Decomposition of an aqueous solution of [11C]Ro 15-4513: Implication of hydrated electrons in the radiolysis of [11C]Ro 15-4513

Nuclear Medicine and Biology

Volumn 30, Issue 4, 2003, Pages 389-395

  Fukumura, Toshimitsu ^a,b   Akaike, Shihori ^a,c   Yoshida, Yuichirou ^a,d   Suzuki, Kazutoshi ^a  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^b JAPAN STEEL WORKS LTD   (Japan)

^c KEIO UNIVERSITY   (Japan)

^d 141 0032   (Japan)

Author keywords

Hydrated electron; PET; Radiolysis; 11C Ro 15 4513

Indexed keywords

8 AZIDO 5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLIC ACID ETHYL ESTER; AMINE; CARBON 11; COBALT 60; HYDROXYL RADICAL; SCAVENGER; SODIUM NITRITE;

AQUEOUS SOLUTION; ARTICLE; CHEMICAL PARAMETERS; CHEMICAL PROCEDURES; CHEMICAL STRUCTURE; DRUG DECOMPOSITION; ELECTRON; HYDRATION; MOLECULAR WEIGHT; RADIOACTIVITY; RADIOLYSIS; STRUCTURE ANALYSIS;

EID: 0037720336     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8051(03)00018-0     Document Type: Article

References (14)

1. Anber M., Neta P. Rate constants for the reactions of hydrated electrons, hydrogen atoms and hydroxyl radicals in aqueous solutions. Int. J. Appl. Radiat. Isot. 18:1967;493.
2. 11C]Ro 15-4513, a ligand for visualization of benzodiazepine receptor binding. Preparation, autoradiography and positron emission tomography. Psychopharmacology (Berl). 108:1992;16-22.
3. 11C]Ro15-4513 in human brain measured with PET. Neurosci. Lett. 12:1992;133-136.
4. Kennedy A.R., Symons M.C. 'Water structure' versus 'radical scavenger' theories as explanations for the suppressive effects of DMSO and related compounds on radiation-induced transformation in vitro. Carcinogenesis. 8:1987;683-688.
5. MacGregor R.R., Schlyer D.J., Fowler J.S., Wolf A.P., Shiue C.Y. Fluorine-18-N-methylspiroperidol radiolytic decomposition as a consequence of high specific activity and high dose levels . J. Nucl. Med. 28:1987;60-67.
6. 3H]Ro 15-4513 in rat hippocampus comparison between in vitro and in vivo binding . Neurosci. Lett. 250:1998;161-164.
7. 11C]Ro15-4513 synthesis. J. Labeled. Compds. Radiopharm. 44:(Suppl 1):2001;S995-S996.
8. 11C]FLB 457 binding measured by PET. Synapse. 41:2001;87-95.
9. Suhara T., Sudo Y., Okauchi T., Maeda J., Kawabe K., Suzuki K., Okubo Y., Nakashima Y., Ito H., Tanada S., Halldin C., Farde L. Extrastriatal dopamine D2 receptor density and affinity in the human brain measured by 3D PET. Int. J. Neuropsychopharmacol. 2:1999;73-82.
10. 11C]RO 15-1788 for PET studies of benzodiazepine receptors. Int. J. App. Radiat. Isot. 36:1985;971-976.
11. 11C]methylspiperone with high specific activity and high radiochemical purity for PET studies suppression of its radiolysis . Appl. Radiat. Isot. 41:1990;593-599.
12. 11C]Ro15-4513-. J. Labeled. Compds. Radiopharm. 42:(suppl 1):1999;S129-S131.
13. 2 gas target effect of irradiation dose, irradiation history, oxygen content and beam energy . Radiochim. Acta. 88:2000;211-215.
14. Wild D., Dirr A. Synthesis of 2-azido-3-methylimidazo[4,5-f]quinoline and photolytic generation of a highly reactive and mutagenic IQ derivative. Carcinogenesis. 9:1988;869-871.