Aggravation of absence seizures by carbamazepine in a genetic rat model does not induce neuronal c-Fos activation

Clinical Neuropharmacology

Volumn 28, Issue 2, 2005, Pages 60-65

  Wallengren, Charlott ^a   Li, Simon ^a   Morris, Margaret J ^a   Jupp, Bianca ^a   O'Brien, Terence J ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Absence epilepsy; Carbamazepine; cFos immunohistochemistry; Seizure aggravation; Thalamocortical circuitry

Indexed keywords

CARBAMAZEPINE; PROTEIN C FOS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL SYNCHRONIZATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ACTIVITY; DISEASE DURATION; DISEASE EXACERBATION; ELECTRODE; FEMALE; IMMUNOHISTOCHEMISTRY; NERVE CELL; NONHUMAN; ONCOGENE C FOS; OVARIECTOMY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; RAT STRAIN; RESPONSE TIME; SEIZURE; SPIKE WAVE; THALAMOCORTICAL TRACT;

ANIMALS; ANTICONVULSANTS; BRAIN; CARBAMAZEPINE; DISEASE MODELS, ANIMAL; ELECTROENCEPHALOGRAPHY; EPILEPSY, ABSENCE; FEMALE; IMMUNOHISTOCHEMISTRY; NEURAL PATHWAYS; NEURONS; OVARIECTOMY; PROTO-ONCOGENE PROTEINS C-FOS; RATS; RATS, MUTANT STRAINS; TIME FACTORS;

EID: 16344395867     PISSN: 03625664     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.wnf.0000159955.87511.bc     Document Type: Article

References (26)

1. Perucca E, Gram L, Avanzini G, et al. Antiepileptic drugs as a cause of worsening seizures. Epilepsia. 1998;39:5-17.
2. Soderpalm B. Anticonvulsants: aspects of their mechanisms of action. Eur J Pain. 2002;6:3-9.
3. Kohling R. Voltage-gated sodium channels in epilepsy. Epilepsia. 2002; 43:1278-1295.
4. Staak R, Pape HC. Contribution of GABA(A) and GABA(B) receptors to thalamic neuronal activity during spontaneous absence seizures in rats. J Neurosci. 2001;21:1378-1384.
5. Perez-Reyes E. Molecular physiology of low-voltage-activated t-type calcium channels. Physiol Rev. 2003;83:117-161.
6. Marescaux C, Vergnes M, Depaulis A. Genetic absence epilepsy in rats from Strasbourg - a review. J Neural Transm Suppl. 1992;35:37-69.
7. Tsakiridou E, Bertollini L, de Curtis M, et al. Selective increase in t-type calcium conductance of reticular thalamic neurons in a rat model of absence epilepsy. J Neurosci. 1995;15:3110-3117.
8. Granger P, Biton B, Faure C, et al. Modulation of the gamma-aminobutyric acid type A receptor by the antiepileptic drugs carbamazepine and phenytoin. Mol Pharmacol. 1995;47:1189-1196.
9. Zhang JD, Saito K. Carbamazepine facilitates effects of GABA on rat hippocampus slices. Chung Kuo Yao Li Hsueh Pao. 1997;18:230-233.
10. Danober L, Deransart C, Depaulis A, et al. Pathophysiological mechanisms of genetic absence epilepsy in the rat. Prog Neurobiol. 1998;55:27-57.
11. Avoli M, Gloor P. Pathophysiology of focal and generalized non-convulsive seizures. In: Wolf P, ed. Epileptic Seizures and Syndromes. London: Libbey & Co, 1994, pp 547-561.
12. Sagar SM, Sharp FR, Curran T. Expression of c-fos protein in the brain: metabolic mapping at the cellular level. Science. 1988;240:1328-1331.
13. Morgan JI, Cohen DR, Hempstead JL, et al. Mapping patterns of c-fos expression in the central nervous system after seizure. Science. 1987;237:192-197.
14. Micheletti G, Vergnes M, Marescaux C, et al. Antiepileptic drug evaluation in a new animal model: spontaneous petit mal epilepsy in the rat. Arzneimittelforschung. 1985;35:483-485.
15. Graumlich JF, McLaughlin RG, Birkhahn D, et al. Carbamazepine pharmacokinetics - pharmacodynamics in genetically epilepsy-prone rats. Eur J Pharmacol. 1999;369:305-311.
16. Barcia JA, Rubio P, Alos M, et al. Anticonvulsant and neurotoxic effects of intracerebroventricular injection of phenytoin, Phenobarbital and carbamazepine in the amygdala-kindling model of epilepsy in the rat. Epilepsy Res. 1999;33:159-166.
17. McLean KJ, O'Brien TJ, Cook MJ, et al. The influence of gender on the aggravation of absence seizures by in the low-dose pentylenetetrazol rat model. Seizure. 2004;13:208-216.
18. Marescaux C, Micheletti G, Vergnes M, et al. A model of chronic spontaneous petit mal-like seizures in the rat: comparison with pentylenetetrazol-induced seizures. Epilepsia. 1984;25:326-331.
19. Jensen FE, Firkusny IR, Mower GD. Differences in c-fos immunoreactivity due to age and mode of seizure induction. Brain Res Mol Brain Res. 1993;17:185-193.
20. Shehab S, Coffey P, Dean P, et al. Regional expression of Fos-like immunoreactivity following seizures induced by pentylenetetrazole and maximal electroshock. Exp Neurol 1992;118:261-274.
21. André V, Pineau N, Motte JE, et al. Mapping of neuronal networks underlying generalized seizures induced by increasing doses of pentylenetetrazol in the immature and adult rat: a c-fos immunohistochemical study. Eur J Neurosci. 1998;10:2094-2106.
22. Zhang X, Ju G, Le Gal La Salle G. Fos expression in GHB-induced generalized absence epilepsy in the thalamus of the rat. Neuroreport. 1991;2:469-472.
23. Willoughby JO, Mackenzie L, Hiscock JJ, et al. Nonconvulsive spike - wave discharges do not induce Fos in cerebro-cortical neurons. Mol Brain Res. 1993;18:178-180.
24. Pinault D. Cellular interactions in the rat somatosensory thalamocortical system during normal and epileptic 5-9 Hz oscillations. J Physiol. 2003;552:881-905.
25. Song I, Kim D, Choi S, et al. Role of the alpha1G T-type calcium channel in spontaneous absence seizures in mutant mice. J Neurosci. 2004;24:5249-5257.
26. Buoni S, Grosso S, Fois A. Lamotrigine in typical absence epilepsy. Brain Dev. 1999;21:303-306.