Evaluation of the Antidysrhythmic Effects of δ- and κ-Opioid Receptor Agonists and Antagonists on Calcium Chloride-, Adrenaline- and Ischemia/Reperfusion-Induced Arrhythmias in Rats

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 26, Issue 1, 2004, Pages 31-38

  Valtchanova Matchouganska, A ^a   Missankov, A ^b   Ojewole, John A O ^a  

^a UNIVERSITY OF KWAZULU NATAL   (South Africa)

^b SEFAKO MAKGATHO HEALTH SCIENCES UNIVERSITY   (South Africa)

Author keywords

and opioid receptors; Ischemia and reperfusion arrhythmias; Ischemic preconditioning

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE METHANESULFONATE; ADRENALIN; AMIODARONE; ANTIARRHYTHMIC AGENT; CALCIUM CHLORIDE; CHELERYTHRINE; DELTA OPIATE RECEPTOR; DELTA OPIATE RECEPTOR AGONIST; DELTA OPIATE RECEPTOR ANTAGONIST; ENKEPHALIN[2 DEXTRO ALANINE 5 DEXTRO LEUCINE]; GLIBENCLAMIDE; KAPPA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR AGONIST; KAPPA OPIATE RECEPTOR ANTAGONIST; NALTRIBEN; NALTRINDOLE; NORBINALTORPHIMINE; POTASSIUM CHANNEL BLOCKING AGENT; PROPRANOLOL; PROTEIN KINASE C INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; EVALUATION; HEART ARRHYTHMIA; HEART INFARCTION; HEART INFARCTION PREVENTION; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; MALE; NONHUMAN; QT PROLONGATION; RAT;

ANALGESICS, OPIOID; ANIMALS; ANTI-ARRHYTHMIA AGENTS; ARRHYTHMIA; CALCIUM CHLORIDE; DRUG EVALUATION, PRECLINICAL; EPINEPHRINE; MALE; MYOCARDIAL REPERFUSION INJURY; NARCOTIC ANTAGONISTS; RATS; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, KAPPA;

EID: 1542375838     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: 10.1358/mf.2004.26.1.793470     Document Type: Article

References (34)

1. Murry, C.E., Jennings, R.B., Reimer, K.A. Preconditioning with ischemia: A delay of lethal cell injury in ischemic myocardium. Circulation 1986, 74: 1124-36.
2. Liu, Y., Downey, J.M. Ischemic preconditioning protects against infarction in rat heart. Am J Physiol 1992, 263: H1107-12.
3. + channel blocker. Circulation 1994, 90: 700-5.
4. Schultz, J.E., Rose, E., Yao, Z., Gross G.J. Evidence for involvement of opioid receptors in ischemic preconditioning in rat hearts. Am J Physiol 1995, 268: H2157-61.
5. Chien, G.L., Van Vinkle, D.M. Naloxone blockade of myocardial ischemic preconditioning is stereoselective. J Mol Cell Cardiol 1996, 28: 1895-900.
6. Miki, T., Cohen, M.V., Downey, J.M. Opioid receptor contributes to ischemic preconditioning through protein kinase C activation in rabbits. Mol Cell Biochem 1998, 186: 3-12.
7. Wu, S., Li, H.Y., Wong, T.M. Cardioprotection of preconditioning by metabolic inhibition in rat ventricular myocyte: Involvement of opioid receptor. Circ Res 1999, 84: 1388-95.
8. Ventura, C., Bastagli, L., Bernardi, P., Caldarera, C.M., Guarnieri, C. Opioid receptors in rat cardiac sarcolemma: Effect of phenylephrine and isoproterenol. Biochem Biophys Acta 1989, 987: 69-74.
9. 1 Opioid agonist acutely increases hypoxic tolerance. J Pharmacol Exp Ther 1994, 268: 74-7.
10. Pogwizd, S.M., Corr, P.B. Mechanisms of arrhythmogenesis during myocardial ischemia and reperfusion: A perspective of our current understanding. J Mol Cell Cardiol 1986, 18: 43-7.
11. Kane, K.A., Parratt, J.R., Williams, F.M. An investigation into the characteristics of reperfusion-induced arrhythmias in the anesthetized rat and their susceptibility to antiarrhythmic agents. Br J Pharmacol 1984, 82: 349-57.
12. ATP-channels. Eksp Klin Farmakol., 2001, 64: 27-30.
13. Wang, X.C., Wong, T.M., Wu, G.Y., Pei, S., Yu, J.M. κ- But not δ-opioid receptors mediate effects of ischemic preconditioning on both infarct and arrhythmia in rats. Am J Physiol 2001, 280: H384-91.
14. 2-induced arrhythmias in rats. Experientia 1966, 22: 524-5.
15. Barrett, A.M., Cullum, V.A. The biological properties of the optical isomers of propranolol and their effects on cardiac arrhythmias. Br J Pharmacol 1968, 34: 43-55.
16. Maxwell, M.P., Hearse, D.J., Yellon, D.M. Species variations in the coronary collateral circulation during regional myocardial ischemia: A critical determinant of the rate of evolution and extent of myocardial infarction. Cardiovasc Res 1987, 21: 737-46.
17. Halpern, M.H. The dual blood supply of the heart. Am J Anat 1957, 101: 1-16.
18. Sarne, Y., Flitstein, A., Oppenheimer, E. Anti-arrhythmic activities of opioid agonists and antagonists and their stereoisomers. Br J Pharmacol 1991, 102: 696-8.
19. Vaughan Williams, E.M. Significance of classifying antiarrhythmic actions since the cardiac arrhythmia suppression trial. J Clin Pharmacol., 1991, 31: 123-35.
20. Weirich, J., Antoni, H. Neue aspekte zar frequenzabhangigen wirkung von klasse-1- antiarrhythmika. Eine kritische analyse der gebrauchlichen subklassifikation. Zeitschrift Kardiol 1991, 80: 177-86.
21. 5-enkephalin. Eur J Pharmacol 1978, 47: 223-5.
22. Gillan, M.G., Kosterlitz, M. Spectrum of μ-, δ- and κ-binding sites in homogenates of rat brain. Br J Pharmacol., 1982, 88: 461-9.
23. 2 opioid receptors in acute dependence on morphine in mice. J Pharmacol Exp Ther 1993, 265: 1325-7.
24. Parkhill A.L., Bidlack, J.M. Several δ-opioid receptor ligands display no subtype selectivity to the human delta-opioid receptor. Eur J Pharmacol 2002, 451: 257-64.
25. 2 opioid receptor subtypes. Life Sci 1994, 55: 79-84.
26. Wettstein, J.G., Grouhel, A. Opioid antagonist profile of SC norbinaltorphimine in the formalin paw assay. Pharmacol Biochem Behav 1996, 53: 411-16.
27. Herbert, J.M., Augerean, J.M., Maffrand, J.P. Chelerythrine is a potent and specific inhibitor of protein kinase C. Biochem Biophys Res Comm 1990, 172: 993-9.
28. Schultz, J.E., Gross, G.J. Opioids and cardioprotection. Pharmacol Ther 2001, 89: 123-37.
29. Curtis, M.J., Hearse, D.J. Ischemia-induced and reperfusion-induced arrhythmias differ in their sensitivity to potassium: implications for mechanisms of initiation and maintenance of ventricular fibrillation. J Mol Cell Cardiol 1989, 21: 21-40.
30. Janse, M.J., Van Capelle, F.J.L., Morsink, H. et al. Flow of injury current and patterns of excitation during early ventricular arrhythmias in acute regional myocardial ischemia in isolated porcine and canine hearts. Circ Res 1980, 47: 151-65.
31. Janse, M.J. Electrophysiology of arrhythmias. Arch Mal Coeur Vaiss 1999, 92: 9-16.
32. Schomig, A., Fischer, S., Kurtz, T., Richardt, G., Schomig, E. Nonexocytolic release of endogenous noradrenaline in the ischemic and anoxic rat heart: Mechanisms and metabolic requirements. Circ Res 1987, 60: 194-205.
33. + exchange inhibitor, on reperfusion ventricular arrhythmias in rat heart. Eur J Pharmacol 1997, 339: 121-7.
34. Carmeliet, E. Cardiac ionic currents and acute ischemia: From channels to arrhythmias. Physiol Rev., 1999, 79: 917-1017.