mRNA expression levels of E2F transcription factors correlate with dihydrofolate reductase, reduced folate carrier, and thymidylate synthase mRNA expression in osteosarcoma

Molecular Cancer Therapeutics

Volumn 2, Issue 6, 2003, Pages 535-541

  Sowers, Rebecca ^a   Toguchida, Junya ^d   Qin, Jing ^a   Meyers, Paul A ^a   Healey, John H ^b   Huvos, Andrew ^a   Banerjee, Debabrata ^c   Bertino, Joseph R ^c   Gorlick, Richard ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^d KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; CELL CYCLE PROTEIN; DIHYDROFOLATE REDUCTASE; DNA; DNA BINDING PROTEIN; E2F1 PROTEIN, HUMAN; E2F4 PROTEIN, HUMAN; MESSENGER RNA; METHOTREXATE; REDUCED FOLATE CARRIER; RNA; THYMIDYLATE SYNTHASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR E2F; TRANSCRIPTION FACTOR E2F1; TRANSCRIPTION FACTOR E2F4;

ADOLESCENT; ADULT; AGED; ARTICLE; BIOSYNTHESIS; CHEMISTRY; CHILD; DRUG RESISTANCE; ENZYMOLOGY; FEMALE; HUMAN; MALE; METABOLISM; MIDDLE AGED; OSTEOSARCOMA; PRESCHOOL CHILD; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADOLESCENT; ADULT; AGED; CARRIER PROTEINS; CELL CYCLE PROTEINS; CHILD; CHILD, PRESCHOOL; DNA; DNA-BINDING PROTEINS; DRUG RESISTANCE, NEOPLASM; E2F TRANSCRIPTION FACTORS; E2F1 TRANSCRIPTION FACTOR; E2F4 TRANSCRIPTION FACTOR; FEMALE; HUMANS; MALE; MEMBRANE TRANSPORT PROTEINS; METHOTREXATE; MIDDLE AGED; OSTEOSARCOMA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; RNA, MESSENGER; TETRAHYDROFOLATE DEHYDROGENASE; THYMIDYLATE SYNTHASE; TRANSCRIPTION FACTORS;

EID: 1542754612     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Meyers, P. A., and Gorlick, R. Osteosarcoma. Pediatr. Clin. N. Am., 44: 973-990, 1997.
2. Meyers, P. A., Heller, G., Healey, J. H., Huvos, A., Lane, J., Marcove, R., Applewhite, A., Vlamis, V., and Rosen, G. Chemotherapy for nonmetastatic osteogenic sarcoma: the Memorial Sloan-Kettering experience. J. Clin. Oncol., 10: 5-15, 1992.
3. Meyers, P. A., Gorlick, R., Heller, G., Casper, E., Lane, J., Huvos, A., and Healey, J. Intensification of preoperative chemotherapy for osteogenic sarcoma: the results of the Memorial Sloan-Kettering (T12) protocol. J. Clin. Oncol., 16: 2452-2458, 1998. (Pubitemid 28309040)
4. Jaffe, N., Frei, E., Watts, H., and Traggis, D. High-dose methotrexate in osteogenic sarcoma: a 5-year experience. Cancer Treat. Rep., 62: 259-264, 1978. (Pubitemid 8287340)
5. Saeter, G., Alvegard, T. A., Elomaa, I., Stenwig, A. E., Holmstrom, T., and Solheim, O. P. Treatment of osteosarcoma of the extremities with the T-10 protocol, with emphasis on the effects of preoperative chemotherapy with single-agent high-dose methotrexate: a Scandinavian Sarcoma Group study. J. Clin. Oncol., 9: 1766-1775, 1991.
6. Guo, W., Healey, J. H., Meyers, P. A., Ladanyi, M., Huvos, A. G., Bertino, J. R., and Gorlick, R. Mechanisms of methotrexate resistance in osteosarcoma. Clin. Cancer Res., 5: 621-627, 1999. (Pubitemid 29131973)
7. Kasahara, M., Takahashi, Y., Nagata, T., Asai, S., Eguchi, T., Ishii, Y., Fujii, M., and Ishikawa, K. Thymidylate synthase expression correlates closely with E2F1 expression in colon cancer. Clin. Cancer Res., 6: 2707-2711, 2000. (Pubitemid 30482108)
8. Johnston, P. G., Lenz, H. J., Leichman, C. G., Danenberg, K. D., Allegra, C. J., Danenberg, P. V., and Leichman, L. Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors. Cancer Res., 55: 1407-1412, 1995.
9. Johnston, P. G., Fisher, E. R., Rockette, H. E., Fisher, B., Wolmark, N., Drake, J. C., Chabner, B. A., and Allegra, C. J. The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer. J. Clin. Oncol., 12: 2640-2647, 1994. (Pubitemid 24379651)
10. Banerjee, D., Gorlick, R., Liefshitz, A., Danenberg, K., Danenberg, P. C., Danenberg, P. V., Klimstra, D., Jhanwar, S., Cordon-Cardo, C., Fong, Y., Kemeny, N., and Bertino, J. R. Levels of E2F-1 expression are higher in lung metastasis of colon cancer as compared with hepatic metastasis and correlate with levels of thymidylate synthase. Cancer Res., 60: 2365-2367, 2000. (Pubitemid 30262423)
11. Wells, J. M., Illeneye, S., Magae, J., Wu, C. L., and Heintz, N. H. Accumulation of E2F-4-DP-1 DNA binding complexes correlates with induction of dhfr gene expression during the G1 to S phase transition. J. Biol. Chem., 272: 4483-4492, 1997. (Pubitemid 27078527)
12. 1-S-regulatory genes. Mol. Cell Biol., 15: 4215-4224, 1995.
13. Banerjee, D., Schnieders, B., Fu, J. Z., Adhikari, D., Zhao, S. C., and Bertino, J. R. Role of E2F-1 in chemosensitivity. Cancer Res., 58: 4292-4296, 1998. (Pubitemid 28450028)
14. Whetstine, J. R., and Matherly, L. H. The basal promoters for the human reduced folate carrier gene are regulated by a GC-box and a cAMP-response element/AP-1-like element. J. Biol. Chem., 276: 6350-6358, 2001.
15. User bulletin no. 2. ABI PRISM 7700 sequence detection system, revision A, pp. 11-13, 1997.
16. Nevins, J. R. E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. Science (Wash. DC), 258: 424-429, 1992.
17. Gorlick, R., Goker, E., Trippet, T., Waltham, M., Banerjee, D., and Bertino, J. R. Drug therapy: intrinsic and acquired resistance to methotrexate in acute leukemia. N. Engl. J. Med., 335: 1041-1048, 1996. (Pubitemid 26338736)
18. Pellin, A., Ferrero-Boix, J., Carpio, D., Lopez-Terranda, D., Carda, C., Navarro, S., Peydro-Olaya, A., Triche, T. J., and Llombart-Bosh, A. Molecular alterations of the RB1, TP53, and MDM2 genes in primary and xenografted human osteosarcomas. Diagn. Mol. Pathol., 6: 333-341, 1997. (Pubitemid 28175933)
19. Feugeas, O., Guriec, N., Babin-Boilletot, A., Marcellin, L., Simon, P., Babin, S., Thyss, A., Hofman, P., Terrier, P., Kalifa, C., Brunat-Mentigny, M., Patricot, L. M., and Oberling, F. Loss of heterozygosity of the RB gene is a poor prognostic factor in patients with osteosarcoma. J. Clin. Oncol., 14: 467-472, 1996. (Pubitemid 26051009)
20. Miller, C. W., Aslo, A., Campbell, M. J., Kawamata, N., Lampkin, B. C., and Koeffler, H. P. Alterations of the p53, Rb, and MDM2 genes in osteosarcoma. J. Cancer Res. Clin. Oncol., 122: 559-565, 1996. (Pubitemid 26284557)
21. Wadayama, B., Toguchida, J., Shimizu, T., Ishizaki, K., Sasaki, M. S., Kotoura, Y., and Yamamuro, T. Mutation spectrum of the retinoblastoma gene in osteosarcoma. Cancer Res., 54: 3042-3048, 1994. (Pubitemid 24187793)
22. Li, W., Fan, J., Hochhauser, D., Banerjee, D., Zielinski, Z., Almasan, A., Yin, Y., Kelly, R., Wahl, G. M., and Bertino, J. R. Lack of functional retinoblastoma protein mediates increased resistance to antimetabolites in human sarcoma cell lines. Proc. Natl. Acad. Sci. USA, 92: 10436-10440, 1995.
23. Spears, C. P., Gustavsson, B. G., Berne, M., Frosing, R., Bernstein, L., and Hayes, A. A. Mechanisms of innate resistance to thymidylate synthase inhibition after 5-fluorauracil. Cancer Res., 48: 5894-5900, 1988.
24. Peters, G. J., van der Wilt, C. L., van Groeningen, C. J., Smid, K., Meijer, S., and Pinedo, H. M. Thymidylate synthase inhibition after administration of fluorouracil with or without leucovorin in colon cancer patients: implications for treatment with fluorouracil. J. Clin. Oncol., 12: 2035-2042, 1994. (Pubitemid 24356018)
25. Pinedo, H. M., and Peters, G. F. Fluorouracil: biochemistry and pharmacology. J. Clin. Oncol., 6: 1653-1664, 1988.
26. Peters, G. J., van der Wilt, C. L., van, T. B., Codacci, P. G., Johnston, P. G., van Groeningen, C. J., and Pinedo, H. M. Thymidylate synthase and drug resistance. Eur. J. Cancer, 1299-1305, 1995.
27. Worm, J., Kirkin, A. F., Dzhandzhugazyan, K. N., and Guldberg, P. Methylation-dependent silencing of the reduced folate carrier gene in inherently methotrexate-resistant human breast cancer cell. J. Biol. Chem., 276: 39990-40000, 2001.