Topical application of a selective cyclooxygenase inhibitor suppresses UVB mediated cutaneous inflammation

Prostaglandins and Other Lipid Mediators

Volumn 62, Issue 4, 2000, Pages 367-384

  Wilgus, Traci A ^a   Ross, Mary S ^a   Parrett, Michelle L ^a   Oberyszyn, Tatiana M ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELECOXIB; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2 INHIBITOR; IBUPROFEN; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; EDEMA; ENZYME INHIBITION; FEMALE; LEUKOCYTE ACTIVATION; MOUSE; NONHUMAN; NUDE MOUSE; RADIATION INJURY; SKIN INFLAMMATION; SUNBURN; ULTRAVIOLET B RADIATION;

ADMINISTRATION, TOPICAL; ANIMAL; COMPARATIVE STUDY; CYCLOOXYGENASE INHIBITORS; DERMATITIS; DINOPROSTONE; EDEMA; EPIDERMIS; FEMALE; IBUPROFEN; ISOENZYMES; MICE; MICE, INBRED HRS; NEUTROPHILS; PEROXIDASE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASE; SKIN; SULFONAMIDES; SUNBURN; SUPPORT, U.S. GOV'T, P.H.S.; ULTRAVIOLET RAYS;

EID: 0033791612     PISSN: 00906980     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0090-6980(00)00089-7     Document Type: Article

References (82)

1. Photocarcinogenesis in the Skin
2. Sunlight and the onset of skin cancer
3. Immunological effects of ultraviolet radiation
4. Ultraviolet radiation effects on immune processes
5. Genetic variation in low-dose UV-induced suppression of contact hypersensitivity and in the skin photocarcinogenesis response
6. Immunological unresponsiveness induced by ultraviolet radiation
7. The role of IL-4, IL-10 and TNF-α in the immune suppression induced by ultraviolet radiation
8. Ultraviolet B radiation-induced production of interleukin 1alpha and interleukin 6 in human squamous carcinoma cell line is wavelength-dependent and can be inhibited by pharmacological agents
9. Mechanisms of UV-induced inflammation
10. Ultraviolet radiation-induced phospholipase A2 activation occurs in mammalian cell membrane preparations
11. A methodology for analysis of tissue sulfhydryl components
12. 2 in human skin
13. Increased levels of 6-oxo-PBF1α in human skin after ultraviolet B irradiation
14. 2α in human skin at 6 and 24 h after ultraviolet B irradiation (290-320 nm)
15. Pharmacological agents released in ultraviolet inflammation studies by continuous skin perfusion
16. Prostaglandin in human and albino rat skin
17. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain
18. Inducible isoforms of cyclooxygenase and nitric oxide synthase in inflammation
19. Eicosanoids and multi-stage carcinogenesis in NMRI mouseskin: Role of prostaglandin E1 and F in conversion (first stage of tumor promotion) and promotion (second stage of tumor promotion)
20. Multifactor regulation of prostaglandin H synthase-2 in murine keratinocytes
21. Differential expression of prostaglandin H synthase isozymes during multistage carcinogenesis in mouse epidermis
22. 2 synthesis by human epidermoid carcinoma cells
23. The production of prostanoids in human cancers and their implications for tumor progression
24. Altered eicosanoid levels in human colon cancer
25. Measurement of arachidonate and its metabolites extracted from human normal and malignant gastrointestinal tissues
26. Prostaglandins in squamous cell carcinomas of the head and neck
27. Prostaglandins, NSAIDs, cytoprotection
28. Prostaglandin synthase 2
29. Cyclooxygenase 2 induction: Molecular mechanism and pathophysiologic roles
30. Induction of cyclooxygenase-2 by Interleukin-1 (IL-1)α
31. Human cyclooxygenase-2 cDNA
32. COX-2 expression is induced by UVB exposure in human skin: Implications for the development of skin cancer
33. Aspirin and the potential role of prostaglandins in colon cancer
34. The role of nonsteroidal anti-inflammatory drugs in colorectal cancer prevention
35. Inhibition of initiation and promotion of N-methylnitrosourea-induced colon carcinogenesis in rats by nonsteroidal anti-inflammatory agent indomethacin
36. Inhibitory effect of aspirin on azoxymethane-induced colon carcinogenesis in F344 rats
37. Inhibition of mammary carcinogenesis by flurbiprofen, anonsteroidal anti-inflammatory agent
38. In vivo effects of indomethacin on the growth of murine mammary tumors
39. Chemopreventative activity of celecoxib, a specific cyclooxygenase inhibitor, and indomethacin against ultraviolet light-induced skin carcinogenesis
40. Ibuprofen-induced inhibition of cyclooxygenase isoform gene expression and regression of rat mammary carcinomas
41. Reduction of UV-induced skin tumors in hairless mice by selective COX-2 inhibition
42. Inhibition of human polymorphonuclear leukocyte cell responses by ibuprofen
43. Chemotactic factor-induced generation of superoxide radicals by human neutrophils. Effect of metabolic inhibitors and anti-inflammatory drugs
44. The effects of indomethacin, 5,8,11,14-eicosatetraynoic acid, and p-bromophenacyl bromide on lysosomal enzyme release and superanion generation by human polymorphonuclear leukocytes
45. Effects of benoxaprofen on human neutrophil function
46. Clinical implications of prostaglandin and thromboxane A2 formation (1,2)
47. The clinical significance of inhibition of renal prostaglandin synthesis
48. Preliminary study of the safety and efficacy of SC-58635, anovel cyclooxygenase 2 inhibitor: Efficacy and safety in two placebo-controlled trials in osteoarthritis and rheumatoid arthritis, and studies of gastrointestinal and platelet effects
49. Analgesic efficacy and plasma levels of a highly selective inhibitor of COX-2 (SC-58635;SC) in patients with post-surgical dental pain
50. Practical implications of cyclooxygenase-2-specific inhibitors in orthopedics
51. Kinetic basis for selective inhibition of cyclo-oxygenases
52. Annotation: Role of childhood in the development of skin cancer
53. The role of childhood exposure to sunlight in the development of solar keratoses and non-melanocytic skin cancer
54. Sunlight exposure, pigmentary factors, and risk of nonmelanocytic skin cancer. I. Basal cell carcinoma
55. Analysis of two inbred strains of mice derived from the SENCAR stock with different susceptibility to skin tumor progression
56. Acute effects of ultraviolet radiation on the skin
57. Cutaneous effects of topical indomethacin, an inhibitor of prostaglandin synthesis, on UV-damaged skin
58. 2 production on the photosensitivity in xeroderma pigmentosum group A model mice
59. Measurement of skin-fold thickness in the guinea pig. Assessment of edema-inducing capacity of cutting fluids, acids, alkalis, formalin and dimethyl sulfoxide
60. Inhibitory effects of pentoxifylline on ultraviolet B light induced cutaneous inflammation
61. Polyphenolic antioxidant (-)-epigallocatechin-3-gallate from green tea reduces UVB-induced inflammatory responses and infiltration of leukocytes in human skin
62. Activation of neutrophil membrane-associated oxidative metabolism by ultraviolet radiation
63. Hypochlorous acid activates the tumor suppressor protein p53 in cultured human skin fibroblasts
64. Myeloperoxidase as a biomarker of skin irritation and inflammation
65. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain
66. Regulation of the immune response by prostaglandins
67. Xenobiotic metabolism by prostaglandin H synthase
68. Transcriptional regulation of cyclooxygenase-2 gene expression: Novel effects of nonsteroidal anti-inflammatory drugs
69. Induction of cyclooxygenase-2 expression by peroxisome proliferators and non-tetradecanoylphorbol-12,13-myristate-type tumor promoters in immortalized mouse liver cells
70. The sunburn cell
71. Characterization of sunburn cells after exposure to ultraviolet light
72. The study of ultraviolet B-induced apoptosis in cultured mouse keratinocytes and in mouse skin
73. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2
74. Photoprotective effect of topical indomethacin-an experimental study
75. Expression of cyclooxygenase-1 and-2 in human colorectal cancer
76. Cyclooxygenase-2 gene expression in human breast cancer
77. Cyclooxygenase regulates angiogenesis induced by colon cancer cells
78. Evaluation of cyclooxygenase-2 inhibitor for potential chemopreventive properties in colon carcinogenesis
79. Modulation of keratinocyte proliferation in vitro by endogenous prostaglandin synthesis
80. Differential expression of prostaglandin H synthase isozymes during multistage carcinogenesis in mouse epidermis