Radiolysis of an aqueous [11C]iomazenil solution

Radiochimica Acta

Volumn 92, Issue 2, 2004, Pages 119-123

  Fukumura, Toshimitsu ^a,b   Yamaguchi, Masatoshi ^c   Suzuki, Kazutoshi ^a  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^b Ion Beam Group   (Japan)

^c FUKUOKA UNIVERSITY   (Japan)

Author keywords

11C iomazenil; Deiodination; Hydrated electrons; Radiolysis

Indexed keywords

CARBON; IOMAZENIL;

ARTICLE; DEGRADATION; DEIODINATION; ELECTRON TRANSPORT; PURIFICATION; RADIOCHEMISTRY; RADIOLYSIS; REACTION ANALYSIS;

EID: 1642275264     PISSN: 00338230     EISSN: None     Source Type: Journal    
DOI: 10.1524/ract.92.2.119.27464     Document Type: Article

References (18)

1. Beer, H.-F., Blauenstein, P. A., Hasler, P. H., Delaloye, B., Riccabona, G., Bangerl, I., Hunkeler, W., Bonetti, E. P., Pieri, L., Richards, J. G., Schubiger, P. A.: In vitro and in vivo evaluation of iodine-123-Ro 16-0154: a new imaging agent for SPECT investigations of benzodiazepine receptors. J. Nucl. Med. 31, 1007 (1990).
2. Bremner, J. D., Innis, R. B., White, T., Fujita, M., Silbersweig, D., Goddard, A. W., Staib, L., Stem, E., Cappiello, A., Woods, S., Baldwin, R., Charney, D. S.: SPECT [I-123]iomazenil measurement of the benzodiazepine receptor in panic disorder. Biol. Psychiatry 47, 96 (2000).
3. Dong, Y., Fukuyama, H., Nabatame, H., Yamauchi, H., Shibasaki, H., Yonekura, Y.: Assessment of benzodiazepine receptors using iodine-123-labeled iomazenil single-photon emission computed tomography in patients with ischemic cerebrovascular disease. A comparison with PET study. Stroke 28, 1776 (1997).
4. Ishibashi, M., Sakai, T., Matsuishi, T., Yonekura, Y., Yamashita, Y., Abe,T., Ohnishi, Y., Hayabuchi, N.: Decreased benzodiazepine receptor binding in Machado-Joseph disease. J. Nucl. Med. 39, 1518 (1998).
5. Koshi, Y., Kitamura, S., Ohyama, M., Komiyama, T., Komaba; Y., Sakayori, O., Mishina, M., Ishiwata, A., Terashi, A., Katayama, Y.: Benzodiazepine receptor imaging with iomazenil SPECT in aphasic patients with cerebral infarction. Ann. Nucl. Med. 13, 223 (1999).
6. 123I-iomazenil SPECT. Radiat. Med. 15, 163 (1997).
7. 11C]iomazenil. Nucl. Med. Biol. 22, 659 (1995).
8. 11C-iomazenil. J. Label. Compds. Radiopharm. 32, 169 (1993).
9. 123I]iomazenil: preliminary results of a direct comparison in healthy human subjects. Psychiatry Res. 91, 79 (1999).
10. 11C]Iomazenil in healthy human subjects. Synapse 35, 68 (2000).
11. 11C]RO 15-1788 for PET studies of benzodiazepine receptors. Int. J. Appl. Radiat. Isot. 36, 971 (1985).
12. 11C]Ro 15-4513. Nucl. Med. Biol. 30, 389 (2003).
13. 11C]methylspiperone with high specific activity and high radiochemical purity for PET studies: suppression of its radiolysis. Appl. Rad. Isot. 41, 593 (1990).
14. Anbar, M., Neta, P.: Rate constants for the reactions of hydrated electrons, hydrogen atoms and hydroxyl radicals in aqueous solutions. Int. J. Appl. Radiat. Isot. 18, 493 (1967).
15. Hart, E. J., Gordon, S., Thomas, J. K.: Rate constants of hydrated electron with organic compounds: J. Phys. Chem. 68, 1271 (1964).
16. Anbar, M., Hart, E. J.: The reactivity of aromatic compounds toward hydrated electrons. J. Amer. Chem. Soc. 86, 5633 (1964).
17. Koster, R., Asmus, K.-D.: Reaction of fluorinated benzene with hydrated electrons and hydroxyl radical in aqueous solutions. J. Phys. Chem. 77, 749 (1973).
18. Szutka, A., Thomas, J. K., Gordon, S., Hart, E. J.: Rate constants of hydrated electron reactions with some aromatic acids, alkyl halides, heterocyclic compounds, and Werner complexes. J. Phys. Chem. 69, 289 (1965).