mehvar R, Jamali F: Bioequivalence of chiral drugs: stereospecific versus non-stereospecific methods. Clin Pharmacokin 1997;33:122-141.
    • (1997) Clin Pharmacokin , vol.33 , pp. 122-141
    • Mehvar, R.1    Jamali, F.2
  • 28
    • 0033840256 scopus 로고    scopus 로고
    • Stereoselective metabolism of cibenzoline, an antiarrhythmic drug, by human and rat liver microsomes: Possible involvement of CYP2D and CYP3A
    • Niwa T, Shiraga T, Mitani Y, Terakawa M, Tokuma Y, Kagayama A: Stereoselective metabolism of cibenzoline, an antiarrhythmic drug, by human and rat liver microsomes: possible involvement of CYP2D and CYP3A. Drug Metob Dispos 2000;28:1128-1134.
    • (2000) Drug Metob Dispos , vol.28 , pp. 1128-1134
    • Niwa, T.1    Shiraga, T.2    Mitani, Y.3    Terakawa, M.4    Tokuma, Y.5    Kagayama, A.6
  • 29
    • 0035103370 scopus 로고    scopus 로고
    • Stereoselective pharmacokinetics of pantoprazole, a proton pump inhibitor, in extensive and poor metabolizers of S-mephenytoin
    • Tanaka M, Ohkubo T, Otani K, Suzuki A, Kaneko S, Sugawara K, et al: Stereoselective pharmacokinetics of pantoprazole, a proton pump inhibitor, in extensive and poor metabolizers of S-mephenytoin. Clin Pharmacol Ther 2001;69:108.
    • (2001) Clin Pharmacol Ther , vol.69 , pp. 108
    • Tanaka, M.1    Ohkubo, T.2    Otani, K.3    Suzuki, A.4    Kaneko, S.5    Sugawara, K.6
  • 30
    • 0032954533 scopus 로고    scopus 로고
    • Stereoselective disposition of the antiarrhythmic agent mexiletine during the concomitant administration of caffeine
    • Labbe L, Abolfathi Z, Robitaille NM, St. Maurice F, Gilbert M, Turgeon J: Stereoselective disposition of the antiarrhythmic agent mexiletine during the concomitant administration of caffeine. Ther Drug Monitor 1999;21:191.
    • (1999) Ther Drug Monitor , vol.21 , pp. 191
    • Labbe, L.1    Abolfathi, Z.2    Robitaille, N.M.3    St. Maurice, F.4    Gilbert, M.5    Turgeon, J.6
  • 32
    • 0033786474 scopus 로고    scopus 로고
    • Role of cytochrome P450 2D6 (CYP2D6) in the stereospecific metabolism of E- and Z-doxepin
    • Haritos VS, Ghabiral H, Ahokas JT, Ching MS: Role of cytochrome P450 2D6 (CYP2D6) in the stereospecific metabolism of E- and Z-doxepin. Pharmacogenetics 2000;10:591.
    • (2000) Pharmacogenetics , vol.10 , pp. 591
    • Haritos, V.S.1    Ghabiral, H.2    Ahokas, J.T.3    Ching, M.S.4
  • 33
    • 0034075099 scopus 로고    scopus 로고
    • Is therapeutic drug monitoring a case for optimizing clinical outcome and avoiding interactions of the selective serotonin reuptake inhibitors?
    • Rasmussen BB, Brosen K: Is therapeutic drug monitoring a case for optimizing clinical outcome and avoiding interactions of the selective serotonin reuptake inhibitors? Ther Drug Monitor 2000;22:143.
    • (2000) Ther Drug Monitor , vol.22 , pp. 143
    • Rasmussen, B.B.1    Brosen, K.2
  • 34
    • 0035660655 scopus 로고    scopus 로고
    • Role of CYP3A4 and CYP2C19 in the stereoselective metabolism of lansoprazole by human liver microsomes
    • Katsuki H, Hamada A, Nakamura C, Arimori K, Nakano M: Role of CYP3A4 and CYP2C19 in the stereoselective metabolism of lansoprazole by human liver microsomes. Eur J Clin Pharmacol 2001;57:709-715.
    • (2001) Eur J Clin Pharmacol , vol.57 , pp. 709-715
    • Katsuki, H.1    Hamada, A.2    Nakamura, C.3    Arimori, K.4    Nakano, M.5
  • 35
    • 0032440352 scopus 로고    scopus 로고
    • The effects of genetic polymorphisms of CYP2C9 and CYP2C19 on phenytoin metabolism in Japanese adult patients with epilepsy: Studies in stereoselective hydroxylation and population pharmacokinetics
    • Mamiya K, Leiri I, Shimamoto J, Yukawa E, Imai J, Ninomiya H, et al: The effects of genetic polymorphisms of CYP2C9 and CYP2C19 on phenytoin metabolism in Japanese adult patients with epilepsy: studies in stereoselective hydroxylation and population pharmacokinetics. Epilepsia 1998;39:1317.
    • (1998) Epilepsia , vol.39 , pp. 1317
    • Mamiya, K.1    Leiri, I.2    Shimamoto, J.3    Yukawa, E.4    Imai, J.5    Ninomiya, H.6
  • 37
    • 0033668829 scopus 로고    scopus 로고
    • Dose proportional and stereospecific pharmacokinetics of methylphenidate delivered using an osmotic controlled release oral delivery system
    • Modi NB, Wang B, Noveck RJ, Gupta SK: Dose proportional and stereospecific pharmacokinetics of methylphenidate delivered using an osmotic controlled release oral delivery system. J Clin Pharmacol 2000;40:1141.
    • (2000) J Clin Pharmacol , vol.40 , pp. 1141
    • Modi, N.B.1    Wang, B.2    Noveck, R.J.3    Gupta, S.K.4
  • 38
    • 0027525916 scopus 로고
    • Enantioselective pharmacokinetics of dl-threo-methylphenidate in humans
    • Srinivas NR, Hubbard JW, Korchinski ED, Midha KK: Enantioselective pharmacokinetics of dl-threo-methylphenidate in humans. Pharm Res 1993;10:14.
    • (1993) Pharm Res , vol.10 , pp. 14
    • Srinivas, N.R.1    Hubbard, J.W.2    Korchinski, E.D.3    Midha, K.K.4
  • 39
    • 0024854898 scopus 로고
    • Enantioselective aspects of the disposition of dl-threo-methylphenidate after the administration of a sustained-release formulation to children with attention deficit-hyperactivity disorder
    • Hubbard JW, Srinivas NR, Quinn D, Midha KK: Enantioselective aspects of the disposition of dl-threo-methylphenidate after the administration of a sustained-release formulation to children with attention deficit-hyperactivity disorder. J Pharm Sci 1989;78:944.
    • (1989) J Pharm Sci , vol.78 , pp. 944
    • Hubbard, J.W.1    Srinivas, N.R.2    Quinn, D.3    Midha, K.K.4
  • 40
    • 0036227517 scopus 로고    scopus 로고
    • Influence of input rate on the stereospecific and nonstereospecific first pass metabolism and pharmacokinetics of metoprolol extended release formulations
    • Mistry B, Leslie JL, Eddington ND: Influence of input rate on the stereospecific and nonstereospecific first pass metabolism and pharmacokinetics of metoprolol extended release formulations. Chirality 2002;14:297-304.
    • (2002) Chirality , vol.14 , pp. 297-304
    • Mistry, B.1    Leslie, J.L.2    Eddington, N.D.3
  • 41
    • 0030773341 scopus 로고    scopus 로고
    • Bioequivalence, pharmacokinetic and pharmacodynamic response to combined extended release formulations of felodipine and metoprolol in healthy volunteers
    • Aberg J, Abrahamsson B, Grind M, Nyberg G, Olofsson B: Bioequivalence, pharmacokinetic and pharmacodynamic response to combined extended release formulations of felodipine and metoprolol in healthy volunteers. Eur J Clin Pharmacol 1997;52:471-477.
    • (1997) Eur J Clin Pharmacol , vol.52 , pp. 471-477
    • Aberg, J.1    Abrahamsson, B.2    Grind, M.3    Nyberg, G.4    Olofsson, B.5
  • 42
    • 0025734474 scopus 로고
    • Comparative bioavailability of two flurbiprofen products: Stereospecific versus conventional approach
    • Jamali F, Collins DS, Berry BW, Molder S, Cheung R, McColl K, et al: Comparative bioavailability of two flurbiprofen products: stereospecific versus conventional approach. Biopharm Drug Disp 1991;12:435-445.
    • (1991) Biopharm Drug Disp , vol.12 , pp. 435-445
    • Jamali, F.1    Collins, D.S.2    Berry, B.W.3    Molder, S.4    Cheung, R.5    McColl, K.6
  • 43
    • 0006340099 scopus 로고
    • Alterations in apparent bioequivalency of ibuprofen based on isomer analysis
    • Walker SE, Hardy BG: Alterations in apparent bioequivalency of ibuprofen based on isomer analysis. J Clin Pharmacol 1992;32:957.
    • (1992) J Clin Pharmacol , vol.32 , pp. 957
    • Walker, S.E.1    Hardy, B.G.2
  • 44
    • 0023812439 scopus 로고
    • Comparative human study of ibuprofen enantiomer plasma comcentrations produced by two commercially available ibuprofen tablets
    • Cox SR, Brown MA, Squires DJ, Murrill EA, Lednicer D, Knuth DW: Comparative human study of ibuprofen enantiomer plasma comcentrations produced by two commercially available ibuprofen tablets. Biopharm Drug Disp 1988;9:539-549.
    • (1988) Biopharm Drug Disp , vol.9 , pp. 539-549
    • Cox, S.R.1    Brown, M.A.2    Squires, D.J.3    Murrill, E.A.4    Lednicer, D.5    Knuth, D.W.6
  • 45
    • 9044226528 scopus 로고    scopus 로고
    • Bioequivalence of two tablet formulations of nadolol using single and multiple dose data: Assessment using stereospecific and nonstereospecific assays
    • Srinivas NR, Barr WH, Shyu WC, Mohandoss E, Chow S, Staggers J, et al: Bioequivalence of two tablet formulations of nadolol using single and multiple dose data: assessment using stereospecific and nonstereospecific assays. J Pharm Sci 1996;85:299.
    • (1996) J Pharm Sci , vol.85 , pp. 299
    • Srinivas, N.R.1    Barr, W.H.2    Shyu, W.C.3    Mohandoss, E.4    Chow, S.5    Staggers, J.6
  • 46
    • 0029962695 scopus 로고    scopus 로고
    • The roles of stereochemistry and partial areas in a parallel design study to assess the bioequivalence of two formulations of hydroxychloroquine: A drug with a very long half life
    • Midha KK, Hubbard JW, Rawson MJ, Schwede R: The roles of stereochemistry and partial areas in a parallel design study to assess the bioequivalence of two formulations of hydroxychloroquine: a drug with a very long half life. Eur J Pharm Sci 1996;4:283-292.
    • (1996) Eur J Pharm Sci , vol.4 , pp. 283-292
    • Midha, K.K.1    Hubbard, J.W.2    Rawson, M.J.3    Schwede, R.4
  • 47
    • 0030012868 scopus 로고    scopus 로고
    • The impact of stereoisomerism in a bioequivalence study on two formulations of doxepin
    • Midha KK, Hubbard JW, Rawson MJ, Schwede R: The impact of stereoisomerism in a bioequivalence study on two formulations of doxepin. Eur J Pharm Sci 1996;4:133-138.
    • (1996) Eur J Pharm Sci , vol.4 , pp. 133-138
    • Midha, K.K.1    Hubbard, J.W.2    Rawson, M.J.3    Schwede, R.4
  • 49
    • 0033926605 scopus 로고    scopus 로고
    • Stereospecific versus nonstereospecific assessments for the bioequivalence of two formulations of racemic chlorpheniramine
    • Bui TH, Fernandez C, Vu K, Nguyen KH, Thuillier A, Farinotti R, et al: Stereospecific versus nonstereospecific assessments for the bioequivalence of two formulations of racemic chlorpheniramine. Chirality 2000;12:599-605.
    • (2000) Chirality , vol.12 , pp. 599-605
    • Bui, T.H.1    Fernandez, C.2    Vu, K.3    Nguyen, K.H.4    Thuillier, A.5    Farinotti, R.6


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