Inhibition of melanoma inhibitory activity (MIA) expression in melanoma cells leads to molecular and phenotypic changes

Pigment Cell Research

Volumn 18, Issue 2, 2005, Pages 92-101

  Tatzel, Jutta ^a   Poser, Ina ^a   Schroeder, Josef ^a   Bosserhoff, Anja K ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Melanoma; Melanoma inhibitory activity; MITF; Pigmentation; Trp 1; Tyrosinase

Indexed keywords

COMPLEMENTARY DNA; MELANIN; MELANOMA INHIBITORY ACTIVITY; MESSENGER RNA; MONOPHENOL MONOOXYGENASE; PIAS3 PROTEIN; PIGMENT; REGULATOR PROTEIN; SECRETORY PROTEIN; TRANSCRIPTION FACTOR PAX3; TYROSINASE RELATED PROTEIN 1; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL CLONE; CELL CONTACT; CELL GROWTH; CELL STRAIN HMB2; CELL STRUCTURE; CONTROLLED STUDY; HUMAN; HUMAN CELL; MELANOGENESIS; MELANOMA CELL; MOLECULAR BIOLOGY; MONOLAYER CULTURE; PHENOTYPE; PIGMENTATION; PROTEIN EXPRESSION; THREE DIMENSIONAL CELL CULTURE; TRANSCRIPTION REGULATION;

ACETYLATION; CELL LINE; DNA, ANTISENSE; DNA-BINDING PROTEINS; EXTRACELLULAR MATRIX PROTEINS; GENE EXPRESSION REGULATION, NEOPLASTIC; HISTONES; HUMANS; MELANOCYTES; MELANOMA; MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR; MOLECULAR CHAPERONES; MONOPHENOL MONOOXYGENASE; NEOPLASM PROTEINS; OXIDOREDUCTASES; PAIRED BOX TRANSCRIPTION FACTORS; PHENOTYPE; PIGMENTATION; PROTEIN INHIBITORS OF ACTIVATED STAT; TRANSCRIPTION FACTORS;

EID: 15944404003     PISSN: 08935785     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0749.2005.00212.x     Document Type: Article

References (42)

1. Aksan, I., and Coding, C.R. (1998). Targeting the microphthalmia basic helix-loop-helix-leucine zipper transcription factor to a subset of E-box elements in vitro and in vivo. Mol Cell Biol. 18, 6930-6938.
2. Alberts, A.S., Geneste, O., and Treisman, R. (1998). Activation of SRF-regulated chromosomal templates by Rho-family GTPases requires a signal that also induces H4 hyperacetylation. Cell. 92, 475-487.
3. Blesch, A., Bosserhoff, A.K., Apfel, R., Behl, C., Hessdoerfer, B., Schmitt, A., Jachimczak, P., Lottspeich, F., Buettner, R., and Bogdahn, U. (1994). Cloning of a novel malignant melanoma-derived growth-regulatory protein, MIA. Cancer Res. 54, 5695-5701.
4. Bosserhoff, A. K., and Buettner, R. (2002). Expression, function and clinical relevance of MIA (melanoma inhibitory activity). Histol Histopathol 17, 289-300.
5. Bosserhoff, A.K., Hein, R., Bogdahn, U., and Buettner, R. (1996). Structure and promoter analysis of the gene encoding the human melanoma-inhibiting protein MIA. J Biol Chem. 271, 490-495.
6. Bosserhoff, A.K., Kaufmann, M., Kaluza, B., Bartke, I., Zirngibl, H., Hein, R., Stolz, W., and Buettner, R. (1997a). Melanoma-inhibiting activity, a novel serum marker for progression of malignant melanoma. Cancer Res. 57, 3149-3153.
7. Bosserhoff, A.K., Kondo, S., Moser, M., Dietz, U.H., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Buettner, R., and Sandell, L.J. (1997b). Mouse CD-RAP/MIA gene: structure, chromosomal localization, and expression in cartilage and chondrosarcoma. Dev Dyn. 208, 516-525.
8. Bosserhoff, A.K., Echtenacher, B., Hein, R., and Buettner, R. (2001). Functional role of melanoma inhibitory activity in regulating invasion and metastasis of malignant melanoma cells in vivo. Melanoma Res. 11, 417-421.
9. Bosserhoff, A.K., Stoll, R., Sleeman, J.P., Bataille, F., Buettner, R., and Holak, T.A. (2003). Active detachment involves inhibition of cell-matrix contacts of malignant melanoma cells by secretion of melanoma inhibitory activity. Lab Invest. 83, 1583-1594.
10. Carreira, S., Dexter, T.J., Yavuzer, U., Easty, D.J., and Goding, C.R. (1998). Brachyury-related transcription factor Tbx2 and repression of the melanocyte-specific TRP-1 promoter. Mol Cell Biol. 18, 5099-5108.
11. Carreira, S., Liu, B., and Goding, C.R. (2000). The gene encoding the T-box factor Tbx2 is a target for the microphthalmia-associated transcription factor in melanocytes. J Biol Chem. 275, 21920-21927.
12. del Marmol, V., and Beermann, F. (1996). Tyrosinase and related proteins in mammalian pigmentation. FEBS Lett. 381, 165-168.
13. Eberle, J., Wagner, M., and MacNeil, S. (1998). Human melanoma cell lines show little relationship between expression of pigmentation genes and pigmentary behaviour in vitro. Pigment Cell Res. 11, 134-142.
14. Gaggioli, C., Busca, R., Abbe, P., Ortonne, J.P., and Ballotti, R. (2003). Microphthalmia-associated transcription factor (MITF) is required but is not sufficient to induce the expression of melanogenic genes. Pigment Cell Res. 16, 374-382.
15. Galibert, M.D., Yavuzer, U., Dexter, T.J., and Coding, C.R. (1999). Pax3 and regulation of the melanocyte-specific tyrosinase-related protein-1 promoter. J Biol Chem. 274, 26894-26900.
16. Golob, M., Buettner, R., and Bosserhoff, A.K. (2000). Characterization of a transcription factor binding site, specifically activating MIA transcription in melanoma. J Invest Dermatol. 115, 42-47.
17. van Groningen, J.J., Bloemers, H.P., and Swart, G.W. (1995). Identification of melanoma inhibitory activity and other differentially expressed messenger RNAs in human melanoma cell lines with different metastatic capacity by messenger RNA differential display. Cancer Res. 55, 6237-6243.
18. Guba, M., Bosserhoff, A.K., Steinbauer, M., Abels, C., Anthuber, M., Buettner, R., and Jauch, K.W. (2000). Overexpression of melanoma inhibitory activity (MIA) enhances extravasation and metastasis of A-mel 3 melanoma cells in vivo. Br J Cancer. 83, 1216-1222.
19. Hearing, V.J., and Tsukamoto, K. (1991). Enzymatic control of pigmentation in mammals. FASEB J. 5, 2902-2909.
20. Hodgkinson, C.A., Moore, K.J., Nakayama, A., Steingrimsson, E., Copeland, N.G., Jenkins, N.A., and Arnheiter, H. (1993). Mutations at the mouse microphthalmia locus are associated with defects in a gene encoding a novel basic-helix-loop-helix-zipper protein. Cell. 74, 395-404.
21. Jimenez-Cervantes, C., Solano, F., Kobayashi, T., Urabe, K., Hearing, V.J., Lozano, J.A., and Garcia-Borron, J.C. (1994). A new enzymatic function in the melanogenic pathway. The 5,6-dihydroxyindole-2-carboxylic acid oxidase activity of tyrosinase-related protein-1 (TRP1). J Biol Chem. 269, 17993-18000.
22. Kim, D.S., Hwang, E.S., Lee, J.E., Kim, S.Y., Kwon, S.B., and Park, K.C. (2003). Sphingosine-1-phosphate decreases melanin synthesis via sustained ERK activation and subsequent MITF degradation. J Cell Sci. 116, 1699-1706.
23. Kobayashi, T., Urabe, K., Winder, A., Jimenez-Cervantes, C., Imokawa, G., Brewington, T., Solano, F., Garcia-Borron, J.C., and Hearing, V.J. (1994). Tyrosinase related protein 1 (TRP1) functions as a DHICA oxidase in melanin biosynthesis. EMBO J 13, 5818-5825.
24. Levy, C., Nechushtan, H., and Razin, E. (2002). A new role for the STAT3 inhibitor, PIAS3: a represser of microphthalmia transcription factor. J Biol Chem. 277, 1962-1966.
25. Levy, C., Sonnenblick, A., and Razin, E. (2003). Role played by microphthalmia transcription factor phosphorylation and its Zip domain in its transcriptional inhibition by PIAS3. Mol Cell Biol. 23, 9073-9080.
26. Li, G., Satyamoorthy, K., and Herlyn, M. (2002). Dynamics of cell interactions and communications during melanoma development. Crit Rev Oral Biol Med. 13, 62-70.
27. Lougheed, J.C., Holton, J.M., Alber, T., Bazan, J.F., and Handel, T.M. (2001). Structure of melanoma inhibitory activity protein, a member of a recently identified family of secreted proteins. Proc Natl Acad Sci USA. 98, 5515-5520.
28. Mielzynska, I., Smok-Ragankiewicz, A., and Szczurek, Z. (1989). [Cytologic prints of primary and metastatic melanomas. Preliminary report]. Patol Pol 40, 181-185.
29. Moore, K.J. (1995). Insight into the microphthalmia gene. Trends Genet. 11, 442-448.
30. Murre, C., McCaw, P.S., and Baltimore, D. (1989a). A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins. Cell 56, 777-783.
31. Murre, C., McCaw, P.S., Vaessin, H., Caudy, M., Jan, L.Y., Jan, Y.N., Cabrera, C.V., Buskin, J.N., Hauschka, S.D., Lassar, A.B. et al. (1989b). Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence. Cell 58, 537-544.
32. Orlow, S.J., Silvers, W.K., Zhou, B.K., and Mintz, B. (1998). Comparative decreases in tyrosinase, TRP-1, TRP-2, and Pmel 17/silver antigenic proteins from melanotic to amelanotic stages of syngeneic mouse cutaneous melanomas and metastases. Cancer Res. 58, 1521-1523.
33. Poser, I., Golob, M., Weidner, M., Buettner, R., and Bosserhoff, A.K. (2002). Down-regulation of COOH-terminal binding protein expression in malignant melanomas leads to induction of MIA expression. Cancer Res. 62, 5962-5966.
34. Poser, I., Golob, M., Buettner, R., and Bosserhoff, A.K. (2003). Upregulation of HMG1 leads to melanoma inhibitory activity expression in malignant melanoma cells and contributes to their malignancy phenotype. Mol Cell Biol. 23, 2991-2998.
35. Poser, I., Tatzel, J., Kuphal, S., and Bosserhoff, A.K. (2004). Functional role of MIA in melanocytes and early development of melanoma. Oncogene 23, 6115-6124.
36. Scholl, F.A., Kamarashev, J., Murmann, O.V., Geertsen, R., Dummer, R., and Schafer, B.W. (2001). PAX3 is expressed in human melanomas and contributes to tumor cell survival. Cancer Res. 61, 823-826.
37. Steingrimsson, E., Moore, K.J., Lamoreux, M.L., Ferre-D'Amare, A.R., Burley, S.K., Zimring, D.C., Skow, L.C., Hodgkinson, C.A., Arnheiter, H., and Copeland, N.G. (1994). Molecular basis of mouse microphthalmia (mi) mutations helps explain their developmental and phenotypic consequences. Nat Genet. 8, 256-263.
38. Stoll, R., Renner, C., Zweckstetter, M., Bruggert, M., Ambrosius, D., Palme, S., Engh, R.A., Golob, M., Breibach, I., Buettner, R. et al. (2001). The extracellular human melanoma inhibitory activity (MIA) protein adopts an SH3 domain-like fold. EMBO J. 20, 340-349.
39. Vachtenheim, J., Novotna, H., and Ghanem, G. (2001). Transcriptional repression of the microphthalmia gene in melanoma cells correlates with the unresponsiveness of target genes to ectopic microphthalmia-associated transcription factor. J Invest Dermatol. 117, 1505-1511.
40. Wellbrock, C., Weisser, C., Geissinger, E., Troppmair, J., and Schartl, M. (2002). Activation of p59(Fyn) leads to melanocyte dedifferentiation by influencing MKP-1-regulated mitogen-activated protein kinase signaling. J Biol Chem. 277, 6443-6454.
41. Wu, M., Hemesath, T.J., Takemoto, C.M., Horstmann, M.A., Wells, A.G., Price, E.R., Fisher, D.Z., and Fisher, D.E. (2000). c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi. Genes Dev. 14, 301-312.
42. Yasumoto, K., Yokoyama, K., Shibata, K., Tomita, Y., and Shibahara, S. (1994). Microphthalmia-associated transcription factor as a regulator for melanocyte-specific transcription of the human tyrosinase gene. Mol Cell Biol. 14, 8058-8070.