Gene structures of the human non-neuronal monoamine transporters EMT and OCT2

Human Genetics

Volumn 106, Issue 6, 2000, Pages 627-635

  Gründemann, Dirk ^a   Schömig, Edgar ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; CARRIER PROTEIN; CATECHOLAMINE; DOPAMINE; HISTAMINE; MONOAMINE; NORADRENALIN; SEROTONIN; TRANSCRIPTION FACTOR;

ARTICLE; BINDING SITE; CPG ISLAND; EXON; GENE STRUCTURE; GENETIC VARIABILITY; HUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; TATA BOX; TRANSCRIPTION REGULATION;

BASE COMPOSITION; BASE SEQUENCE; BIOGENIC MONOAMINES; CARRIER PROTEINS; EXONS; GENOMIC LIBRARY; HUMANS; INTRONS; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; ORGANIC CATION TRANSPORT PROTEINS; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS); SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, NUCLEIC ACID; TRANSCRIPTION, GENETIC;

EID: 18844465361     PISSN: 03406717     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004390050035     Document Type: Article

References (43)

1. Barnes WM (1994) PCR amplification of up to 35-kb DNA with high fidelity and high yield from lambda bacteriophage templates. Proc Natl Acad Sci USA 91:2216-2220
2. Breidert T, Spitzenberger F, Gründemann D, Schömig E (1998) Catecholamine transport by the organic cation transporter type 1 (OCT1). Br J Pharmacol 125:218-224
3. Brown L, Baer R (1994) HEN1 encodes a 20-kilodalton phosphoprotein that binds an extended e box motif as a homodimer. Mol Cell Biol 14:1245-1255
4. Bucher P (1990) Weight matrix descriptions of four eukaryotic RNA polymerase II promoter elements derived from 502 unrelated promoter sequences. J Mol Biol 212:563-578
5. Busch AE, Karbach U, Miska D, Gorboulev V, Akhoundova A, Volk C, Arndt P, Ulzheimer JC, Sonders MS, Baumann C, Waldegger S, Lang F, Koepsell H (1998) Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine. Mol Pharmacol 54:342-352
6. Chomczynski P (1992) One-hour downward alkaline capillary transfer for blotting of DNA and RNA. Anal Biochem 201:134-139
7. Cross SH, Bird AP (1995) CpG islands and genes. Curr Opin Genet Dev 5:309-314
8. Eisenhofer G, McCarty R, Pacak K, Russ H, Schömig E (1996) Disprocynium 24, a novel inhibitor of the extraneuronal monoamine transporter, has potent effects on the inactivation of circulating noradrenaline and adrenaline in conscious rat. Naunyn-Schmiedebergs Arch Pharmacol 354:287-294
9. Gardiner-Garden M, Frommer M (1987) CpG islands in vertebrate genomes. J Mol Biol 196:261-282
10. Gorboulev V, Ulzheimer JC, Akhoundova A, Ulzheimer-Teuber I, Karbach U, Quester S, Baumann C, Lang F, Busch AE, Koepsell H (1997) Cloning and characterization of two human polyspecific organic cation transporters. DNA Cell Biol 16: 871-881
11. Gründemann D, Gorboulev V, Gambaryan S, Veyhl M, Koepsell H (1994) Drug excretion mediated by a new prototype of poly-specific transporter. Nature 372:549-552
12. Gründemann D, Babin-Ebell J, Martel F, Örding N, Schmidt A, Schömig E (1997) Primary structure and functional expression of the apical organic cation transporter from kidney epithelial LLC-PK1 cells. J Biol Chem 272:10408-10413
13. Gründemann D, Schechinger B, Rappold GA, Schömig E (1998a) Molecular identification of the corticosterone-sensitive extraneuronal monoamine transporter. Nat Neurosci 1:349-351
14. Gründemann D, Köster S, Kiefer N, Breidert T, Engelhardt M, Spitzenberger F, Obermüller N, Schömig E (1998b) Transport of monoamine transmitters by the organic cation transporter type 2 (OCT2). J Biol Chem 273:30915-30920
15. Gründemann D, Liebich G, Kiefer N, Köster S, Schömig E (1999) Selective substrates for non-neuronal monoamine transporters. Mol Pharmacol 56:1-10
16. Ioannou PA, Amemiya CT, Garnes J, Kroisel PM, Shizuya H, Chen C, Batzer MA, Jong PJ de (1994) A new bacteriophage P1-derived vector for the propagation of large human DNA fragments. Nat Genet 6:84-89
17. Iversen LL (1965) The uptake of catechol amines at high perfusion concentrations in the rat isolated heart: a novel catechol amine uptake process. Br J Pharmacol 25:18-33
18. Javahery R, Khachi A, Lo K, Zenzie-Gregory B, Smale ST (1994) DNA sequence requirements for transcriptional initiator activity in mammalian cells. Mol Cell Biol 14:116-127
19. Kadonaga JT, Jones KA, Tijan R (1986) Promoter-specific activation of RNA polymerase II transcription by SpI. Trends Biochem Sci 11:20-23
20. Kekuda R, Prasad PD, Wu X, Wang H, Fei Y-J, Leibach FH, Ganapathy V (1998) Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta. J Biol Chem 273:15971-15979
21. Koehler MR, Wissingor B, Gorboulev V, Koepsell H, Schmid M (1997) The two human organic cation transporter genes SLC22A1 and SLC22A2 are located on chromosome 6q26. Cytogenet Cell Genet 79:198-200
22. Lam DM-K, Fei J, Zhang X-Y, Tam ACW, Zhu L-H, Huang F, King SC, Guo L-H (1993) Molecular cloning and structure of the human (GABATHG) GABA transporter gene. Mol Brain Res 19:227-232
23. Luo DF, Bui MM, Muir A, Maclaren NK, Thomson G, She JX (1995) Affected-sib-pair mapping of a novel susceptibility gene to insulin-dependent diabetes mellitus (IDDM 8) on chromosome 6q25-q27. Am J Hum Genet 57:911-919
24. Mooslehner KA, Allen ND (1999) Cloning of the mouse organic cation transporter 2 gene, Slc22a2, from an enhancer-trap transgene integration locus. Mamm Genome 10:218-224
25. Nagel G, Volk C, Friedrich T, Ulzheimer JC, Bamberg E, Koepsell H (1997) A reevaluation of substrate specificity of the rat cation transporter rOCT1. J Biol Chem 272:31953-31956
26. Okuda M, Saito H, Urakami Y, Takano M, Inui K (1996) cDNA cloning and functional expression of a novel rat kidney organic cation transporter, OCT2. Biochem Biophys Res Commun 224:500-507
27. Overdier DG, Ye H, Peterson RS, Clcvidence DE, Costa RH (1997) The winged helix transcriptional activator HFH-3 is expressed in the distal tubules of embryonic and adult mouse kidney. J Biol Chem 272:13725-13730
28. Russ H, Engel W, Schömig E (1993) Isocyanines and pseudoisocyanines as a novel class of potent noradrenaline transport inhibitors: synthesis, detection, and biological activity. J Med Chem 36:4208-4213
29. Russ H, Staudt K, Martel F, Gliese M, Schömig E (1996) The extraneuronal transporter for monoamine transmitters exists in cells derived from human central nervous system glia. Eur J Neurosci 8:1256-1264
30. Schaefer BC (1995) Revolutions in rapid amplification of cDNA ends: new strategies for polymerase chain reaction cloning of full-length cDNA ends. Anal Biochem 227:255-273
31. Schömig E, Babin-Ebell J, Russ H (1993) 1,1'-Diethyl-2,2'-cyanine (decynium 22) potently inhibits the renal transport of organic cations. Naunyn Schmiedebergs Arch Pharmacol 347: 379-383
32. Schömig E, Spitzenberger F, Engelhardt M, Martel F, Örding N, Gründemann D (1998) Molecular cloning and characterization of two novel transport proteins from rat kidney. FEBS Lett 425:79-86
33. Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai Y, Endou H (1998) Identification of multispedfic organic anion transporter 2 expressed predominantly in the liver. FEBS Lett 429:179-182
34. Senapathy P, Shapiro MB, Harris NL (1990) Splice junctions, branch point sites, and exons: sequence statistics, identification, and applications to genome project. Methods Enzymol 183:252-278
35. Simonson GD, Iwanij V (1995) Genomic organization and promoter sequence of a gene encoding a rat liver-specific type-I transport protein. Gene 154:243-247
36. Simonson GD, Vincent AC, Roberg KJ, Huang Y, Iwanij V (1994) Molecular cloning and characterization of a novel liver-specific transport protein. J Cell Sci 107:1065-1072
37. Strathmann M, Hamilton BA, Mayeda CA, Simon MI, Mcyerowitz EM, Palazzolo MJ (1991) Transposon-facilitated DNA sequencing. Proc Natl Acad Sci USA 88:1247-1250
38. Sumner C, Shinohara T, Durham L, Traub R, Major EO, Amemiya K (1996) Expression of multiple classes of the nuclear factor-1 family in the developing human brain: differential expression of two classes of NF-1 genes. J Neurovirol 2:87-100
39. Tamai I, Ohashi R, Nezu J, Yabuuchi H, Oku A, Shimane M, Sai Y, Tsuji A (1998) Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2. J Biol Chem 273:20378-20382
40. Verhaagh S, Schweifer N, Barlow DP, Zwart R (1999) Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27. Genomics 55:209-218
41. Williams T, Tijan R (1991) Analysis of the DNA-binding and activation properties of the human transcription factor AP-2. Genes Dev 5:670-682
42. Windenger E, Dietze P, Karas H, Knüppel R (1996) TRANSFAC: a database on transcription factors and their DNA binding sites. Nucleic Acids Res 24:238-241
43. Wu X, Prasad PD, Leibach FH, Ganapathy V (1998) cDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family. Biochem Biophys Res Commun 246:589-595