Glioblastomatous transformation of ganglioglioma: Case report with reference to molecular genetic and flow cytometric analysis

Pathology International

Volumn 53, Issue 12, 2003, Pages 874-882

  Kim, Na Rae ^a   Wang, Kyu Chang ^b   Bang, Jae Seung ^b   Choe, Gheeyoung ^b   Park, Young ^b   Kim, Seung Ki ^b   Cho, Byung Kyu ^b   Chi, Je G ^b  

^a Gachon University College of Medicine   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

Flow cytometry; Ganglioglioma; Malignant transformation; p16; p53

Indexed keywords

ANTINEOPLASTIC AGENT; KI 67 ANTIGEN; PROTEIN P16; PROTEIN P53;

ANAMNESIS; ARTICLE; CANCER CHEMOTHERAPY; CANCER GRADING; CANCER RADIOTHERAPY; CANCER SURGERY; CASE REPORT; CLINICAL EXAMINATION; CLINICAL FEATURE; DISEASE COURSE; FEMALE; FLOW CYTOMETRY; GENE DELETION; GENE MUTATION; GENETIC ANALYSIS; GLIOBLASTOMA; GLIOMA; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; LABELING INDEX; METHYLATION; MOLECULAR BIOLOGY; MOLECULAR GENETICS; PREDICTION; PRESCHOOL CHILD; PRIORITY JOURNAL; TUMOR GROWTH;

BRAIN; BRAIN NEOPLASMS; CELL TRANSFORMATION, NEOPLASTIC; CHILD, PRESCHOOL; COMBINED MODALITY THERAPY; DNA, NEOPLASM; FEMALE; FLOW CYTOMETRY; GANGLIOGLIOMA; GLIOBLASTOMA; HUMANS; MAGNETIC RESONANCE IMAGING; MOLECULAR BIOLOGY; MUTATION; NEOPLASM RECURRENCE, LOCAL; NEOPLASMS, SECOND PRIMARY; POLYPLOIDY; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL;

EID: 1642481065     PISSN: 13205463     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1827.2003.01574.x     Document Type: Article

References (33)

1. Prayson RA, Khajavi K, Comair YG. Cortical architectural abnormalities and MIB1 immunoreactivity in gangliogliomas: A study of 60 patients with intracranial tumors. J Neuropathol Exp Neurol 1995; 54: 513-20.
2. Wolf HK, Muller MB, Spanle M, Zentner J, Schramm J, Wiestler OD. Ganglioglioma: A detailed histopathological and immunohistochemical analysis of 61 cases. Acta Neuropathol 1994; 88: 166-73.
3. Bowles AP Jr,, Pantazis CG, Allen MB Jr,, Martinez J, Allsbrook WC Jr. Ganglioglioma, a malignant tumor? Correlation with flow deoxyribonucleic acid cytometric analysis. Neurosurgery 1988; 23: 376-81.
4. Aronica E, Leenstra S, van Veelen CW et al. Glioneuronal tumors and medically intractable epilepsy: a clinical study with long-term follow-up of seizure outcome after surgery. Epilepsy Res 2001; 43: 179-91.
5. Jay V, Squire J, Becker LE, Humphreys R. Malignant transformation in a ganglioglioma with anaplastic neuronal and astrocytic components. Cancer 1994; 73: 2862-8.
6. Jay V, Squire J, Blaser S, Hoffman HJ, Hwang P. Intracranial and spinal metastases from a ganglioglioma with unusual cytogenetic abnormalities in a patient with complex partial seizures. Child's Nerv Syst 1997; 13: 550-55.
7. Kalyan-Raman UP, Olivero WC. Ganglioglioma. A correlative clinicopathological and radiological study of ten surgically treated cases with follow up. Neurosurgery 1987; 20: 428-33.
8. Russell DS, Rubinstein LJ. Ganglioglioma: A case with long history and malignant evolution. J Neuropathol Exp Neurol 1962; 21: 185-93.
9. Russell DS, Rubinstein LJ, eds. Pathology of the Tumours of the Nervous System, 6th edn. London: Arnold, 1998.
10. Sasaki A, Hirato J, Nakazato Y, Tamura M, Kadowaki H. Recurrent anaplastic ganglioglioma: pathological characterization of tumor cells. J Neurosurg 1996; 84: 1055-9.
11. Hedley DW, Friedlander ML, Taylor IW, Rugg CA, Musgrove EA. Method for analysis of cellular DNA content of paraffin-embedded pathological material using flow cytometry. J Histochem Cytochem 1983; 31: 1333-5.
12. Sambrook J, Fritsch EF, Maniatis T, eds. Molecular Cloning: A Laboratory Manual, 2nd edn. New York: Cold Spring Harbor Laboratory Press, 1989.
13. Herman JG, Graff JR, Myohanen S, Nelkin BD, Baylin SB. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA 1996; 93: 9821-6.
14. Hayashi Y, Ueki K, Waha A. Association of EGFR gene amplification and CDKN2 (p16/MTS1) gene deletion in glioblastoma multiforme. Brain Pathol 1997; 7: 871-5.
15. Hayashi Y, Iwato M, Hasegawa M, Tachibana O, von Deimling A, Yamashita J. Malignant transformation of a gangliocytoma/ ganglioglioma into a glioblastoma multiforme: a molecular genetic analysis: Case report. J Neurosurg 2001; 95: 138-42.
16. Kaba SE, Langford LA, Yung WK, Kyritsis AP. Resolution of recurrent malignant ganglioglioma after treatment with cis-retinoic acid. J Neurooncol 1996; 30: 55-60.
17. Hirose T, Scheithauer BW, Lopes MBS, Gerber HA, Altermatt HJ, VandenBerg SR. Ganglioglioma: an ultrastructural and immunohistochemical study. Cancer 1997; 79: 989-1003.
18. Lang FF, Epstein FJ, Ransohoff J et al. Central nervous system gangliogliomas. Part 2: Clinical outcome. J Neurosurg 1993; 79: 867-73.
19. Dash RC, Provenzale JM, McComb RD, Perry DA, Longee DC, McLendon RE. Malignant supratentorial ganglioglioma (ganglion cell-giant cell glioblastoma): a case report and review of the literature. Arch Pathol Lab Wed 1999; 123: 342-5.
20. David KM, Sanctis SD, Lewis PD, Noury MS, Edwards JMR. Neuroblastomatous recurrence of ganglioglioma. Case report. J Neurosurg 2000; 93: 698-700.
21. Campos MG, Zentner J, Ostertun B, Wolf HK, Schramm J. Anaplastic ganglioglioma: Case report and review of the literature. Neurol Res 1994; 16: 317-20.
22. Hall WA, Yunis EJ, Albright AL. Anaplastic ganglioglioma in an infant: Case report and review of the literature. Neurosurgery 1986; 19: 1016-20.
23. Katoh M, Aida T, Sugimoto S et al. Immunohistochemical analysis of giant cell glioblastoma. Pathol Int 1995; 45: 275-82.
24. Lindboe CF, Cappelen J, Kepes JJ. Pleomorphic xanthoastrocytoma as a component of a cerebellar ganglioglioma: Case report. Neurosurgery 1992; 31: 353-5.
25. Mittler MA, Walters BC, Fried AH, Sotomayor EA, Stopa EG. Malignant glial tumor arising from the site of a previous hamartoma/ganglioglioma: Coincidence or malignant transformation? Pediatr Neurosurg 1999; 30: 132-4.
26. Nigro JM, Baker SJ, Preisinger AC et al. Mutations in the p53 gene occur in diverse human tumour types. Nature 1989; 342: 705-8.
27. Bookwalter JW III,, Selker RG, Schiffer L, Randall M, Iannuzzi D, Kristofik M. Brain-tumor cell kinetics correlated with survival. J Neurosurg 1986; 65: 795-8.
28. Mickle JP. Ganglioglioma in children. A review of 32 cases at the University of Florida. Pediatr Neurosurg 1992; 18: 310-14.
29. Cheng Y, Ng HK, Ding M, Zhang SF, Pang JC, Lo KW. Molecular analysis of microdissected de novo glioblastomas and paired astrocytic tumors. J Neuropathol Exp Neurol 1999; 58: 120-28.
30. Watanabe K, Tachibana O, Sata K, Yonekawa Y, Kleihues P, Ohgaki H. Overexpression of the EGF receptor and p53 mutations are mutually exclusive in the evolution of primary and secondary glioblastomas. Brain Pathol 1996; 6: 217-24.
31. Burns KL, Ueki K, Jhung SL, Koh J, Louis DN. Molecular genetic correlates of p16, cdk4, and pRb immunohistochemistry in glioblastomas. J Neuropathol Exp Neurol 1998; 57: 122-30.
32. Fueyo J, Gomez-Manzano C, Bruner JM et al. Hypermethylation of the CpG island of p16/CDKN2 correlates with gene inactivation in gliomas. Oncogene 1996; 13: 1615-19.
33. De Souza Nascimento P, Maciel CM, Kawamura MT et al. Molecular analysis of CDKN2 (p16) in gliornas associated with clinical data. Oncol Rep 2001; 8: 1039-43.