Structural Studies of Inhibition of S-Adenosylmethionine Synthetase by Slow, Tight-Binding Intermediate and Product Analogues

Biochemistry

Volumn 43, Issue 12, 2004, Pages 3415-3425

  Markham, George D ^a   Reczkowski, Robert S ^a,b  

^a FOX CHASE CANCER CENTER   (United States)

^b TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CATALYSIS; ELECTRONIC STRUCTURE; ENZYME INHIBITION; ENZYMES; HEAVY IONS; PARAMAGNETIC RESONANCE; PERTURBATION TECHNIQUES; PHOSPHORUS; ULTRAVIOLET SPECTROSCOPY;

AROMATIC PROTEINS; ENERGETIC FEASIBILITY;

BIOCHEMISTRY;

DIIMIDOTRIPHOSPHATE; MAGNESIUM ION; METHIONINE ADENOSYLTRANSFERASE; PHOSPHORUS DERIVATIVE; TRIPOLYPHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CALCULATION; ENZYME INHIBITOR INTERACTION; IONIZATION; ISOMERIZATION; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; REACTION ANALYSIS;

ADENYLYL IMIDODIPHOSPHATE; BINDING, COMPETITIVE; DIPHOSPHONATES; ELECTRON SPIN RESONANCE SPECTROSCOPY; ENZYME INHIBITORS; MAGNESIUM; MANGANESE; METHIONINE ADENOSYLTRANSFERASE; NITROGEN ISOTOPES; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PHOSPHORUS ISOTOPES; POLYPHOSPHATES; PROTEIN BINDING; PROTONS; S-ADENOSYLMETHIONINE; SPECTROPHOTOMETRY, ULTRAVIOLET; THERMODYNAMICS;

EID: 1642328781     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi035953z     Document Type: Article

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