Corosolic acid isolated from the fruit of Crataegus pinnatifida var. psilosa is a protein kinase C inhibitor as well as a cytotoxic agent

Planta Medica

Volumn 64, Issue 5, 1998, Pages 468-470

  Ahn, Kyung Seop ^a   Hahm, Moon Sun ^a   Park, Eun Jin ^a   Lee, Hyeong Kyu ^a   Kim, Ik Hwan ^b  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b Korea University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

COROSOLIC ACID; CRATAEGUS EXTRACT; CYTOTOXIC AGENT; PROTEIN KINASE C INHIBITOR; STAUROSPORINE; UNCLASSIFIED DRUG; URSOLIC ACID;

ARTICLE; BREAST CARCINOMA; CANCER CELL; CONTROLLED STUDY; CYTOTOXICITY; DRUG ISOLATION; DRUG MECHANISM; FRUIT; HUMAN; HUMAN CELL; LEUKEMIA CELL;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; ENZYME INHIBITORS; HUMANS; PLANTS, MEDICINAL; PROTEIN KINASE C; TRITERPENES; TUMOR CELLS, CULTURED;

EID: 15644369131     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2006-957487     Document Type: Article

References (15)

1. Han, D. S. (1992) Pharmacognosy, 4th edn., Dongmyongsa Press, Seoul.
2. Park, S. W., Yook, C. S., Lee, H.-K. (1994) Kor. J. Pharmacogn. 25, 328-335.
3. Liu, J. ( 1995) J. Ethnopharmacol. 49, 57-68.
4. Cha, H. J., Bae, S. K., Lee, H. Y., Lee, O. H., Sato, H., Seiki, M., Park, B. C., Kim, K. W. (1996) Cancer Res. 56, 2281-2284.
5. Es-Saady, D., Simon, A., Jayat-Vignoles, C., Chulia, A. J., Delage, C. (1996) Anticancer Res. 16, 481-486.
6. Huang, M. T., Ho, C. T., Wang, Z. Y., Ferraro, T., Lou, Y. R., Stauber, K., Ma, W., Georgiadis, C., Laskin, J. D., Conney, A. H. (1994) Cancer Res. 54, 701-708.
7. Serra, C., Lampis, G., Pompei, R., Pinza, M. (1994) Pharmacol. Res. 29, 359-366.
8. Osada, H., Magae, J., Watanabe, C., Isono, K. (1988) J. Antibiot. 41, 925-931.
9. Wang, B. H, Polya, G. M. (1996) Phytochemistry 41, 55-63.
10. Liu, J., Liu, Y., Mao, Q., Klassen, C. D. (1994) Fundam. Appl. Toxicol. 22, 34-40.
11. Sauvage, C., Cash, C. B., Maitre, M. (1991) Biochem. Biophys. Res. Comm. 174, 593-599.
12. Schwartz, G. K., Arkin, H., Holland, J. F., Ohnuma, T. (1991) Cancer Res. 51, 55-61.
13. Kojima, H., Ogura, H. (1986) Phytochemistry 25, 729-733.
14. Ahn, K. S., Sim, W. S., Kim, I. H. (1996) Planta Med. 62, 7-9.
15. Skehan, P., Storeng, R., Scudiero, D. A., Monks, A., McMahon, J., Vistica, D., Warren, J. T., Bokesch, H., Kenny, S., Boyd, M. R. (1990) J. Natl. Cancer Inst. 82, 1107-1112.