Treatment of lethal cowpox virus respiratory infections in mice with 2-amino-7-[(1,3-dihydroxy-2-propoxy)methyl]purine and its orally active diacetate ester prodrug

Antiviral Research

Volumn 54, Issue 2, 2002, Pages 113-120

  Smee, Donald F ^a   Bailey, Kevin W ^a   Sidwell, Robert W ^a  

^a UTAH STATE UNIVERSITY   (United States)

Author keywords

Acyclic purine; Antiviral; Cidofovir; Cowpox virus; Orthopox virus

Indexed keywords

2 AMINO 7 [(1,3 DIHYDROXY 2 PROPOXY)METHYL]PURINE; CIDOFOVIR; HOE 961; PRODRUG; PURINE NUCLEOSIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CELL CULTURE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; COWPOX VIRUS; DOSE RESPONSE; DRUG EFFICACY; DRUG POTENCY; DRUG SCREENING; FEMALE; FIBROBLAST; GROWTH INHIBITION; INOCULATION; MOUSE; NONHUMAN; ORTHOPOXVIRUS; PRIORITY JOURNAL; RESPIRATORY TRACT INFECTION; VERO CELL; VIRUS CULTURE; VIRUS INFECTION; VIRUS REPLICATION; VIRUS STRAIN; VIRUS TITRATION; WILD TYPE;

ANIMALS; ANTIVIRAL AGENTS; AREA UNDER CURVE; BODY WEIGHT; CERCOPITHECUS AETHIOPS; COWPOX; COWPOX VIRUS; CYTOSINE; DISEASE MODELS, ANIMAL; FEMALE; LUNG; MICE; MICE, INBRED BALB C; NASAL MUCOSA; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHONIC ACIDS; PRODRUGS; PURINES; STATISTICS, NONPARAMETRIC; VERO CELLS;

COWPOX VIRUS; ORTHOPOXVIRUS; VACCINIA VIRUS;

EID: 0036228068     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-3542(01)00217-0     Document Type: Article

References (25)

1. Cidofovir (HPMPC) protects mice against lethal aerosol or intranasal cowpox virus challenge
2. Poxvirus dilemmas - Monkeypox, smallpox and biological terrorism
3. Topical cidofovir for severe molluscum contagiosum
4. Vaccinia virus inhibitors as a paradigm for the chemotherapy of poxvirus infections
5. Intracellular metabolism of the antiherpes agent (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine
6. Poxvirus dilemmas
7. Efficacy of cidofovir in the treatment of recalcitrant molluscum contagiosum in an AIDS patient
8. Progressive vaccinia treated with ribavirin and vaccinia immune globulin
9. Deoxycytidine kinase from calf thymus. Substrate and inhibitor specificity
10. Resolution of recalcitrant molluscum contagiosum virus lesions in human immunodeficiency virus-infected patients treated with cidofovir
11. Parapoxviruses are strongly inhibited in vitro by cidofovir
12. Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine for the treatment of lethal vaccinia virus infections in severe combined immune deficiency (SCID) mice
13. Efficacy of 2-amino-7-(1,3-dihydroxy-2-propoxymethyl)purine for the treatment of vaccinia virus (orthopoxvirus) infections in mice
14. The N-7-substituted acyclic nucleoside analog 2-amino-7-[(1,3-dihydroxy-2-propoxy)methyl]purine is a potent and selective inhibitor of herpesvirus replication
15. In vivo antiherpesvirus activity of N-7-substituted acyclic nucleoside analog 2-amino-7-[(1,3-dihydroxy-2-propoxy)methyl]purine
16. Intracellular metabolism of the N7-substituted acyclic nucleoside analog 2-amino-7-[(1,3-dihydroxy-2-propoxy)methyl]purine, a potent inhibitor of herpesvirus replication
17. Protective effect of 5-iodo-2′-deoxyuridine (IDU) against vaccinia virus infections in SCID mice
18. Escape from Moscow
19. Antiviral activities of nucleosides and nucleotides against wild-type and drug-resistant strains of murine cytomegalovirus
20. Treatment of cowpox virus respiratory infections in mice with ribavirin as a single agent or followed sequentially by cidofovir
21. Intranasal treatment of cowpox virus respiratory infections in mice with cidofovir
22. Effects of cidofovir on the pathogenesis of a lethal vaccinia virus respiratory infection in mice
23. (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, a potent and selective inhibitor of human cytomegalovirus replication
24. Topical cidofovir: A novel treatment for recalcitrant molluscum contagiosum in children infected with human immunodeficiency virus 1
25. Pharmacokinetics, safety and bioavailability of HPMPC (cidofovir) in human immunodeficiency virus-infected subjects