Sparfloxacin but not levofloxacin or ofloxacin prolongs cardiac repolarization in rabbit Purkinje fibers

Fundamental and Clinical Pharmacology

Volumn 12, Issue 1, 1998, Pages 70-76

  Adamantidis, M M ^a   Dumotier, B M ^a   Caron, J F ^a   Bordet, R ^a  

^a UNIV LILLE   (France)

Author keywords

Cardiac Purkinje fibers; Early afterdepolarization; Levofloxacin; Ofloxacin; Repolarization; Sparfloxacin

Indexed keywords

LEVOFLOXACIN; OFLOXACIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SPARFLOXACIN;

ACTION POTENTIAL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; HEART ELECTROPHYSIOLOGY; HEART REPOLARIZATION; IN VITRO STUDY; MICROELECTRODE; NONHUMAN; PRIORITY JOURNAL; PURKINJE FIBER; QT INTERVAL; RABBIT;

EID: 0031881199     PISSN: 07673981     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1472-8206.1998.tb00926.x     Document Type: Article

References (32)

1. Adamantidis MM, Kerram P, Caron JF, Dupuis BA, Droperidol exerts dual effects on repolarization and induces early afterdepolarizations and triggered activity in rabbit Purkinje fibers. J Pharmacol Exp Ther 1993 ; 266 : 884-93
2. Adamantidis MM, Kerram P, Dupuis BA. In vitro electrophysiological detection of iatrogenic arrhythmogenicity. Fundam Clin Pharmacol 1994 ; 8 : 391-407
3. Adamantidis MM, Lacroix DL, Caron JF, Dupuis BA. Electrophysiological and arrhythmogenic effects of the histamine type I-receptor antagonist astemizole on rabbit Purkinje fibers : clinical relevance. J Cardiovasc Pharmacol 1995 ; 26 : 319-27
4. Antzelevitch C, Sicouri S. Clinical relevance of cardiac arrhythmias generated by early afterdepolarizations. Role of M cells in the generation of U waves, triggered activity and torsades de pointes. J Am Coll Cardiol 1994 ; 23 : 259-77
5. Asano Y, Davidenko JM, Baxter WT, Gray RA, Jalife J. Optical mapping of drug-induced polymorphic arrhythmias and torsades de pointes in isolated rabbit heart. J Am Coll Cardiol 1997 ; 29 : 831-42
6. Benedict CR. The QT interval and drug-associated torsades de pointes. Drug Invest 1993 ; 5 : 69-79
7. Botstein P. Is QT interval prolongation harmful? A regulatory perspective. Am J Cardiol 1993 ; 72 : 50B-2B
8. Brachmann J, Scherlag BJ, Rosenshtraukh LV, Lazzara R. Bradycardia-dependent triggered activity ; relevance to drug-induced multiform ventricular tachycardia. Circulation 1983 ; 68 : 846-56
9. Davidenko JM, Cohen L, Goodrow R. Quinidine-induced action potential prolongation, early afterdepolarizations, and triggered activity in canine Purkinje fibers. Effects of stimulation rate, potassium, and magnesium. Circulation 1989 ; 79 : 674-86
10. Davis R, Bryson HM. Levofloxacin. A review of its antibacterial activity, pharmacokinetics and therapeutic efficacy. Drugs 1994 ; 47 Suppl 4 : 677-700
11. Demolis JL, Charransol A, Funck-Brentano C, Jaillon P. Effects of a single oral dose of sparfloxacin on ventricular repolarization in healthy volunteers. Br J Clin Pharmacol 1996 ; 41 : 499-503
12. El-Sherif N, Zeiler RH, Craelius W, Gough WB, Henkin R. QTU prolongation and polymorphic tachyarrhythmias due to bradycardia-dependent early afterdepolarizations. Afterdepolarizations and ventricular arrhythmias. Circ Res 1988 ; 63 : 286-305
13. El-Sherif N, Careb EP, Yin H, Restivo M. The electrophysiological mechanism of ventricular arrhythmias in the long QT syndrome. Tridimensional mapping of activation and recovery patterns. Circ Res 1996 ; 79 : 474-492
14. Funck-Brentano C. Rate-dependence of class III actions in the heart. Fundam Clin Pharmacol 1993 ; 7 : 51-9
15. Gilmour RF, Moise SN. Triggered activity as a mechanism for inherited ventricular arrhythmias in German shepherd dogs. J Am Coll Cardiol 1996 ; 27 : 1526-33
16. Han HL, Hou CJY, Lauer MR, Sung RJ. Electrophysiologic mechanisms of the long QT interval syndromes and torsades de pointes. Ann Intern Med 1995 ; 122 : 701-14
17. Hondeghem LM, Snyders DJ. Class III antiarrhythmic agents have a lot of potential but a long way to go. Reduced effectiveness and dangers of reverse use-dependence. Circulation 1990 ; 81 : 686-90
18. Iida M, Yasuba M, Nakajima F, Maeda J, Matsuda N, Onishi K. Four-week oral subacute toxicity study of sparfloxacin in beagle dogs. Chemotherapy (Tokyo) 1991 ; 39 Suppl 4 : 195-202
19. Jaillon P, Morganroth J, Brumpt I, Talbot G and The Sparfloxacin Safety Group. Overview of electrocardiographic and cardiovascular safety data for sparfloxacin. J Antimicrob Chemother 1996 ; 37 Suppl A : 161-7
20. Michiels M, Van Peer A, Woestenborghs R, Heykants J. Pharmacokinetics and tissue distribution in the dog. Drug Dev Res 1986 ; 8 : 53-62
21. Mizuki Y, Fujiwara I, Yamaguchi T. Pharmacokinetic interaction related to the chemical structures of fluoroquinoloncs. J Antimicrob Chemother 1996 ; 37 Suppl A : 41-55
22. Montay G. Pharmacokinetics of sparfloxacin in healthy volunteers and patients: a review. J Antimicrob Chemother 1996 ; 37 Suppl A : 27-39
23. Morganroth J. Relation of QTc prolongation on the electrocardiogram to torsades de pointes: definition and mechanisms. Am J Cardiol 1993 ; 72 : 10-13B
24. Nakatsuji K, Kii Y, Miura Y, Ito T. General pharmacology of sparfloxacin, a new quinolone antibacterial agent. 2. Effects on the respiratory, cardiovascular and autonomic nervous system functions. Pharmacometrics 1991 ; 41 Suppl 2 : 157-64
25. Nattel S, Zeng FD. Frequency-dependent effects of antiarrhythmic drugs on action potential duration and refractoriness of canine cardiac Purkinje fibers. J Pharmacol Exp Ther 1984 ; 229 : 283-91
26. Nattel S, Quantz MA. Pharmacological response of quinidine-induced early afterdepolarisations in canine cardiac Purkinje fibres: insights into underlying ionic mechanisms. Cardiovasc Res 1988 ; 22 : 808-17
27. Puisieux FL, Adamantidis MM, Dumotier BM, Dupuis BA. Cisapride-induced prolongation of cardiac action potential and early afterdepolarizations in rabbit Purkinje fibers. Br J Pharmacol 1996 ; 117 : 1377-9
28. Roden DM, Lazzara R, Rosen MR, Schwartz PJ, Towbin J, Vincent M. Multiple mechanisms in the long QT syndrome. Current knowledge, gaps and future direction. Circulation 1996 ; 94 : 1996-2012
29. Rubart M, Pressler ML, Pride HP, Zipes DP. Electrophysiological mechanisms in a canine model of erythromycin-associated long QT syndrome. Circulation 1993 ; 88 : 1832-44
30. Singh BN. When is QT prolongation antiarrhythmic and when is it proarrhythmic? Am J Cardiol 1989 ; 63 : 867-9
31. Surawicz B. Electrophysiologic substrate of torsades de pointes: dispersion of repolarization or early afterdepolarizations? J Am Coll Cardiol 1989 ; 14 : 172-84
32. +-induce early afterdepolarizations in Purkinje fibers. J Cardiovasc Electrophysiol 1994 ; 5 : 933-44