Nifedipine inhibits tumor necrosis factor-α-induced upregulation of monocyte chemoattractant protein-1 mRNA levels by suppressing CD40 expression in endothelial cells

Drugs under Experimental and Clinical Research

Volumn 31, Issue 1, 2005, Pages 13-17

  Yamagishi, Sho Ichi ^a   Takeuchi, M ^b  

^a KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b HOKURIKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ANTAGONIST; CD40 ANTIGEN; CELL SURFACE RECEPTOR; DIHYDROPYRIDINE DERIVATIVE; MESSENGER RNA; MONOCLONAL ANTIBODY; MONOCYTE CHEMOTACTIC PROTEIN 1; NIFEDIPINE; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA RECEPTOR;

ANTIGEN EXPRESSION; ARTICLE; ATHEROSCLEROSIS; BLOOD VESSEL FUNCTION; CHRONIC INFLAMMATION; CONTROLLED STUDY; DRUG MECHANISM; DRUG TARGETING; ENDOTHELIUM CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PATHOGENESIS; SIGNAL TRANSDUCTION; UMBILICAL VEIN;

ANTIGENS, CD40; CALCIUM CHANNEL BLOCKERS; CHEMOKINE CCL2; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; HUMANS; NIFEDIPINE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA; UMBILICAL VEINS; UP-REGULATION;

EID: 16244411639     PISSN: 03786501     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Taddei S., Virdis A., Ghiadoni L., Sudanom I., Salvetti A. Antihypertensive drugs and reversing of endothelial dysfunction in hypertension. Curr. Hypertens. Rep., 2, 64, 2000.
2. Taddei S., Virdis A., Ghiadoni L., et al. Effect of calcium antagonist or beta blockade treatment on nitric oxide-dependent vasodilation and oxidative stress in essential hypertensive patients. J. Hypertens., 19, 1379, 2001.
3. Zanchetti A., Bond M.G., Hennig M., et al. European Lacidipine Study on Atherosclerosis investigators. Calcium antagonist lacidipine slows down progression of asymptomatic carotid atherosclerosis: Principal results of the European Lacidipine Study on Atherosclerosis (ELSA), a randomized, double-blind, long-term trial. Circulation, 106, 2422, 2002.
4. Nayler W.G. Review of preclinical data of calcium channel blockers and atherosclerosis. J. Cardiolvasc. Pharmacol., 33(Suppl. 2), S7, 1999.
5. Mark I.T., Weglicki W.B. Antioxidant activity of calcium channel blocking drugs. Methods Enzymol., 234, 620, 1994.
6. Yamagishi S., Inagaki Y., Kikuchi S. Nifedipine inhibits tumor necrosis factor-α-induced monocyte chemoattractant protein-1 overexpression by blocking NADPH oxidase-mediated reactive oxygen species generation. Drugs Exptl. Clin. Res., 24, 147, 2003.
7. Yamagishi S., Inagaki Y., Abe R., Kikuchi S., Sasaki N., Takeuchi M. Nifedipine inhibits apoptotic cell death of cultured endothelial cells induced by tumor necrosis factor-α. Drugs Exptl. Clin. Res., 24, 141, 2003.
8. Yamagishi S., Inagaki Y., Nakamura K., Imaizumi T. Azelnidipine, a newly developed long-acting calcium antagonist, inhibits tumor necrosis factor-α-induced interleukin-8 expression in endothelial cells through its anti-oxidative properties. J. Cardiovasc. Pharmacol., 43, 724, 2004.
9. Rollins B.J., Yoshimura T., Leonard E.J., Pober J.S. Cytokine-activated human endothelial cells synthesize and secrete a monocyte chemoattractant, MCP-1/JE. Am. J. Pathol., 136, 1229, 1990.
10. Nelken N.A., Coughlin S.R., Gordon D., Wilcox J.N. Monocyte chemoattractant protein-1 in human atheromatous plaques. J. Clin. Invest., 88, 1121, 1991.
11. Boring L., Gosling J., Cleary M., Charo I.F. Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis. Nature, 394, 894, 1998.
12. Ross R. Atherosclerosis: An inflammatory disease. N. Eng. J. Med., 340, 115, 1999.
13. Manitovani A., Bussolino F., Dejana E. Cytokine regulation of endothelial cell function. FASEB J., 6, 2591, 1992.
14. van Kooten C., Banchereau J. CD40-CD40 ligand. J. Leukocyte Biol., 67, 2, 2000.
15. Schonbeck U., Libby P. CD40 signaling and plaque instability. Cir. Res., 89, 1092, 2001.
16. Schonbeck M.F., Libby P. CD40 signaling in vascular cells: A key role in atherosclerosis? Atherosclerosis, 137, S89, 1998.
17. Stamenkovic I., Clark E.A., Seed B. A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas. EMBO J., 8, 1403, 1989.
18. Inagaki Y., Yamagishi S., Amano S., Okamoto T., Koga K., Makita Z. Interferon-gamma-induced apoptosis and activation of THP-1 macrophages. Life Sci., 71, 2499, 2002.
19. Yamagishi S., Okamoto T., Amano S., et al. Palmitate-induced apoptosis of microvascular endothelial cells and pericytes. Mol. Med., 8, 178, 2002.
20. Yamagishi S., Inagaki Y., Amano S., et al. Advanced glycation end product-induced apoptosis and overexpression of vascular endothelial growth factor and monocyte chemoattractant protein-1 in human-cultured mesangial cells. J. Biol. Chem., 277, 20309, 2002.
21. Yamagishi S., Amano S., Inagaki Y., et al. Angiotensin II-type 1 receptor interaction upregulates vascular endothelial growth factor messenger RNA levels in retinal pericytes through intracellular reactive oxygen species generation. Drugs. Exp. Clin. Res., 24, 75, 2003.
22. Yamagishi S., Inagaki Y., Okamoto T., Amano S., Koga K., Takeuchi M. Advanced glycation end products inhibit de novo protein synthesis and induce TGF-beta overexpression in proximal tubular cells. Kidney Int., 62, 464, 2003.
23. Lutgens E., Gorelik L., Daemen M.J., et al. Requirement of CD154 in the progression of atherosclerosis. Nat. Med., 5, 1313, 1999.
24. Mach F., Schonbeck U., Sukhova G.K., Atkinson E., Libby P. Reduction of atherosclerosis in mice by inhibition of CD40 signaling. Nature, 394, 200, 1998.
25. Wagner A.M., Gebauer M., Pollok-Kopp B., Hecker M. Cytokine-inducible CD40 expression in human endothelial cells is mediated by interferon regulatory factor-1. Blood. 99, 520, 2002.
26. Li D., Liu L., Chen H., Sawamura T., Mehta J.L. LOX-1, an oxidized LDL endothelial receptor, induces CD40/CD40L signaling in human coronary artery endothelial cells. Arterioscle. Throm. Vasc. Biol., 23, 816, 2003.
27. Mahta J.L. The role of LOX-1, a novel lectin-like receptor for oxidized low density lipoprotein, in atherosclerosis. Can. J. Cardiology, 20, 32, 2004.
28. Vehaar M.C., Honing M.L., van Dam T., et al. Nifedipine improves endothelial function in hypercholesterolemia, independently of an effect on blood pressure or plasma lipids. Cardiovasc. Res., 42, 752, 1999.
29. Herbette L.G., Vant Erve Y.M., Rhodes D.G. Interaction of 1,4 dihydropyridine calcium channel antagonists with biological membranes: Lipid bilayer partitioning could occur before drug binding to receptors. J. Mol. Cell Cardiol., 21, 187, 1989.