Role of cdk4, p16INK4, and Rb expression in the prognosis of bronchioloalveolar carcinomas

Respiration

Volumn 72, Issue 1, 2005, Pages 68-73

  Ghazizadeh, Mohammad ^a   Jin, Enjing ^a   Shimizu, Hajime ^a   Fujiwara, Masakazu ^a   Arai, Satoru ^a   Ohaki, Yoshiharu ^a   Takemura, Tamiko ^b   Kawanami, Oichi ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

^b Kochi Red Cross Hospital   (Japan)

Author keywords

Bronchioloalveolar carcinoma; Cyclin dependent kinase 4; p16INK4; Retinoblastoma protein

Indexed keywords

CYCLIN DEPENDENT KINASE 4; PROTEIN P16INK4A; RETINOBLASTOMA PROTEIN; CDK4 PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE; MONOCLONAL ANTIBODY; ONCOPROTEIN; TUMOR MARKER;

ADULT; AGED; ARTICLE; CANCER SURVIVAL; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; LUNG ALVEOLUS CELL CARCINOMA; MALE; MUCINOUS CARCINOMA; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; SURVIVAL RATE; BIOSYNTHESIS; CANCER STAGING; COMPARATIVE STUDY; IMMUNOLOGY; LUNG ALVEOLUS; LUNG TUMOR; METABOLISM; MIDDLE AGED; PATHOLOGY; WESTERN BLOTTING;

ADENOCARCINOMA, BRONCHIOLO-ALVEOLAR; AGED; ANTIBODIES, MONOCLONAL; BLOTTING, WESTERN; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASES; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; MALE; MIDDLE AGED; NEOPLASM STAGING; PROGNOSIS; PROTO-ONCOGENE PROTEINS; PULMONARY ALVEOLI; RETINOBLASTOMA PROTEIN; TUMOR MARKERS, BIOLOGICAL;

EID: 16344383202     PISSN: 00257931     EISSN: None     Source Type: Journal    
DOI: 10.1159/000083403     Document Type: Article

References (26)

1. Anttila MA, Kosma VM, Hongxiu J, Puolakka J, Juhola M, Saarikoski S, Syrjanen K: p21/WAF1 expression as related to p53, cell proliferation and prognosis in epithelial ovarian cancer. Br J Cancer 1999;79:1870-1878.
2. Rudolph P, Olsson H, Bonatz G, Ratjen V, Botle H, Baldetorp B, Ferno M, Parwaresch R, Alm P: Correlation between p53, c-erbB-2, and topoisomerase II alpha expression. DNA ploidy, hormonal receptor status and proliferation in 356 node-negative breast carcinoma: Prognostic implication. J Pathol 1999;187:207-216.
3. Ghazizadeh M, Sasaki Y, Araki T, Aihara K: Prognostic value of proliferative activity of ovarian carcinoma as revealed by PCNA and AgNOR analyses. Am J Clin Pathol 1997;107:451-458.
4. Imamura H, Haga S, Shimizu T, Watanabe O, Kajiwara T, Aiba M: Prognostic significance of MIB1 -determined proliferative activities in intraductal components and invasive foci associated with invasive ductal breast carcinoma. Br J Cancer 1999;79:172-178.
5. Serrano M, Hannon GJ, Beach D: A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 1993;366:704-707.
6. Kamb A, Gruis NA, Weaver-Feldhaus J, Liu Q, Harshman K, Tavtigian SV, Stockert E, Day RS, Johnson BE, Skolinick MH: A cell cycle regulator potentially involved in genesis of many tumor types. Science 1994;264:436-440.
7. Marx J: Link to hereditary melanoma brightens mood for p16 gene. Science 1994;265:1364-1365.
8. Nobori T, Miura K, Wu DJ, Lois A, Takabayashi K, Carson DA: Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature 1994;368:753-756.
9. INK4A inactivation in non-small cell lung cancer cell lines. Cancer Res 1995;55:6200-6209.
10. Barsky SH, Cameron R, Osann KE, et al: Rising incidence of bronchioloalveolar lung carcinoma and its clinicopathologic features. Cancer 1994;73:1163-1170.
11. INK4 expression in resected non-small cell lung tumors. Cancer Res 1996;56:3415-3420.
12. INK4 and retinoblastoma protein status in non-small cell lung cancer: Potential synergistic effect with altered p53 protein on proliferative activity. Cancer Res 1996;56:5557-5562.
13. General Rules for Clinical and Pathological Record of Lung Cancer. The Japan Lung Cancer Society, ed 4. Tokyo, Kanehara, 1995.
14. INK4A in archival human solid tumors: Correlation with retinoblastoma protein expression. Cancer Res 1995;55:6006-6011.
15. Shapiro GI, Edwards CD, Kobzik L, Godleski J, Richards W, Sugarbaker DJ, Rollins BJ: Reciprocal Rb inactivation and p16 expression in primary lung cancers and cell lines. Cancer Res 1995;55:505-509.
16. Sakaguchi M, Fujii Y, Hirabayashi H, Yoon HE, Komoto Y, Oue T, Kusafuka T, Okada A, Matsuda H: Inversely correlated expression of p16 and Rb protein in non-small cell lung cancers: An immunohistochemical study. Int J Cancer 1996;65:442-445.
17. Tsuchiya A, Sakamoto M, Yasuda J, Chuma M, Ohta T, Ohki M, Yasugi T, Taketani Y, Hirohashi S: Expression profiling in ovarian clear cell carcinoma: Identification of hepatocyte nuclear factor-1 beta as a molecular marker and a possible molecular target for therapy of ovarian clear cell carcinoma. Am J Pathol 2003;163:2503-2512.
18. Brambilla E, Moro D, Gazzeri S, Brambilla C: Alterations of expression of Rb, p16 (INK4A) and cyclin D1 in non-small cell lung carcinoma and their clinical significance. J Pathol 1999;188:351-360.
19. McDonald JW, Pilgram TK: Nuclear expression of p53, p21 and cyclin D1 is 14 increased in bronchioloalveolar carcinoma. Histopathology 1999;34:439-446.
20. Ewen ME, Sluss HK, Sherr CJ, Matsushime H, Kato J, Livingston DM: Functional interactions of retinoblastoma protein with mammalian D-type cyclins. Cell 1993;73:487-497.
21. INK4A in ovarian cancer is associated with progression and unfavorable prognosis. Int J Cancer 1997;74:57-63.
22. Halvorsen OJ, Hostmark J, Haukaas S, Hoisaeter PA, Akslen LA: Prognostic significance of p16 and cdk4 proteins in localized prostate carcinoma. Cancer 2000;88:416-424.
23. Alonso SR, Ortiz P, Pollan M, Prez-Gomez B, Sanchez L, Acuna MJ, Pajares R, Martinez-Tello FJ, Hortelano CM, Piris MA, Rodriguez-Peralto JL: Progression in cutaneous malignant melanoma is associated with distinct expression profiles: A tissue microarray-based study. Am J Pathol 2004;164:193-203.
24. INK4a, p53, MDM2, and Rb. Ann Surg 2002;235:51-59.
25. Esposito V, Baldi A, Tonini G, Vincenzi B, Santini M, Ambrogi V, Mineo TC, Persichetti P, Liuzzi G, Montesarchio V, Wolner E, Baldi F, Groeger AM: Analysis of cell cycle regulator proteins in non-small cell lung cancer. J Clin Pathol 2004;57:58-63.
26. INK4B/MTS2, and p18 genes in primary and metastatic lung cancer. Cancer Res 1995;55:1448-1451.