Transgene-driven expression of the Doppel protein in Purkinje cells causes Purkinje cell degeneration and motor impairment

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 10, 2004, Pages 3644-3649

  Anderson, Lucy ^a,c   Rossi, Daniela ^a,d   Linehan, Jackie ^a   Brandner, Sebastian ^a,b   Weissmann, Charles ^a  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; DOPPEL PROTEIN; PRION PROTEIN; UNCLASSIFIED DRUG;

ALLELISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATAXIA; CARBOXY TERMINAL SEQUENCE; CELL DEATH; CELL DEGENERATION; CELL SURVIVAL; CONTROLLED STUDY; CORRELATION ANALYSIS; KNOCKOUT MOUSE; MOTOR DYSFUNCTION; MOUSE; NERVE DEGENERATION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; PURKINJE CELL; SIGNAL TRANSDUCTION; TRANSGENE;

ANIMALS; BASE SEQUENCE; CEREBELLAR ATAXIA; DNA, COMPLEMENTARY; GENETIC COMPLEMENTATION TEST; IN SITU HYBRIDIZATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; NERVE DEGENERATION; PHENOTYPE; PRIONS; PURKINJE CELLS; RECOMBINANT PROTEINS;

ANIMALIA; MUS MUSCULUS;

EID: 1542618236     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0308681101     Document Type: Article

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