Studies on the in vitro inversion of flurbiprofen

Chirality

Volumn 9, Issue 3, 1997, Pages 317-319

  Lombard, Anna ^a   Rossetti, Valeria ^b   Cassone, Maria Chiara ^b  

^a UNIVERSITY OF TURIN   (Italy)

^b NONE

Author keywords

(+) (R) 1 phenylethylamides; He Ne laser; HPLC separation; metabolic pathway; NSAID metabolism; rat liver microsomes

Indexed keywords

FLURBIPROFEN;

ARTICLE; CHIRALITY; DRUG METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IRRADIATION; MICROSOME; PRIORITY JOURNAL; STEREOCHEMISTRY;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; COENZYME A; CYTOCHROME P-450 ENZYME SYSTEM; FLURBIPROFEN; LASERS; MALE; MICROSOMES, LIVER; NADP; RATS; RATS, WISTAR; STEREOISOMERISM;

EID: 0031005073     PISSN: 08990042     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-636X(1997)9:3<317::AID-CHIR20>3.0.CO;2-P     Document Type: Article

References (17)

1. Jamali, F., Berry, B.W., Tehrani, M.R., Russell, A.S. Stereoselective pharmacokinetics of flurbiprofen in humans and rats. J. Pharm. Sci. 77:666-669, 1988.
2. Mayer, J.M. Stereoselective metabolism of antiinflammatory 2-arylpropionates. Acta Pharm. Nord. 2:197-216, 1990.
3. Knihinicki, R.D., Day, R.O., Graham, G.G., Williams, K.M. Stereoselective disposition of ibuprofen and flurbiprofen in rats. Chirality 2: 134-140, 1990.
4. Mayer, J.M., Bartolucci, C., Maitre, J.M., Testa, B. Metabolic chiral inversion of antiinflammatory 2-arylpropionates: lack of reaction in liver homogenates and study of methine proton activity. Xenobiotica 18:533-543, 1988.
5. Knihinicki, R.D., Williams, K.M., Day, R.O. Chiral inversion of 2-arylpropionic acid nonsteroidal antiinflammatory drugs. 1 - In vitro studies of ibuprofen and flurbiprofen. Biochem. Pharmacol. 38:4389-4395, 1989.
6. Porubeck, D.J., Sanins, S.M., Steffens, J.R., Grillo, M.P., Kaiser, D.G., Halstead, G.W., Adams, W.J., Baillie, T.A. Metabolic chiral inversion of flurbiprofen-CoA in vitro. Biochem. Pharmacol. 42:R1-R4, 1991.
7. Knights, K.M., Drew, R., Meffin, P.J. Enantiospecific formation of fenoprofen coenzyme A thioester in vitro. Biochem. Pharmacol. 37:3539-3542, 1988.
8. Lombard, A., Rossetti, V., Buffa, M., Gabriel, L., Miglietta, A. In vitro studies on the stereoselective inversion of R(-) to S(+)-ketoprofen. IRCS Med. Sci. 13:1025, 1985.
9. Rossetti, V., Lombard, A., Buffa, M., Cassone, M.C. Studies on the stereoisomeric inversion of ketoprofen in rats. Med. Sci. Res. 14:256-257, 1986.
10. Lombard, A., Rossetti, V., Buffa, M., Cassone, M.C. Stereospecific metabolism of indoprofen in rats. Med. Sci. Res. 18:209-210, 1990.
11. Rossetti, V., Lombard, A., Buffa, M., Miglietta, A., Olivero, A., Gadoni, E. The in vitro metabolic inversion of R(-) to S(+)-indoprofen. Eur. J. Drug Metab. Pharmacokinet. 17:183-186, 1992.
12. Karu, T.I. Photobiology of low-power laser therapy. In: Laser Science and Technology, vol. 8. Letokhov, V.S., Shank, C.V., Shen, Y.R., Walther, H., eds. Chur: Harwood Academic Publishers, 1989.
13. Rossetti, V., Lombard, A., Buffa, M. The HPTLC resolution of the enantiomers of some 2-arylpropionic acid anti-inflammatory drugs. J. Pharm. Biomed. Anal. 4:673-676, 1986.
14. Nakamura, Y., Yamaguchi, T., Takahashi, S., Hashimoto, S., Iwatani, K., Nagakawa, Y. Optical isomerization mechanism of R(-)hydratropic acid derivatives. J. Pharmacol. Biodynam. 4:s-1, 1981.
15. Hugh, D.H., Hunter, J.K. Photomodulation of enzymes. J. Photochem. Photobiol. B 10:3-22, 1991.
16. Ostuni, A., Passarella, S., Quagliariello, E.J. Photomodulation of glutamate dehydrogenase properties by red light. J. Photochem. Photobiol. B 20:101-111, 1993.
17. Rossetti, V., Lombard, A, Urciuoli, R., Cassone, M.C., Rolfo, P.M. Rat brain metabolism enzyme activity variations following He-Ne laser irradiation. Mol. Chem. Neuropathol. 15:185-191, 1991.