Forced lytic replication impairs host colonization by a latency-deficient mutant of murine gammaherpesvirus-68

Journal of General Virology

Volumn 85, Issue 1, 2004, Pages 137-146

  May, Janet S ^a   Coleman, Heather M ^a   Smillie, Belinda ^a   Efstathiou, Stacey ^a   Stevenson, Philip G ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSACTIVATOR PROTEIN; VIRUS DNA;

5' UNTRANSLATED REGION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; FIBROBLAST CULTURE; GENE EXPRESSION REGULATION; GENE INSERTION; GENETIC TRANSCRIPTION; HERPES VIRUS; HERPES VIRUS INFECTION; IMMUNE DEFICIENCY; IN VITRO STUDY; IN VIVO STUDY; INFECTIOUS MONONUCLEOSIS; LYSIS; MOUSE; NONHUMAN; OPEN READING FRAME; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; SPLEEN; TRANSCRIPTION REGULATION; VIRUS ATTENUATION; VIRUS CELL INTERACTION; VIRUS LATENCY; VIRUS MUTANT; VIRUS REPLICATION; WILD TYPE;

ANIMALS; BASE SEQUENCE; CELL LINE; CRICETINAE; FEMALE; GAMMAHERPESVIRINAE; GENE EXPRESSION REGULATION, VIRAL; HERPESVIRIDAE INFECTIONS; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; MUTATION; NIH 3T3 CELLS; OPEN READING FRAMES; VIRAL PROTEINS; VIRULENCE; VIRUS ACTIVATION; VIRUS LATENCY; VIRUS REPLICATION;

ANIMALIA; DNA VIRUSES; HERPES; HERPESVIRIDAE; MURINAE;

EID: 1642421746     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/vir.0.19599-0     Document Type: Article

References (39)

1. Addison, C. L., Hitt, M., Kunsken, D. & Graham, F. L. (1997). Comparison of the human versus murine cytomegalovirus immediate early gene promoters for transgene expression by adenoviral vectors. J Gen Virol 78, 1653-1661.
2. Adler, H., Messerle, M., Wagner, M. & Koszinowski, U. H. (2000). Cloning and mutagenesis of the routine gammaherpesvirus 68 genome as an infectious bacterial artificial chromosome. J Virol 74, 6964-6974.
3. Adler, H., Messerle, M. & Koszinowski, U. H. (2001). Virus reconstituted from infectious bacterial artificial chromosome (BAC)-cloned inurine gammaherpesvirus 68 acquires wild-type properties in vivo only after excision of BAC vector sequences. J Virol 75, 5692-5696.
4. Ahn, J. W., Powell, K. L., Kellam, P. & Alber, D. G. (2002). Gammaherpesvirus lytic gene expression as characterized by DNA array. J Virol 76, 6244-6256.
5. Binne, U. K., Amon, W. & Farrell, P. J. (2002). Promoter sequences required for reactivation of Epstein-Barr virus from latency. J Virol 76, 10282-10289.
6. Blasdell, K., McCracken, C., Morris, A., Nash, A. A., Begon, M., Bennett, M. & Stewart, J. P. (2003). The wood mouse is a natural host for Murid herpesvirus 4. J Gen Virol 84, 111-113.
7. Blaskovic, D., Stancekova, M., Svobodova, J. & Mistrikova, J. (1980). Isolation of five strains of herpesviruses from two species of free living small rodents. Acta Virol 24, 468.
8. Boname, J. M., Coleman, H. M., May, J. S. & Stevenson, P. G. (2004). Protection against wild-type murine gammaherpesvirus-68 latency by a latency-deficient MHV-68 mutant. J Gen Virol 85, 131-135.
9. Bowden, R. J., Simas, J. P., Davis, A. J. & Efstathiou, S. (1997). Murine gammaherpesvirus 68 encodes tRNA-like sequences which are expressed during latency. J Gen Virol 78, 1675-1687.
10. Bridgeman, A., Stevenson, P. G., Simas, J. P. & Efstathiou, S. (2001). A secreted chemokine binding protein encoded by murine gammaherpesvirus-68 is necessary for the establishment of a normal latent load. J Exp Med 194, 301-312.
11. Chen, J., Ueda, K., Sakakibara, S., Okuno, T., Parravicini, C., Corbellino, M. & Yamanishi, K. (2001). Activation of latent Kaposi's sarcoma-associated herpesvirus by demethylation of the promoter of the lytic transactivator. Proc Natl Acad Sci U S A 98, 4119-4124.
12. Coleman, H. M., de Lima, B., Morton, V. & Stevenson, P. G. (2003). Murine gammaherpesvirus 68 lacking thymidine kinase shows severe attenuation of lyric cycle replication in vivo but still establishes latency. J Virol 77, 2410-2417.
13. Doherty, P. C., Christensen, J. P., Belz, G. T., Stevenson, P. G. & Sangster, M. Y. (2001). Dissecting the host response to a gammaherpesvirus. Philos Trans R Soc Lond B Biol Sci 356, 581-593.
14. Dorsch-Hasler, K., Keil, G. M., Weber, F., Jasin, M., Schaffner, W. & Koszinowski, U. H. (1985). A long and complex enhancer activates transcription of the gene coding for the highly abundant immediate early mRNA in murine cytomegalovirus. Proc Natl Acad Sci U S A 82, 8325-8329.
15. Dutia, B. M., Allen, D. J., Dyson, H. & Nash, A. A. (1999). Type I interferons and IRF-1 play a critical role in the control of a gammaherpesvirus infection. Virology 261, 173-179.
16. Efstathiou, S., Ho, Y. M. & Minson, A. C. (1990). Cloning and molecular characterization of the murine herpesvirus 68 genome. J Gen Virol 71, 1355-1364.
17. Flano, E., Husain, S. M., Sample, J. T., Woodland, D. L. & Blackman, M. A. (2000). Latent murine gamma-herpesviru s infection is established in activated B cells, dendritic cells, and macrophages. J Immunol 165, 1074-1081.
18. Flano, E., Kim, I. J., Woodland, D. L. & Blackman, M. A. (2002). Gamma-herpesvirus latency is preferentially maintained in splenic germinal center and memory B cells. J Exp Med 196, 1363-1372.
19. Gangappa, S., Kapadia, S. B., Speck, S. H. & Virgin, H. W. (2002). Antibody to a lytic cycle viral protein decreases gammaherpesvirus latency in B-cell-deficient mice. J Virol 76, 11460-11468.
20. Gilbert, M. J., Riddell, S. R., Plachter, B. & Greenberg, P. D. (1996). Cytomegalovirus selectively blocks antigen processing and presentation of its immediate-early gene product. Nature 383, 720-722.
21. Gradoville, L., Gerlach, J., Grogan, E., Shedd, D., Nikiforow, S., Metroka, C. & Miller, G. (2000). Kaposi's sarcoma-associated herpesvirus open reading frame 50/Rta protein activates the entire viral lytic cycle in the HH-B2 primary effusion lymphoma cell line. J Virol 74, 6207-6212.
22. Jacoby, M. A., Virgin, H. W. & Speck, S. H. (2002). Disruption of the M2 gene of murine gammaherpesvirus 68 alters splenic latency following intranasal, but not intraperitoneal, inoculation. J Virol 76, 1790-1801.
23. Liu, R., Baillie, J., Sissons, J. G. & Sinclair, J. H. (1994). The transcription factor YY1 binds to negative regulatory elements in the human cytomegalovirus major immediate early enhancer/promoter and mediates repression in non-permissive cells. Nucleic Acids Res 22, 2453-2459.
24. Liu, S., Pavlova, I. V., Virgin, H. W. & Speck, S. H. (2000). Characterization of gammaherpesvirus 68 gene 50 transcription. J Virol 74, 2029-2037.
25. Lukac, D. M., Kirshner, J. R. & Ganem, D. (1999). Transcriptional activation by the product of open reading frame 50 of Kaposi's sarcoma-associated herpesvirus is required for lytic viral reactivation in B cells. J Virol 73, 9348-9361.
26. Marques, S., Efstathiou, S., Smith, K. G., Haury, M. & Simas, J. P. (2003). Selective gene expression of latent murine gamma herpesvirus 68 in B lymphocytes. J Virol 77, 7308-7318.
27. Simas, J. P. & Efstathiou, S. (1998). Murine gammaherpesvirus 68: a model for the study of gammaherpesvirus pathogenesis. Trends Microbiol 6, 276-282.
28. Simas, J. P., Bowden, R. J., Paige, V. & Efstathiou, S. (1998). Four tRNA-like sequences and a serpin homologue encoded by murine gammaherpesvirus 68 are dispensable for lytic replication in vitro and latency in vivo. J Gen Virol 79, 149-153.
29. Stevenson, P. G., May, J. S., Smith, X. G., Marques, S., Adler, H., Koszinowski, U. H., Simas, J. P. & Efstathiou, S. (2002). K3-mediated evasion of CD8(+) T cells aids amplification of a latent gamma-herpesvirus. Nat Immunol 3, 733-740.
30. Stewart, J. P., Usherwood, E. J., Ross, A., Dyson, H. & Nash, T. (1998). Lung epithelial cells are a major site of murine gammaherpesvirus persistence. J Exp Med 187, 1941-1951.
31. Sun, R., Lin, S. F., Gradoville, L., Yuan, Y., Zhu, F. & Miller, G. (1998). A viral gene that activates lytic cycle expression of Kaposi's sarcoma-associated herpesvirus. Proc Natl Acad Sci U S A 95, 10866-10871.
32. Sunil-Chandra, N. P., Efstathiou, S. & Nash, A. A. (1992a). Murine gammaherpesvirus 68 establishes a latent infection in mouse B lymphocytes in vivo. J Gen Virol 73, 3275-3279.
33. Sunil-Chandra, N. P., Efstathiou, S., Arno, J. & Nash, A. A. (1992b). Virological and pathological features of mice infected with murine gammaherpesvirus 68. J Gen Virol 73, 2347-2356.
34. Sunil-Chandra, N. P., Efstathiou, S. & Nash, A. A. (1993). interactions of murine gammaherpesvirus 68 with B and T cell lines. Virology 193, 825-833.
35. Usherwood, E. J., Ross, A. J., Allen, D. J. & Nash, A. A. (1996). Murine gammaherpesvirus-induced splenomegaly: a critical role for CD4 T cells. J Gen Virol 77, 627-630.
36. Virgin, H. W., Latreille, P., Wamsley, P., Hallsworth, K., Weck, K. E., Dal Canto, A. J. & Speck, S. H. (1997). Complete sequence and genomic analysis of murine gammaherpesvirus 68. J Virol 71, 5894-5904.
37. Weck, K. E., Kim, S. S., Virgin, H. W. & Speck, S. H. (1999). Macrophages are the major reservoir of latent murine gammaherpesvirus 68 in peritoneal cells. J Virol 73, 3273-3283.
38. Wu, T. T., Usherwood, E. J., Stewart, J. P., Nash, A. A. & Sun, R. (2000). Rta of murine gammaherpesvirus 68 reactivates the complete lytic cycle from latency. J Virol 74, 3659-3667.
39. Wu, T. T., Tong, L., Rickabaugh, T., Speck, S. & Sun, R. (2001). Function of Rta is essential for lytic replication of murine gammaherpesvirus 68. J Virol 75, 9262-9273.