The roles of stereochemistry and partial areas in a parallel design study to assess the bioequivalence of two formulations of hydroxychloroquine: A drug with a very long half life

European Journal of Pharmaceutical Sciences

Volumn 4, Issue 5, 1996, Pages 283-292

  Midha, K K ^a   Hubbard, J W ^a   Rawson, M J ^a   McKay, G ^a   Schwede, R ^b  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b Geneva Pharmaceuticals   (United States)

Author keywords

Bioequivalence; Enantioselective; Hydroxychloroquine; Parallel design; Partial areas

Indexed keywords

HYDROXYCHLOROQUINE;

ADULT; AREA UNDER THE CURVE; ARTICLE; BIOAVAILABILITY; BIOEQUIVALENCE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG FORMULATION; HUMAN; HUMAN EXPERIMENT; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PHARMACOKINETICS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STEREOCHEMISTRY;

EID: 0029962695     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/0928-0987(96)00178-9     Document Type: Article

References (3)

1. Bell, C.L. (1983) Hydroxychloroquine sulfate in rheumatoid arthritis: long-term response rate and predictive parameters. Am. J. Med. 75, 46-51.
2. Blume, H.H. and Midha, K.K. (1993) Bio-International 92, Conference on Bioavailability, Bioequialence, and Pharmacokinetic Studies. J. Pharm. Sci. 82, 1186-1189.
3. Brocks, D.R., Skeith, K.J., Johnston, C., Emamibafrani, J., Davis, P., Russell, A.S. and Jumali, F. (1944) Hematologic disposition of hydroxychloroquine enantiomers. J. Clin. Pharmacol. 34, 1088-1097.