Prulifloxacin: In vitro (HERG current) and in vivo (conscious dog) assessment of cardiac risk

European Journal of Pharmacology

Volumn 477, Issue 1, 2003, Pages 69-72

  Lacroix, Pierre ^a   Crumb, William J ^b   Durando, Lucia ^c   Ciottoli, Giovanni B ^c  

^a Porsolt and Partners Pharmacology   (France)

^b ZENAS TECHNOLOGIES LLC   (United States)

^c Università Politecnica delle Marche ACRAF Gruppo Angelini   (Italy)

Author keywords

Cardiac risk assessment; ECG (electrocardiogram); HERG current; Prulifloxacin; QT prolongation

Indexed keywords

AF 3013; AMOXICILLIN; ANTIBIOTIC AGENT; DRUG METABOLITE; MOXIFLOXACIN; PHENOBARBITAL; POTASSIUM CHANNEL HERG; PRULIFLOXACIN; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOTOXICITY; CARDIOVASCULAR RISK; CONCENTRATION RESPONSE; CONSCIOUSNESS; CONTROLLED STUDY; DOG; DRUG SCREENING; EMBRYO; HUMAN; HUMAN CELL; IC 50; INHIBITION KINETICS; NONHUMAN; PRIORITY JOURNAL; QT INTERVAL; QT PROLONGATION; RISK ASSESSMENT; TELEMETRY;

ADMINISTRATION, ORAL; ANIMALS; ANTI-BACTERIAL AGENTS; AZA COMPOUNDS; CELL LINE; CIPROFLOXACIN; DIOXOLANES; DNA-BINDING PROTEINS; DOGS; FLUOROQUINOLONES; PATCH-CLAMP TECHNIQUES; PIPERAZINES; POTASSIUM CHANNEL BLOCKERS; QUINOLINES; QUINOLONES; TELEMETRY; TRANS-ACTIVATORS;

EID: 1642388705     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(03)02180-0     Document Type: Article

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