Chimeric Donor Cells Play an Active Role in Both Induction and Maintenance Phases of Transplantation Tolerance Induced by Mixed Chimerism

Journal of Immunology

Volumn 172, Issue 3, 2004, Pages 1444-1448

  Kanamoto, Akira ^a   Maki, Takashi ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

ALLOGRAFT; ANIMAL CELL; ANIMAL MODEL; ARTICLE; CHIMERA; CONTROLLED STUDY; GRAFT REJECTION; GRAFT SURVIVAL; MODEL; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SKIN TRANSPLANTATION;

EID: 1642485255     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.172.3.1444     Document Type: Article

References (12)

1. Sharabi, Y., and D. H, Sachs. 1989. Mixed chimerism and permanent specific transplantation tolerance induced by a nonlethal preparative regimen. J. Exp. Med. 169:493.
2. Colson, Y. L., H. Li, S. S. Boggs, K. D. Patrene, P. C. Johnson, and S. T. Ildstad. 1996. Durable mixed allogeneic chimerism and tolerance by a non-lethal radiation based cytoreductive approach. J. Immunol. 157:2820.
3. Tomita, Y., D. H. Sachs, A. Khan, and M. Sykes. 1996. Additional monoclonal antibody (mAb) injections can replace thymic irradiation to allow induction of mixed chimerism and tolerance in mice receiving bone marrow transplantation after conditioning with anti-T cell mAbs and 3-Gy whole body irradiation. Transplantation 61:469.
4. Sharabi, Y., M. Abraham. M. Sykes, and D. H. Sachs. 1992. Mixed allogeneic chimeras prepared by a non-myeloablative regimen: requirement for chimerism to maintain tolerance. Bone Marrow Transplant. 9:191.
5. Ko, S., A. Deiwick, M. D. Jager, A. Kinkel, F. Rohde, R. Fischer, T. Y. Tsui, K. L. Rittmann, K. Wonigeit, and H. J. Schlitt. 1999. The functional relevance of passenger leukocytes and microchimerism for heart allograft acceptance in the rat. Nat. Med. 5:1292.
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7. Anderson, C. C., and P. Matzinger. 2001. Immunity or tolerance: opposite outcomes of microchimerism from skin grafts. Nat. Med. 7:80.
8. Umemura, A, H. Morita, X. C. Li, S. Tahan, A. P. Monaco, and T. Maki. 2001. Dissociation of hematopoietic chimerism and allograft tolerance after allogeneic bone marrow transplantation. J. Immunol. 167:3043.
9. Umemura, A., A. P. Monaco, and T. Maki. 2000. Donor MHC class II antigen is essential for induction of transplantation tolerance by bone marrow cells. J. Immunol. 164:4452.
10. Peters, S. O., K. Bauermeister, J. P. Simon, B. Branke, and T. Wagner. 2002. Quantitative polymerase chain reaction-based assay with fluorogenic Y-chromosome specific probes to measure bone marrow chimerism in mice. J. Immunol. Methods. 260:109.
11. Taniguchi, H., M. Abe, T. Shirai, K. Fukao, and H. Nakauchi. 1995. Reconstitution ratio is critical for alloreactive T cell deletion and skin graft survival in mixed bone marrow chimeras. J. Immunol. 155:5631.
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