Hydroxyzine- and cetirizine-loaded liposomes: Effect of duration of thin film hydration, freeze-thawing, and changing buffer pH on encapsulation and stability

Drug Development and Industrial Pharmacy

Volumn 31, Issue 3, 2005, Pages 281-291

  Elzainy, Abeer A W ^a   Gu, Xiaochen ^a   Simons, F Estelle R ^b   Simons, Keith J ^a,b  

^a UNIVERSITY OF MANITOBA   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

Author keywords

Cetirizine; Freeze thawing; Hydroxyzine; L phosphatidylcholine; Liposomes; pH; Stability

Indexed keywords

ANTIHISTAMINIC AGENT; CETIRIZINE; HYDROXYZINE; LIPOSOME; PHOSPHATIDYLCHOLINE;

ARTICLE; BATCH PROCESS; DRUG FORMULATION; DRUG STABILITY; DRUG STORAGE; ENCAPSULATION; FILM; FREEZE THAWING; HYDRATION; LOW TEMPERATURE PROCEDURES; PARTICLE SIZE; PH; PHYSICAL CHEMISTRY; TEMPERATURE DEPENDENCE; TRANSMISSION ELECTRON MICROSCOPY;

CETIRIZINE; CHEMISTRY, PHARMACEUTICAL; DRUG STABILITY; FREEZING; HISTAMINE H1 ANTAGONISTS; HYDROGEN-ION CONCENTRATION; HYDROXYZINE; LIPOSOMES; PHOSPHATIDYLCHOLINES; TIME FACTORS;

EID: 16244368828     PISSN: 03639045     EISSN: None     Source Type: Journal    
DOI: 10.1081/DDC-52070     Document Type: Article

References (32)

1. Avanti Polar Lipids, INC. Products Catalog Edition VI Revision II.
2. Balen, G. P. V., Caron, G., Ermondi, G., Pagliara, A., Grandi, T., Bouchard, G., Fruttero, R., Carrupt, P. A., & Testa, B. (2001). Lipophilicity behaviour of the zwitterionic antihistamine cetirizine in phosphatidylcholine liposomes/water systems. Pharmaceutical Research, 18, 694-701.
3. Bangham, A. D., Standish, M. M., & Watkins, J. C. (1965). Diffusion of univalent ions across the lamellae of swollen phospholipids. Journal of Molecular Biology, 13, 238-252.
4. Batzri, S., & Korn, E. D. (1973). Single bilayer liposomes prepared without sonication. Biochimica et Biophysica Acta, 298, 1015-1019.
5. Bawati, M. J. (1999). Evaluation of the Disposition and Efficacy of Hydroxyzine in Liposome Formulations Applied Topically to Rabbits. Master Thesis: University of Manitoba, 36-37.
6. Betageri, G. V. (1993). Liposomal encapsulation and stability of dideoxyinosine triphosphate. Drug Development and Industrial Pharmacy, 19, 531-539.
7. Betageri, G. V., & Kulkarni, Sh. B. (1999). Preparation of liposomes. Arshady, R. (Ed.). Microspheres, Microcapsules and Liposomes: Preparation and Chemical Applications. Vol. 1. London: Citus Books, 490-521.
8. Coderch, L., Fonollosa, J., De Pera, M., Estelrich, J., De La Maza, A., & Parra, J. L. (2000). Influence of cholesterol on liposome fluidity by EPR. Relationship with percutaneous absorption. Journal of Controlled Release, 68, 85-95.
9. Elzainy, A. A. W., Gu, X., Simons, F. E. R., & Simons, K. J. (2003). Hydroxyzine form topical phospholipid liposomal formulations: evaluation of peripheral antihistaminic activity and systemic absorption in a rabbit model. AAPS Journal, 5(4), 1-8. (Article 28: http://www.aapsj.org).
10. Elzainy, A. A. W., Gu, X., Simons, F. E. R., & Simons, K. J. (2004). Cetirizine from topical phosphatidylcholine liposomes: evaluation of peripheral antihistaminic activity and systemic absorption in a rabbit model. Biopharmaceutics & Drug Disposition, 25, 359-366.
11. Fang, J. Y., Hong, C. T., Chiu, W. T., & Wang, Y. Y. (2001). Effect of liposomes and niosomes on skin permeation of enoxacin. International Journal of Pharmaceutics, 219, 61-72.
12. Fiume, Z. (2001). Final report on the safety assessment of lecithin and hydrogenated lecithin. International Journal of Toxicology, 20(Suppl. 1), 21-45.
13. Hayat, M. A. (1970). Principle and Techniques of Electron Microscopy: Biological Applications. New York: Van Nostrand Reinhold Company, 101-143.
14. http://www.lipidat.chemistry.ohio-state.edu/ (accessed Dec. 1, 2003).
15. Huston, R. L., Cypcar, D., Cheng, G. S., & Foulds, D. M. (1990). Toxicity from topical administration of diphenhydramine in children. Clinical Pediatrics, 29, 542-545.
16. Idiart, M. A., & Levin, Y. (2004). Rupture of a liposomal vesicle. Physical Review E, Statistical, Nonlinear, and Soft Matter Physics, 69(6 Pt. 1), 061922. Epub 2004 Jun 23.
17. Kommanaboyina, B., & Rhodes, C. T. (1999). Trends in stability testing, with emphasis on stability during distribution and storage. Drug Development and Industrial Pharmacy, 25, 857-868.
18. Kulkarni, S. B., Betageri, G. V., & Singh, M. (1995). Factors affecting microencapsulation of drugs in liposomes. Journal of Microencapsulation, 12, 229-246.
19. Manosroi, A., Kongkaneramit, L., & Manosroi, J. (2004). Stability and transdermal absorption of topical amphotericin B liposome formulations. International Journal of Pharmaceutics, 270, 279-286.
20. Matthews, B. R. (1999). Regulatory aspects of stability testing in Europe. Drug Development and Industrial Pharmacy, 25, 831-856.
21. New Roger, R. R. C. (1995). Influence of liposome characteristics on their properties and fate. In J. R. Philippot & F. Schuber (Eds.), Liposomes as Tools in Basic Research and Industry (pp. 3-20). London: CRC Press, Inc.
22. Ostro, M. J., & Cullis, P. R. (1989). Use of liposomes as injectable-drug delivery systems. American Journal of Hospital Pharmacy, 46, 1576-1587.
23. Patel, V. B., & Misra, A. N. (1999). Encapsulation and stability of clofazimine liposomes. Journal of Microencapsulation, 16, 357-367.
24. Percot, A., Briane, D., Coudert, R., Reynier, P., Bouchemal, N., Lievre, N., Hantz, E., Salzmann, J. L., & Cao, A. (2004). A hydroxyethylated cholesterol-based cationic lipid for DNA delivery: effect of conditioning. International Journal of Pharmaceutics, 278, 143-163.
25. 1-Antihistamines in Allergic Disease. New York, NY: Marcel Dekker, 437-464.
26. 1-receptor antagonist hydroxyzine. Journal of Allergy and Clinical Immunology, 73, 69-75.
27. 1-receptor antagonists in the skin and serum. Journal of Allergy and Clinical Immunology, 95, 759-764.
28. Sriwongsitanont, S., & Ueno, M. (2004). Effect of freeze-thawing and polyethylene glycol (PEG) lipid on fusion and fission of phospholipid vesicles. Chemical and Pharmaceutical Bulletin (Tokyo), 52, 641-642.
29. Valenta, C., Cladera, J., O'shea, P., & Hadgraft, J. (2001). Effect of phloretin on the percutaneous absorption of lignocaine across human skin. Journal of Pharmaceutical Sciences, 90, 485-491.
30. Veatch, S. L., & Keller, S. L. (2003). Separation of liquid phases in giant vesicles of ternary mixtures of phospholipids and cholesterol. Biophysical Journal, 85, 3074-3083.
31. Watson, W. T. A., Simons, K. J., Chen, X. Y., & Simons, F. E. R. (1989). Cetirizine: a pharmacokinetics and pharmacodynamic evaluation in children with seasonal allergic rhinitis. Journal of Allergy and Clinical Immunology, 84, 457-464.
32. Yarosh, D. B. (2001). Liposomes in investigative dermatology. Photodermatology, Photoimmunology & Photomedicine, 17, 203-212.