Human leukocyte elastase gene expression is regulated by PU.1 in conjunction with closely associated cytidine-rich and Myb binding sites

Biochimica et Biophysica Acta - Gene Structure and Expression

Volumn 1676, Issue 1, 2004, Pages 104-111

  Sturrock, Anne ^a   Franklin, Kerry F ^a   Norman, Kimberly ^a   Hoidal, John R ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF UTAH HEALTH SCIENCES CENTER   (United States)

Author keywords

Cytidine rich site; Gene transcription; Leukocyte elastase; PU.1; Serine proteinase

Indexed keywords

LEUKOCYTE ELASTASE; ONCOPROTEIN; PROTO ONCOGENE PROTEIN SPI 1; PROTO-ONCOGENE PROTEIN SPI-1; TRANSACTIVATOR PROTEIN;

ARTICLE; B LYMPHOCYTE; BINDING SITE; CELL MATURATION; CHROMOSOME 19; ERYTHROLEUKEMIA CELL; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE LOCUS; GENETIC VARIABILITY; HUMAN; HUMAN CELL; NEUTROPENIA; NEUTROPHIL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN INTERACTION; T LYMPHOCYTE; CELL LINE; DNA SEQUENCE; GEL MOBILITY SHIFT ASSAY; GENETICS; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; SITE DIRECTED MUTAGENESIS;

BASE SEQUENCE; BINDING SITES; CELL LINE; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; HUMANS; LEUKOCYTE ELASTASE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS; SEQUENCE ANALYSIS, DNA; TRANS-ACTIVATORS;

EID: 1642321744     PISSN: 01674781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbaexp.2003.10.005     Document Type: Article

References (36)

1. Watanabe H., Hattori S., Katsuda S., Nakanishi I., Nagai Y. Human neutrophil ealastase: degradation of the basement membrane components and immunolocalization in the tissue. J. Biochem. 108:1990;753-759.
2. Sinha S., Watorek W., Karr S., Giles J., Bode W., Travis J. Primary structure of human neutrophil elastase. Proc. Natl. Acad. Sci. U. S. A. 84:1987;2228-2232.
3. Bieth J.G. Human leukocyte elastase. Pathol. Biol. 36:1988;1108-1111.
4. Vered M., Simon S., Dearing R., Janoff A. Inhibition of neutrophil elastase by bacterial polyanions. Exp. Lung Res. 14:1988;67-83.
5. Dale D.C., Person R.E., Bolyard A.A., Aprikyan A.G., Bos C., Bonilla M.A., Boxer L.A., Kannourakis G., Zeidler C., Welte K., Benson K.F., Horwitz M. Mutations in the gene encoding neutrophil elastase in congenital and cyclic neutropenia. Blood. 96:2000;2317-2322.
6. Takahashi H., Nukiwa T., Yoshimura K., Quick C.D., States D.J., Holmes M.D., Whang-Peng J., Knutsen T., Crystal R.G. Structure of the human neutrophil elastase gene. J. Biol. Chem. 263:1988;14739-14747.
7. Zimmer M., Medcalf R.L., Fink T.M., Mattmann C., Lichter P., Jenne D.E. Three human elastase-like genes coordinately expressed in myelomonocytic lineage are organized as a single genetic locus on 19pter. Proc. Natl. Acad, Sci. U. S. A. 89:1992;8215-8223.
8. Wong E.T.L., Jenne D.E., Zimmer M., Porter S.D., Gilks C.B. Changes in chromatin organization at the neutrophil elastase locus associated with myeloid differentiated. Blood. 94:1999;3730-3736.
9. Sakaue H., Ogawa W., Matsumoto M., Kuroda S., Takata M., Sugimoto T., Spiegelman B.M., Kasuga M. Postranslational control of adipocyte differentiation through activation of phosphoinositide-3-kinase. J. Biol. Chem. 273:1998;28945-28952.
10. Zhang D.E., Hohaus S., Voso M., Chen H.M., Smith L.T., Hetherington C.J., Tenen D.G. Function of PU.1, C/EBP and AML1 in early myelopoiesis: regulation of multiple myeloid CSF receptor promoters. Curr. Top. Microbiol. Immunol. 211:1996;137-147.
11. Sturrock A., Franklin K.F., Hoidal J.R. Human proteinase-3 expression is regulated by PU.1 in conjunction with a cytidine-rich element. J. Biol. Chem. 271:1996;32392-32402.
12. Gardi C., Caverra E., Calzoni P., Marcolongo P., de Santi M., Martorana P.A., Lungarell G. Neutrophil lysosomal dysfunctions in mutant C57 Bl/6J mice: interstrain variations in the content of lysosomal elastase. Biochem. J. 299:1994;237-245.
13. Sanger F., Nicklen S., Coulsen A.R. DNA sequencing with chain terminating inhibitors. Proc. Natl. Acad. Sci. U. S. A. 74:1977;5463-5467.
14. J. Schlug, G.C. Overton, "TESS: Transcription element search software on the WWW. Technical Report CBIL-TR-1997-1001-v0.0 of the Computational Biology and Informatics Laboratory of the School of Medicine, University of Pennsylvania.
15. Fujisawa J.I., Seiki M., Kiyokawa T., Yoshida M. Functional activation of the long terminal repeat of human T-cell leukemia virus type I by transcription factor. Proc. Natl. Acad. Sci. U. S. A. 82:1985;2277-2281.
16. Digman J.D., Leibovitz R.M., Roeder R.G. Accurate transcription is initiated by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1983;1475-1481.
17. Nuchprayoon I., Meyers S., Scott L.M., Suzow J., Hiebert S., Friedman A.D. PEBP2/CBF, the murine homolog of the human myeloid AML1 and PEBP2β/CBFβ proto-oncogenes regulate the murine myeloperoxidase and neutrophil elastase genes in immature myeloid cells. Mol. Cell. Biol. 14:1994;5558-5568.
18. DeKoter R.P., Walsh J.C., Singh H. PU.1 regulates both cytokine dependent proliferation and differentiation of granulocyte/macrophage progenitors. EMBO J. 17:1998;4456-4460.
19. Olson M.C., Scott E.W., Hack A.A., Sa G.H., Tenen D.G., Singh H., Simon M.C. PU.1 is not essential for early myeloid gene expression but is required for terminal myeloid differentiation. Immunity. 3:1995;703-714.
20. Han J., Ulap T., Rado T.A. Expression of the human neutrophil elastase gene: positive and negative transcriptional elements in the 5′ flanking region. Biochem. Biophys. Res. Commun. 181:1991;1462-1468.
21. Srikanth S., Rado T.A. A 30-base pair element is responsible for the myeloid-specific activity of the human neutrophil elastase promoter. J. Biol. Chem. 269:1994;32626-32633.
22. Srikanth S., Rado T.A. PU.1 regulates the expression of the human neutrophil elastase gene. Biochim. Biophys. Acta. 1398:1998;215-223.
23. Berge T., Bergholtz S.L., Brevik Andersson K., Gabrielsen O.S. A novel yeast system for in vivo selection of recognition sequences: defining an optimal c-Myb-responsive element. Nucleic Acids Res. 29:2001;99-111.
24. Nuchprayoon I., Simkevich C.P., Luo M., Friedman A.D., Rosmarin A.G. GABPα cooperates with cMyb and C/EBP to activate the neutrophil elastase promoter. Blood. 89:1997;4546-4554.
25. Rosmarin A.G., Caprio D.G., Kirsch D.G., Handa H., Simkevich C.P. GABPα and PU.1 compete for binding yet cooperate to increase CD 18 (β2 leukocyte integrin) transcription. J. Biol. Chem. 270:1995;23627-23633.
26. Oelgeschlager M., Nuchprayoon I., Lucher B., Friedman A.D. C/EBP, cMyb and PU.1 cooperate to regulate the neutrophil elastase promoter. Mol. Cell. Biol. 16:1996;4717-4725.
27. Fisher R.C., Scott E.W. The role of PU.1 in hematopoiesis. Stem Cells. 16:1998;25-37.
28. Henkel G.W., McKercher S.R., Leenan P.J.M., Maki R.A. Commitment to the monocytic lineage occurs in the absence of the transcription factor PU.1. Blood. 93:1999;2849-2858.
29. Horwitz M., Benson K.F., Person R.E., Aprikyan A.G., Dale D.C. Mutations in LE encoding neutrophil elastase, define a 21-day biological clock in cyclic haematopoiesis. Nat. Genet. 23:1999;433-436.
30. Li F.-Q., Horwitz M. Characterization of mutant elastase in severe congenital neutropenia. J. Biol. Chem. 276:2001;14230-14241.
31. Germeshausen M., Schulze H., Ballmaier M., Zeidler C., Welte K. Mutations in the gene encoding neutrophil elastase (LE) are not sufficient to cause the phenotype of congenital neutropenia. Brit. J. Haematol. 115:2001;222-224.
32. Dong F., Brynes R.K., Tidow N., Welte K., Lowenberg B., Touw I.P. Mutations in the gene for the granulocyte colony-stimulating-factor receptor in patients with acute myeloid leukemia is preceded by severe congenital neutropenia. N. Engl. J. Med. 333:1995;487-493.
33. Tidow N., Pliz C., Teichmann B., Muller-Brechlin A., Germeshausen M., Kasper B., Rauprich P., Sykora S.W., Welte K. Clinical relevance of point mutations in the cytoplasmic domain of the granulocyte-colony-stimulating factor receptor gene in patients with severe congenital neutropenia. Blood. 89:1997;2369-2375.
34. Tidow N., Pliz C., Kasper B., Welte K. Frequency of point mutations in the gene for the G-CSF receptor in patients with chronic neutropenia undergoing G-CSF therapy. Stem Cells. 15(Suppl. 1):1997;113-119.
35. Ganz T., Metcalf J.A., Galin J.I., Boxer L.A., Lehrer R.I. Microbicidal/cytotoxic proteins of neutrophils are deficient in two disorders: Chediak-Higashi syndrome and "specific" granule deficiency. J. Clin. Invest. 82:1988;552-556.
36. Belaaouaj A., McCarthy R., Baumann M., Gao J., Ley T.J., Abraham S.N., Shapiro S.W. Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis. Nat. Med. 4:1998;615-618.