Attenuation of Renal Ischemia-Reperfusion Injury by Trimetazidine: Evidence of an in Vivo Antioxidant Effect

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 25, Issue 10, 2003, Pages 803-809

  Kaur, H ^a   Padi, S S V ^a   Chopra, Kanwaljit ^a  

^a PANJAB UNIVERSITY   (India)

Author keywords

Anti ischemic agent; Oxidative stress; Renal ischemia reperfusion injury; Trimetazidine

Indexed keywords

EOTAXIN; HEMATOXYLIN; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TRIMETAZIDINE; UREA;

ACUTE KIDNEY FAILURE; ALLOGRAFT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTERY CLAMP; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CREATININE CLEARANCE; DRUG EFFECT; HISTOPATHOLOGY; IN VIVO STUDY; KIDNEY DYSFUNCTION; KIDNEY FUNCTION; KIDNEY HOMOGENATE; KIDNEY INJURY; KIDNEY ISCHEMIA; KIDNEY MEDULLA; KIDNEY TUBULE NECROSIS; LIPID PEROXIDATION; NONHUMAN; RAT; REVASCULARIZATION; UREA NITROGEN BLOOD LEVEL;

ANIMALS; ANTIOXIDANTS; BLOOD PRESSURE; BLOOD UREA NITROGEN; CREATININE; DISEASE MODELS, ANIMAL; DRUG ADMINISTRATION SCHEDULE; FEMALE; INJECTIONS, INTRAPERITONEAL; INJECTIONS, INTRAVENOUS; KIDNEY; LIPID PEROXIDATION; LIPID PEROXIDES; MALE; RATS; RATS, WISTAR; RENAL ARTERY OBSTRUCTION; REPERFUSION INJURY; TRIMETAZIDINE; UREA;

EID: 1642471696     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: 10.1358/mf.2003.25.10.793329     Document Type: Article

References (37)

1. Bronphy, D., Najarian, J.S., Kjellstrand, C.M. Acute tubular necrosis after renal transplantation. Transplantation 1980, 29: 245-54.
2. Weinberg, J.M. The cell biology of ischemic renal injury. Kidney Int 1991, 39: 476-83.
3. Paller, M.S., Hoidal, J.R., Ferris, T.F. Oxygen free radicals in ischemic acute renal failure. J Clin Invest 1984, 74: 1156-64.
4. Weight, S.C., Bell, P.R.F., Nicholson, M.L. Renal ischemia-reperfusion injury. Brit J Surg 1996, 83: 162-70.
5. 2 metabolites cause reperfusion injury after short but not prolonged renal ischemia. Am J Physiol 1987, 253: F685-92.
6. Hellberg, P.O.A., Kallskog, T.O.K. Neutrophil-mediated post ischemic tubular leakage in the rat kidney. Kidney Int 1989, 36: 555-61.
7. Linas, S.L., Withemberg, G. Parsons, P.E., Repine, J.E. Ischemia increases neutrophil retention and worsens acute renal failure: Role of oxygen metabolites and ICAM-1. Kidney Int 1995, 48: 1584-91.
8. Kehrer, J.P. Free radicals as mediators of tissue injury and disease. Critic Rev Toxicol 1993, 23: 21-48.
9. Gutteridge, J.M. Lipid peroxidation and antioxidants as biomarkers of tissue damage. Clin Chem 1995, 41: 1819-26.
10. Stromski M.E, Cooper K, Thulin J, Gaudio K.M, Siegel N.J, Shulman R.J. Chemical and functional correlates of post-ischemic ATP levels. Proc Natl Acad Sci USA 1986, 83: 6142-54.
11. Schrier R.W, Arnold, P.E, Van Putten V.J, Burke, T.J. Cellular calcium in ischemic acute renal failure: Role of calcium entry blockers. Kidney Int 1987, 32: 313-21.
12. Conger J.D, Robinette J.B, Schrier R.W. Smooth muscle calcium and endothelium-derived relaxing factor in the abnormal vascular responses of acute renal failure. J Clin Invest 1988, 82: 532-7.
13. 1 angiotensin II receptors in renal ischemic injury. Am J Physiol (Renal Physiol. 43) 1998, 274: F79-90.
14. Lopez-Farre, A., RamonyCajal, S., Braquet, P., Lopez-Novoa, J.M. Platelet activating factor antagonists protect against post-ischemic renal failure in rats. J Pharmacol Exp Ther 1990, 253: 328-33.
15. Donohoe, J.F., Venkatachalam, M.A., Bernard, D.B., Levinsky, N.G. Tubular leakage and obstruction after renal ischemia structural and functional correlation. Kidney Int 1978, 13: 208-22.
16. Allibardi S, Chierchia S.L, Maegonato V. Effects of trimetazidine on metabolic and functional recovery of post-ischemic rat hearts. Cardiovasc Drugs Ther 1998, 12: 543-9.
17. Salducci, M.D., Chauvet-Monges, A.M., Tillement, J.P. Trimetazidine reverses calcium accumulation and impairment of phosphorylation induced by cyclosporine A isolated rat liver mitochondria. J Pharmacol Exp Ther 1996, 277: 417-22.
18. Hauet, T, Bauza, G, Goujon, J.M. et al. Effect of trimetazidine on lipid peroxidation and phosphorous metabolites during cold storage and reperfusion of isolated rat perfused kidneys. J Pharmacol Expt Ther 1998, 285: 1061-7.
19. Maridonneau-Parini, I., Harpey, C. Effect of trimetazidine on membrane damage induced by oxygen free radicals in human red cells. Brit J Clin Pharmacol 1985, 20: 148-51.
20. Ohkawa, H., Oshishi, N., Yagi, K. Assay of lipid peroxidation in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979, 95: 331-58.
21. Brady, H.R, Singer, G.G. Acute renal failure. Lancet 1995, 346: 1533-40.
22. Finn, W.F., Chevalier, R.L. Recovery from post-ischemic renal failure in the rat. Kidney Int 1979, 16: 113-6.
23. Cronin, R.E., Erickson, A.M., De Torrente, A. Norepinephrine induced acute renal failure. Kidney Int 1978, 14: 187-91.
24. Pincemail, J., Defraigne, J.O., Fransen, C., Bonnett, P. Evidence for free radical formation during human kidney transplantation. Free Radic Biol Med 1993, 15: 343-8.
25. Guanieri, C., Muscari, C. Effect of trimetazidine on mitochondrial function and oxidative damage during reperfusion ischemic hypertrophied rat myocardium. Pharmacology 1997, 46: 324-31.
26. Kay, L., Finelli, C., Aussidat, J. Improvement of the long-term preservation of the isolated arrested rat heart by trimetazidine: Effects on the energy state and mitochondrial function. Am J Cardiol 1995, 76: 45-9B.
27. Hauet, T., Goujon, J-M., Vandewalle, A. et al. Trimetazidine reduces renal dysfunction by limiting the cold ischemia-reperfusion injury in autotransplanted pig kidneys. J Am Soc Nephrol 2000, 11: 138-48.
28. Salvi, A., Carrupt, P., Tillement, J. and Testa, B. Structural damage to proteins caused by free radicals: assessment, protection by antioxidants, and influence of protein binding (1). Biochem Pharmacol 2001, 61: 1237-42.
29. Satyanarayana, P.S.V., Singh, D., Chopra, K. Quercetin, a bioflavonoid, protects against oxidative stress related renal dysfunction by cyclosporine in rats. Methods Find Exp Clin Pharmacol 2001, 23: 175-81.
30. Galat, J.A., Robinson, A.V., Rhodes, R.S. Oxygen free radical mediated renal dysfunction. J Surg Res 1989, 46: 520-7.
31. Kim, S.J., Lim, Y.T., Kim, B.S. et al. Mechanism of reduced GFR in rabbits with ischemic acute renal failure. Renal Fail 2000, 22: 129-41.
32. Baud, L., Ardaillou, R. Involvement of reactive oxygen species in kidney damage. Br Med Bull 1993, 49: 621-629.
33. Perico, N., Benigni, A., Zojam, C., Delaini, F., Remuzzi, G. Functional significance of exaggerated renal thromboxane A2 synthesis induced by cyclosporine A. Am J Physiol 1986, 251: F581-7.
34. Yoo, J., Schlondorff, D., Neugartan, J. Thromaboxane mediates the renal haemodynamic effect of platelet activating factor. J Pharmacol Exp Ther 1990, 253: 743-8.
35. Kon, V., Huntley, T.E., Fogo, A. Combined antagonism of endothelin A/B receptors links endothelin to vasoconstriction whereas angiotensin II affects fibrosis. Transplantation 1995, 60: 89-95.
36. Shibouta, Y., Suzuki, N., Shino, A. et al. Pathophysiological role of endothelin in acute renal failure. Life Sci 1990, 46: 1611-20.
37. Sutton, A., Molitoris, B.A. Mechanisms of cellular injury in ischemic acute renal failure. Semin Nephrol 1998, 18: 490-7.