Profile of Candida albicans-secreted aspartic proteinase elicited during vaginal infection

Infection and Immunity

Volumn 73, Issue 3, 2005, Pages 1828-1835

  Taylor, Brad N ^a   Staib, Peter ^b   Binder, Ayfer ^b   Biesemeier, Antje ^a   Sehnal, Miriam ^a   Röllinghoff, Martin ^a   Morschhäuser, Joachim ^b   Schröppel, Klaus ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC PROTEINASE; GREEN FLUORESCENT PROTEIN; PROTEIN SAP4; PROTEIN SAP5; UNCLASSIFIED DRUG; VIRULENCE FACTOR; FUNGAL PROTEIN; SAP4 PROTEIN, CANDIDA ALBICANS; SAP5 PROTEIN, CANDIDA ALBICANS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANDIDA ALBICANS; CHILDBIRTH; CONTROLLED STUDY; ENZYME ANALYSIS; FEMALE; FUNGAL GENE; FUNGUS GROWTH; FUNGUS HYPHAE; GENE EXPRESSION REGULATION; GENE SWITCHING; GENETIC ANALYSIS; GENETIC RECOMBINATION; IN VIVO STUDY; MORPHOGENESIS; MOUSE; NONHUMAN; OPPORTUNISTIC INFECTION; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPORTER GENE; RISK FACTOR; SAP1 GENE; SAP2 GENE; SAP3 GENE; SAP4 GENE; SAP5 GENE; SAP6 GENE; SIGNAL TRANSDUCTION; VAGINA CANDIDIASIS; VAGINITIS; ANIMAL; BAGG ALBINO MOUSE; ENZYMOLOGY; GENE EXPRESSION PROFILING; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; METABOLISM; MICROBIOLOGY; PATHOGENICITY; PATHOPHYSIOLOGY;

ANIMALS; ASPARTIC ENDOPEPTIDASES; CANDIDA ALBICANS; CANDIDIASIS, VULVOVAGINAL; FEMALE; FUNGAL PROTEINS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, FUNGAL; HUMANS; HYPHAE; MICE; MICE, INBRED BALB C;

EID: 15544379826     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.73.3.1828-1835.2005     Document Type: Article

References (50)

1. Barelle, C. J., C. L. Manson, D. M. MacCallum, F. C. Odds, N. A. Gow, and A. J. Brown. 2004. GFP as a quantitative reporter of gene regulation in Candida albicans. Yeast 21:333-340.
2. Borg-von Zepelin, M., S. Beggah, K. Boggian, D. Sanglard, and M. Monod. 1998. The expression of the secreted aspartyl proteinases SAP4 to SAP6 from Candida albicans in murine macrophages. Mol. Microbiol. 28:543-554.
3. Calderone, R. A. (ed.). 2002. Candida and candidiasis, 1st ed. ASM Press, Washington, D.C.
4. Calderone, R. A., and W. A. Fonzi. 2001. Virulence factors of Candida albicans. Trends Microbiol. 9:327-335.
5. De Bernardis, F., S. Arancia, L. Morelli, B. Hube, D. Sanglard, W. Schäfer, and A. Cassone. 1999. Evidence that members of the secretory aspartyl proteinase gene family, in particular SAP2, are virulence factors for Candida vaginitis. J. Infect. Dis. 179:201-208.
6. De Bernardis, F., F. A. Mühlschlegel, A. Cassone, and W. A. Fonzi. 1998. The pH of the host niche controls gene expression in and virulence of Candida albicans. Infect. Immun. 66:3317-3325.
7. Felk, A., W. Schäfer, and B. Hube. 2000. Candida albicans secretory aspartic proteinase (SAP) gene. Accession number AF1464400.
8. Fidel, P. L., Jr. 1998. Candida albicans: from commensal to pathogen, p. 441-476. In Medical importance of the normal microflora. Chapman and Hall, London, United Kingdom.
9. Fidel, P. L., Jr., M. E. Lynch, and J. D. Sobel. 1993. Candida-specific cell-mediated immunity is demonstrable in mice with experimental vaginal candidiasis. Infect. Immun. 61:1990-1995.
10. Fidel, P. L., Jr., and J. D. Sobel. 1996. Immunopathogenesis of recurrent vulvovaginal candidiasis. Contracept Fertil. Sex. 24:33-40.
11. Fonzi, W. A., and M. V. Irwin. 1993. Isogenic strain construction and gene mapping in Candida albicans. Genetics 134:717-728.
12. Geiger, A. M., and B. Foxman. 1996. Risk factors for vulvovaginal candidiasis: a case-control study among university students. Epidemiology 7:182-187.
13. Geiger, A. M., B. Foxman, and B. W. Gillespie. 1995. The epidemiology of vulvovaginal candidiasis among university students. Am. J. Public Health 85:1146-1148.
14. Ghannoum, M. A. 2000. Potential role of phospholipases in virulence and fungal pathogenesis. Clin. Microbiol. Rev. 13:122-143.
15. Gillum, A. M., E. Y. Tsay, and D. R. Kirsch. 1984. Isolation of the Candida albicans gene for orotidine-5′-phosphate decarboxylase by complementation of S. cerevisiae ura3 and E. coli pyrF mutations. Mol. Gen. Genet. 198:179-182.
16. Gow, N. A. 1997. Germ tube growth of Candida albicans. Curr. Top. Med. Mycol. 8:43-55.
17. Hellstein, J., H. Vawter-Hugart, P. Fotos, J. Schmid, and D. R. Soll. 1993. Genetic similarity and phenotypic diversity of commensal and pathogenic strains of Candida albicans isolated from the oral cavity. J. Clin. Microbiol. 31:3190-3199.
18. Hube, B. 1996. Candida albicans secreted aspartyl proteinases. Curr. Top. Med. Mycol. 7:55-69.
19. Hube, B. 1998. Possible role of secreted proteinases in Candida albicans infection. Rev. Iberoam. Micol. 15:65-68.
20. Hube, B., M. Monod, D. A. Schofield, A. J. Brown, and N. A. Gow. 1994. Expression of seven members of the gene family encoding secretory aspartyl proteinases in Candida albicans. Mol. Microbiol. 14:87-99.
21. Hube, B., and J. Naglik. 2001. Candida albicans proteinases: resolving the mystery of a gene family. Microbiology 147:1997-2005.
22. Hurley, R., and J. De Louvois. 1979. Candida vaginitis. Postgrad. Med. J. 55:645-647.
23. Kretschmar, M., A. Felk, P. Staib, M. Schaller, D. Hess, M. Callapina, J. Morschhäuser, W. Schäfer, H. C. Korting, H. Hof, B. Hube, and T. Nichterlein. 2002. Individual acid aspartic proteinases (Saps) 1-6 of Candida albicans are not essential for invasion and colonization of the gastrointestinal tract in mice. Microb. Pathog. 32:61-70.
24. Meysick, K. C., and G. E. Garber. 1992. Interactions between Trichomonas vaginalis and vaginal flora in a mouse model, J. Parasitol. 78:157-160.
25. Michel, S., S. Ushinsky, B. Klebl, E. Leberer, D. Thomas, M. Whiteway, and J. Morschhäuser. 2002. Generation of conditional lethal Candida albicans mutants by inducible deletion of essential genes. Mol. Microbiol. 46:269-280.
26. Monod, M., B. Hube, D. Hess, and D. Sanglard. 1998. Differential regulation of SAP8 and SAP9, which encode two new members of the secreted aspartic proteinase family in Candida albicans. Microbiology 144:2731-2737.
27. Monod, M., G. Togni, B. Hube, and D. Sanglard. 1994. Multiplicity of genes encoding secreted aspartic proteinases in Candida species. Mol. Microbiol. 13:357-368.
28. Morschhäuser, J., S. Michel, and J. Hacker. 1998. Expression of a chromosomally integrated, single-copy GFP gene in Candida albicans, and its use as a reporter of gene regulation. Mol. Gen. Genet. 257:412-420.
29. Naglik, J. R., S. J. Challacombe, and B. Hube. 2003. Candida albicans secreted aspartyl proteinases in virulence and pathogenesis. Microbiol. Mol. Biol. Rev. 67:400-428.
30. Naglik, J. R., C. A. Rodgers, P. J. Shirlaw, J. L. Dobbie, L. L. Fernandes-Naglik, D. Greenspan, N. Agabian, and S. J. Challacombe. 2003. Differential expression of Candida albicans secreted aspartyl proteinase and phospholipase B genes in humans correlates with active oral and vaginal infections. J. Infect. Dis. 188:469-479.
31. Nyirjesy, P. 2001. Chronic vulvovaginal candidiasis. Am. Fam. Physician 63:697-702.
32. Odds, F. C. 1994. Candida species and virulence. ASM News 60:313-318.
33. Ryley, J. F., and S. McGregor. 1986. Quantification of vaginal Candida albicans infections in rodents. J. Med. Vet. Mycol. 24:455-460.
34. Schaller, M., M. Bein, H. C. Korting, S. Baur, G. Hamm, M. Monod, S. Beinhauer, and B. Hube. 2003. The secreted aspartyl proteinases Sap1 and Sap2 cause tissue damage in an in vitro model of vaginal candidiasis based on reconstituted human vaginal epithelium. Infect. Immun. 71:3227-3234.
35. Schaller, M., W. Schäfer, H. C. Korting, and B. Hube. 1998. Differential expression of secreted aspartyl proteinases in a model of human oral candidosis and in patient samples from the oral cavity. Mol. Microbiol. 29:605-615.
36. Schröppel, K., K. Sprösser, M. Whiteway, D. Y. Thomas, M. Röllinghoff, and C. Csank. 2000. Repression of hyphal proteinase expression by the mitogen-activated protein (MAP) kinase phosphatase Cpp1p of Candida albicans is independent of the MAP kinase Cek1p. Infect. Immun. 68:7159-7161.
37. Schweizer, A., S. Rupp, B. N. Taylor, M. Röllinghoff, and K. Schröppel. 2000. The TEA/ATTS transcription factor CaTec1p regulates hyphal development and virulence in Candida albicans. Mol. Microbiol. 38:435-445.
38. Sobel, J. D. 1985. Epidemiology and pathogenesis of recurrent vulvovaginal candidiasis. Am. J. Obstet. Gynecol. 152:924-935.
39. Sobel, J. D. 1997. Vaginitis. N. Engl. J. Med. 337:1896-1903.
40. Sobel, J. D., S. Faro, R. W. Force, B. Foxman, W. J. Ledger, P. R. Nyirjesy, B. D. Reed, and P. R. Summers. 1998. Vulvovaginal candidiasis: epidemiologic, diagnostic, and therapeutic considerations. Am. J. Obstet. Gynecol. 178:203-211.
41. Sobel, J. D., G. Muller, and H. R. Buckley. 1984. Critical role of germ tube formation in the pathogenesis of candidal vaginitis. Infect. Immun. 44:576-580.
42. Sobel, J. D., G. Muller, and J. F. McCormick. 1985. Experimental chronic vaginal candidosis in rats. Sabouraudia 23:199-206.
43. Soll, D. R., C. J. Langtimm, J. McDowell, J. Hicks, and R. Galask. 1987. High-frequency switching in Candida strains isolated from vaginitis patients. J. Clin. Microbiol. 25:1611-1622.
44. Staib, P., M. Kretschmar, T. Nichterlein, H. Hof, and J. Morschhäuser. 2000. Differential activation of a Candida albicans virulence gene family during infection. Proc. Natl. Acad. Sci. USA 97:6102-6107.
45. Staib, P., M. Kretschmar, T. Nichterlein, H. Hof, and J. Morschhäuser. 2002. Host versus in vitro signals and intrastrain allelic differences in the expression of a Candida albicans virulence gene. Mol. Microbiol. 44:1351-1366.
46. Staib, P., M. Kretschmar, T. Nichterlein, H. Hof, and J. Morschhäuser. 2002. Transcriptional regulators Cph1p and Efg1p mediate activation of the Candida albicans virulence gene SAP5 during infection. Infect. Immun. 70:921-927.
47. Staib, P., M. Kretschmar, T. Nichterlein, G. Kohler, S. Michel, H. Hof, J. Hacker, and J. Morschhäuser. 1999. Host-induced, stage-specific virulence gene activation in Candida albicans during infection. Mol. Microbiol. 32:533-546.
48. Sweet, S. P. 1997. Selection and pathogenicity of Candida albicans in HIV infection. Oral Dis. 3(Suppl. 1):S88-S95.
49. Vargas, K., S. A. Messer, M. Pfaller, S. R. Lockhart, J. T. Stapleton, J. Hellstein, and D. R. Soll. 2000. Elevated phenotypic switching and drug resistance of Candida albicans from human immunodeficiency virus-positive individuals prior to first thrush episode. J. Clin. Microbiol. 38:3595-3607.
50. White, T. C., and N. Agabian. 1995. Candida albicans secreted aspartyl proteinases: isoenzyme pattern is determined by cell type, and levels are determined by environmental factors. J. Bacteriol. 177:5215-5221.