Effects of Ethanol Administration and Induction of Anxiety-Related Affective States on the Acoustic Startle Reflex in Sons of Alcohol-Dependent Fathers

Alcoholism: Clinical and Experimental Research

Volumn 28, Issue 3, 2004, Pages 424-432

  Zimmermann, Ulrich ^a,b   Spring, Konstanze ^a   Wittchen, Hans Ulrich ^a   Holsboer, Florian ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^b CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

Author keywords

Alcohol Effects; Anxiety; Fear Potentiation; Genetic Risk; Startle Reflex

Indexed keywords

PLACEBO;

ADULT; AFFECT; ALCOHOL CONSUMPTION; ALCOHOLISM; ANXIETY; CLINICAL ARTICLE; CLINICAL TRIAL; COMORBIDITY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; ELECTROSTIMULATION; EMOTION; FATHER; FEAR; GENETIC RISK; HUMAN; MALE; PHOTOGRAPHY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REVIEW; STARTLE REFLEX;

ACOUSTIC STIMULATION; ADOLESCENT; ADULT; ALCOHOLISM; ANALYSIS OF VARIANCE; ANXIETY; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ETHANOL; FATHERS; HUMANS; MALE; NUCLEAR FAMILY; STARTLE REACTION;

EID: 1642333087     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ALC.0000117835.49673.CF     Document Type: Review

References (29)

1. Allen NB, Trinder J, Brennan C (1999) Affective startle modulation in clinical depression: preliminary findings. Biol Psychiatry 46:542-550.
2. Corr PJ, Wilson GD, Fotiadou M, Kumari V, Gray NS, Checkley SA, Gray JA (1995) Personality and affective modulation of the startle reflex. Person Individ Diff 19:543-553.
3. Cotton NS (1979) The familial incidence of alcoholism. J Stud Alcohol 40:89-116.
4. Curtin JJ, Lang AR, Patrick CJ, Stritzke WG (1998) Alcohol and fear-potentiated startle: the role of competing cognitive demands in the stress-reducing effects of intoxication. J Abnorm Psychol 107: 547-557.
5. Davis M, Falls WA, Campeau S, Kim M (1993) Fear-potentiated startle: a neural and pharmacological analysis. Behav Brain Res 58:175-198.
6. Davis M, Gendelman D, Tischler M, Gendelman P (1982) A primary acoustic startle circuit; lesion and stimulation studies. J Neurosci 2:791-805.
7. Dirks A, Pattij T, Bouwknecht JA, Westphal TT, Hijzen TH, Groenink L, van der Gugten J, Oosting RS, Hen R, Geyer MA, Olivier B (2001) 5-HT1B receptor knockout, but not 5-HT1A receptor knockout mice, show reduced startle reactivity and footshock-induced sensitization, as measured with the acoustic startle response. Behav Brain Res 118:169-178.
8. Filion DL, Dawson ME, Schell AM (1998) The psychological significance of human startle eyeblink modification: a review. Biol Psychol 47:1-43.
9. Finn PR, Earleywine M, Pihl RO (1992) Sensation seeking, stress reactivity, and alcohol dampening discriminate the density of a family history of alcoholism. Alcohol Clin Exp Res 16:585-590.
10. Finn PR, Zeitouni NC, Pihl RO (1990) Effects of alcohol on psychophysiological hyperreactivity to nonaversive and aversive stimuli in men at high risk for alcoholism. J Abnorm Psychol 99:79-85.
11. Grillon C, Ameli R, Foot M, Davis M (1993) Fear-potentiated startle: relationship to the level of state/trait anxiety in healthy subjects. Biol Psychiatry 33:566-574.
12. Grillon C, Ameli R, Woods SW, Merikangas KR, Davis M (1991) Fear-potentiated startle in humans: effects of anticipatory anxiety on the acoustic blink reflex. Psychophysiology 28:588-595.
13. Grillon C, Dierker L, Merikangas KR (1997) Startle modulation in children at risk for anxiety disorders and/or alcoholism. J Am Acad Child Adolesc Psychiatry 36:925-932.
14. Grillon C, Dierker L, Merikangas KR (1998) Fear-potentiated startle in adolescent offspring of parents with anxiety disorders. Biol Psychiatry 44:990-997.
15. Grillon C, Sinha R, Ameli R, O'Malley S (2000) Effects of alcohol on baseline startle and prepulse inhibition in young men at risk for alcoholism and/or anxiety disorders. J Stud Alcohol 61:46-54.
16. Hamm AO, Cuthbert BN, Globisch J, Vailtl D (1997) Fear and the startle reflex: blink modulation and autonomic response patterns in animal and mutilation fearful subjects. Psychophysiology 34:97-107.
17. Harden PW, Pihl RO (1995) Cognitive function, cardiovascular reactivity, and behavior in boys at high risk for alcoholism. J Abnorm Psychol 104:94-103.
18. King AC, Houle T, de Wit H, Holdstock L, Schuster A (2002) Biphasic alcohol response differs in heavy versus light drinkers. Alcohol Clin Experiment Res 26:827-835.
19. Lang PJ, Öhman A, Vaitl D (1988) The international affective picture system (Photographic slides). Center for Research in Psychophysiology, University of Florida, Gainesville, FL.
20. Laux L, Glanzmann P, Schaffner P, Spielberger CD (1981) Das State-Trait-Angstinventar. Theoretische Grundlagen und Handanweisung. Beltz, Weinheim.
21. Levenson RW, Oyama ON, Meek PS (1987) Greater reinforcement from alcohol for those at risk: parental risk, personality risk, and sex. J Abnorm Psychol 96:242-253.
22. Lieb R, Isensee B, von Sydow K, Wittchen HU (2000) The early developmental stages of psychopathology study (EDSP): a methodological update. Eur Addict Res 6:170-182.
23. Mathew RJ, Wilson WH, Blazer DG, George LK (1993) Psychiatric disorders in adult children of alcoholics: data from the epidemiologic catchment area project. Am J Psychiatry 150:793-800.
24. Miranda R, Meyerson LA, Buchanan TW, Lovallo WR (2002) Altered emotion-modulated startle in young adults with a family history of alcoholism. Alcohol Clin Exp Res 26:441-448.
25. Prescott CA, Kendler KS (1999) Genetic and environmental contributions to alcohol abuse and dependence in a population-based sample of male twins. Am J Psychiatry 156:34-40.
26. Sinha R, Robinson J, O'Malley S (1998) Stress response dampening: effects of gender and family history of alcoholism and anxiety disorders. Psychopharmacology 137:311-320.
27. Stritzke WGK, Patrick CJ, Lang AR (1995) Alcohol and human emotion: a multidimensional analysis incorporating startle-probe methodology. J Abnorm Psychol 104:114-122.
28. Zuckerman M, Buchsbaum MS, Murphy DL (1980) Sensation seeking and its biological correlates. Psychol Bull 88:187-214.
29. Zimmermann U, Spring K, Kunz S, Lachner G, Uhr M, Wittchen HU, Holsboer F (2004) Effect of ethanol on hypothalamic-pituitary-adrenal system response to psychosocial stress in sons of alcohol-dependent fathers. Neuropsychopharmacology, in press. Published online 01/02/04: www.acnp.org/citations/npp01020403330/default.pdf