메뉴 건너뛰기




Volumn 53, Issue 4, 2004, Pages 296-304

The efficacy of the combination therapy of 5-fluorouracil, cisplatin and leucovorin for hepatocellular carcinoma and its predictable factors

Author keywords

Chemotherapy; Dihydropyrimidine dehydrogenase; Hepatocellular carcinoma; Thymidylate synthase

Indexed keywords

CISPLATIN; DIHYDROPYRIMIDINE DEHYDROGENASE; FLUOROURACIL; FOLINIC ACID; PYRIMIDINE DERIVATIVE; THYMIDYLATE SYNTHASE;

EID: 1642375906     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-003-0725-6     Document Type: Article
Times cited : (29)

References (50)
  • 1
    • 0030942752 scopus 로고    scopus 로고
    • A novel chemotherapy for advanced hepatocellular carcinoma with tumor thrombosis of the main trunk of the portal vein
    • Ando E, Yamashita F, Tanaka M, Tanikawa K (1997) A novel chemotherapy for advanced hepatocellular carcinoma with tumor thrombosis of the main trunk of the portal vein. Cancer 79:1890
    • (1997) Cancer , vol.79 , pp. 1890
    • Ando, E.1    Yamashita, F.2    Tanaka, M.3    Tanikawa, K.4
  • 2
    • 0032997572 scopus 로고    scopus 로고
    • Immunohistochemical quantitation of thymidylate synthase expression in colorectal cancer metastases predicts for clinical outcome to fluorouracil-based chemotherapy
    • Aschele C, Debernardis D, Casazza S, Antonelli G, Tunesi G, Baldo C, Lionetto R, Maley F, Sobrero A (1999) Immunohistochemical quantitation of thymidylate synthase expression in colorectal cancer metastases predicts for clinical outcome to fluorouracil-based chemotherapy. J Clin Oncol 17:1760
    • (1999) J Clin Oncol , vol.17 , pp. 1760
    • Aschele, C.1    Debernardis, D.2    Casazza, S.3    Antonelli, G.4    Tunesi, G.5    Baldo, C.6    Lionetto, R.7    Maley, F.8    Sobrero, A.9
  • 4
    • 0016379917 scopus 로고
    • Relationships between inhibition constants and fractional inhibition in enzyme-catalyzed reactions with different numbers of reactants, different reaction mechanisms, and different types and mechanisms of inhibition
    • Chou TC (1974) Relationships between inhibition constants and fractional inhibition in enzyme-catalyzed reactions with different numbers of reactants, different reaction mechanisms, and different types and mechanisms of inhibition. Mol Pharmacol 10:235
    • (1974) Mol Pharmacol , vol.10 , pp. 235
    • Chou, T.C.1
  • 5
    • 0017706693 scopus 로고
    • A simple generalized equation for the analysis of multiple inhibitions of Michaelis-Menten kinetic systems
    • Chou TC, Talalay P (1977) A simple generalized equation for the analysis of multiple inhibitions of Michaelis-Menten kinetic systems. J Biol Chem 252:6438
    • (1977) J Biol Chem , vol.252 , pp. 6438
    • Chou, T.C.1    Talalay, P.2
  • 6
    • 0021118703 scopus 로고
    • Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors
    • Chou TC, Talalay P (1984) Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 22:27
    • (1984) Adv Enzyme Regul , vol.22 , pp. 27
    • Chou, T.C.1    Talalay, P.2
  • 7
    • 0028153260 scopus 로고
    • Computerized quantitation of synergism and antagonism of taxol, topotecan, and cisplatin against human teratocarcinoma cell growth: A rational approach to clinical protocol design
    • Chou TC, Motzer RJ, Tong Y, Bosl GJ (1994) Computerized quantitation of synergism and antagonism of taxol, topotecan, and cisplatin against human teratocarcinoma cell growth: a rational approach to clinical protocol design. J Natl Cancer Inst 86:1517
    • (1994) J Natl Cancer Inst , vol.86 , pp. 1517
    • Chou, T.C.1    Motzer, R.J.2    Tong, Y.3    Bosl, G.J.4
  • 10
    • 0019415841 scopus 로고
    • Effect of excess folates and deoxyinosine on the activity and site of action of 5-fluorouracil
    • Evans RM, Laskin JD, Hakala MT (1981) Effect of excess folates and deoxyinosine on the activity and site of action of 5-fluorouracil. Cancer Res 41:3288
    • (1981) Cancer Res , vol.41 , pp. 3288
    • Evans, R.M.1    Laskin, J.D.2    Hakala, M.T.3
  • 12
  • 13
    • 0018885426 scopus 로고
    • Pharmacokinetics of 5-fluorouracil administered orally, by rapid intravenous and by slow infusion
    • Fraile RJ, Baker LH, Buroker TR, Horwitz J, Vaitkevicius VK (1980) Pharmacokinetics of 5-fluorouracil administered orally, by rapid intravenous and by slow infusion. Cancer Res 40:2223
    • (1980) Cancer Res , vol.40 , pp. 2223
    • Fraile, R.J.1    Baker, L.H.2    Buroker, T.R.3    Horwitz, J.4    Vaitkevicius, V.K.5
  • 14
    • 0032994009 scopus 로고    scopus 로고
    • 5-Fluorouracil plus high dose levofolinic acid and oral hydroxyurea for the treatment of primary hepatocellular carcinomas: Results of a phase II multicenter study of the Southern Italy Oncology Group (G.O.I.M.)
    • Gebbia V, Maiello E, Serravezza G, Giotta F, Testa A, Borsellino N, Pezzella G, Colucci G (1999) 5-Fluorouracil plus high dose levofolinic acid and oral hydroxyurea for the treatment of primary hepatocellular carcinomas: results of a phase II multicenter study of the Southern Italy Oncology Group (G.O.I.M.). Anticancer Res 19:1407
    • (1999) Anticancer Res , vol.19 , pp. 1407
    • Gebbia, V.1    Maiello, E.2    Serravezza, G.3    Giotta, F.4    Testa, A.5    Borsellino, N.6    Pezzella, G.7    Colucci, G.8
  • 15
    • 0034906625 scopus 로고    scopus 로고
    • Thymidine kinase, thymidylate synthase, and dihydropyrimidine dehydrogenase profiles of cell lines of the National Cancer Institute's Anticancer Drug Screen
    • Grem JL, Danenberg KD, Behan K, Parr A, Young L, Danenberg PV, Nguyen D, Drake J, Monks A, Allegra CJ (2001) Thymidine kinase, thymidylate synthase, and dihydropyrimidine dehydrogenase profiles of cell lines of the National Cancer Institute's Anticancer Drug Screen. Clin Cancer Res 7:999
    • (2001) Clin Cancer Res , vol.7 , pp. 999
    • Grem, J.L.1    Danenberg, K.D.2    Behan, K.3    Parr, A.4    Young, L.5    Danenberg, P.V.6    Nguyen, D.7    Drake, J.8    Monks, A.9    Allegra, C.J.10
  • 16
    • 0027229211 scopus 로고
    • A multivariate analysis of risk factors for hepatocellular carcinogenesis: A prospective observation of 795 patients with viral and alcoholic cirrhosis
    • Ikeda K, Saitoh S, Koida I, Arase Y, Tsubota A, Chayama K, Kumada H, Kawanishi M (1993) A multivariate analysis of risk factors for hepatocellular carcinogenesis: a prospective observation of 795 patients with viral and alcoholic cirrhosis. Hepatology 18:47
    • (1993) Hepatology , vol.18 , pp. 47
    • Ikeda, K.1    Saitoh, S.2    Koida, I.3    Arase, Y.4    Tsubota, A.5    Chayama, K.6    Kumada, H.7    Kawanishi, M.8
  • 17
    • 0032945491 scopus 로고    scopus 로고
    • Dihydropyrimidine dehydrogenase activity and messenger RNA level may be related to the antitumor effect of 5-fluorouracil on human tumor xenografts in nude mice
    • Ishikawa Y, Kubota T, Otani Y, Watanabe M, Teramoto T, Kumai K, Kitajima M, Takechi T, Okabe H, Fukushima M (1999) Dihydropyrimidine dehydrogenase activity and messenger RNA level may be related to the antitumor effect of 5-fluorouracil on human tumor xenografts in nude mice. Clin Cancer Res 5:883
    • (1999) Clin Cancer Res , vol.5 , pp. 883
    • Ishikawa, Y.1    Kubota, T.2    Otani, Y.3    Watanabe, M.4    Teramoto, T.5    Kumai, K.6    Kitajima, M.7    Takechi, T.8    Okabe, H.9    Fukushima, M.10
  • 20
    • 0036511359 scopus 로고    scopus 로고
    • Mechanism(s) of antitumor action in protracted infusion of low dose 5-fluorouracil and cisplatin in gastric carcinoma
    • Kim R, Tanabe K, Inoue H, Toge T (2002) Mechanism(s) of antitumor action in protracted infusion of low dose 5-fluorouracil and cisplatin in gastric carcinoma. Int J Oncol 20:549
    • (2002) Int J Oncol , vol.20 , pp. 549
    • Kim, R.1    Tanabe, K.2    Inoue, H.3    Toge, T.4
  • 22
    • 0025013836 scopus 로고
    • Doxorubicin for unresectable hepatocellular carcinoma. A prospective study on the addition of verapamil
    • Lai EC, Choi TK, Cheng CH, Mok FP, Fan ST, Tan ES, Wong J (1990) Doxorubicin for unresectable hepatocellular carcinoma. A prospective study on the addition of verapamil. Cancer 66:1685
    • (1990) Cancer , vol.66 , pp. 1685
    • Lai, E.C.1    Choi, T.K.2    Cheng, C.H.3    Mok, F.P.4    Fan, S.T.5    Tan, E.S.6    Wong, J.7
  • 23
    • 0032975767 scopus 로고    scopus 로고
    • Small hepatocellular carcinoma: Treatment with radio-frequency ablation versus ethanol injection
    • Livraghi T, Goldberg SN, Lazzaroni S, Meloni F, Solbiati L, Gazelle GS (1999) Small hepatocellular carcinoma: treatment with radio-frequency ablation versus ethanol injection. Radiology 210:655
    • (1999) Radiology , vol.210 , pp. 655
    • Livraghi, T.1    Goldberg, S.N.2    Lazzaroni, S.3    Meloni, F.4    Solbiati, L.5    Gazelle, G.S.6
  • 25
    • 0023462787 scopus 로고
    • Controlled clinical trial of doxorubicin and tamoxifen versus doxorubicin alone in hepatocellular carcinoma
    • Melia WM, Johnson PJ, Williams R (1987) Controlled clinical trial of doxorubicin and tamoxifen versus doxorubicin alone in hepatocellular carcinoma. Cancer Treat Rep 71:1213
    • (1987) Cancer Treat Rep , vol.71 , pp. 1213
    • Melia, W.M.1    Johnson, P.J.2    Williams, R.3
  • 27
    • 0023735134 scopus 로고
    • Chemotherapy of malignant hepatomas with sequential intraarterial doxorubicin and systemic 5-fluorouracil and semustine
    • O'Connell MJ, Hahn RG, Rubin J, Moertel CG (1988) Chemotherapy of malignant hepatomas with sequential intraarterial doxorubicin and systemic 5-fluorouracil and semustine. Cancer 62:1041
    • (1988) Cancer , vol.62 , pp. 1041
    • O'Connell, M.J.1    Hahn, R.G.2    Rubin, J.3    Moertel, C.G.4
  • 29
    • 0033128413 scopus 로고    scopus 로고
    • Hepatic arterial infusion chemotherapy with continuous low dose administration of cisplatin and 5-fluorouracil for multiple recurrence of hepatocellular carcinoma after surgical treatment
    • Okuda K, Tanaka M, Shibata J, Ando E, Ogata T, Kinoshita H, Eriguchi N, Aoyagi S, Tanikawa K (1999) Hepatic arterial infusion chemotherapy with continuous low dose administration of cisplatin and 5-fluorouracil for multiple recurrence of hepatocellular carcinoma after surgical treatment. Oncol Rep 6:587
    • (1999) Oncol Rep , vol.6 , pp. 587
    • Okuda, K.1    Tanaka, M.2    Shibata, J.3    Ando, E.4    Ogata, T.5    Kinoshita, H.6    Eriguchi, N.7    Aoyagi, S.8    Tanikawa, K.9
  • 30
    • 0023520170 scopus 로고
    • A prospective randomized trial of 5-fluorouracil versus 5-fluorouracil and high-dose leucovorin versus 5-fluorouracil and methotrexate in previously untreated patients with advanced colorectal carcinoma
    • Petrelli N, Herrera L, Rustum Y, Burke P, Creaven P, Stulc J, Emrich LJ, Mittelman A (1987) A prospective randomized trial of 5-fluorouracil versus 5-fluorouracil and high-dose leucovorin versus 5-fluorouracil and methotrexate in previously untreated patients with advanced colorectal carcinoma. J Clin Oncol 5:1559
    • (1987) J Clin Oncol , vol.5 , pp. 1559
    • Petrelli, N.1    Herrera, L.2    Rustum, Y.3    Burke, P.4    Creaven, P.5    Stulc, J.6    Emrich, L.J.7    Mittelman, A.8
  • 31
    • 0028800995 scopus 로고
    • 5-Fluorouracil and d,1-leucovorin calcium are active to treat unresectable hepatocellular carcinoma patients: Preliminary results of a phase II study
    • Porta C, Moroni M, Nastasi G, Arcangeli G (1995) 5-Fluorouracil and d,1-leucovorin calcium are active to treat unresectable hepatocellular carcinoma patients: preliminary results of a phase II study. Oncology 52:487
    • (1995) Oncology , vol.52 , pp. 487
    • Porta, C.1    Moroni, M.2    Nastasi, G.3    Arcangeli, G.4
  • 32
    • 0018879695 scopus 로고
    • Increased thymidylate synthetase in 5-fluorodeoxyuridine resistant cultured hepatoma cells
    • Priest DG, Ledford BE, Doig MT (1980) Increased thymidylate synthetase in 5-fluorodeoxyuridine resistant cultured hepatoma cells. Biochem Pharmacol 29:1549
    • (1980) Biochem Pharmacol , vol.29 , pp. 1549
    • Priest, D.G.1    Ledford, B.E.2    Doig, M.T.3
  • 33
    • 0020354139 scopus 로고
    • Thymidylate synthetase overproduction in 5-fluorodeoxyuridine-resistant mouse fibroblasts
    • Rossana C, Gollakota Rao L, Johnson LF (1982) Thymidylate synthetase overproduction in 5-fluorodeoxyuridine-resistant mouse fibroblasts. Mol Cell Biol 2:1118
    • (1982) Mol Cell Biol , vol.2 , pp. 1118
    • Rossana, C.1    Gollakota Rao, L.2    Johnson, L.F.3
  • 35
    • 0037080269 scopus 로고    scopus 로고
    • Combined intraarterial 5-fluorouracil and subcutaneous interferon-alpha therapy for advanced hepatocellular carcinoma with tumor thrombi in the major portal branches
    • Sakon M, Nagano H, Dono K, Nakamori S, Umeshita K, Yamada A, Kawata S, Imai Y, Iijima S, Monden M (2002) Combined intraarterial 5-fluorouracil and subcutaneous interferon-alpha therapy for advanced hepatocellular carcinoma with tumor thrombi in the major portal branches. Cancer 94:435
    • (2002) Cancer , vol.94 , pp. 435
    • Sakon, M.1    Nagano, H.2    Dono, K.3    Nakamori, S.4    Umeshita, K.5    Yamada, A.6    Kawata, S.7    Imai, Y.8    Iijima, S.9    Monden, M.10
  • 37
    • 0022886092 scopus 로고
    • Biochemical basis for cisplatin and 5-fluorouracil synergism in human ovarian carcinoma cells
    • Scanlon KJ, Newman EM, Lu Y, Priest DG (1986) Biochemical basis for cisplatin and 5-fluorouracil synergism in human ovarian carcinoma cells. Proc Natl Acad Sci U S A 83:8923
    • (1986) Proc Natl Acad Sci U S A , vol.83 , pp. 8923
    • Scanlon, K.J.1    Newman, E.M.2    Lu, Y.3    Priest, D.G.4
  • 39
    • 0032882457 scopus 로고    scopus 로고
    • Efficacy of an implanted drug delivery system for advanced hepatocellular carcinoma using 5-fluorouracil, epirubicin and mitomycin C
    • Seno H, Ito K, Kojima K, Nakajima N, Chiba T (1999) Efficacy of an implanted drug delivery system for advanced hepatocellular carcinoma using 5-fluorouracil, epirubicin and mitomycin C. J Gastroenterol Hepatol 14:811
    • (1999) J Gastroenterol Hepatol , vol.14 , pp. 811
    • Seno, H.1    Ito, K.2    Kojima, K.3    Nakajima, N.4    Chiba, T.5
  • 40
    • 0029945320 scopus 로고    scopus 로고
    • Hepatocellular carcinoma in the United States. Prognostic features, treatment outcome, and survival
    • Stuart KE, Anand AJ, Jenkins RL (1996) Hepatocellular carcinoma in the United States. Prognostic features, treatment outcome, and survival. Cancer 77:2217
    • (1996) Cancer , vol.77 , pp. 2217
    • Stuart, K.E.1    Anand, A.J.2    Jenkins, R.L.3
  • 41
    • 0032945057 scopus 로고    scopus 로고
    • Synergistic induction of ICAM-1 expression by cisplatin and 5-fluorouracil in a cancer cell line via a NF-kappaB independent pathway
    • Takizawa K, Kamijo R, Ito D, Hatori M, Sumitani K, Nagumo M (1999) Synergistic induction of ICAM-1 expression by cisplatin and 5-fluorouracil in a cancer cell line via a NF-kappaB independent pathway. Br J Cancer 80:954
    • (1999) Br J Cancer , vol.80 , pp. 954
    • Takizawa, K.1    Kamijo, R.2    Ito, D.3    Hatori, M.4    Sumitani, K.5    Nagumo, M.6
  • 42
    • 0035149476 scopus 로고    scopus 로고
    • Pretreatment with 5-fluorouracil enhances cytotoxicity and retention of DNA-bound platinum in a cisplatin resistant human ovarian cancer cell line
    • Tanaka T, Masuda H, Naito M, Tamai H (2001) Pretreatment with 5-fluorouracil enhances cytotoxicity and retention of DNA-bound platinum in a cisplatin resistant human ovarian cancer cell line. Anticancer Res 21:2463
    • (2001) Anticancer Res , vol.21 , pp. 2463
    • Tanaka, T.1    Masuda, H.2    Naito, M.3    Tamai, H.4
  • 44
    • 0029052408 scopus 로고
    • The efficacy of continuous local arterial infusion of 5-fluorouracil and cisplatin through an implanted reservoir for severe advanced hepatocellular carcinoma
    • Toyoda H, Nakano S, Kumada T, Takeda I, Sugiyama K, Osada T, Kiriyama S, Suga T, Takahashi M (1995) The efficacy of continuous local arterial infusion of 5-fluorouracil and cisplatin through an implanted reservoir for severe advanced hepatocellular carcinoma. Oncology 52:295
    • (1995) Oncology , vol.52 , pp. 295
    • Toyoda, H.1    Nakano, S.2    Kumada, T.3    Takeda, I.4    Sugiyama, K.5    Osada, T.6    Kiriyama, S.7    Suga, T.8    Takahashi, M.9
  • 45
    • 0033636060 scopus 로고    scopus 로고
    • Regulation of dihydropyrimidine dehydrogenase and pyrimidine nucleoside phosphorylase activities by growth factors and subsequent effects on 5-fluorouracil sensitivity in tumor cells
    • Ueda M, Kitaura K, Kusada O, Mochizuki Y, Yamada N, Terai Y, Kumagai K, Ueki K, Ueki M (2000) Regulation of dihydropyrimidine dehydrogenase and pyrimidine nucleoside phosphorylase activities by growth factors and subsequent effects on 5-fluorouracil sensitivity in tumor cells. Jpn J Cancer Res 91:1185
    • (2000) Jpn J Cancer Res , vol.91 , pp. 1185
    • Ueda, M.1    Kitaura, K.2    Kusada, O.3    Mochizuki, Y.4    Yamada, N.5    Terai, Y.6    Kumagai, K.7    Ueki, K.8    Ueki, M.9
  • 46
    • 0031612291 scopus 로고    scopus 로고
    • Clinical pilot study of intrahepatic arterial chemotherapy with methotrexate, 5-fluorouracil, cisplatin and subcutaneous interferon-alpha-2b for patients with locally advanced hepatocellular carcinoma
    • Urabe T, Kaneko S, Matsushita E, Unoura M, Kobayashi K (1998) Clinical pilot study of intrahepatic arterial chemotherapy with methotrexate, 5-fluorouracil, cisplatin and subcutaneous interferon-alpha-2b for patients with locally advanced hepatocellular carcinoma. Oncology 55:39
    • (1998) Oncology , vol.55 , pp. 39
    • Urabe, T.1    Kaneko, S.2    Matsushita, E.3    Unoura, M.4    Kobayashi, K.5
  • 47
    • 0026566322 scopus 로고
    • 5-Fluorouracil and leucovorin in hepatocellular carcinoma
    • van Eeden H, Falkson G, Burger W, Ansell SM (1992) 5-Fluorouracil and leucovorin in hepatocellular carcinoma. Ann Oncol 3:404
    • (1992) Ann Oncol , vol.3 , pp. 404
    • Eeden, H.1    Falkson, G.2    Burger, W.3    Ansell, S.M.4
  • 48
    • 0020067869 scopus 로고
    • Thymidylate synthetase levels as a factor in 5-fluorodeoxyuridine and methotrexate cytotoxicity in gastrointestinal tumor cells
    • Washtien WL (1982) Thymidylate synthetase levels as a factor in 5-fluorodeoxyuridine and methotrexate cytotoxicity in gastrointestinal tumor cells. Mol Pharmacol 21:723
    • (1982) Mol Pharmacol , vol.21 , pp. 723
    • Washtien, W.L.1
  • 49
    • 0036590485 scopus 로고    scopus 로고
    • Novel arterial infusion chemotherapy using cisplatin, 5-fluorouracil, and leucovorin for patients with advanced hepatocellular carcinoma
    • Yamasaki T, Kurokawa F, Shirahashi H, Kusano N, Hironaka K, Masuhara M, Okita K (2002) Novel arterial infusion chemotherapy using cisplatin, 5-fluorouracil, and leucovorin for patients with advanced hepatocellular carcinoma. Hepatol Res 23:7
    • (2002) Hepatol Res , vol.23 , pp. 7
    • Yamasaki, T.1    Kurokawa, F.2    Shirahashi, H.3    Kusano, N.4    Hironaka, K.5    Masuhara, M.6    Okita, K.7
  • 50
    • 0020660706 scopus 로고
    • Relationship of cellular folate cofactor pools to the activity of 5-fluorouracil
    • Yin MB, Zakrzewski SF, Hakala MT (1983) Relationship of cellular folate cofactor pools to the activity of 5-fluorouracil. Mol Pharmacol 23:190
    • (1983) Mol Pharmacol , vol.23 , pp. 190
    • Yin, M.B.1    Zakrzewski, S.F.2    Hakala, M.T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.