Expediting target identification and validation through RNAi: 17-18 November 2003, London, UK

Expert Opinion on Biological Therapy

Volumn 4, Issue 3, 2004, Pages 427-429

  Kurreck, Jens ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Cancer; Infectious diseases; Pain; RNA interference; Small interfering RNAs; Target identification; Target validation

Indexed keywords

DOUBLE STRANDED RNA; INTERFERON; SMALL INTERFERING RNA;

CANCER; CHRONIC PAIN; CONFERENCE PAPER; GENE EXPRESSION; GENE SILENCING; MAMMAL CELL; RNA INTERFERENCE; VIRUS INFECTION;

ANIMALS; DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION; GENE TARGETING; HUMANS; RNA INTERFERENCE; RNA, SMALL INTERFERING;

ANIMALIA; MAMMALIA; RNA VIRUSES;

EID: 1542782911     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.4.3.427     Document Type: Conference Paper

References (6)

1. ELBASHIR SM, HARBORTH J, LENDECKEL W, YALCIN A, WEBER K, TUSCHL T: Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature (2001) 411:494-498.
2. BRUMMELKAMP TR, NIJMAN SMB, DIRAC AMG, BERNARDS R: Loss of cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB. Nature (2003) 424:797-801.
3. CZAUDERNA F, SANTEL A, HINZ M et al.: Inducible shRNA expression for application in a prostate cancer mouse model. Nucleic Acids Res. (2003) 31:e127.
4. LEWIS DL, HAGSTROM JE, LOOMIS AG, WOLFF JA, HERWEIJER H: Efficient delivery of siRNA for inhibition of gene expression in posnatal mice. Nat. Genet. (2002) 32:107-108.
5. JACKSON AL, BARTZ SR, SCHELTER J et al.: Expression profiling reveals off-target gene regulation by RNAi. Nat. Biotechnol. (2003) 21:635-637.
6. SLEDZ CA, HOLKO M, DE VEER MJ, SILVERMAN RH, WILLIAMS BRG: Activation of the interferon system by short-interfering RNAs. Nat. Cell Biol. (2003) 5:834-839.