A Multidisciplinary Approach to the Focal Form of Congenital Hyperinsulinism Leads to Successful Treatment by Partial Pancreatectomy

Journal of Pediatric Surgery

Volumn 39, Issue 3, 2004, Pages 270-275

  Adzick, N Scott ^a,b   Thornton, Paul S ^a,b   Stanley, Charles A ^a,b   Kaye, Robin D ^a,b   Ruchelli, Eduardo ^a,b   Bagolan, P ^a   Spitz, L ^a   O'Neill, J ^a  

^a Children's Hospital of Philadelphia ^*

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

Hyperinsulinism; Hypoglycemia; Pancreatectomy

Indexed keywords

POTASSIUM CHANNEL;

BLOOD SAMPLING; CHYLOUS ASCITES; CLINICAL ARTICLE; CLINICAL PROTOCOL; CONFERENCE PAPER; DISEASE CLASSIFICATION; FEMALE; FOLLOW UP; FROZEN SECTION; GENE MUTATION; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; HYPERINSULINISM; HYPOGLYCEMIA; INFANT; LAPAROTOMY; MALE; NEWBORN; OUTCOMES RESEARCH; PANCREAS BIOPSY; PANCREAS ISLET BETA CELL; PANCREAS RESECTION; PANCREATICOJEJUNOSTOMY; PORTAL VEIN BLOOD; PRACTICE GUIDELINE; PREOPERATIVE EVALUATION; PRESCHOOL CHILD; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SMALL INTESTINE OBSTRUCTION; SURGICAL TECHNIQUE;

EID: 1542618112     PISSN: 00223468     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpedsurg.2003.11.019     Document Type: Conference Paper

References (21)

1. Stanley CA: Hyperinsulinism in infants and children. Pediatr Clin North Am 44:363-374, 1997
2. Nestorowicz A, Inagaki N, Gonoi T, et al: A nonsense mutation in the inward rectifier potassium channel gene. Kir6.2, is associated with familial hyperinsulinism. Diabetes 46:1743-1748. 1997
3. Thomas PM, Cote GJ, Wohlk N, et al: Mutations in the sulfonylurea receptor gene in familial persistent hyperinsulinism of infancy. Science 268:426-429, 1995
4. Glaser B, Thornton P, Otonkoski T, et al: Genetics of neonatal hyperinsulinism. Arch Dis Child 82:F79-F86, 2000
5. ATP channels in pancreatic beta-cells causes persistent hyperinsulinemic hypoglycemia of infancy. Nature Medicine 2:1344-1347, 1996
6. Stanley CA, Lieu YK, Hsu BY, et al: Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene. N Engl J Med 338:1352-1357, 1998
7. Verkarre V, Fournet JC, De Lonlay P, et al: Paternal mutation of the sulfonylurea receptor (SURI) gene and maternal loss of 11p15 imprinted genes lead to persistent hyperinsulinism in focal adenomatous hyperplasia. J Clin Invest 102:1286-1291, 1998
8. De Lonlay P, Poggi-Travert F, Founet JC, et al: Clinical features of 52 neonates with hyperinsulinism. N Engl J Med 340:1169-1175, 1999
9. Shilyansky J, Bhargava RK, Grant DB, et al: Is 95% pancreatectomy the procedure of choice for treatment of persistent hyperinsulinemic hypoglycemia of the neonate? J Pediatr Surg. 32:342-346, 1997
10. Grimberg A, Ferry RJ, Kelly A, et al: Dysregulation of insulin secretion in children with congenital hyperinsulinism due to sulfonylurea receptor mutations. Diabetes 50:322-328, 2001
11. Ferry RJ, Kelly A, Grimberg A, et al: Calcium-stimulated insulin increase in diffuse and focal forms of congenital hyperinsulinism. J Pediatr 137:239-246, 2000
12. Doppman JL, Miller DL, Chang R, et al: Insulinomas: Localization with selective intraarterial of calcium. Radiology 178:237-241, 1991
13. Brunelle F, Negre V, Barth MO, et al: Pancreatic venous samplings in infants and children with primary hyperinsulinism. Pediatr Radiol 19:100-113, 1989
14. Rahier J, Sempoux C, Fournet JC, et al: Partial or near-total pancreatectomy for persistent neonatal hyperinsulinemic hypoglycaemia: The pathologist's role. Histopathology 32:15-19, 1998
15. Sempoux C, Guiot Y, Dubois D, et al: Pancreatic B-cell proliferation in peristent hyperinsulinemic hypoglycemia of infancy: An immunohistochemical study of 18 cases. Mod Pathol 11:444-449, 1998
16. Hamilton JP, Baker L, Kaye R, et al: Subtotal pancreatectomy the management of severe persistent idiopathic hypoglycemia in children. Pediatrics 39:49-58, 1967
17. Lovvorn HN III, Nance ML, Ferry RJ Jr, et al: Congenital hyperinsulinism and the surgeon: Lessons learned over 35 years. J Pediatr Surg 34:786-793, 1999
18. Cretolle C, Nihoul-Fékété C, Jan D, et al: Partial pancreatectomy is curative in focal form of permanent hyperinsulinemic hypoglycaemia of infancy: A report of 45 cases from 1983 to 2000. J Pediatr Surg 37:155-158, 2002
19. Menni F, De Lonlay P, Sevin C, et al: Neurologic outcomes of 90 neonates and infants with persistent hyperinsulinemic hypoglycemia. Pediatrics 107:476-479, 2001
20. Albright SV, McCart JA, Libutti SK, et al: Rapid measurement of insulin using the Abbott Imx: Application to the management of insulinoma. Ann Clin Biochem 39:513-515, 2002
21. Stanley CA, Baker L: The causes of neonatal hypoglycemia. N Engl J Med 340:1200-1201, 1999