Ethanol and Aloe Emodin Alter the p53 Mutational Spectrum in Ultraviolet Radiation-Induced Murine Skin Tumors

Molecular Carcinogenesis

Volumn 39, Issue 3, 2004, Pages 127-138

  Badgwell, Donna B ^a   Walker, Christopher M ^a   Baker, Whitney T ^a   Strickland, Faith M ^a,b  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b HENRY FORD HEALTH SCIENCES CENTER   (United States)

Author keywords

Aloe emodin; Anthraquinone; Chronic UV; Skin cancer; Tumor suppressor

Indexed keywords

ALCOHOL; ALOE EMODIN; COSMETIC; PROTEIN P53;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENICITY; DNA SEQUENCE; GENE MUTATION; HUMAN; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN CARCINOGENESIS; SKIN TUMOR; SUN EXPOSURE; TUMOR SUPPRESSOR GENE; ULTRAVIOLET RADIATION;

ANIMALS; BASE SEQUENCE; DNA PRIMERS; EMODIN; ETHANOL; FEMALE; GENES, P53; MICE; MICE, INBRED C3H; NEOPLASMS, RADIATION-INDUCED; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; SKIN NEOPLASMS; ULTRAVIOLET RAYS;

ALOE; MURINAE;

EID: 1542723468     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/mc.10170     Document Type: Article

References (65)

1. de Gruijl FR, Longstreth J, Norval M, et al. Health effects from stratospheric ozone depletion and interactions with climate change. Photochem Photobiol Sci 2003;2:16-28.
2. Leffell DJ, Brash DE. Sunlight and skin cancer. Sci Am 1996;275:52-53.
3. Black HS, deGruijl FR, Forbes PD, et al. Photocarcinogenesis: An overview. J Photochem Photobiol B Biol 1997;40:29-47.
4. Service NH. Vital Statistics of the United States, 1991. Public Health Service, Washington, DC, 1994.
5. Ananthaswamy HN, Loughlin SM, Cox P, Evans RL, Ullrich SE, Kripke ML. Sunlight and skin cancer: Inhibition of p53 mutations in UV-irradiated mouse skin by sunscreens. Nat Med 1997;3:510-514.
6. Ananthaswamy HN, Ullrich SE, Mascotto RE, et al. Inhibition of solar simulator-induced p53 mutations and protection against skin cancer development in mice by sunscreens. J Invest Dermatol 1999;112:763-768.
7. Wolfle D, Schmutte C, Westendorf J, Marquardt H. Hydroxyanthraquinones as tumor promoters: Enhancement of malignant transformation of C3H mouse fibroblasts and growth stimulation of primary rat hepatocytes. Cancer Res 1990;50:6540-6544.
8. Westendorf J, Marquardt H, Poginsky B, Dominiak M, Schmidt J, Marquart H. Genotoxicity of naturally occurring hydroxyanthraquinones. Mutat Res 1990;240:1-12.
9. Strickland FM, Muller HK, Stephens LC, et al. Induction of primary cutaneous melanomas in C3H mice by combined treatment with ultraviolet radiation ethanol and aloe emodin. Photochem Photobiol 2000;72:407-414.
10. Harris CC. Chemical and physical carcinogenesis: Advances and perspectives for the 1990s. Cancer Res 1991;51:5023s-5044s.
11. Greenblatt MS, Bennett WP, Hollstein M, Harris CC. Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis. Cancer Res 1994;54:4855-4878.
12. Hussain SP, Harris CC. Molecular epidemiology of human cancer: Contribution of mutation spectra studies of tumor suppressor genes. Cancer Res 1998;58:4023-4037.
13. Kress S, Sutter C, Strickland PT, Mukhtar H, Schweizer J, Schwarz M. Carcinogen-specific mutational pattern in the p53 gene in ultraviolet B radiation-induced squamous cell carcinomas of mouse skin. Cancer Res 1992;52:6400-6403.
14. Kanjilal S, Pierceall WE, Cummings KK, Kripke ML, Ananthaswamy HN. High frequency of p53 mutations in ultraviolet radiation-induced murine skin tumors: Evidence for strand bias and tumor heterogeneity. Cancer Res 1993;53:2961-2964.
15. Soussi T, Dehouche K, Beroud C. p53 website and analysis of p53 gene mutations in human cancer: Forging a link between epidemiology and carcinogenesis. Hum Mutat 2000;15:105-113.
16. Wikonkal NM, Brash DE. Ultraviolet radiation induced signature mutations in photocarcinogenesis. J Invest Dermatol Symp Proc 1999;4:6-10.
17. Yoon JH, Lee CS, O'Connor TR, Yasui A, Pfeifer GP. The DNA damage spectrum produced by simulated sunlight. J Mol Biol 2000;299:681-693.
18. Ruggeri B, Camano J, Goodrow T, et al. Alterations of the p53 tumor suppressor gene during mouse skin tumor progression. Cancer Res 1991;51:6615-6621.
19. Brash DE, Ziegler A, Jonason AS, Simon JA, Kunala S, Leffell DJ. Sunlight and sunburn in human skin cancers: p53, apoptosis, and tumor promotion. J Invest Dermatol Symp Proc 1996;1:136-142.
20. Nataraj AJ, Trent JC, Ananthaswamy HN. p53 gene mutations and photocarcinogenesis. Photochem Photobiol 1995;62:218-230.
21. Okorokov AL. p53 in a crosstalk between DNA repair and cell cycle checkpoints. Cell Cycle 2003;2:233-235.
22. Ouhtit A, Muller HK, Davis DW, Ullrich SE, McConkey D, Ananthaswamy HN. Temporal events in skin injury and the early adaptive responses in ultraviolet-irradiated mouse skin. Am J Pathol 2000;156:201-207.
23. Ananthaswamy HN, Ouhtit A, Evans RL, et al. Persistence of p53 mutations and resistance of keratinocytes to apoptosis are associated with the increased susceptibility of mice lacking the XPC gene to UV carcinogenesis. Oncogene 1999;18:7395-7398.
24. McGregor WG. DNA repair, DNA replication, and UV mutagenesis. J Invest Dermatol Symp Proc 1999;4:1-5.
25. Franceschi S, Gloghini A, Maestro R, et al. Analysis of the p53 gene in relation to tobacco and alcohol in cancers of the upper aero-digestive tract. Int J Cancer 1995;60:872-876.
26. Dumaz N, van Kranen HJ, de Vries A, et al. The role of UV-B light in skin carcinogenesis through the analysis of p53 mutations in squamous cell carcinomas of hairless mice. Carcinogenesis 1997;18:897-904.
27. Olshan AF, Weisser MC, Pei H, Conway K. p53 mutations in head and neck cancer: New data and evaluation of mutational spectra. Cancer Epidemiol Biomarkers Prev 1997;6:499-504.
28. Hussain SP, Amstad P, Raja K, et al. Mutability of p53 hotspot codons to benzo[a]pyrene diol epoxide and the frequency of p53 mutations in nontumorous human lung. Cancer Res 2001;61:6350-6355.
29. Ahrendt SA, Chow JT, Yang SC, et al. Alcohol consumption and cigarette smoking increases the frequency of p53 mutations in non-small cell lung cancer. Cancer Res 2000;60:3155-3159.
30. Brennan JA, Boyle JO, Koch WM, et al. Association between cigarette smoking and mutation of the p53 gene in squamous-cell carcinoma of the head and neck. N Engl J Med 1995;332:712-717.
31. Hernandez-Broussard TM, Hainaut PA. Specific spectrum of p53 mutations in lung cancer from smokers: Review of mutations compiled in the IARC p53 database. (Published erratum in Environ Health Perspect 1998;106:A421.) Environ Health Perspect 1998;106:385-391.
32. Hernandez-Broussard TM, Hainaut PA. Specific spectrum of p53 mutations in lung cancer from smokers: Review of mutations compiled in the IARC p53 database. (Published erratum in Environ Health Perspect 1998;106:A421.) Environ Health Perspect 1998;106:385-391.
33. van Kranen HJ, de Gruijl FR, de Vries A, et al. Frequent p53 alterations but low incidence of ras mutations in UV-B-induced skin tumors of hairless mice. Carcinogenesis 1995;16:1141-1147.
34. Ren Z-P, Hedrum A, Ponten F, et al. Human epidermal cancer and accompanying precursors have identical p53 mutations different from p53 mutations in adjacent areas of clonally expanded non-neoplastic keratinocytes. Oncogene 1996;12:765-773.
35. Ouhtit A, Nakazawa H, Armstrong BK, et al. UV-radiation-specific p53 mutation frequency in normal skin as a predictor of risk of basal cell carcinoma. J Natl Cancer Inst 1998;90:523-531.
36. Adams WT, Skopek TR. Statistical test for the comparison of samples from mutational spectra. J Mol Biol 1987;194:391-395.
37. Rideout WM III, Coetzee GA, Olumi AF, Jones PA. 5-Methyl cytosine as an endogenous mutagen in human LDL receptor and p53 genes. Science 1990;249:1288-1290.
38. LePage F, Margor A, Grollman AP, Sarasin A, Gentil A. Mutagenicity of a unique 8-oxyguanine in a human Ha-ras sequence in mammalian cells. Carcinogenesis 1995;16:2779-2784.
39. Dumaz N, Stary A, Soussi T, Daya-Grosjean L, Sarasin A. Can we predict solar ultraviolet radiation as the causal event in human tumours by analysing the mutation spectra of the p53 gene? Mutat Res 1994;307:375-386.
40. Wamer WG, Vath P, Falvey DE. In vitro studies on the photobiological properties of Aloe Emodin and Aloin A. Free Radical Biol Med 2003;34:233-242.
41. Duran N, Song PS. Hypericin and its photodynamic action. Photochem Photobiol 1986;43:677-680.
42. Vath P, Wamer WG, Falvey DE. Photochemistry and phototoxicity of aloe emodin. Photochem Photobiol 2002;75:346-352.
43. Jaruga P, Dizdaroglu M. Repair of products of oxidative DNA base damage in human cells. Nucleic Acid Res 1996;24:1389-1394.
44. Enright M, Miller MJ, Hays R, Floyd RA, Hibbel RP. Preferential targeting of oxidative damage to internucleosomal DNA. Carcinogenesis 1996;17:1175-1177.
45. Takeuchi T, Matsugo S, Morimoto K. Mutagenicity of oxidative DNA damage in Chinese hamster V79 cells. Carcinogenesis 1977;18:2051-2055.
46. Zhang H, Xu Y, Kamendulis LM, Klaunig JE. Morphological transformation by 8-hydroxy-2′-deoxyguanosine in Syrian hamster embryo (SHE) cells. Toxicol Sci 2000;56:303-312.
47. Daya-Grosjean L, Dumaz N, Sarasin A. The specificity of p53 mutation spectra in sunlight-induced human cancers. J Photochem Photobiol B Biol 1995;28:115-124.
48. Ananthaswamy HN, Fourtanier A, Evans RL, et al. p53 Mutations in hairless SKH-hr1 mouse skin tumors induced by a solar simulator. Photochem Photobiol 1998;67:227-232.
49. You Y-H, Szabó PE, Pfeifer GP. Cyclobutane pyrimidine dimers form preferentially at the major p53 mutational hotspot in UVB-induced mouse skin tumors. Carcinogenesis 2000;21:2113-2117.
50. Carbone D. Smoking and cancer. Am J Med 1992;93(Suppl 1A):13S-17S.
51. Choi SY, Kahyo H. Effect of cigarette smoking and alcohol consumption in the aetiology of cancer of the oral cavity, pharynx, larynx. Int J Epidemiol 1991;20:878-885.
52. Tuyns AJ. Alcohol. In: Schottenfeld D, Fraumeni JF, Jr., editors. Cancer epidemiology and prevention. Philadelphia, PA: WB Saunders Co.; 1982. pp 293-303.
53. DeGruijl FR, Sterenborg HJ, Forbes PD, et al. Wavelength dependence of skin cancer induction by ultraviolet irradiation of albino hairless mice. Cancer Res 1993;53:53-60.
54. Burren R, Scaletta C, Frenk E, Panizzon RG, Applegate LA. Sunlight and carcinogenesis: Expression of p53 and pyrimidine dimers in human skin following UVA I, UVA I + II and solar simulating radiations. Int J Cancer 1998;76:201-206.
55. Queille S, Seite S, Tison S, et al. p53 mutations in cutaneous lesions induced in the hairless mouse by a solar ultraviolet light simulator. Mol Carcinog 1998;22:167-174.
56. Drobetsky EA, Turcotte J, Chateauneuf A. A role for ultraviolet A in solar mutagenesis. Proc Natl Acad Sci USA 1995;92:2350-2354.
57. Hutchinson F. Induction of tandem-base change mutations. Mutat Res 1994;309:11-15.
58. Jemal A, Devesa SS, Fears TR, Hartge P. Cancer surveillance series: Changing patterns of cutaneous malignant melanoma mortality rates among whites in the United States. J Natl Cancer Institute 2000;92:811-818.
59. Setlow RB, Grist E, Thompson K, Woodhead AD. Wavelength effective in induction of malignant melanoma. Proc Natl Acad Sci USA 1993;90:6666-6670.
60. Hsu TC, Furlong C. The role of ethanol in oncogenesis of the upper aerodigestive tract: Inhibition of DNA repair. Anticancer Res 1991;11:1995-1998.
61. Hsu TC, Furlong C, Spitz MR. Ethyl alcohol as a cocarcinogen with special reference to the aerodigestive tract: A cytogenetic study. Anticancer Res 1991;11:1097-1102.
62. Obe G, Anderson D. Genetic effects of ethanol. Mutat Res 1987;186:177-200.
63. Lin Y-C, Ho I-C, Lee T-C. Ethanol and acetaldehyde potentiate the clastogenicity of ultraviolet light, methane-sulfonate, mitomycin C, and bleomycin in Chinese hamster ovary cells. Mutat Res 1989;216:93-99.
64. Preston RJ. The use of inhibitors of DNA repair in the study of mechanism of induction of chromosome aberrations. Cytogenet Cell Genet 1982;33:20-26.
65. Natarajan AT, Csukas I, Degrassi F, et al. Influence of inhibition of repair enzymes on the induction of chromosomal aberrations by physical and chemical agents. In: Natarajan AT, Obe G, Altman H, editors. Progress in mutation research. Vol. 4. Amsterdam: Elsevier Biomedical Press; 1982. pp 47-59.