Design and validation of anti-inflammatory peptides from human parotid secretory protein

Journal of Dental Research

Volumn 84, Issue 2, 2005, Pages 149-153

  Geetha, C ^a,b   Venkatesh, S G ^a   Bingle, L ^c   Bingle, C D ^c   Gorr, S U ^a  

^a UNIVERSITY OF LOUISVILLE SCHOOL OF MEDICINE   (United States)

^b Avestha Gengraine Technologies Pvt Ltd   (India)

^c UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

C20orf70; Cationic peptides; Endotoxin; Inflammation; Lipopolysaccharide; PLUNC; Saliva

Indexed keywords

ANTIINFECTIVE AGENT; ANTIMICROBIAL CATIONIC PEPTIDE; BACTERICIDAL PERMEABILITY INCREASING PROTEIN; C20ORF70 PROTEIN, HUMAN; GLYCOPROTEIN; MEMBRANE PROTEIN; PHOSPHOPROTEIN; PLASMA PROTEIN; PLUNC PROTEIN, HUMAN; RNA; SALIVA PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

AMINO ACID SEQUENCE; ANALYSIS OF VARIANCE; ARTICLE; CELL LINE; CHEMISTRY; CYTOLOGY; DRUG EFFECT; GENETICS; HUMAN; MACROPHAGE; METHODOLOGY; MOLECULAR CLONING; MOLECULAR GENETICS; PROTEIN ENGINEERING; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; SYNTHESIS; VALIDATION STUDY;

AMINO ACID SEQUENCE; ANALYSIS OF VARIANCE; ANTI-BACTERIAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; BLOOD PROTEINS; CELL LINE; CLONING, MOLECULAR; GLYCOPROTEINS; HUMANS; MACROPHAGES; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; PHOSPHOPROTEINS; PROTEIN ENGINEERING; RNA; SALIVARY PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, PROTEIN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 15544376642     PISSN: 00220345     EISSN: None     Source Type: Journal    
DOI: 10.1177/154405910508400208     Document Type: Article

References (30)

1. Altschul S, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W, et al. (1997). Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 25:3389-3402.
2. Azuma M, Aota K, Tamatani T, Motegi K, Yamashita T, Ashida Y, et al. (2002). Suppression of tumor necrosis factor alpha-induced matrix metalloproteinase 9 production in human salivary gland acinar cells by cepharanthine occurs via down-regulation of nuclear factor kappaB: a possible therapeutic agent for preventing the destruction of the acinar structure in the salivary glands of Sjögren's syndrome patients. Arthritis Rheum 46:1585-1594.
3. Battafarano RJ, Dahlberg PS, Ratz CA, Johnston JW, Gray BH, Haseman JR, et al. (1995). Peptide derivatives of three distinct lipopolysaccharide binding proteins inhibit lipopolysaccharide-induced tumor necrosis factor-alpha secretion in vitro. Surgery 118:318-324.
4. Bingle CD, Craven CJ (2002). PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx. Hum Mol Genet 11:937-943.
5. Bingle CD, Gorr SU (2004). Host defense in oral and airway epithelia: chromosome 20 contributes a new protein family. Int J Biochem Cell Biol 36:2144-2152.
6. Bradshaw J (2003). Cationic antimicrobial peptides: issues for potential clinical use. BioDrugs 17:233-240.
7. Campos MA, Abreu AR, Nlend MC, Cobas MA, Conner GE, Whitney PL (2004). Purification and characterization of PLUNC from human tracheobronchial secretions. Am J Respir Cell Mol Biol 30:184-192.
8. Cole AM, Liao HI, Stuchlik O, Tilan J, Pohl J, Ganz T (2002). Cationic polypeptides are required for antibacterial activity of human airway fluid. J Immunol 169:6985-6991.
9. Dankesreiter S, Hoess A, Schneider-Mergener J, Wagner H, Miethke T (2000). Synthetic endotoxin-binding peptides block endotoxin-triggered TNF-alpha production by macrophages in vitro and in vivo and prevent endotoxin-mediated toxic shock. J Immunol 164:4804-4811.
10. Ganz T (2003). Defensins: antimicrobial peptides of innate immunity. Nat Rev Immunol 3:710-720.
11. Geetha C, Venkatesh SG, Dunn BH, Gorr SU (2003). Expression and anti-bacterial activity of human parotid secretory protein (PSP). Biochem Soc Trans 31(Pt 4):815-818.
12. Ghafouri B, Kihlstrom E, Stahlbom B, Tagesson C, Lindahl M (2003). PLUNC (palate, lung and nasal epithelial clone) proteins in human nasal lavage fluid. Biochem Soc Trans 31(Pt 4):810-814.
13. Gupta N, Asp E, Levan G, Mirels L (2000). Structure and chromosomal localization of the rat salivary Psp and Smgb genes. Gene 243(1-2):1-18.
14. Kelley LA, MacCallum RM, Sternberg MJ (2000). Enhanced genome annotation using structural profiles in the program 3D- PSSM. J Mol Biol 299:499-520.
15. LeClair EE (2003). Four reasons to consider a novel class of innate immune molecules in the oral epithelium. J Dent Res 82:944-950.
16. Little RG, Kelner DN, Lim E, Burke DJ, Conlon PJ (1994). Functional domains of recombinant bactericidal/permeability increasing protein (rBPI23). J Biol Chem 269:1865-1872.
17. Madsen HO, Hjorth JP (1985). Molecular cloning of mouse PSP mRNA. Nucleic Acids Res 13:1-13.
18. Mirels L, Ball WD (1992). Neonatal rat submandibular-gland protein SMG-A and parotid secretory protein are alternatively regulated members of a salivary protein multigene family. J Biol Chem 267:2679-2687.
19. Nieuw Amerongen AV, Veerman EC (2002). Saliva-the defender of the oral cavity. Oral Dis 8:12-22.
20. Rajan GH, Morris CA, Carruthers VR, Wilkins RJ, Wheeler TT (1996). The relative abundance of a salivary protein, bSP30, is correlated with susceptibility to bloat in cattle herds selected for high or low bloat susceptibility. Anim Genet 27:407-414.
21. Stokes DC, Shenep JL, Fishman M, Hildner WK, Bysani GK, Rufus K (1989). Polymyxin B prevents lipopolysaccharide-induced release of tumor necrosis factor-alpha from alveolar macrophages. J Infect Dis 160:52-57.
22. Taylor AH, Heavner G, Nedelman M, Sherris D, Brunt E, Knight D, et al. (1995). Lipopolysaccharide (LPS) neutralizing peptides reveal a lipid A binding site of LPS binding protein. J Biol Chem 270:17934-17938.
23. Tenovuo J (1998). Antimicrobial function of human saliva-how important is it for oral health? Acta Odontol Scand 56:250-256.
24. Thompson JD, Higgins DG, Gibson TJ (1994). CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res 22:4673-4680.
25. Uknis ME, Wasiluk KR, Acton RD, Klaemer HG, Dahlberg PS, Ilyina EE, et al. (1997). Design of a potent novel endotoxin antagonist. Surgery 122:380-385.
26. Ulmer AJ, Rietschel ET, Zahringer U, Heine H (2002). Lipopolysaccharide: structure, bioactivity, receptors, and signal transduction. Trends Glycosci Glycotechnol 14(76):53-68.
27. Weinberg A, Krisanaprakornkit S, Dale BA (1998). Epithelial antimicrobial peptides: review and significance for oral applications. Crit Rev Oral Biol Med 9:399-414.
28. Wheeler TT, Haigh BJ, McCracken JY, Wilkins RJ, Morris CA, Grigor MR (2002). The BSP30 salivary proteins from cattle, LUNX/PLUNC and von Ebner's minor salivary gland protein are members of the PSP/LBP superfamily of proteins. Biochim Biophys Acta 1579(2-3):92-100.
29. Wu AJ, Lafrenie RM, Park C, Apinhasmit W, Chen ZJ, Birkedal-Hansen H, et al. (1997). Modulation of MMP-2 (gelatinase A) and MMP-9 (gelatinase B) by interferon-gamma in a human salivary gland cell line. J Cell Physiol 171:117-124.
30. Yin HF, Zhao ZH, Fan BL, Liu ZL, Lu W, Liu YF, et al. (2004). cDNA cloning, genomic structure, chromosomal mapping, and expression analysis of parotid secretory protein in pig. Genomics 83:9-18.