Regulation of the Cyp2a5 gene involves an aryl hydrocarbon receptor-dependent pathway

Molecular Pharmacology

Volumn 67, Issue 4, 2005, Pages 1325-1333

  Arpiainen, Satu ^a   Raffalli Mathieu, Françoise ^b   Lang, Matti A ^b   Pelkonen, Olavi ^a   Hakkola, Jukka ^a  

^a UNIVERSITY OF OULU   (Finland)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 3 METHYLCHOLANTHRENE; AROMATIC HYDROCARBON RECEPTOR; COUMARIN 7 HYDROXYLASE; CYCLOHEXIMIDE; CYTOCHROME P450 2A5; GENOMIC DNA; LIGAND; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYP2A5 GENE; ENZYME ASSAY; GENE; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; HEPATOMA CELL; LIVER CELL; LIVER CELL CULTURE; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; DNA-BINDING PROTEINS; ENZYME INDUCTION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MIXED FUNCTION OXYGENASES; RECEPTORS, ARYL HYDROCARBON; RNA, MESSENGER; TETRACHLORODIBENZODIOXIN; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 15744390146     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.104.008078     Document Type: Article

References (40)

1. Aitio A (1978) A Simple and sensitive assay of 7-ethoxycoumarin deethylation. Anal Biochem 85:488-491.
2. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
3. Camus AM, Geneste O, Honkakoski P, Bereziat JC, Henderson CJ, Wolf CR, Bartsch H, and Lang MA (1993) High variability of nitrosamine metabolism among individuals: role of cytochromes P450 2A6 and 2E1 in the dealkylation of N-nitrosodimethylamine and N-nitrosodiethylamine in mice and humans. Mol Carcinog 7:268-275.
4. Chang C, Smith DR, Prasad VS, Sidman CL, Nebert DW, and Puga A (1993) Ten nucleotide differences, five of which cause amino acid changes, are associated with the Ah receptor locus polymorphism of C57BL/6 and DBA/2 mice. Pharmacogenetics 3:312-321.
5. Chirgwin JM, Przybyla AE, MacDonald RJ, and Rutter WJ (1979) Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18:5294-5299.
6. Denison MS, Fisher JM, and Whitlock JP Jr (1988) The DNA recognition site for the dioxin-Ah receptor complex. Nucleotide sequence and functional analysis. J Biol Chem 263:17221-17224.
7. Donato MT, Viitala P, Rodriguez-Antona C, Lindfors A, Castell JV, Raunio H, Gomez-Lechon MJ, and Pelkonen O (2000) CYP2A5/CYP2A6 expression in mouse and human hepatocytes treated with various in vivo inducers. Drug Metab Dispos 28:1321-1326.
8. Ema M, Ohe N, Suzuki M, Mimura J, Sogawa K, Ikawa S, and Fujii-Kuriyama Y (1994) Dioxin binding activities of polymorphic forms of mouse and human arylhydrocarbon receptors. J Biol Chem 269:27337-27343.
9. Fukunaga BN and Hankinson O (1996) Identification of a novel domain in the aryl hydrocarbon receptor required for DNA binding. J Biol Chem 271:3743-3749.
10. Glisovic T, Ben David Y, Lang MA, and Raffalli-Mathieu F (2003a) Interplay between HnRNP A1 and a cis-acting element in the 3′ UTR of CYP2A5 mRNA is central for high expression of the gene. FEBS Lett 535:147-152.
11. Glisovic T, Soderberg M, Christian K, Lang M, and Raffalli-Mathieu F (2003b) Interplay between transcriptional and post-transcriptional regulation of Cyp2a5 expression. Biochem Pharmacol 65:1653-1661.
12. Gokhale MS, Bunton TE, Zurlo J, and Yager JD (1997) Cytochrome P450 isoenzyme activities in cultured rat and mouse liver slices. Xenobiotica 27:341-355.
13. Hakkola J, Hu Y, and Ingelman-Sundberg M (2003) Mechanisms of Down-Regulation of CYP2E1 expression by inflammatory cytokines in rat hepatoma cells. J Pharmacol Exp Ther 304:1048-1054.
14. Hakkola J, Pasanen M, Hukkanen J, Pelkonen O, Maenpaa J, Edwards RJ, Boobis AR, and Raunio H (1996) Expression of xenobiotic-metabolizing cytochrome P450 forms in human full-term placenta. Biochem Pharmacol 51:403-411.
15. Hankinson O (1994) A genetic analysis of processes regulating cytochrome P4501A1 expression. Adv Enzyme Regul 34:159-171.
16. Hankinson O (1995) The aryl hydrocarbon receptor complex. Annu Rev Pharmacol Toxicol 35:307-340.
17. Hoffer A, Chang CY, and Puga A (1996) Dioxin induces transcription of Fos and Jun genes by Ah receptor-dependent and -independent pathways. Toxicol Appl Pharmacol 141:238-247.
18. Kaipainen P and Lang M (1985) Comparison of kidney, lung and liver coumarin 7-hydroxylases in phenobarbital pretreated DBA/2J and C57BL/6J mice. Biochem Pharmacol 34:1987-1991.
19. Kimura S, Kozak CA, and Gonzalez FJ (1989) Identification of a novel P450 expressed in rat lung: CDNA cloning and sequence, chromosome mapping and induction by 3-methylcholanthrene. Biochemistry 28:3798-3803.
20. Kobliakov V, Kulikova L, Samoilov D, and Lang MA (1993) High expression of cytochrome P450 2a-5 (coumarin 7-hydroxylase) in mouse hepatomas. Mol Carcinog 7:276-280.
21. Koskela S, Hakkola J, Hukkanen J, Pelkonen O, Sorri M, Saranen A, Anttila S, Fernandez-Salguero P, Gonzalez F, and Raunio H (1999) Expression of CYP2A genes in human liver and extrahepatic tissues. Biochem Pharmacol 57:1407-1413.
22. Kurose K, Tohkin M, and Fukuhara M (1999) A novel positive regulatory element that enhances hamster CYP2A8 gene expression mediated by xenobiotic responsive element. Mol Pharmacol 55:279-287.
23. Lavery DJ, Lopez-Molina L, Margueron R, Fleury-Olela F, Conquet F, Schibler U, and Bonfils C (1999) Circadian expression of the steroid 15 alpha-hydroxylase (Cyp2a4) and coumarin 7-hydroxylase (Cyp2a5) genes in mouse liver is regulated by the PAR leucine zipper transcription factor DBP. Mol Cell Biol 19:6488-6499.
24. Lees MJ and Whitelaw ML (2002) Effect of ARA9 on dioxin receptor mediated transcription. Toxicology 181-182:143-146.
25. Lush IE and Andrews KM (1978) Genetic variation between mice in their metabolism of coumarin and its derivatives. Genet Res 31:177-186.
26. Nakajima M, Yamamoto T, Nunoya K, Yokoi T, Nagashima K, Inoue K, Funae Y, Shimada N, Kamataki T, and Kuroiwa Y (1996) Role of human cytochrome P4502A6 in C-oxidation of nicotine. Drug Metab Dispos 24:1212-1217.
27. Ohtake F, Takeyama K, Matsumoto T, Kitagawa H, Yamamoto Y, Nohara K, Tohyama C, Krast A, Mimura J, Chambon P, et al. (2003) Modulation of oestrogen receptor signalling by association with the activated dioxin receptor. Nature (Lond) 423:545-550.
28. Pelkonen O, Raunio H, Rautio A, Pasanen M, and Lang MA (1997a) The metabolism of coumarin, in Coumarins: Biology, Applications and Mode of Action (O'Kennedy R and Thornes RD eds) pp 67-92, John Wiley, Chichester.
29. Pelkonen P, Lang MA, Negishi M, Wild CP, and Juvonen RO (1997b) Interaction of aflatoxin B1 with cytochrome P450 2A5 and its mutants: correlation with metabolic activation and toxicity. Chem Res Toxicol 10:85-90.
30. Puga A, Barnes SJ, Dalton TP, Chang C, Knudsen ES, and Maier MA (2000) Aromatic hydrocarbon receptor interaction with the retinoblastoma protein potentiates repression of E2F-dependent transcription and cell cycle arrest. J Biol Chem 275:2943-2950.
31. Reisz-Porszasz S, Probst MR, Fukunaga BN, and Hankinson O (1994) Identification of functional domains of the aryl hydrocarbon receptor nuclear translocator protein (ARNT). Mol Cell Biol 14:6075-6086.
32. Rivera SP, Saarikoski ST, and Hankinson O (2002) Identification of a novel dioxin-inducible cytochrome P450. Mol Pharmacol 61:255-259.
33. Salonpaa P, Pelkonen O, Kojo A, Pasanen M, Negishi M, and Raunio H (1994) Cytochrome P4502A5 expression and inducibility by phenobarbital is modulated by camp in mouse primary hepatocytes. Biochem Biophys Res Commun 205:631-637.
34. Schreiber E, Matthias P, Muller MM, and Schaffner W (1989) Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. Nucleic Acids Res 17:6419.
35. Shen ES and Whitlock JP Jr (1992) Protein-DNA Interactions at a dioxin-responsive enhancer. Mutational analysis of the DNA-binding site for the liganded Ah receptor. J Biol Chem 267:6815-6819.
36. Su T, Sheng JJ, Lipinskas TW, and Ding X (1996) Expression of CYP2A genes in rodent and human nasal mucosa. Drug Metab Dispos 24:884-890.
37. Thomas PE, Reik LM, Ryan DE, and Levin W (1981) Regulation of three forms of cytochrome P-450 and epoxide hydrolase in rat liver microsomes. Effects of age, sex and induction. J Biol Chem 256:1044-1052.
38. Tian Y, Ke S, Denison MS, Rabson AB, and Gallo MA (1999) Ah receptor and NF-κB interactions, a potential mechanism for dioxin toxicity. J Biol Chem 274:510-515.
39. Ulvila J, Arpiainen S, Pelkonen O, Aida K, Sueyoshi T, Negishi M, and Hakkola J (2004) Regulation of Cyp2a5 transcription in mouse primary hepatocytes: roles of hepatocyte nuclear factor 4 and nuclear factor I. Biochem J 381:887-894.
40. Zhang J, Watson AJ, Probst MR, Minehart E, and Hankinson O (1996) Basis for the loss of aryl hydrocarbon receptor gene expression in clones of a mouse hepatoma cell line. Mol Pharmacol 50:1454-1462.