Oxysterols Induce Cyclooxygenase-2 Expression in Cholangiocytes: Implications for Biliary Tract Carcinogenesis

Hepatology

Volumn 39, Issue 3, 2004, Pages 732-738

  Yoon, Jung Hwan ^a   Canbay, Ali E ^b   Werneburg, Nathan W ^b   Lee, Sum P ^c   Gores, Gregory J ^b  

^a Seoul National University College of Medicine   (South Korea)

^b MAYO CLINIC COLLEGE OF MEDICINE   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL DERIVATIVE; CYCLOOXYGENASE 2; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; OXYSTEROL; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE 1; UNCLASSIFIED DRUG;

ARTICLE; BILE DUCT; BILE DUCT CARCINOMA; CANCER CELL CULTURE; CANCER GROWTH; CARCINOGENESIS; CELL LEVEL; CHOLANGIOCYTE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME STABILITY; EPITHELIUM CELL; HUMAN; HUMAN CELL; MOLECULAR STABILITY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

BILE DUCT NEOPLASMS; BILE DUCTS; CELL LINE, TUMOR; CYCLOOXYGENASE 2; ENZYME INDUCTION; ENZYME STABILITY; HUMANS; HYDROXYCHOLESTEROLS; ISOENZYMES; MEMBRANE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RNA STABILITY; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 1542724860     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.20125     Document Type: Article

References (28)

1. Yoon JH, Gores GJ. Diagnosis, staging, and treatment of cholangiocarcinoma. Curr Treat Options Gastroenterol 2003;6:105-112.
2. de Groen PC, Gores GJ, LaRusso NF, Gunderson LL, Nagorney DM. Biliary tract cancers. N Engl J Med 1999;341:1368-1378.
3. Torok N, Gores GJ. Cholangiocarcinoma. Semin Gastrointest Dis 2001; 12:125-132.
4. Eberhart CE, Coffey RJ, Radhika A, Giardiello FM, Ferrenbach S, DuBois RN. Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas. Gastroenterology 1994;107:1183-1188.
5. Gupta RA, Dubois RN. Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2. Nat Rev Cancer 2001;1:11-21.
6. Tsujii M, DuBois RN. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell 1995;83:493-501.
7. Tsujii M, Kawano S, Tsuji S, Sawaoka H, Hori M, DuBois RN. Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell 1998; 93:705-716.
8. Chariyalertsak S, Sirikulchayanonta V, Mayer D, Kopp-Schneider A, Furstenberger G, Marks F, Muller-Decker K. Aberrant cyclooxygenase isozyme expression in human intrahepatic cholangiocarcinoma. Gut 2001;48:80-86.
9. Hayashi N, Yamamoto H, Hiraoka N, Dono K, Ito Y, Okami J, Kondo M, et al. Differential expression of cycIooxygenase-2 (COX-2) in human bile duct epithelial cells and bile duct neoplasm. HEPATOLOGY 2001;34:638-650.
10. Haigh WG, Lee SP. Identification of oxysterols in human bile and pigment gallstones. Gastroenterology 2001;121:118-123.
11. Schroepfer GJ Jr. Oxysterols: modulators of cholesterol metabolism and other processes. Physiol Rev 2000;80:361-554.
12. Panini SR, Sinensky MS. Mechanisms of oxysterol-induced apoptosis. Curr Opin Lipidol 2001;12:529-533.
13. Ares MP, Porn-Ares MI, Moses S, Thyberg J, Juntti-Berggren L, Berggren P, Hultgardh-Nilsson A, et al. 7beta-hydroxycholesterol induces Ca(2+) oscillations, MAP kinase activation and apoptosis in human aortic smooth muscle cells. Atherosclerosis 2000;153:23-35.
14. Harnois DM, Que FG, Celli A, LaRusso NF, Gores GJ. Bcl-2 is overexpressed and alters the threshold for apoptosis in a cholangiocarcinoma cell line. HEPATOLOGY 1997;26:884-890.
15. Faubion WA, Guicciardi ME, Miyoshi H, Bronk SF, Roberts PJ, Svingen PA, Kaufmann SH, Gores GJ. Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas. J Clin Invest 1999;103:137-145.
16. Inoue H, Yokoyama C, Hara S, Tone Y, Tanabe T. Transcriptional regulation of human prostaglandin-endoperoxide synthase-2 gene by lipopolysaccharide and phorbol ester in vascular endothelial cells. Involvement of both nuclear factor for interleukin-6 expression site and cAMP response element. J Biol Chem 1995;270:24965-24971.
17. Sheng H, Shao J, Dixon DA, Williams CS, Prescott SM, DuBois RN, Beauchamp RD. Transforming growth factor-beta 1 enhances Ha-ras-induced expression of cyclooxygenase-2 in intestinal epithelial cells via stabilization of mRNA. J Biol Chem 2000;275:6628-6635.
18. de Urquiza AM, Liu S, Sjoberg M, Zetterstrom RH, Griffiths W, Sjovall J, Perlmann T. Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain. Science 2000;290:2140-2144.
19. Nzeako UC, Guicciardi ME, Yoon JH, Bronk SF, Gores GJ. COX-2 inhibits Fas-mediated apoptosis in cholangiocarcinoma cells. HEPATOLOGY 2002;35:552-559.
20. Yoon JH, Higuchi H, Werneburg NW, Kaufmann SH, Gores GJ. Bile acids induce cyclooxygenase-2 expression via the epidermal growth factor receptor in a human cholangiocarcinoma cell line. Gastroenterology 2002; 122:985-993.
21. Yoshida T, Matsuzaki Y, Haigh WG, Fukushima S, Ikezawa K, Tanaka N, Lee SP. Origin of oxysterols in hepatic bile of patients with biliary infection. Am J Gastroenterol 2003;98:2275-2280.
22. Guo YS, Hellmich MR, Wen XD, Townsend CM Jr. Activator protein-1 transcription factor mediates bombesin-stimulated cyclooxygenase-2 expression in intestinal epithelial cells. J Biol Chem 2001;276:22941-22947.
23. Karin M. The regulation of AP-1 activity by mitogen-activated protein kinases. J Biol Chem 1995;270:16483-16486.
24. Whitmarsh AJ, Davis RJ. Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways. J Mol Med 1996;74:589-607.
25. Gupta S, Stravitz RT, Dent P, Hylemon PB. Down-regulation of cholesterol 7alpha-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway. J Biol Chem 2001;276:15816-15822.
26. Dean JL, Brook M, Clark AR, Saklatvala J. p38 mitogen-activated protein kinase regulates cyclooxygenase-2 mRNA stability and transcription in lipopolysaccharide-treated human monocytes. J Biol Chem 1999;274:264-269.
27. Ristimaki A, Narko K, Hla T. Down-regulation of cytokine-induced cyclo-oxygenase-2 transcript isoforms by dexamethasone: evidence for posttranscriptional regulation. Biochem J 1996;318(Pt 1):325-331.
28. Jacobson A, Peltz SW. Interrelationships of the pathways of mRNA decay and translation in eukaryotic cells. Annu Rev Biochem 1996;65: 693-739.