Tat and amyloid: Multiple interactions

AIDS

Volumn 19, Issue 2, 2005, Pages 203-204

  Nath, Avindra ^a,c   Hersh, Louis B ^b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c 509 Pathology ^*  (United States)

Author keywords

Aging; Brain; Dementia; HIV; Neurotoxicity

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PROTEIN; TRANSACTIVATOR PROTEIN;

AGING; ALZHEIMER DISEASE; AMYLOIDOSIS; DEMENTIA; EDITORIAL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NEUROTOXICITY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RISK FACTOR;

EID: 15744362464     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-200501280-00013     Document Type: Editorial

References (9)

1. Marcus MB. Aging of AIDS. The silent risk group for HIV infection: senior citizens. US News World Rep 2002; 133:40-41.
2. Walsh DM, Selkoe DJ. Oligomers on the brain: the emerging role of soluble protein aggregates in neurodegeneration. Protein Pept Lett 2004; 11:213-228.
3. Gelman BB, Schuenke K. Brain aging in acquired immunodeficiency syndrome: increased ubiquitin-protein conjugate is correlated with decreased synaptic protein but not amyloid plaque accumulation. J Neurovirol 2004; 10:98-108.
4. Corder EH, Robertson K, Lannfelt L, Bogdanovic N, Eggertsen G, Wilkins J, et al. HIV-infected subjects with the E4 allele for APOE have excess dementia and peripheral neuropathy [see comments]. Nat Med 1998; 4:1182-1184.
5. Liu Y, Jones M, Hingtgen CM, Bu G, Laribee N, Tanzi RE, et al. Uptake of HIV-1 tat protein mediated by low-density lipoprotein receptor-related protein disrupts the neuronal metabolic balance of the receptor ligands. Nat Med 2000; 6:1380-1387.
6. Hersh LB. Peptidases, proteases and amyloid beta-peptide catabolism. Curr Pharm Des 2003; 9:449-454.
7. Nath A, et al. Identification of a human immunodeficiency virus type 1 Tat epitope that is neuroexcitatory and neurotoxic. J Virol 1996; 70:1475-1480.
8. Weeks BS, et al. Neurotoxicity of the human immunodeficiency virus type 1 Tat transactivator to PC12 cells requires the Tat amino acid 49-58 basic domain. J Neurosci Res 1995; 42:34-40.
9. Ranga U, et al. Tat protein of human immunodeficiency virus type 1 subtype C strains is a defective chemokine. J Virol 2004; 78:2586-2590.