Role of Neuronal KATP Channels and Extraneuronal Monoamine Transporter on Norepinephrine Overflow in a Model of Myocardial Low Flow Ischemia

Journal of Pharmacology and Experimental Therapeutics

Volumn 309, Issue 1, 2004, Pages 42-48

  Burgdorf, Christof ^a   Dendorfer, Andreas ^a   Kurz, Thomas ^a   Schömig, Edgar ^b   Stölting, Ines ^a   Schütte, Frank ^a   Richardt, Gert ^c  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^c Herzzentrum Segeberger Kliniken GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 2 CHLORO 6 N CYCLOPENTYLADENOSINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE A1 RECEPTOR; CARRIER PROTEIN; CORTICOSTEROID; CORTICOSTERONE; CROMAKALIM; DESIPRAMINE; DIAZOXIDE; EXTRANEURONAL MONOAMINE TRANSPORTER; GLIBENCLAMIDE; NORADRENALIN; POTASSIUM CHANNEL; UNCLASSIFIED DRUG; MEMBRANE PROTEIN; MITOCHONDRIAL K(ATP) CHANNEL; TRITIUM;

ANIMAL TISSUE; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; HEART MUSCLE ISCHEMIA; ISOLATED HEART; MALE; NONHUMAN; NORADRENALIN RELEASE; PRIORITY JOURNAL; RAT; SYMPATHETIC TONE; TRANSPORT KINETICS; ANIMAL; DISEASE MODEL; METABOLISM; NERVE CELL; WISTAR RAT;

1-METHYL-4-PHENYLPYRIDINIUM; ANIMALS; DISEASE MODELS, ANIMAL; MALE; MEMBRANE PROTEINS; MYOCARDIAL ISCHEMIA; NEURONS; NOREPINEPHRINE; POTASSIUM CHANNELS; RATS; RATS, WISTAR; RECEPTOR, ADENOSINE A1; TRITIUM;

EID: 1642310908     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.059832     Document Type: Article

References (40)

1. Aguilar-Bryan L, Nichols CG, Wechsler SW, Clement JP 4th, Boyd AE 3rd, Gonzalez G, Herrera-Sosa H, Nguy K, Bryan J, and Nelson DA (1995) Cloning of the beta cell high-affinity sulfonylurea receptor: a regulator of insulin secretion. Science (Wash DC) 268:423-426.
2. Babenko AP, Gonzalez G, Aguilar-Bryan L, and Bryan J (1998) Reconstituted human cardiac KATP channels: functional identity with the native channels from the sarcolemma of human ventricular cells. Circ Res 83:1132-1143.
3. Boehm S and Kubista H (2002) Fine tuning of sympathetic transmitter release via ionotropic and metabotropic presynaptic receptors. Pharmacol Rev 54:43-99.
4. Bryan-Lluka LJ and Vuocolo HE (1993) The effects of (-)-cromakalim and glibenclamide on uptake2 in guinea-pig trachealis muscle. Naunyn-Schmiedeberg's Arch Pharmacol 348:65-69.
5. Burgdorf C, Richardt D, Kurz T, Seyfarth M, Jain D, Katus HA, and Richardt G (2001) Adenosine inhibits norepinephrine release in the postischemic rat heart: the mechanism of neuronal stunning. Cardiovasc Res 49:713-720.
6. Carlsson L, Abrahamsson T, and Almgren O (1986) Release of noradrenaline in myocardial ischemia-importance of local inactivation by neuronal and extraneuronal mechanisms. J Cardiovasc Pharmacol 8:545-553.
7. D'hahan N, Moreau C, Prost AL, Jacquet H, Alekseev AE, Terzic A, and Vivaudou M (1999) Pharmacological plasticity of cardiac ATP-sensitive potassium channels toward diazoxide revealed by ADP. Proc Natl Acad Sci USA 96:12162-12167.
8. Du XJ and Riemersma RA (1991) Reduced neuronal noradrenaline overflow in the ischaemic rat heart: importance of the severity of coronary flow reduction. Basic Res Cardiol 86:11-20.
9. Dunn-Meynell AA, Rawson NE, and Levin BE (1998) Distribution and phenotype of neurons containing the ATP-sensitive K+ channel in rat brain. Brain Res 814:41-54.
10. Dunn-Meynell AA, Routh VH, McArdle JJ, and Levin BE (1997) Low-affinity sulfonylurea binding sites reside on neuronal cell bodies in the brain. Brain Res 745:1-9.
11. Fredholm BB, IJzerman AP, Jacobson KA, Klotz KN and Linden J (2001) International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol Rev 53:527-552.
12. Grover GJ and Garlid KD (2000) ATP-sensitive potassium channels: a review of their cardioprotective pharmacology. J Mol Cell Cardiol 32:677-695.
13. Gründemann D, Schechinger B, Rappold GA, and Schömig E (1998) Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter. Nat Neurosci 1:349-351.
14. Gründemann D and Schömig E (2000) Gene structures of the human non-neuronal monoamine transporters EMT and OCT2. Hum Genet 106:627-635.
15. Hatta E, Maruyama R, Marshall SJ, Imamura M, and Levi R (1999) Bradykinin promotes ischemic norepinephrine release in guinea pig and human hearts. J Pharmacol Exp Ther 288:919-927.
16. Imamura M, Lander HM, and Levi R (1996) Activation of histamine H3-receptors inhibits carrier-mediated norepinephrine release during protracted myocardial ischemia. Comparison with adenosine A1-receptors and alpha2-adrenoceptors. Circ Res 78:475-481.
17. Inagaki N, Gonoi T, Clement JP 4th, Namba N, Inazawa J, Gonzalez G, Aguilar-Bryan L, Seino S, and Bryan J (1995) Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor. Science (Wash DC) 270:1166-1170.
18. Javitch JA, D'Amato RJ, Strittmatter SM, and Snyder SH (1985) Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity. Proc Natl Acad Sci USA 82:2173-2177.
19. Kekuda R, Prasad PD, Wu X, Wang H, Fei YJ, Leibach FH, and Ganapathy V (1998) Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta. J Biol Chem 273:15971-15979.
20. Kurz T, Richardt G, Hagl S, Seyfarth M, and Schömig A (1995) Two different mechanisms of noradrenaline release during normoxia and simulated ischemia in human cardiac tissue. J Mol Cell Cardiol 27:1161-1172.
21. Levi R and Smith NC (2000) Histamine H(3)-receptors: a new frontier in myocardial ischemia. J Pharmacol Exp Ther 292:825-830.
22. Mazenot C, Durand A, Ribuot C, Demenge P, and Godin-Ribuot D (1999) Histamine H3-receptor stimulation is unable to modulate noradrenaline release by the isolated rat heart during ischaemia-reperfusion. Fundam Clin Pharmacol 13:455-460.
23. McLeod RL, Gertner SB, and Hey JA (1994) Species differences in the cardiovascular responses to histamine H3 receptor activation. Eur J Pharmacol 259:211-214.
24. Miura T, Kawamura S, Tatsuno H, Ikeda Y, Mikami S, Iwamoto H, Okamura T, Iwatate M, Kimura M, Dairaku Y, et al. (2001) Ischemic preconditioning attenuates cardiac sympathetic nerve injury via ATP-sensitive potassium channels during myocardial ischemia. Circulation 104:1053-1058.
25. Mohan RM and Paterson DJ (2000) Activation of sulphonylurea-sensitive channels and the NO-cGMP pathway decreases the heart rate response to sympathetic nerve stimulation. Cardiovasc Res 47:81-89.
26. Mubagwa K and Flameng W (2001) Adenosine, adenosine receptors and myocardial protection: an updated overview. Cardiovasc Res 52:25-39.
27. Obst OO, Rose H, and Kammermeier H (1996) Characterization of catecholamine uptake2 in isolated cardiac myocytes. Mol Cell Biochem 163/164:181-183.
28. Oe K, Sperlagh B, Santha E, Matko I, Nagashima H, Foldes FF, and Vizi ES (1999) Modulation of norepinephrine release by ATP-dependent K(+)-channel activators and inhibitors in guinea-pig and human isolated right atrium. Cardiovasc Res 43:125-134.
29. Oka J, Imamura M, Hatta E, Maruyama R, Isaka M, Murashita T, and Yasuda K (2002) Carrier-mediated norepinephrine release and reperfusion arrhythmias induced by protracted ischemia in isolated perfused guinea pig hearts: effect of presynaptic modulation by alpha(2)-adrenoceptor in mild hypothermic ischemia. J Pharmacol Exp Ther 303:681-687.
30. Remme CA, Schumacher CA, de Jong JW, Fiolet JW, de Groot JR, Coronel R, and Wilde AA (2001) K(ATP) channel opening during ischemia: effects on myocardial noradrenaline release and ventricular arrhythmias. J Cardiovasc Pharmacol 38:406-416.
31. Russ H, Gliese M, Sonna J, and Schömig E (1992) The extraneuronal transport mechanism for noradrenaline (uptake2) avidly transports 1-methyl-4-phenylpyridinium (MPP+). Naunyn-Schmiedeberg's Arch Pharmacol 346:158-165.
32. Schömig A (1990) Catecholamines in myocardial ischemia. Systemic and cardiac release. Circulation 82 (Suppl II):II13-II22.
33. Schömig A, Dart AM, Dietz R, Mayer E, and Kübler W (1984) Release of endogenous catecholamines in the ischemic myocardium of the rat. Part A: Locally mediated release. Circ Res 55:689-701.
34. Schömig A, Fischer S, Kurz T, Richardt G, and Schömig E (1987) Nonexocytotic release of endogenous noradrenaline in the ischemic and anoxic rat heart: mechanism and metabolic requirements. Circ Res 60:194-205.
35. Schömig A, Haass M, and Richardt G (1991) Catecholamine release and arrhythmias in acute myocardial ischaemia. Eur Heart J 12 (Suppl F):38-47.
36. Schömig E, Babin-Ebell J, Russ H, and Trendelenburg U (1992) The force driving the extraneuronal transport mechanism for catecholamines (uptake2). Naunyn-Schmiedeberg's Arch Pharmacol 345:437-443.
37. Sesti C, Koyama M, Broekman MJ, Marcus AJ, and Levi R (2003) Ectonucleotidase in sympathetic nerve endings modulates ATP and norepinephrine exocytosis in myocardial ischemia. J Pharmacol Exp Ther 306:238-244.
38. Seyfarth M, Feng Y, Hagl S, Sebening F, Richardt G, and Schömig A (1993) Effect of myocardial ischemia on stimulation-evoked noradrenaline release. Modulated neurotransmission in rat, guinea pig and human cardiac tissue. Circ Res 73:496-502.
39. Wu X, Kekuda R, Huang W, Fei YJ, Leibach FH, Chen J, Conway SJ, and Ganapathy V (1998) Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain. J Biol Chem 273:32776-32786.
40. Yokoshiki H, Sunagawa M, Seki T, and Sperelakis N (1998) ATP-sensitive K+ channels in pancreatic, cardiac and vascular smooth muscle cells. Am J Physiol 274:C25-C37.