-
1
-
-
0344188096
-
An adenovirus mutant that replicates selectively in p53-deficient human tumor cells
-
Bischoff, J. R., Kirn, D. H., Williams, A., Heise, C., Horn, S., Muna, M., Ng, L., Nye, J. A., Sampson-Johannes, A., Fattaey, A., and McCormick, F. An adenovirus mutant that replicates selectively in p53-deficient human tumor cells. Science (Wash. DC), 274: 373-376, 1996.
-
(1996)
Science (Wash. DC)
, vol.274
, pp. 373-376
-
-
Bischoff, J.R.1
Kirn, D.H.2
Williams, A.3
Heise, C.4
Horn, S.5
Muna, M.6
Ng, L.7
Nye, J.A.8
Sampson-Johannes, A.9
Fattaey, A.10
McCormick, F.11
-
2
-
-
0030332823
-
Replicating viruses as selective cancer therapeutics
-
Kirn, D. H., and McCormick, F. Replicating viruses as selective cancer therapeutics. Mol. Med. Today, 2: 519-527, 1996.
-
(1996)
Mol. Med. Today
, vol.2
, pp. 519-527
-
-
Kirn, D.H.1
McCormick, F.2
-
3
-
-
0033926002
-
Replicative adenoviruses for cancer therapy
-
Alemany, R., Balague, C., and Curiel, D. T. Replicative adenoviruses for cancer therapy. Nat. Biotechnol., 18: 723-727, 2000.
-
(2000)
Nat. Biotechnol.
, vol.18
, pp. 723-727
-
-
Alemany, R.1
Balague, C.2
Curiel, D.T.3
-
4
-
-
0034722892
-
Replication-selective oncolytic adenoviruses: Virotherapy aimed at genetic targets in cancer
-
Kirn, D. Replication-selective oncolytic adenoviruses: virotherapy aimed at genetic targets in cancer. Oncogene, 19: 6660-6669, 2000.
-
(2000)
Oncogene
, vol.19
, pp. 6660-6669
-
-
Kirn, D.1
-
5
-
-
0035887153
-
A Phase I trial of CV706, a replication-competent, PSA selective oncolytic adenovirus, for the treatment of locally recurrent prostate cancer following radiation therapy
-
DeWeese, T. L., van der Poel, H., Li, S., Mikhak, B., Drew, R., Goemann, M., Hamper, U., DeJong, R., Detorie, N., Rodriguez, R., Haulk, T., DeMarzo, A. M., Piantadosi, S., Yu, D. C., Chen, Y., Henderson, D. R., Carducci, M. A., Nelson, W. G., and Simons, J. W. A Phase I trial of CV706, a replication-competent, PSA selective oncolytic adenovirus, for the treatment of locally recurrent prostate cancer following radiation therapy. Cancer Res., 61: 7464-7472, 2001.
-
(2001)
Cancer Res.
, vol.61
, pp. 7464-7472
-
-
DeWeese, T.L.1
Van Der Poel, H.2
Li, S.3
Mikhak, B.4
Drew, R.5
Goemann, M.6
Hamper, U.7
DeJong, R.8
Detorie, N.9
Rodriguez, R.10
Haulk, T.11
DeMarzo, A.M.12
Piantadosi, S.13
Yu, D.C.14
Chen, Y.15
Henderson, D.R.16
Carducci, M.A.17
Nelson, W.G.18
Simons, J.W.19
-
6
-
-
0036144266
-
Tumor-targeted gene therapy for nasopharyngeal carcinoma
-
Li, J. H., Chia, M., Shi, W., Ngo, D., Strathdee, C. A., Huang, D., Klamut, H., and Liu, F. F. Tumor-targeted gene therapy for nasopharyngeal carcinoma. Cancer Res., 62: 171-178, 2002.
-
(2002)
Cancer Res.
, vol.62
, pp. 171-178
-
-
Li, J.H.1
Chia, M.2
Shi, W.3
Ngo, D.4
Strathdee, C.A.5
Huang, D.6
Klamut, H.7
Liu, F.F.8
-
7
-
-
0035881263
-
A conditional replication-competent adenoviral vector, Ad-OC-E1a, to cotarget prostate cancer and bone stroma in an experimental model of androgen-independent prostate cancer bone metastasis
-
Matsubara, S., Wada, Y., Gardner, T. A., Egawa, M., Park, M. S., Hsieh, C. L., Zhau, H. E., Kao, C., Kamidono, S., Gillenwater, J. Y., and Chung, L. W. A conditional replication-competent adenoviral vector, Ad-OC-E1a, to cotarget prostate cancer and bone stroma in an experimental model of androgen-independent prostate cancer bone metastasis. Cancer Res., 61: 6012-6019, 2001.
-
(2001)
Cancer Res.
, vol.61
, pp. 6012-6019
-
-
Matsubara, S.1
Wada, Y.2
Gardner, T.A.3
Egawa, M.4
Park, M.S.5
Hsieh, C.L.6
Zhau, H.E.7
Kao, C.8
Kamidono, S.9
Gillenwater, J.Y.10
Chung, L.W.11
-
8
-
-
0031036350
-
A mammalian telomerase-associated protein
-
Harrington, L., McPhail, T., Mar, V., Zhou, W., Oulton, R., Bass, M. B., Arruda, I., and Robinson, M. O. A mammalian telomerase-associated protein. Science (Wash. DC), 275: 973-977, 1997.
-
(1997)
Science (Wash. DC)
, vol.275
, pp. 973-977
-
-
Harrington, L.1
McPhail, T.2
Mar, V.3
Zhou, W.4
Oulton, R.5
Bass, M.B.6
Arruda, I.7
Robinson, M.O.8
-
9
-
-
0030745448
-
hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization
-
Meyerson, M., Counter, C. M., Eaton, E. N., Ellisen, L. W., Steiner, P., Caddle, S. D., Ziaugra, L., Beijersbergen, R. L., Davidoff, M. J., Liu, Q., Bacchetti, S., Haber, D. A., and Weinberg, R. A. hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell, 90: 785-795, 1997.
-
(1997)
Cell
, vol.90
, pp. 785-795
-
-
Meyerson, M.1
Counter, C.M.2
Eaton, E.N.3
Ellisen, L.W.4
Steiner, P.5
Caddle, S.D.6
Ziaugra, L.7
Beijersbergen, R.L.8
Davidoff, M.J.9
Liu, Q.10
Bacchetti, S.11
Haber, D.A.12
Weinberg, R.A.13
-
10
-
-
0031809832
-
Expression of TERT in early premalignant lesions and a subset of cells in normal tissues
-
Kolquist, K. A., Ellisen, L. W., Counter, C. M., Meyerson, M., Tan, L. K., Weinberg, R. A., Haber, D. A., and Gerald, W. L. Expression of TERT in early premalignant lesions and a subset of cells in normal tissues. Nat. Genet., 19: 182-186, 1998.
-
(1998)
Nat. Genet.
, vol.19
, pp. 182-186
-
-
Kolquist, K.A.1
Ellisen, L.W.2
Counter, C.M.3
Meyerson, M.4
Tan, L.K.5
Weinberg, R.A.6
Haber, D.A.7
Gerald, W.L.8
-
11
-
-
0028564951
-
Specific association of human telomerase activity with immortal cells and cancer
-
Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L., Coviello, G. M., Wright, W. E., Weinrich, S. L., and Shay, J. W. Specific association of human telomerase activity with immortal cells and cancer. Science (Wash. DC), 266: 2011-2015, 1994.
-
(1994)
Science (Wash. DC)
, vol.266
, pp. 2011-2015
-
-
Kim, N.W.1
Piatyszek, M.A.2
Prowse, K.R.3
Harley, C.B.4
West, M.D.5
Ho, P.L.6
Coviello, G.M.7
Wright, W.E.8
Weinrich, S.L.9
Shay, J.W.10
-
12
-
-
0033082526
-
Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells
-
Takakura, M., Kyo, S., Kanaya, T., Hirano, H., Takeda, J., Yutsudo, M., and Inoue, M. Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells. Cancer Res., 59: 551-557, 1999.
-
(1999)
Cancer Res.
, vol.59
, pp. 551-557
-
-
Takakura, M.1
Kyo, S.2
Kanaya, T.3
Hirano, H.4
Takeda, J.5
Yutsudo, M.6
Inoue, M.7
-
13
-
-
0035030329
-
The telomerase reverse transcriptase promoter drives efficacious tumor suicide gene therapy while preventing hepatotoxicity encountered with constitutive promoters
-
Majumdar, A. S., Hughes, D. E., Lichtsteiner, S. P., Wang, Z., Lebkowski, J. S., and Vasserot, A. P. The telomerase reverse transcriptase promoter drives efficacious tumor suicide gene therapy while preventing hepatotoxicity encountered with constitutive promoters. Gene Ther., 8: 568-578, 2001.
-
(2001)
Gene Ther.
, vol.8
, pp. 568-578
-
-
Majumdar, A.S.1
Hughes, D.E.2
Lichtsteiner, S.P.3
Wang, Z.4
Lebkowski, J.S.5
Vasserot, A.P.6
-
14
-
-
0028559768
-
An effcient and flexible system for construction of adenovirus vectors with insertion or deletions in early regions 1 and 3
-
Bett, A. J., Haddara, W., Prevec, L., and Graham, F. L. An effcient and flexible system for construction of adenovirus vectors with insertion or deletions in early regions 1 and 3. Proc. Natl. Acad. Sci. USA, 91: 8802-8806, 1994.
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 8802-8806
-
-
Bett, A.J.1
Haddara, W.2
Prevec, L.3
Graham, F.L.4
-
15
-
-
0032478271
-
A simplified system for generating recombinant adenoviruses
-
He, T. C., Zhou, S., da Costa, L. T., Yu, J., Kinzler, K. W., and Vogelstein, B. A simplified system for generating recombinant adenoviruses. Proc. Natl. Acad. Sci. USA, 95: 2509-2514, 1998.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 2509-2514
-
-
He, T.C.1
Zhou, S.2
Da Costa, L.T.3
Yu, J.4
Kinzler, K.W.5
Vogelstein, B.6
-
16
-
-
0029315806
-
Methods for construction of adenovirus vectors
-
Graham, F. L., and Prevec, L. Methods for construction of adenovirus vectors. Mol. Biotechnol., 3: 207-220, 1995.
-
(1995)
Mol. Biotechnol.
, vol.3
, pp. 207-220
-
-
Graham, F.L.1
Prevec, L.2
-
17
-
-
0028281493
-
An improved MTT assay using the electron-coupling agent menadione
-
Garn, H., Krause, H., Enzmann, V., and Drossler, K. An improved MTT assay using the electron-coupling agent menadione. J. Immunol. Methods, 168: 253-256, 1994.
-
(1994)
J. Immunol. Methods
, vol.168
, pp. 253-256
-
-
Garn, H.1
Krause, H.2
Enzmann, V.3
Drossler, K.4
-
18
-
-
0037033736
-
ONYX-015: Mechanisms of action and clinical potential of a replication-selective adenovirus
-
Ries, S., and Korn, W. M. ONYX-015: mechanisms of action and clinical potential of a replication-selective adenovirus. Br. J. Cancer, 86: 5-11, 2002.
-
(2002)
Br. J. Cancer
, vol.86
, pp. 5-11
-
-
Ries, S.1
Korn, W.M.2
-
19
-
-
0032665398
-
Onyx plans Phase III trial of ONYX-015 for head and neck cancer
-
Oncologist Magazine
-
Oncologist Magazine. Onyx plans Phase III trial of ONYX-015 for head and neck cancer. Oncologist, 4: 432, 1999.
-
(1999)
Oncologist
, vol.4
, pp. 432
-
-
-
20
-
-
0033831080
-
A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer
-
Khuri, F. R., Nemunaitis, J., Ganly, I., Arseneau, J., Tannock, I. F., Romel, L., Gore, M., Ironside, J., MacDougall, R. H., Heise, C., Randlev, B., Gillenwater, A. M., Bruso, P., Kaye, S. B., Hong, W. K., and Kirn, D. H. A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer. Nat. Med., 6: 879-885, 2000.
-
(2000)
Nat. Med.
, vol.6
, pp. 879-885
-
-
Khuri, F.R.1
Nemunaitis, J.2
Ganly, I.3
Arseneau, J.4
Tannock, I.F.5
Romel, L.6
Gore, M.7
Ironside, J.8
MacDougall, R.H.9
Heise, C.10
Randlev, B.11
Gillenwater, A.M.12
Bruso, P.13
Kaye, S.B.14
Hong, W.K.15
Kirn, D.H.16
-
21
-
-
0030790684
-
Prostate attenuated replication competent adenovirus (ARCA) CN706: A selective cytotoxic for prostate-specific antigen-positive prostate cancer cells
-
Rodriguez, R., Schuur, E. R., Lim, H. Y., Henderson, G. A., Simons, J. W., and Henderson, D. R. Prostate attenuated replication competent adenovirus (ARCA) CN706: a selective cytotoxic for prostate-specific antigen-positive prostate cancer cells. Cancer Res., 57: 2559-2563, 1997.
-
(1997)
Cancer Res.
, vol.57
, pp. 2559-2563
-
-
Rodriguez, R.1
Schuur, E.R.2
Lim, H.Y.3
Henderson, G.A.4
Simons, J.W.5
Henderson, D.R.6
-
22
-
-
0035863499
-
Antitumor synergy of CV787, a prostate cancer-specific adenovirus, and paclitaxel and docetaxel
-
Yu, D. C., Chen, Y., Dilley, J., Li, Y., Embry, M., Zhang, H., Nguyen, N., Amin, P., Oh, J., and Henderson, D. R. Antitumor synergy of CV787, a prostate cancer-specific adenovirus, and paclitaxel and docetaxel. Cancer Res., 61: 517-525, 2001.
-
(2001)
Cancer Res.
, vol.61
, pp. 517-525
-
-
Yu, D.C.1
Chen, Y.2
Dilley, J.3
Li, Y.4
Embry, M.5
Zhang, H.6
Nguyen, N.7
Amin, P.8
Oh, J.9
Henderson, D.R.10
-
23
-
-
0033199188
-
The addition of adenovirus type 5 region E3 enables calydon virus 787 to eliminate distant prostate tumor xenografts
-
Yu, D. C., Chen, Y., Seng, M., Dilley, J., and Henderson, D. R. The addition of adenovirus type 5 region E3 enables calydon virus 787 to eliminate distant prostate tumor xenografts. Cancer Res., 59: 4200-4203, 1999.
-
(1999)
Cancer Res.
, vol.59
, pp. 4200-4203
-
-
Yu, D.C.1
Chen, Y.2
Seng, M.3
Dilley, J.4
Henderson, D.R.5
-
24
-
-
0033805534
-
Selectivity of a replication-competent adenovirus for human breast carcinoma cells expressing the MUC1 antigen
-
Kurihara, T., Brough, D. E., Kovesdi, I., and Kufe, D. W. Selectivity of a replication-competent adenovirus for human breast carcinoma cells expressing the MUC1 antigen. J. Clin. Investig., 106: 763-771, 2000.
-
(2000)
J. Clin. Investig.
, vol.106
, pp. 763-771
-
-
Kurihara, T.1
Brough, D.E.2
Kovesdi, I.3
Kufe, D.W.4
-
25
-
-
0035100867
-
Tissue-specific, tumor-selective, replication-competent adenovirus vector for cancer gene therapy
-
Doronin, K., Kuppuswamy, M., Toth, K., Tollefson, A. E., Krajcsi, P., Krougliak, V., and Wold, W. S. Tissue-specific, tumor-selective, replication-competent adenovirus vector for cancer gene therapy. J. Virol., 75: 3314-3324, 2001.
-
(2001)
J. Virol.
, vol.75
, pp. 3314-3324
-
-
Doronin, K.1
Kuppuswamy, M.2
Toth, K.3
Tollefson, A.E.4
Krajcsi, P.5
Krougliak, V.6
Wold, W.S.7
-
26
-
-
0035503241
-
A midkine promoter-based conditionally replicative adenovirus for treatment of pediatric solid tumors and bone marrow tumor purging
-
Adachi, Y., Reynolds, P. N., Yamamoto, M., Wang, M., Takayama, K., Matsubara, S., Muramatsu, T., and Curiel, D. T. A midkine promoter-based conditionally replicative adenovirus for treatment of pediatric solid tumors and bone marrow tumor purging. Cancer Res., 61: 7882-7888, 2001.
-
(2001)
Cancer Res.
, vol.61
, pp. 7882-7888
-
-
Adachi, Y.1
Reynolds, P.N.2
Yamamoto, M.3
Wang, M.4
Takayama, K.5
Matsubara, S.6
Muramatsu, T.7
Curiel, D.T.8
-
27
-
-
19044386714
-
Selectively replicating adenoviruses targeting deregulated E2F activity are potent, systemic antitumor agents
-
Johnson, L., Shen, A., Boyle, L., Kunich, J., Pandey, K., Lemmon, M., Hermiston, T., Giedlin, M., McCormick, F., and Fattaey, A. Selectively replicating adenoviruses targeting deregulated E2F activity are potent, systemic antitumor agents. Cancer Cell, 1: 325-337, 2002.
-
(2002)
Cancer Cell
, vol.1
, pp. 325-337
-
-
Johnson, L.1
Shen, A.2
Boyle, L.3
Kunich, J.4
Pandey, K.5
Lemmon, M.6
Hermiston, T.7
Giedlin, M.8
McCormick, F.9
Fattaey, A.10
-
28
-
-
17944378992
-
Traditional and emerging molecular markers in neuroblastoma prognosis: The good, the bad and the ugly
-
Poremba, C., Hero, B., Goertz, H. G., Scheel, C., Wai, D., Schaefer, K. L., Christiansen, H., Berthold, F., Juergens, H., Boecker, W., and Dockhorn-Dworniczak, B. Traditional and emerging molecular markers in neuroblastoma prognosis: the good, the bad and the ugly. Klin. Padiatr., 213: 186-190, 2001.
-
(2001)
Klin. Padiatr.
, vol.213
, pp. 186-190
-
-
Poremba, C.1
Hero, B.2
Goertz, H.G.3
Scheel, C.4
Wai, D.5
Schaefer, K.L.6
Christiansen, H.7
Berthold, F.8
Juergens, H.9
Boecker, W.10
Dockhorn-Dworniczak, B.11
-
29
-
-
0035131129
-
Telomerase activity as a prognostic factor in neuroblastomas
-
Streutker, C. J., Thorner, P., Fabricius, N., Weitzman, S., and Zielenska, M. Telomerase activity as a prognostic factor in neuroblastomas. Pediatr. Dev. Pathol., 4: 62-67, 2001.
-
(2001)
Pediatr. Dev. Pathol.
, vol.4
, pp. 62-67
-
-
Streutker, C.J.1
Thorner, P.2
Fabricius, N.3
Weitzman, S.4
Zielenska, M.5
-
30
-
-
0033521960
-
Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation
-
Greenberg, R. A., O'Hagan, R. C., Deng, H., Xiao, Q., Hann, S. R., Adams, R. R., Lichtsteiner, S., Chin, L., Morin, G. B., and DePinho, R. A. Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation. Oncogene, 18: 1219-1226, 1999.
-
(1999)
Oncogene
, vol.18
, pp. 1219-1226
-
-
Greenberg, R.A.1
O'Hagan, R.C.2
Deng, H.3
Xiao, Q.4
Hann, S.R.5
Adams, R.R.6
Lichtsteiner, S.7
Chin, L.8
Morin, G.B.9
DePinho, R.A.10
-
31
-
-
0032911694
-
Direct activation of TERT transcription by c-MYC
-
Wu, K. J., Grandori, C., Amacker, M., Simon-Vermot, N., Polack, A., Lingner, J., and Dalla-Favera, R. Direct activation of TERT transcription by c-MYC. Nat. Genet., 21: 220-224, 1999.
-
(1999)
Nat. Genet.
, vol.21
, pp. 220-224
-
-
Wu, K.J.1
Grandori, C.2
Amacker, M.3
Simon-Vermot, N.4
Polack, A.5
Lingner, J.6
Dalla-Favera, R.7
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