Noradrenergic and Serotonergic Neuroendocrine Responses in Prepubertal, Peripubertal, and Postpubertal Rats Pretreated with Desipramine and Sertraline

Journal of the American Academy of Child and Adolescent Psychiatry

Volumn 41, Issue 8, 2002, Pages 999-1006

  Carrey, Normand J ^a,c   Dursun, Serdar ^a   Clements, Robert ^b   Renton, Ken ^b   Waschbusch, Dan ^a   MacMaster, Frank P ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

^b DALHOUSIE UNIVERSITY   (Canada)

^c IWK Grace H C Children W/F   (Canada)

Author keywords

Antidepressant; Desipramine; Development; Growth hormone; Prolactin; Sertraline

Indexed keywords

CLONIDINE; DESIPRAMINE; FENFLURAMINE; GROWTH HORMONE; NEUROHORMONE; PROLACTIN; SERTRALINE; ADRENERGIC RECEPTOR; SEROTONIN RECEPTOR;

ADULTHOOD; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG SAFETY; HORMONE ACTION; HORMONE BLOOD LEVEL; MALE; NERVE CELL DIFFERENTIATION; NEUROENDOCRINE SYSTEM; NEUROTRANSMITTER RELEASE; NONHUMAN; NORADRENERGIC SYSTEM; PREPUBERTY; PRIORITY JOURNAL; PUBERTY; RAT; SEROTONINERGIC SYSTEM; ANIMAL; BLOOD; COMPARATIVE STUDY; DOSE RESPONSE; NEUROSECRETION; PREMEDICATION; SEXUAL MATURATION; SPRAGUE DAWLEY RAT;

ANIMALS; CLONIDINE; DESIPRAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; FENFLURAMINE; GROWTH HORMONE; MALE; NEUROSECRETORY SYSTEMS; PREMEDICATION; PROLACTIN; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC; RECEPTORS, SEROTONIN; SERTRALINE; SEXUAL MATURATION;

EID: 1542409177     PISSN: 08908567     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004583-200208000-00019     Document Type: Article

References (44)

1. Abelson J, Glitz D, Cameron O, Lee M, Bronzo M, Curris G (1991), Blunted growth hormone response to clonidine in patients with generalized anxiety disorder. Arch Gen Psychiatry 48:157-162
2. Andersen S, Rutstein M, Benzo J, Hostetter J, Teicher M (1997), Sex differences in dopamine receptor overproduction and elimination. Neuroreport 8:1495-1498
3. Aston-Jones G, Rakkowski J, Cohen J (2000), Locus ceruleus and regulation of behavioral flexibility and attention. In: Progress in Brain Research, Uylings H, Van Eden C, De Bruin J, Feenstra M, Pennartz C, eds. New York: Elsevier Science BV
4. Bel N, Artigas F (1993), Chronic treatment with fluvoxamine increases extracellular serotonin in frontal cortex but not in the raphe nuclei. Synapse 15:243-245
5. Bero LA, Kuhn CM (1987), Differential ontogeny of opioid, dopaminergic and serotonergic regulation of prolactin secretion. J Pharmacol Exp Ther 240:825-830
6. Biegon A, Greuner N (1992), Age-related changes in serotonin 5-HT-2 receptors on human blood platelets. Psychopharmacology 108:304-317
7. Birmaher B, Ryan ND, Williamson DE et al. (1996), Childhood and adolescent depression: a review of the past 10 years, part I. J Am Acad Child Adolesc Psychiatry 35:1427-1439
8. Caccia S, Fracasso C, Garattini S, Guiso G, Sarati S (1992), Effects of short and long-term administration of fluoxetine on the monoamine content of the brain. Neuropsychopharmacology 31:343-347
9. Chugani D, Muzik O, Chakraborty P, Mangner T, Chugani H (1997), Human brain serotonin synthesis capacity measured in vivo with alpha-[C-11]methyl-L-tryptophan. Synapse 28:33-43
10. Coccaro E, Kavoussi R, Cooper T, Hauger R (1996), Responses to d- and l-fenfluramine in healthy human subjects. Neuropsychopharmacology 15:595-607
11. El Mansari M, Blier P (1996), Functional characterization of 5-HT 1D autoreceptors on the modulation of 5-HT release in guinea pig mesencephalic raphe, hippocampus and frontal cortex. Br J Pharmacol 118:681-689
12. Emslie GJ, Rush AJ, Weinberg WA et al. (1997), A double blind, randomized, placebo-controlled trial of fluoxetine in children and adolescents with depression. Arch Gen Psychiatry 54:1031-1037
13. Geller B, Reising D, Leonard H, Riddle M, Walsh T (1999), Critical review of tricyclic antidepressant use in children and adolescents. J Am Acad Child Adolesc Psychiatry 38:513-516
14. Geller B, Todd RD, Luby J, Botteron KN (1996), Treatment-resistant depression in children and adolescents. Psychiatr Clin North Am 19:253-267
15. Grealy M, O'Donnell JM (1991), Secretion of growth hormone elicited by intravenous desipramine in the conscious, unrestrained rat. Br J Pharmacol 102:369-372
16. Halperin J, Newcorn J, Schwartz S et al. (1997), Age-related changes in the association between serotonergic function and aggression in boys with ADH D. Biol Psychiatry 41:682-689
17. Harms PG, Ojeda SR (1974), A rapid and simple procedure for chronic cannulation of the rat jugular vein. J Appl Physiol 36:391-392
18. Keller M, Ryan N, Strober M et al. (2001), Efficacy of paroxetine in the treatment of adolescent major depression: a randomized controlled trial. J Am Acad Child Adolesc Psychiatry 40:762-772
19. Kimura F, Nakamura S (1987), Postnatal development of alpha-adrenoceptor-mediated autoinhibition in the locus ceruleus. Brain Res 432:21-26
20. Koe B, Weissman A, Welsh W (1983), Sertraline, a new uptake inhibitor with selectivity for serotonin. J Pharmacol Exp Ther 226:686-700
21. Kutcher S, Boulos C, Ward B et al. (1994), Response to desipramine treatment in adolescent depression: a fixed-dose, placebo-controlled trial. J Am Acad Child Adolesc Psychiatry 33:686-694
22. Lucey J, O'Keane V, Butcher G, Clare A, Dinan T (1992), Cortisol and prolactin responses to d-fenfluramine in non-depressed patients with obsessive-compulsive disorder: a comparison with depressed and healthy controls. Br J Psychiatry 161:517-521
23. McCracken J, Poland R (1995), Reduced effect of antidepressant treatment on prolactin response to a serotonin agonist in prepubertal rats. J Child Adolesc Psychopharmacol 5:115-120
24. Moll G, Hause S, Ruther E, Rothenberger A, Huether G (2001), Early methylphenidate administration to young rats causes a persistent reduction of the striatal dopamine transporters. J Child Adolesc Psychopharmacol 11:15-24
25. O'Donnell JM, Grealy M (1992), Neuroendocrine response to clonidine and 8-OH-DPAT in rats following chronic administration of desipramine or sertraline. Br J Pharmacol 105:863-868
26. O'Keane V, Moloney B, O'Neil H, O'Conner A, Smith C, Dinan T (1992), Blunted prolactin responses to d-fenfluramine in sociopathy: evidence for subsensitivity of central serotonergic function. Br J Psychiatry 160:643-646
27. Olpe H, Steinmann M (1982), Age-related decline in the activity of noradrenergic neurons of the rat locus coeruleus. Brain Res 251:174-176
28. Pineyro G, Blier P (1996), Regulation of [3H]5-HT release from rat midbrain raphe nuclei by 5-HT-1D receptors: effects of tetrodotoxin, G protein in activation and long term antidepressant administration. J Pharmacol Exp Ther 276:697-707
29. Pineyro G, Blier P (1999), Autoregulation of serotonin neurons: role in antidepressant drug action. Pharmacol Rev 51:533-579
30. Power AC, Cowen PJ (1992), Neuroendocrine challenge tests: assessment of 5-HT function in anxiety and depression. MolAspects Med 13:205-220
31. Reinstein D, Isaacson R (1977), Clonidine sensitivity in the developing rat. Brain Res 135:378-382
32. Richardson M, Haugland G, Craig T (1991), Neuroleptic use, parkinsonian symptoms, tardive dyskinesia, and associated features in child and adolescent psychiatric patients. Am J Psychiatry 148:1322-1328
33. Sallee F, Richman H, Sethuraman G, Dougherty D, Sine L, Altman-Hamamdzic S (1998), Clonidine challenge in childhood anxiety disorder. J Am Acad Child Adolesc Psychiatry 37:655-662
34. Sallee F, Vrindavanam N, Liu H, Sethuraman G, Sine L (2000), Fenfluramine challenge in anxious children. Hum Psychopharmacol Clin Exp 15:619-629
35. Saxena F (1995), Serotonin receptors: subtypes, functional responses and therapeutic relevance. Pharmacol Ther 66:339-368
36. Simonovic M, Gudelsky G, Meltzer H (1984), Effect of 8-hydroxy-2-(di-n-propylamino) tetralin on rat prolactin secretion. J Neural Transm 59:143-149
37. Tang S, Seeman P (1980), Effects of antidepressant drugs on serotonergic and adrenergic receptors. Naunyn Schmiedebergs Arch Pharmacol 311:255-261
38. Teicher M, Baldessarini R (1987), Developmental pharmacodynamics. In: Psychiatric Pharmacosciences of Children and Adolescents, Charles Popper, ed. Washington, DC: American Psychiatric Press, pp 47-80
39. Trouvin J, Gardier A, Chanut E, Pages N, Jacquot C (1993), Time course of brain serotonin metabolism after cessation of long-term fluoxetine treatment in the rat. Life Sci 52:187-192
40. Van de Kar LD (1991), Neuroendocrine pharmacology of serotonergic (5-HT) neurons. Annu Rev Pharmacol Toxicol 31:289-320
41. Wegerer V, Moll G, Bagli M, Rothenberger A, Ruther D, Muether G (1999), Persistently increased density of serotonin transporters in the frontal cortex of rats treated with fluoxetine during early juvenile life. J Child Adolesc Psychopharmacol 9:13-24
42. Whitaker-Azmitia P (1991), Role of serotonin and other neurotransmitters systems in brain development: basis of developmental pharmacology. Pharmacol Rev 43:553-561
43. Whitaker-Azmitia P, Azmitia E (1994), Astroglial 5-HT1a receptors and S-100 beta in development and plasticity. Perspect Dev Neurobiol 2:233-238
44. Zito J, Safer D, dosReis S, Gardner J, Boles M, Lynch F (2000), Trends in the prescribing of psychotropic medication to preschoolers. JAMA 283:1059-1060