Dietary nucleotides accelerate changes in intestinal lymphocyte maturation in weanling mice

Journal of Pediatric Gastroenterology and Nutrition

Volumn 37, Issue 4, 2003, Pages 453-461

  Manzano, Manuel ^a   Abadía Molina, Ana Clara ^b   Olivares, Enrique García ^b   Gil, Angel ^b   Rueda, Ricardo ^a  

^a ABBOTT LABORATORIES   (Spain)

^b UNIVERSITY OF GRANADA   (Spain)

Author keywords

Epithelium; Intestinal lymphocytes; Lamina propria; Mice at weaning; Nucleotides; Peyer's patches

Indexed keywords

ADENOSINE PHOSPHATE; B LYMPHOCYTE ANTIGEN; CD22 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD45 ANTIGEN; CD5 ANTIGEN; CD8 ANTIGEN; CD8ALPHA ANTIGEN; CD8BETA ANTIGEN; CYTOSINE MONOPHOSPHATE; GUANOSINE PHOSPHATE; MEMBRANE ANTIGEN; NUCLEIC ACID; NUCLEOTIDE DERIVATIVE; T LYMPHOCYTE ANTIGEN; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; T LYMPHOCYTE RECEPTOR DELTA CHAIN; T LYMPHOCYTE RECEPTOR GAMMA CHAIN; UNCLASSIFIED DRUG; URIDINE PHOSPHATE; LEUKOCYTE ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; NUCLEOTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ARTICLE; ARTIFICIAL MILK; CELL MATURATION; CONTROLLED STUDY; DIETARY INTAKE; IMMUNOSTIMULATION; INTESTINAL LYMPHOCYTE; INTESTINE CELL; INTESTINE EPITHELIUM; LAMINA PROPRIA; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE MATURATION; LYMPHOCYTE SUBPOPULATION; MOUSE; NONHUMAN; NUTRIENT; PEYER PATCH; PRIORITY JOURNAL; WEANING; ANIMAL; B LYMPHOCYTE; BAGG ALBINO MOUSE; CELL DIFFERENTIATION; CYTOLOGY; DIET; DRUG EFFECT; EPITHELIUM CELL; IMMUNOLOGY; INTESTINE; LYMPHOCYTE; LYMPHOCYTE COUNT; T LYMPHOCYTE;

ANIMALIA; MAMMALIA;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD3; ANTIGENS, CD45; ANTIGENS, CD5; B-LYMPHOCYTES; CELL DIFFERENTIATION; DIET; EPITHELIAL CELLS; INTESTINES; LYMPHOCYTE COUNT; LYMPHOCYTES; MICE; MICE, INBRED BALB C; NUCLEOTIDES; PEYER'S PATCHES; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES; WEANING;

EID: 1542645139     PISSN: 02772116     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005176-200310000-00010     Document Type: Article

References (37)

1. Brandtzaeg P. History of oral tolerance and mucosal immunity. Ann NY Acad Sci 1996;778:1-27.
2. Kelsall B, Strober W. Gut-associated lymphoid tissue: antigen handling and T-lymphocyte responses. In: Ogra PL, Mestecky J, Lamm ME, et al., eds. Mucosal Immunology. 2nd ed. San Diego: Academic Press, Inc; 1999:293-317.
3. Nagafuchi S, Totsuka M, Hachimura S, et al. Dietary nucleotides increase the proportion of a TCRγδ+ subset of intraepithelial lymphocytes (IEL) and IL-7 production by intestinal epithelial cells (IEC): implications for modification of cellular and molecular cross-talk between IEL and IEC by dietary nucleotides. Biosci Biotechnol Biochem 2000;64:1459-65.
4. Nagafuchi S, Hachimura S, Totsuka M, et al. Dietary nucleotides can up-regulate antigen-specific Th1 immune responses and suppress antigen-specific IgE responses in mice. Int Arch Allergy Immunol 2000;122:33-41.
5. Navarro J, Maldonado J, Narbona E, et al. Influence of dietary nucleotides on plasma immunoglobulin levels and lymphocyte subsets of preterm infants. BioFactors 1999;10:67-76.
6. Zomborszky-Kovacs M, Bardos L, Biro H, et al. Effect of beta-carotene and nucleotide base supplementation on blood composition and immune response in weaned pigs. Acta Vet Hung 2000;48:301-11.
7. Cosgrove M. Nucleotides. Nutrition 1998;14:748-51.
8. Gil A. Funciones de los nucleótidos de la dieta. Ars Pharmaceutica 1994;35:61-73.
9. Leleiko NS, Bronstein AD, Baliga S, et al. De novo purine nucleotide synthesis in the rat small and large intestine: effect of dietary protein and purines. J Pediatr Gastroenterol Nutr 1983;2:313-9.
10. Sánchez-Pozo A, Rueda R, Fontana L, et al. Dietary nucleotides and cell growth. Trends in Comparative Biochemistry and Physiology 1998;5:99-111.
11. Brunser O, Espinoza J, Araya M, et al. Effect of dietary nucleotide supplementation on diarrhoeal disease in infants. Acta Paediatr 1994;883:188-91.
12. Lama-More RA, Gil-Alberdi González B. Efecto de la suplementación dietética con nucleótidos sobre la diarrea en el lactante sano. An Esp Pediatr 1998;48:371-5.
13. Carver JD. Dietary nucleotides: cellular immune, intestinal and hepatic system effects. J Nutr 1994;124:144S-8S.
14. Carver JD. Dietary nucleotides: effects on the immune and gastrointestinal systems. Acta Paediatr Suppl 1999;430:83-8.
15. Grimble GK, Westwood OM. Nucleotides as immunomodulators in clinical nutrition. Curr Opin Clin Nutr Metab Care 2001;4:57-64.
16. Jyonouchi H. Nucleotide actions on humoral immune responses. J Nutr 1994;124:138S-43S.
17. American Institute of Nutrition. Report of the American Institute of Nutrition Ad Hoc Committee on standards for nutritional studies. J Nutr 1977;107:1340-8.
18. Gautreaux MD, Deitch EA, Berg RD. T lymphocytes in host defense against bacterial translocation from the gastrointestinal tract. Infect Immun 1994;62:2874-84.
19. Steege J, Burman WA, Forget PP. The neonatal development of intraepithelial and lamina propria lymphocytes in the murine small intestine. Dev Immunol 1997;5:121-8.
20. Vazquez E, Gil A, García-Olivares E, et al. Weaning induces an increase in the number of specific cytokine-secreting intestinal lymphocytes in mice. Cytokine 2000;12:1267-70.
21. Manzano M, Abadía-Molina A, García-Olivares E, et al. Absolute counts and distribution of lymphocyte subsets in small intestine of BALB/c mice change during weaning. J Nutr 2002;132:2757-62.
22. Cummins AG, Steele TW, LaBrooy JT, et al. Maturation of the rat small intestine at weaning: changes in epithelial cell kinetics, bacterial flora, and mucosal immune activity. Gut 1998;29:1672-9.
23. Van Buren CT, Kulkarni AD, Fanslow WC, et al. Dietary nucleotides, a requirement for helper/inducer T lymphocytes. Transplantation 1985;40:694-7.
24. Kulkarni AD, Fanslow W, Higley H, et al. Expression of immune cell surface markers in vivo and immune competence in mice by dietary nucleotides. Transplant Proc 1989:121-124.
25. Gil A, Martínez-Augustín O, Navarro J. Role of dietary nucleotides in the modulation of the immune response. In: Bellanti JA, Bracc R, Prindull G, et al., eds. Neonatal Hematology and Immunology III. Amsterdam: Elsevier Science; 1997:139-44.
26. Uauy R, Quan R, Gil A. Nucleotides in infant nutrition. In: Gil A, Uauay R, eds. Nutritional and Biologic Significance of Dietary Nucleotides and Nucleic Acids. Barcelona, Spain: Abbott Laboratories, Limpergraf; 1996:169-80.
27. Rudolph FB, Fanslow WC, Kulkarni AD, et al. Effect of dietary nucleotides on lymphocyte maturation. Adv Exp Med Biol 1985;195A:497-501.
28. Kulkarni AD, Kumar S, Pizzini RP, et al. Influence of dietary glutamine and IMPACT on in vivo cell-mediated immune response in mice. Nutrition 1990;6:66-69; discussion, 80-83.
29. Jyonouchi H, Hill RJ, Good RA. RNA/nucleotide enhances antibody production in vitro and is moderately mitogenic to murine spleen lymphocytes. Proc Soc Exp Biol Med 1992;200:101-8.
30. Jyonouchi H, Zhang-Shanbhag L, Georgieff M, et al. Immunomodulating actions of nucleotides: enhancement of immunoglobulin production by human cord blood lymphocytes. Pediatr Res 1993;34:565-71.
31. Jyonouchi H, Zhang-Shanbhag L, Tomita Y. Studies of immunomodulating actions of RNA/nucleotides. RNA/nucleotides enhance in vitro immunoglobulin production by human peripheral blood mononuclear cells in response to T-dependent stimuli. Pediatr Res 1993;34:458-465.
32. Jyonouchi H, Zhang-Shanbhag L, Tomita Y. Nucleotide-free diet impairs T-helper cell functions in antibody production in response to T-dependent antigens in normal C57B1/6 mice. J Nutr 1994;124:475-84.
33. Navarro J, Ruiz-Bravo A, Jiménez-Valera M. Modulation of antibody-forming cell and mitogen-driven lymphoproliferative responses by dietary nucleotides in mice. Immunology Lett 1996;53:141-5.
34. Bandeira A, Mota-Santos T, Itohara S, et al. Localization of γ/δ T cells to the intestinal epithelium is independent of normal microbial colonization. J Exp Med 1990;172:239-44.
35. Guy-Grand DN, Cerf-Bensussan N, Malissen B, et al. Two gut intraepithelial CD8+ lymphocyte populations with different T cell receptors: a role for the gut epithelium in T cell differentiation. J Exp Med 1991;173:471-81.
36. Yoshikai Y, Ishida A, Murosaki S, et al. Sequential appearance of T-cell receptor γδ- and αβ-bearing intestinal intra-epithelial lymphocytes in mice after irradiation. Immunology 1991;74:583-8.
37. Cerf-Bensussan N, Guy Grand D. Intestinal intraepithelial lymphocytes. Gastroenterol Clin North Am 1991;20:542-5.