Synthesis and hydrolysis by cathepsin B of fluorogenic substrates with the general structure benzoyl-X-ARG-MCA containing non-natural basic amino acids at position X

Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology

Volumn 1547, Issue 1, 2001, Pages 82-94

  Melo, Robson L ^a   Barbosa Pozzo, Roseli C ^a   Alves, Lira C ^a   Perissutti, Elisa ^b   Caliendo, Giuseppe ^b   Santagada, Vincenzo ^b   Juliano, Luiz ^a   Juliano, Maria A ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

3 Pyridyl alanine; 4 Aminocyclohexyl alanine; 4 Aminomethyl cyclohexyl alanine; 4 Aminomethyl N isopropyl phenylalanine; 4 Aminomethyl phenylalanine; 4 Guanidine phenylalanine; 4 Piperidinyl alanine; Cathepsin B; Cathepsin L; Nim Dimethyl histidine; Papain; Protease

Indexed keywords

ALANINE DERIVATIVE; ALIPHATIC COMPOUND; ARGININE; AROMATIC COMPOUND; CATHEPSIN B; CATHEPSIN L; COUMARIN DERIVATIVE; DIPEPTIDYLCOUMARIN AMIDE DERIVATIVE; HISTIDINE DERIVATIVE; PAPAIN; PHENYLALANINE; PHENYLALANINE DERIVATIVE; RADICAL; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; CONTROLLED STUDY; ENZYME SPECIFICITY; ENZYME SUBSTRATE; HUMAN; HUMAN TISSUE; HYDROLYSIS; PEPTIDE SYNTHESIS; PRIORITY JOURNAL;

AMINO ACIDS, DIAMINO; CATHEPSIN B; CATHEPSINS; CYSTEINE ENDOPEPTIDASES; DRUG DESIGN; ENDOPEPTIDASES; FLUORESCENT DYES; HUMANS; HYDROLYSIS; KINETICS; MOLECULAR STRUCTURE; PAPAIN; PEPTIDES;

EID: 0035810672     PISSN: 01674838     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4838(01)00171-6     Document Type: Article

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