Anti-CagA and anti-VacA antibodies in Helicobacter pylori-infected patients with and without peptic ulcer disease in Serbia and Montenegro

Scandinavian Journal of Gastroenterology

Volumn 39, Issue 3, 2004, Pages 222-226

  Sokic Milutinovic, A ^a   Wex, T ^b   Todorovic, V ^b   Milosavljevic, T ^b   Malfertheiner, P ^b  

^a CLINICAL CENTER OF SERBIA   (Serbia)

^b NONE

Author keywords

CagA; Dyspepsia; Helicobacter pylori; Prevalence; VacA

Indexed keywords

ANTIBODY; CAGA PROTEIN; VACUOLATING TOXIN;

ADULT; ANTIBODY BLOOD LEVEL; ARTICLE; DISEASE ASSOCIATION; DUODENUM ULCER; DYSPEPSIA; ENDOSCOPY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HISTOLOGY; HUMAN; IMMUNOBLOTTING; MAJOR CLINICAL STUDY; MALE; PEPTIC ULCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEROLOGY; SEROPREVALENCE; STOMACH ULCER; YUGOSLAVIA;

ADULT; ANTIBODIES, ANTI-IDIOTYPIC; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; FEMALE; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; IMMUNOGLOBULIN G; MALE; MIDDLE AGED; PEPTIC ULCER; PROSPECTIVE STUDIES; YUGOSLAVIA;

EID: 1642376145     PISSN: 00365521     EISSN: None     Source Type: Journal    
DOI: 10.1080/00365520310008403     Document Type: Article

References (30)

1. Hunt RH, Lam SK. Helicobacter pylori: from art to science. J Gastroenterol Hepatol 1998;13:21-8.
2. Megraud F. Impact of Helicobacter pylori virulence in the outcome of gastroduodenal diseases: lessons from the microbiologist. Dig Dis 2001;19:99-103.
3. Sande N, Nikulin M, Nilsson I, Wadstrom T, Laxen F, Harkonen M, et al. Increased risk of developing atrophic gastritis in patients infected with CagA+ Helicobacter pylori. Scand J Gastroenterol 2001;36:928-33.
4. Peek RM, Miller GG, Tham KT, Perez-Perez GI, Zhao X, Atherton JC, et al. Heightened inflammatory response and cytokine expression in vivo to CagA+ Helicobacter pylori strains. Lab Invest 1995;73:760-70.
5. Takata T, Fujimoto S, Anzai K, Shirotani T, Okada M, Sawae Y, et al. Analysis of the expression of cag A and vac A and the vacuolating activity in 167 isolates from patients with either peptic ulcers or non ulcer dyspepsia. Am J Gastroenterol 1998; 93:30-4.
6. Segal ED, Cha J, Lo J, Falkow S, Tompkins LS. Altered state: involvement of phosphorylated CagA in the induction of host cellular growth changes by Helicobacter pylori. Procl Natl Acad Sci USA 1999;96:14559-64.
7. Crabtree JE, Farmery SM, Lindley IJD, Figura N, Peichl P, Tompkins DS. CagA+ cytotoxic strains of Helicobacter pylori and interleukin 8 in gastric epithelial cell lines. J Clin Pathol 1994;47:945-50.
8. Rudi J, Kolb C, Maiwald M, Kuck D, Sieg A, Galle P, et al. Diversity of Helicobacter pylori VacA and CagA protein expression, cytotoxin production and associated diseases. J Clin Microbiol 1998;36:944-8.
9. Cover TL. The vacuolating cytotoxin of Helicobacter pylori. Mol Microbiol 1996;20:241-6.
10. Atherton JC, Cao P, Peek RM, Tummuru MK, Blaser MJ, Cover TL. Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori: association of specific vac A types with cytotoxin production and peptic ulceration. J Biol Chem 1995;270:17771-7.
11. Ghiara P, Marchetti M, Blaser MJ, Tummuru MK, Cover TL, Segal ED, et al. Role of Helicobacter pylori virulence factors vacuolating cytotoxin, cag A, and urease in a mouse model of disease. Infect Immunol 1995;63:4154-60.
12. Cover TL, Cao P, Lind CD, Tham KT, Blaser MJ. Correlation between vacuolisating cytotoxin production by Helicobacter pylori isolates in vitro and in vivo. Infect Immun 1993;61:5008-12.
13. Supajatura V, Ushio H, Wada A, Yahiro K, Okumura K, Ogawa H, et al. Cutting edge: VacA, a vacuolating cytotoxin of Helicobacter pylori directly activates mast cell for migration and production of proinflammatory cytokines. J Immunol 2002;168: 2603-7.
14. Pai R, Sasaki E, Tarnawski AS. Helicobacter pylori vacuolating cytotoxin alters cytoskeleton associated proteins and interferes with re-epithelization of wounded gastric epithelial monolayers. Cell Biol Int 2000;24:291-301.
15. Xiang Z, Censini S, Bayeli PF, Telford JL, Figura N, Rappuoli R, et al. Analysis of expression of cag A and vac A virulence factors in 43 strains of Helicobacter pylori reveals that clinical isolates can be divided into 2 major types and that cag A is not necessary for expression of vacuolating cytotoxin. Infect Immun 1995;63: 94-8.
16. Collin-Jones DG. Management of dyspepsia. Report of a working party. Lancet 1988;1:575-9.
17. Malfertheiner P, Megraud F, O'Morain CO, Bell D, Bianchi Porro G, Deltenre M, et al. Current European concepts in the management of Helicobacter pylori infection: the Maastricht consensus report. Eur J Gastroenterol Hepatol 1997;9:91-2.
18. Dixon MF, Genta RM, Yardley JH, Correa P. Classification and grading of gastritis. The updated Sydney System. Am J Surg Pathol 1996;20:1161-81.
19. Wesjnen CF, Hendriks HA, Hoes AW, Verweij WM, Werheij TJM, de Wit NJ. New immunoassay for the detection of Helicobacter pylori infection compared with urease test, 13C test and histology: validation in primary care setting. J Microbiol Meth 2001;46:235-40.
20. Carattoli A, Pezzella C, Pitroiust A, Galante A, Pezzotti P, Luzzi I. Cytotoxin-associated gene A and vacuolating cytotoxin A in human isolates of Helicobacter pylori and their association with the clinical status of ulcer disease. Eur J Gastroenterol Hepatol 2000;12:1207-13.
21. Cover TL, Glupczynski Y, Lage AP, Burette A, Tummuru MKR, Perez-Perez GI, et al. Serologic detection of infection with CagA+ Helicobacter pylori strains. J Clin Microbiol 1995;33: 1496-50.
22. Suadicani P, Hein OH, Gyntelberg F. Genetic and life-style determinants of peptic ulcer. Scand J Gastroenterol Hepatol 1999;34:12-7.
23. Graessle S, Grabher G, Gapp G, Preuss E, Datz C, Sandhofer F, et al. Immune response to natural and recombinant antigens of Helicobacter pylori in patients with dyspeptic complaints. Eur J Clin Microbiol Infect Dis 1999;18:636-42.
24. Weel JFL, van der Hulst RWM, Gerrits Y, Roorda P, Feller M, Dankert J, et al. The interrelationship between cytotoxin associated geneA, vacuolating cytotoxin and Helicobacter pylori related diseases. J Infect Dis 1996;173:1171-5.
25. Orsini B, Ciancio G, Surrenti E, Macri G, Biagini MR, Milani S, et al. Serologic detection of CagA positive Helicobacter pylori infection in Northern Italian population: its association with peptic ulcer disease. Helicobacter 1998;3:15-20.
26. Mahachai V, Tangkijvanich P, Wannachai N, Sumpathankul P, Kullavanijaya P. Cag A and vac A: virulence factors of Helicobacter pylori in Thai patients with gastroduodenal diseases. Helicobacter 1999;4:143-7.
27. El-Mahdi AM, Patchet S, Char S, Domizio P, Fedail S, Kumar P. Does cag A contribute to ulcer pathogenesis in a developing country, such as Sudan. Eur J Gastroenterol Hepatol 1998;10: 313-6.
28. Figura N, Guglielemetti P, Rossolini A. Cytotoxin production by Campylobacter pylori strains isolated from patients with peptic ulcer and from patients with chronic gastritis only. J Clin Microbiol 1989;27:225-6.
29. Sepulveda AR, Coelho LGV. Helicobacter pylori and gastric malignancies. Helicobacter 2002;7 Suppl 1:37-42.
30. Kuipers EJ, Pena AS, van Kamp G, Uyterlinde AM, Pals G, Pels NFM, et al. Seroconversion for Helicobacter pylori. Lancet 1993;342:328-31.