Donor MHC class II antigen is essential for induction of transplantation tolerance by bone marrow cells

Journal of Immunology

Volumn 164, Issue 9, 2000, Pages 4452-4457

  Umemura, Akihisa ^a   Monaco, Anthony P ^a   Maki, Takashi ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LYMPHOCYTE ANTIBODY; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; RAPAMYCIN;

ALLOTRANSPLANTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CHIMERA; CONTROLLED STUDY; GRAFT SURVIVAL; IMMUNOLOGICAL TOLERANCE; IRRADIATION; KNOCKOUT GENE; LYMPHOID CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN ALLOGRAFT; T LYMPHOCYTE; TRANSPLANTATION;

EID: 0034192087     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.164.9.4452     Document Type: Article

References (36)

1. Monaco, A. P., and M. L. Wood. 1970. Studies on heterologous antilymphocyte serum in mice. VII, Optimal cellular antigen for induction of immunologic tolerance with antilymphocyte serum. Transplant. Proc. 2:489.
2. Gozzo, J. J., M. L. Wood, and A. P. Monaco. 1970. Use of allogeneic, homozygous bone marrow cells for the induction of specific immunologic tolerance in mice treated with antilymphocyte serum. Surg. Forum 21:281.
3. Monaco, A. P., A. Liegois, M. L. Wood, and A. W. Clark. 1975. Active enhancement of tissue allografts with antilymphocyte serum and bone marrow. Adv. Nephrol. 5:135.
4. Caridis, T., A. Liegois, I. Barrett, and A. P. Monaco. 1973. Enhanced survival of canine renal allografts of ALS-treated dogs given bone marrow. Transplant. Proc. 5:671.
5. Hartner, W. C., S. R. DeFazio, T. Maki, T. Markees, A. P. Monaco, and J. J. Gozzo. 1986. Prolongation of renal allograft survival in antilymphocyte serum treated dogs by post-operative injection of density gradient fractionated donor bone marrow. Transplantation 42:593.
6. Thomas, F. T., F. M. Carver, M. B. Foil, W. H. Pryor, E. W. Larkin, W. R. Hall, C. E. Haisch, and J. M. Thomas. 1983. Long-term incompatible kidney survival in outbred higher primates without chronic immunosuppression. Ann. Surg. 198: 370.
7. Thomas, J. M., F. M. Carver, P. P. K. Cunningham, J. Gonder, and F. T. Thomas. 1987. Promotion of incompatible allograft acceptance in rhesus monkeys given post-transplant antithymocyte globulin and donor bone marrow. I. In vivo parameters and immunohistologic evidence suggesting microchimerism. Transplantation 43:332.
8. Monaco, A. P., M. L. Wood, T. Maki, P. N. Madras, A. I. Sahyoun, and M. A. Simpson. 1985. Attempt to induce unresponsiveness to human renal allografts with antilymphocyte globulin and donor specific bone marrow. Transplant. Proc. 17:1312.
9. Barber, W. H., J. A. Mankin, D. A. Laskow, M. H. Deierhoi, B. A. Julian, J. J. Curtis, and A. G. Diethelm. 1991. Long-term results of a controlled prospective study with transfusion of donor-specific bone marrow in 57 cadaveric renal allograft recipients. Transplantation 51:70.
10. McDaniel, D.O., J. Naftilan, K. Hulvey, S. Shaneyfelt, J. A. Lemons, S. Lagoo-Deenadayalan, S. Hudson, A. G. Diethelm, and W. H. Barber. 1994. Peripheral blood chimerism in renal allograft recipients transfused with donor bone marrow. Transplantation 57:852.
11. Starzl, T. E., A. J. Demetris, N. Murase, S. Ildstad, C. Ricordi, and M. Trucco. 1992. Cell migration, chimerism, and graft acceptance. Lancet 339:1579.
12. Garcia-Morales, R., M. Carreno, J. Mathew, K. Zucker, R. Cirocco, G. Ciancio, G. Burke, D. Roth, D. Temple, A. Rosen, et al. 1997. The effects of chimeric cells following donor bone marrow infusions as detected by PCR-flow assays in kidney transplant recipients. J. Clin. Invest. 99:1118.
13. Shapiro, R., A. S. Rao, P. Fontes, A. Zeevi, M. Jordan, V. P. Scanlebury, C. Vivas, H. A. Gritsch, R. J. Corry, R. Egidi, et al. 1995. Combined simultaneous kidney/bone marrow transplantation. Transplantation 60:1421.
14. Rao, A.S., P. Fontes, A. Iyengar, R. Shapiro, F. Dodson, R. J. Corry, S. Pham, M. Jordan, A. Zeevi, C. Rastellini, et al. 1997. Augmentation of chimerism with perioperative donor bone marrow infusion in organ transplant recipients: a 44 month follow-up. Transplant. Proc. 29:1184.
15. Ricordi, C., T. Karatzas, J. Nery, M. Webb, G. Selvaggi, L. Fernandez, F. A. Khan, P. Ruiz, E. Schiff, L. Olson, et al. 1997. High-dose donor bone marrow infusions to enhance allograft survival: the effect of timing. Transplantation 63:7.
16. Hale, D. A., R. Gottschalk, T. Fukuzaki, M. L. Wood, T. Maki, and A. P. Monaco. 1997. Superiority of sirolimus (rapamycin) over cyclosporine in augmenting allograft and xenograft survival in mice treated with antilymphocyte serum and donor specific bone marrow. Transplantation 63:359.
17. Hale, D. A., R. Gottschalk, T. Maki, and A. P. Monaco. 1998. Determination of an improved sirolimus (rapamycin)-based regimen for induction of allograft tolerance in mice treated with antilymphocyte serum and donor specific bone marrow. Transplantation 65:473.
18. Monaco, A. P., M. L. Wood, J. G. Gray, and P. S. Russell. 1966. Studies on heterologous antilymphocyte serum in mice. II. Effect on the immune response. J. Immunol. 96:229.
19. Billingham, R. E., L. Brent, and P. B. Medawar. 1951. The technique of free skin grafting in mammals. J. Exp. Biol. 28:385.
20. Wood, M. L., A. P. Monaco, J. J. Gozzo, and A. Liegeois. 1971. Use of homozygous allogeneic bone marrow for induction of tolerance with antilymphocyte serum: dose and timing. Transplant. Proc. 3:676.
21. + cytolytic T cells. Nature 344:742.
22. + T cells in major histocompatibility complex class II-deficient mice. Science 253:1417.
23. + cells but markedly decreased helper cell activity in mice lacking CD4. Nature 353:180.
24. Auchincloss, H. Jr, R. Lee, S. Shea, J. S. Markowitz, M. J. Grusby, and L. H. Glimcher. 1993. The role of "indirect" recognition in initiating rejection of skin grafts from major histocompatibility complex class II-deficient mice. Proc. Natl. Acad. Sci. USA 90:3373.
25. Kaplan, D. R., J. E. Hambor, and M. L. Tykocinski. 1989. An immunoregulatory function for the CD8 molecule. Proc. Natl. Acad. Sci. USA 86:8512.
26. Verbanac, K. M., M. Carver M, C. E. Haisch, and J. M. Thomas. 1994. A role for transforming growth factor-β in the veto mechanism in transplant tolerance. Transplantation 57:893.
27. Van Parijs, L., and A. K. Abbas. 1996. Role of Fas-mediated cell death in the regulation of immune responses. Curr. Opin. Immunol. 8:355.
28. Wahl, S. M. 1994. Transforming growth factor β: the good, the bad, and the ugly. J. Exp. Med. 180:1587.
29. Moore, K.W., A. O'Garra, R. de Waal Malefyt, P. Vieira, and T. R. Mosmann. 1993. Interleukin-10. Annu. Rev. Immunol. 11:165.
30. + T lymhocyles in class II-dericient mice. Proc. Natl. Acad. Sci. USA 90:2779.
31. + T cells with a mouse MHC-restricted TCR in pig thymus grafts. J. Immunol. 161:1320.
32. Sharabi, Y., V. S. Abraham, M. Sykes, and D. H. Sachs. 1992. Mixed allogeneic chimeras prepared by a non-myeloablative regimen: requirement for chimerism to maintain tolerance. Bone Marrow Transplant. 9:191.
33. Calson, Y.L., S. M. Wren, M. J. Schuchert, K. D. Patrene, P. C. Johnson, S. S. Boggs, and S. T. Ildstad. 1995. A nonlethal conditioning approach to achieve durable multilineage mixed chimerism and tolerance across major, minor, and hematopoietic histocompatibility barriers, J. Immunol. 155:4179.
34. Gould, D.S., and H. Auchincloss, Jr. 1992. Direct and indirect recognition: the rol of MHC antigens in graft rejection. Immunol. Today 20:77.
35. Sayegh, M. H., and C. B. Carpenter. 1996. Role of indirect allorecognition in allograft rejection. Int. Rev. Immunol 13:221.
36. Hale, D. A., R. Gottschalk, A. Umemura, T. Maki, and A. P. Monaco. Establishment of stable multilineage hematopoietic chimerism and donor-specific tolerance without irradiation: a unique role for sirolimus. Transplantation. In press.