Comparative investigation of behavioral, neurotoxicological, and immunotoxicological indices in detection of subacute combined exposure with methyl parathion and propoxur in rats

Ecotoxicology and Environmental Safety

Volumn 57, Issue 3, 2004, Pages 270-277

  Institoris, L ^a   Papp, A ^a   Siroki, O ^a   Banerjee, B D ^b  

^a UNIVERSITY OF SZEGED   (Hungary)

^b UNIVERSITY OF DELHI   (India)

Author keywords

Behavioral toxicity; Immunotoxicity; Methyl parathion; Neurotoxicity; Propoxur; Rat

Indexed keywords

PARATHION METHYL; PROPOXUR;

ECOTOXICOLOGY; RODENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL COUNT; CONTROLLED STUDY; DOSE RESPONSE; DRUG MEGADOSE; ENVIRONMENTAL EXPOSURE; EVOKED AUDITORY RESPONSE; EVOKED SOMATOSENSORY RESPONSE; IMMUNOTOXICITY; LIVER WEIGHT; LOW DRUG DOSE; MALE; NEUROTOXICITY; NONHUMAN; OPEN FIELD BEHAVIOR; ORGAN WEIGHT; PREPULSE INHIBITION; RAT; SPLEEN CELL; STARTLE REFLEX;

ANIMALS; BODY WEIGHT; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENDPOINT DETERMINATION; EVOKED POTENTIALS; EXPLORATORY BEHAVIOR; INSECTICIDES; LIVER; MALE; METHYL PARATHION; PROPOXUR; RATS; RATS, WISTAR; SPLEEN; STARTLE REACTION; TOXICITY TESTS;

RATTUS NORVEGICUS;

EID: 1642336235     PISSN: 01476513     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0147-6513(03)00101-5     Document Type: Article

References (49)

1. Agarwal S.B. A clinical, biochemical, neurobehavioral, and sociopsychological study of 190 patients admitted to hospital as a result of acute organophosphate poisoning. Environ. Res. 62:1993;63-70.
2. Alvares A. Pharmacology and toxicology of carbamates. Ballantyne B., Marrs T.C. Clinical and Experimental Toxicology of Organophosphates and Carbamates. 1992;40-46 Butterworth and Heinemann, Oxford, London, Boston.
3. Anda E., Dura G., Lorinczi I. Effects of carbon monoxide on the peripheral nerves. Egészségtudomány. 28:1984;270-277.
4. ATSDR (Agency for Toxic Substances and Disease Registry), 1990. Toxicological Profile for Methyl Parathion. Public Health Service, US Department of Health and Human Services, Washington, DC.
5. Ballmaier M., Casamenti F., Zoli M., Pepeu G., Spano P. Selective immunolesioning of cholinergic neurons in nucleus basalis magnocellularis impairs prepulse inhibition of acoustic startle. Neuroscience. 108:2001;299-305.
6. Crittenden P.L., Carr R., Pruett S.B. Immunotoxicological assessment of methyl parathion in female B6C3F1 mice. J. Toxicol. Environ. Health. 54:1998;1-20.
7. Dési I., Nagymajtényi L. Neurotoxicologic investigation of the pesticide dichlorvos (DDVP). effects on the central and peripheral nervous system Toxicology. 49:1988;141-148.
8. Dési I., Nagymajtényi L. Electrophysiological biomarkers of an organophosphorous pesticide, dichlorvos. Toxicol. Lett. 107:1999;55-64.
9. Dési I., Nagymajtényi L., Schulz H. EEG changes caused by dimethoate treatment in three generations of rats. NeuroToxicology. 15:1994;731-734.
10. Dési I., Nagymajtényi L., Schulz H., Nehéz M. Epidemiological investigations and experimental model studies on exposure of pesticides. Toxicol. Lett. 96/97:1998;351-359.
11. Fendt M., Koch M. Cholinergic modulation of the acoustic startle response in the caudal pontine reticular nucleus of the rat. Eur. J. Pharmacol. 370:1999;101-107.
12. Gralewicz S., Socko R. Persisting behavioral and electroencephalographic effects of exposure to chlorphenvinphos, an organophosphorous pesticide, in laboratory animals. Int. J. Occup. Med. Environ. Health. 10:1997;375-394.
13. Gupta R.C., Patterson G.T., Dettbarn W.D. Mechanisms of toxicity and tolerance to diisopropylphosphofluoridate at the neuromuscular junction of the rat. Toxicol. Appl. Pharmacol. 84:1986;541-550.
14. Hahn T., Ruhnke M., Luppa H. Inhibition of acetylcholinesterase by organophosphorous insecticide methylparathion in the central nervous system of the golden hamster (Mesocricetus auratus). Acta Histochem. 91:1991;13-19.
15. Institóris L., Siroki O., Dési I. Immunotoxicity study of repeated small doses of dimethoate and methylparathion administered to rats over three generations. Hum. Exp. Toxicol. 14:1995;879-883.
16. Institóris L., Siroki O., Fekete K., Dési I. Immunotoxicological investigation of repeated small doses of dichlorvos (DDVP) in three generations of rats. Int. J. Environ. Health Res. 5:1995;239-245.
17. Institóris L., Siroki O., Dési I., Ündeger Ü. Immunotoxicological examination of repeated dose combined exposure by dimethoate and two heavy metals. Hum. Exp. Toxicol. 18:1999;88-94.
18. Institóris L., Siroki O., Nagymajtényi L. Immunotoxicological investigation of combined subacute propoxur and heavy metal (Cd, Pb) exposure in rats. Cent. Eur. J. Occup. Environ. Med. 6:2000;194-201.
19. Institóris L., Siroki O., Ündeger Ü., Basaran N., Banerjee B.D., Dési I. Detection of the effects of repeated dose combined propoxur and heavy metal exposure by measurement of certain toxicological, haematological and immune function parameters in rats. Toxicology. 163:2001;185-193.
20. Kobayashi H., Yuyama A., Kajita T., Shimura K., Okhawa T., Satoh K. Effects of insecticidal carbamates on brain acetylcholine content, acetylcholinesterase activity and behavior in mice. Toxicol. Lett. 29:1985;153-159.
21. Kumar M.V., Desiraju T. Effect of chronic consumption of methylparathion on rat brain regional acetylcholinesterase activity and on levels of biogenic amines. Toxicology. 75:1992;13-20.
22. Lee T.P., Moscati R., Park B.H. Effects of pesticides on human leukocyte functions. Res. Comm. Chem. Pathol. 23:1979;597-609.
23. Metherate R., Cox C.L., Ashe J.H. Cellular bases of neocortical activation. modulation of neural oscillations by the nucleus basalis and endogenous acethylcholine J. Neurocsi. 12:1992;4701-4711.
24. Milatovic D., Dettbarn W.D. Modification of acetylcholinesterase during adaptation to chronic, subacute paraoxon application in rat. Toxicol. Appl. Pharmacol. 136:1996;20-28.
25. Miyoshi T., Goto I. Serial in vivo determinations of nerve conduction velocity in rat tails. Physiological and pathological changes. Electroencephalog. Clin. Neurophysiol. 35:1973;125-131.
26. Nagymajtényi L., Dési I., Lorencz R. Neurophysiological markers as early signs of organophosphate neurotoxicity. Neurotoxicol. Teratol. 10:1988;429-434.
27. Nagymajtényi, L., Schulz, H., Dési, I., 1992. The use of a combined behavioral and neurotoxicological test battery for the investigation of chronic low-level exposure to xenobiotics. In: Proceeding of the International Symposium on Environmental Contamination in Central and Eastern Europe, Budapest, pp. 84-88.
28. Nagymajtényi L., Dési I., Schulz H. Changes of brain evoked potentials caused by dimethoate treatment in three generations of rats. Neurotoxicology. 15:1994;741-744.
29. OHS (Occupational Health Services Inc.) 1991. MSDS for Methyl Parathion. Occupational Health Services, Inc. Secausus, OR, USA.
30. Park, B.H., Lee, T.P., 1978. Effects of pesticides on human leukocyte function. In: Inadvertent Modification of the Immune Response: The Effects of Foods, Drugs, and Environmental Contaminants. Proceeding of the 4th FDA Science Symposium US FDA. Office of Health Affairs, Rockville, MD, USA, pp. 273-274.
31. Rider J.A., Moeller H.C., Puletti E.J., Swader J.I. Toxicity of parathion, systox, octamethyl pyrophosphoramide, and methyl parathion in man. Toxicol. Appl. Pharmacol. 14:1969;603-611.
32. A receptors as a target for paraoxon-induced toxicity in mammalian neurons. Toxicologist. 15:1995;207.
33. Rocha E.S., Swanson K.L., Aracava Y., Goolsby J.E., Maelicke A., Albuquerque E.X. Paraoxon. cholinesterase-independent stimulation of transmitter release and selective block of ligand-gated channels in cultured hippocampal neurons J. Pharmacol. Exp. Ther. 278:1996;1175-1187.
34. Roney P.L. Jr., Costa L.G., Murphy S.D. Conditioned taste aversion induced by organophosphate compounds in rats. Pharmacol. Biochem. Behav. 24:1986;737-742.
35. Ruppert P.H., Cook L.L., Dean K.F., Reiter L.W. Acute behavioral toxicity of carbaryl and propoxur in adult rats. Pharmacol. Biochem. Behav. 18:1983;79-84.
36. Schulz, H., I. Dési, L., Nagymajtényi, L., 1990. Behavioral effects of subchronic intoxication with parathion methyl in male Wistar rats. Neurotoxicol. Teratol. 12, 125-127.
37. Sheets L.P., Hamilton B.F., Sangha G.K., Thyssen J.H. Subchronic neurotoxicity screening studies with six organophosphate insecticides. an assessment of behavior and morphology relative to cholinesterase inhibition Fundam. Appl. Toxicol. 35:1997;101-119.
38. Sipos M.L., Burchnell V., Galbicka G. Effects of selected anticholinergics on acoustic startle response in rats. J. Appl. Toxicol. 21(Suppl):2001;S95-101.
39. Siroki O., Ündeger Ü., Institóris L., Nehéz M., Basaran N., Nagymajtényi L., Dési I. A study on geno- and immunotoxicological effects of subacute propoxur and pirimicarb exposure in rats. Ecotoxicol. Environ. Saf. 50:2001;76-81.
40. Socko R., Gralewicz S., Gorny R. Long-term behavioral effects of a repeated exposure to chlorphenvinphos in rats. Int. J. Occup. Med. Environ. Health. 12:1999;105-117.
41. Street J.C., Sharma R.P. Alteration of induced cellular and humoral immune responses by pesticides and chemicals of environmental concern. Quantitative studies of immunosuppression by ddt, aroclor 1254, carbaryl, carbofuran, and methylparathion Toxicol. Appl. Pharmacol. 32:1975;587-602.
42. Thiesen F.V., Barros H.M., Tannhauser M., Tannhauser S.L. Behavioral changes and cholinesterase activity of rats acutely treated with propoxur. Jpn. J. Pharmacol. 79:1999;25-31.
43. Tsao T.C., Juang Y.C., Lan R.S., Shieh W.B., Lee C.H. Respiratory failure of acute organophosphate and carbamate poisoning. Chest. 98:1990;631-636.
44. Ündeger Ü., Institóris L., Siroki O., Nehéz M., Dési I. Simultaneous geno- and immunotoxicological investigations for early detection of organophosphate toxicity in rats. Ecotoxicol. Environ. Saf. 45:2000;43-48.
45. Venkataraman B.V., Rani M.A., Andrade C., Joseph T. Correlation of time course of blood acetylcholinesterase activity and toxic manifestations of acute methylparathion in antidote treated rats. Indian J. Physiol. Pharmacol. 38:1994;214-216.
46. WHO (World Health Organisation), 1986a. Organophosphorous insecticides: a general introduction. Environmental Health Criteria 63. WHO, Geneva.
47. WHO (World Health Organisation), 1986b. Carbamate pesticides: a general introduction. Environmental Health Criteria 64. WHO, Geneva.
48. WHO/FAO (World Health Organisation/Food and Agriculture Organisation of the United Nations) Working Groups, 1989. Propoxur. FAO Plant Prod. Prot. Pap. 100/2, 183-214.
49. Zilles K. The Cortex of the Rat. A Stereotaxic Atlas:1982;Springer, Verlag, Berlin, Heidelberg, New York, Tokyo.