Characterization of three essential residues in the conserved ATP-binding region of Epstein-Barr virus thymidine kinase

Biochemistry

Volumn 44, Issue 12, 2005, Pages 4785-4793

  Wu, Chung Chun ^a   Hsu, Tsuey Ying ^a   Chen, Jen Yang ^a,b  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; AMINO ACIDS; MEDICAL APPLICATIONS; MUTAGENESIS; PHOSPHATES; VIRUSES;

ANTIVIRAL THERAPY; MUTANTS; NUCLEOTIDE BINDING; THYMIDINE KINASE;

ENZYMES;

THYMIDINE KINASE;

ARTICLE; BINDING AFFINITY; CATALYSIS; ENZYME ACTIVITY; ENZYME ANALYSIS; EPSTEIN BARR VIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN MOTIF;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; BINDING SITES; CONSERVED SEQUENCE; CYTIDINE TRIPHOSPHATE; GLYCINE; GUANOSINE TRIPHOSPHATE; HERPESVIRUS 4, HUMAN; HUMANS; LYSINE; MAGNESIUM; MANGANESE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; THREONINE; THYMIDINE KINASE; THYMINE NUCLEOTIDES; ZINC;

EID: 15444378010     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0484872     Document Type: Article

References (63)

1. Jamieson, A. T., Gentry, G. A., and Subak-Sharpe, J. H. (1974) Induction of both thymidine and deoxycytidine kinase activity by herpes viruses, J. Gen. Virol. 24, 465-480.
2. Epstein, M. A., Achong, B. G., and Barr, Y. M. (1964) Virus particles in cultured lymphoblasts from Burkitt's lymphoma, Lancet 1, 702-703.
3. de-The, G., Geser, A., Day, N. E., Tukei, P. M., Williams, E. H., Beri, D. P., Smith, P. G., Dean, A. G., Bronkamm, G. W., Feorino, P., and Henle, W. (1978) Epidemiological evidence for causal relationship between Epstein-Barr virus and Burkitt's lymphoma from Ugandan prospective study, Nature 274, 756-761.
4. Old, J. L., Boyse, E. A., Oettgen, H. F., de Harven, E., Geering, G., Williamson, B., and Clifford, P. (1966) Precipitating antibody in human serum to an antigen present in cultured Burkitt's lymphoma cells, Proc. Natl. Acad. Sci. U.S.A. 56, 1699-1704.
5. Weiss, L. M., Movahed, L. A., Warnke, R. A., and Sklar, J. (1989) Detection of Epstein-Barr viral genomes in Reed-Sternberg cells of Hodgkin's disease, N. Engl. J. Med. 320, 502-506.
6. Su, I. J., and Hsieh, H. C. (1992) Clinicopathological spectrum of Epstein-Barr virus-associated T cell malignancies, Leuk. Lymph. 7, 47-53.
7. Burke, A. P., Yen, T. S., Shekitka, K. M., and Sobin, L. H. (1990) Lymphoepithelial carcinoma of the stomach with Epstein-Barr virus demonstrated by polymerase chain reaction, Mod. Pathol. 3, 377-380.
8. Cohen, J. I. (1991) Epstein-Barr virus lymphoproliferative disease associated with acquired immunodeficiency, Medicine (Baltimore) 70, 137-160.
9. Baer, R., Bankier, A. T., Biggin, M. D., Deininger, P. L., Farrell, P. J., Gibson, T. J., Hatfull, G., Hudson, G. S., Satchwell, S. C., Seguin, C., Tuffnell, P. S., and Barrell, B. G. (1984) DNA sequence and expression of the B95-8 Epstein-Barr virus genome, Nature 310, 207-211.
10. Westphal, E. M., Mauser, A., Swenson, J., Davis, M. G., Talarico, C. L., and Kenney, S. C. (1999) Induction of lytic Epstein-Barr virus (EBV) infection in EBV-associated malignancies using adenovirus vectors in vitro and in vivo, Cancer Res. 59, 1485-1491.
11. Chung, Y. L., Lee Wu, Y. H., Yen, S. H., and Chi, K. H. (2000) A novel approach for nasopharyngeal carcinoma treatment uses phenylbutytaye as a protein kinase C modulator: Implications for radiosensitization and EBV-targeted therapy, Clin. Cancer Res. 6, 1452-1458.
12. Mentzer, S. J., Fingeroth, J., Reilly, J. J., Perrine, S. P., and Faller, D. V. (1998) Arginine butyrate-induced susceptibility to ganciclovirin an Epstein-Barr-virus-associated lymphoma, Blood Cells Mol. Dis. 24, 114-123.
13. Mentzer, S. J., Perrine, S. P., and Faller, D. V. (2001) Epstein-Barr virus post-transplant lymphoproliferative disease and virus-specific therapy: pharmacological reactivation of viral target genes with arginine butyrate, Transplant. Inf. Dis. 3, 177-185.
14. Moore, S. M., Cannon, J. S., Tanhehco, Y. C., Hamzeh, F. M., and Ambinder, R. F. (2001) induction of Epstein-Barr virus kinases to sensitize tumor cells to nucleoside analogues, Antimicrob. Agents Chemother. 45, 2082-2091.
15. Hsu, T. Y., Pai, C. Y., Shieh, S. M., Cho, S. M., Liu, M. Y., Chen, J. Y., and Yang, C. S. (1992) Use of antigen expressed in bacteria for detection of EBV-specific thymidine kinase antibodies in sera from patients with nasopharyngeal carcinoma, J. Med. Virol. 38, 214-219.
16. Tung, P. P., and Summers, W. C. (1994) Substrate specificity of Epstein-Barr virus thymidine kinase, Antimicrob. Agents Chemother. 38, 2175-2179.
17. Littler, E., and Arrand, J. R. (1988) Characterization of the Epstein-Barr virus-encoded thymidine kinase expressed in heterologous eucaryotic and procaryotic systems, J. Virol. 62, 3892-3895.
18. Hsu, T. Y., Liu, M. W., Chang, Y. R., Pai, C. Y., Liu, M. Y., Yang, C. S., and Chen, J. Y. (1996) Functional analysis of C-terminal deletion mutants of Epstein-Barr virus thymidine kinase, J. Gen. Virol. 77, 1893-1899.
19. Wu, C. C., Chen, M. C., Chang, Y. R., Hsu, T. Y., and Chen, J. Y. (2004) Identification and characterization of the conserved nucleoside binding sites in the Epstein-Barr virus thymidine kinase, Biochem. J. 379, 795-803.
20. Saraste, M., Sibbald, P. R., and Wittinghofer, A. (1990) The P-loop - a common motif in ATP- and GTP-binding proteins, Trends Biochem. Sci. 15, 430-434.
21. Byeon, I. J., Yan, H., Edison, A. S., Mooberry, E. S., Abildgaard, F., Markley, J. L., and Tsai, M. D. (1993) Mechanism of adenylate kinase. 1H, 13C, and 15N NMR assignments, secondary structures, and substrate binding sites, Biochemistry 32, 12508-12521.
22. Balasubramaniam, N. K., Veerisetty, V., and Gentry, G. A. (1990) Herpesviral deoxythymidine kinases contain a site analogous to the phosphoryl-binding arginine-rich region of porcine adenylate kinase; comparison of secondary structure predictions and conservation, J. Gen. Virol. 71, 2979-2987.
23. Liu, Q. Y., and Summers, W. C. (1988) Site-directed mutagenesis of a nucleotide-binding domain in HSV-1 thymidine kinase: effects on catalytic activity, Virology 163, 638-642.
24. Munir, K. M., French, D. C., Dube, D. K., and Loeb, L. A. (1992) Permissible amino acid substitutions within the putative nucleoside binding site of herpes simplex virus type 1 encoded thymidine kinase established by random sequence mutagenesis, J. Biol. Chem. 267, 6584-6589.
25. Black, M. E., and Loeb, L. A. (1993) Identification of important residues within the putative nucleoside binding site of HSV-1 thymidine kinase by random sequence selection: analysis of selected mutants in vitro, Biochemistry 32, 11618-11626.
26. Reddy, E. P., Reynolds, R. K., Santos, E., and Barbacid, M. (1982) A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene, Nature 300, 149-152.
27. Tabin, C. J., Bradley, S. M., Bargmann, C. I., Weinberg, R. A., Papageorge, A. G., Scolnick, E. M., Dhar, R., Lowy, D. R., and Chang, E. H. (1982) Mechanism of activation of a human oncogene, Nature 300, 143-149.
28. Reinstein, J., Schlichting, I., and Wittinghofer, A. (1990) Structurally and catalytically important residues in the phosphate binding loop of adenylate kinase of Escherichia coli, Biochemistry 29, 7451-7459.
29. Liu, M. Y., Pai, C. Y., Shieh, S. M., Hsu, T. Y., Chen, J. Y., and Yang, C. S. (1992) Cloning and expression of cDNA encoding the Epstein-Barr virus thymidine kinase gene, J. Virol. Methods 40, 107-118.
30. Matte, A., Tari, L. W., and Delbaere, L. T. (1998) How do kinases transfer phosphoryl groups, Structure 6, 413-419.
31. Brown, D. G., Visse, R., Sandhu, G., Davies, A., Rizkallah, P. J., Melitz, C., Summers, W. C., and Sanderson, M. R. (1995) Crystal structures of the thymidine kinase from herpes simplex virus type-1 in complex with deoxythymidine and ganciclovir, Nat. Struct. Biol. 2, 876-880.
32. Wild, K., Bohner, T., Aubry, A., Folkers, G., and Schulz, G. E. (1995) The three-dimensional structure of thymidine kinase from herpes simplex virus type 1, FEBS Lett. 368, 289-292.
33. Wild, K., Thomas, B., Gerd, F., and George, S. (1997) The structure of thymidine kinase from herpes simplex virus type 1 in complex with substrate and a substrate analogue, Protein Sci. 6, 2097-2106.
34. Teplyakov, A., Sebastiao, P., Obmolova, G., Perrakis, A., Brush, G. S., Bessman, M. J., and Wilson, K. S. (1996) Crystal structure of bacteriophage T4 deoxynucleotide kinase with its substrates dGMP and ATP, EMBO J. 15, 3487-3497.
35. Pai, E. F., Krengel, U., Petsko, G. A., Goody, R. S., Kabsch, W., and Wittinghofer, A. (1990) Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis, EMBO J. 9, 2351-2359.
36. Abele, U., and Schulz, G. E. (1995) High-resolution structures of adenylate kinase from yeast ligated with inhibitor Ap5A, showing the pathway of phosphoryl transfer, Protein Sci. 4, 1262-1271.
37. Muller-Dieckmann, H. J., and Schulz, G. E. (1994) The structure of uridylate kinase with its substrates, showing the transition state geometry, J. Mol. Biol. 236, 361-367.
38. Berry, M. B., Meador, B., Bilderback, T., Liang, P., Glaser, M., and Phillips, G. N., Jr. (1994) The closed conformation of a highly flexible protein: the structure of E. coli adenylate kinase with bound AMP and AMPPNP, Proteins 19, 183-198.
39. Kjeldgaard, M., Nissen, P., Thirup, S., and Nyborg, J. (1993) The crystal structure of elongation factor EF-Tu from Thermus aquaticus in the GTP conformation, Structure 1, 35-50.
40. Diederichs, K., and Schulz, G. E. (1991) The refined structure of the complex between adenylate kinase from beef heart mitochondrial matrix and its substrate AMP at 1.85 A resolution, J. Mol. Biol. 217, 541-549.
41. Stehle, T., and Schulz, G. E. (1992) Refined structure of the complex between guanylate kinase and its substrate GMP at 2.0 A resolution, J. Mol. Biol. 224, 1127-1141.
42. Cazaux, C., Tiraby, M., Loubiere, L., Hatren, L., Klatzmann, D., and Tiraby, G. (1998) Phosphorylation and cytotoxicity of therapeutic nucleoside analogues: A comparison of α and γ herpesvirus thymidine kinase suicide genes, Cancer Gene Ther. 5, 83-91.
43. Prieto, J., Martin Hernandez, A. M., and Tabares, E. (1991) Loss of pseudorabies virus thymidine kinase activity due to a single base mutation and amino acid substitution, J. Gen. Virol. 72, 1435-1439.
44. Fry, D. C., Kuby, S. A., and Mildvan, A. S. (1986) ATP-binding site of adenylate kinase: mechanistic implications of its homology with ras-encoded p21, F1-ATPase, and other nucleotide-binding proteins, Proc. Natl. Acad. Sci. U.S.A. 83, 907-911.
45. Gentry, G. A. (1992) Viral thymidine kinases and their relatives, Pharmacol. Ther. 54, 319-355.
46. Sigal, I. S., Gibbs, J. B., D'Alonzo, J. S., Temeles, G. L., Wolanski, B. S., Socher, S. H., and Scolnick, E. M. (1986) Mutant ras-encoded proteins with altered nucleotide binding exert dominant biological effects, Proc. Natl. Acad. Sci. U.S.A. 83, 952-956.
47. Kussmann-Gerber, S., Kuonen, O., Folkers, G., Pilger, B. D., and Scapozza, L. (1998) Drug resistance of herpes simplex virus type 1 - structural considerations at the molecular level of the thymidine kinase, Eur. J. Biochem. 255, 472-481.
48. Hashimoto, E., Takio, K., and Krebs, E. G. (1982) Amino acid sequence at the ATP-binding site of cGMP-dependent protein kinase, J. Biol. Chem. 257, 727-733.
49. Kamps, M. P., Taylor, S. S., and Sefton, B. M. (1984) Direct evidence that oncogenic tyrosine kinases and cyclic AMP-dependent protein kinase have homologous ATP-binding sites, Nature 310, 589-592.
50. Dever, T. E., Glynias, M. J., and Merrick, W. C. (1987) GTP-binding domain: three consensus sequence elements with distinct spacing, Proc. Natl. Acad. Sci. U.S.A. 84, 1814-1818.
51. Brands, J. H., Maassen, J. A., van Hemert, F. J., Amons, R., and Moller, W. (1986) The primary structure of the alpha subunit of human elongation factor 1. Structural aspects of guanine-nucleotide-binding sites, Eur. J. Biochem. 155, 167-171.
52. Parada, L. F., Tabin, C. J., Shih, C., and Weinberg, R. A. (1982) Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene, Nature 297, 474-478.
53. Plucienniczak, A., Schroeder, E., Zettlmeissl, G., and Streeck, R. E. (1985) Nucleotide sequence of a cluster of early and late genes in a conserved segment of the vaccinia virus genome, Nucleic Acids Res. 13, 985-998.
54. Bockamp, E. O., Blasco, R., and Vinuela, E. (1991) Escherichia coli thymidine kinase: nucleotide sequence of the gene and relationships to other thymidine kinases, Gene 101, 9-14.
55. Bradshaw, H. D., Jr., and Deininger, P. L. (1984) Human thymidine kinase gene: molecular cloning and nucleotide sequence of a cDNA expressible in mammalian cells, Mol. Cell Biol. 4, 2316-2320.
56. Johansson, M., and Karlsson, A. (1997) Cloning of the cDNA and chromosome localization of the gene for human thymidine kinase 2, J. Biol. Chem. 272, 8454-8458.
57. Konrad, M. (1993) Molecular analysis of the essential gene for adenylate kinase from the fission yeast Schizosaccharomyces pombe, J. Biol. Chem. 268, 11326-11334.
58. Von Zabern, I., Wittmann-Liebold, B., Untucht-Grau, R., Schirmer, R. H., and Pai, E. F. (1976) Primary and tertiary structure of the principal human adenylate kinase, Eur. J. Biochem. 68, 281-290.
59. Kuby, S. A., Palmieri, R. H., Frischat, A., Fischer, A. H., Wu, L. H., Maland, L., and Manship, M. (1984) Studies on adenosine triphosphate transphosphorylases. Amino acid sequence of rabbit muscle ATP-AMP transphosphorylase, Biochemistry 23, 2393-2399.
60. Brune, M., Schumann, R., and Wittinghofer, F. (1985) Cloning and sequencing of the adenylate kinase gene (adk) of Escherichia coli, Nucleic Acids Res. 13, 7139-7151.
61. Broida, J., and Abelson, J. (1985) Sequence organization and control of transcription in the bacteriophage T4 tRNA region, J. Mol. Biol. 185, 545-563.
62. Wood, V., Gwilliam, R., Rajandream, M. A., Lyne, M., Lyne, R., Stewart, A., Sgouros, J., Peat, N., Hayles, J., Baker, S., Basham, D., Bowman, S., Brooks, K., Brown, D., Brown, S., Chillingworth, T., Churcher, C., Collins, M., Connor, R., Cronin, A., Davis, P., Feltwell, T., Fraser, A., Gentles, S., Goble, A., Hamlin, N., Harris, D., Hidalgo, J., Hodgson, G., Holroyd, S., Hornsby, T., Howarth, S., Huckle, E. J., Hunt, S., Jagels, K., James, K., Jones, L., Jones, M., Leather, S., McDonald, S., McLean, J., Mooney, P., Moule, S., Mungall, K., Murphy, L., Niblett, D., Odell, C., Oliver, K., O'Neil, S., Pearson, D., Quail, M. A., Rabbinowitsch, E., Rutherford, K., Rutter, S., Saunders, D., Seeger, K., Sharp, S., Skelton, J., Simmonds, M., Squares, R., Squares, S., Stevens, K., Taylor, K., Taylor, R. G., Tivey, A., Walsh, S., Warren, T., Whitehead, S., Woodward, J., Volckaert, G., Aert, R., Robben, J., Grymonprez, B., Weltjens, I., Vanstreels, E., Rieger, M., Schafer, M., Muller-Auer, S., Gabel, C., Fuchs, M., Fritzc, C., Holzer, E., Moestl, D., Hilbert, H., Borzym, K., Langer, I., Beck, A., Lehrach, H., Reinhardt, R., Pohl, T. M., Eger, P., Zimmermann, W., Wedler, H., Wambutt, R., Purnelle, B., Goffeau, A., Cadieu, E., Dreano, S., Gloux, S., Lelaure, V., Mottier, S., Galibert, F., Aves, S. J., Xiang, Z., Hunt, C., Moore, K., Hurst, S. M., Lucas, M., Rochet, M., Gaillardin, C., Tallada, V. A., Garzon, A., Thode, G., Daga, R. R., Cruzado, L., Jimenez, J., Sanchez, M., del Rey, F., Benito, J., Domýnguez, A., Revuelta, J. L., Moreno, S., Armstrong, J., Forsburg, S. L., Cerrutti, L., Lowe, T., McCombie, W. R., Paulsen, I., Potashkin, J., Shpakovski, G. V., Ussery, D., Barrell, B. G., and Nurse, P. (2002) The genome sequence of Schizosaccharomyces pombe, Nature 415, 871-880.
63. Konrad, M. (1992) Cloning and expression of the essential gene for guanylate kinase from yeast, J. Biol. Chem. 267, 25652-25655.