Antiarrhythmic effects of cariporide, a novel Na+-H+ exchange inhibitor, on reperfusion ventricular arrhythmias in rat hearts

European Journal of Pharmacology

Volumn 339, Issue 2-3, 1997, Pages 121-127

  Aye, Nu Nu ^a   Xue, Yi Xue ^a   Hashimoto, Keitaro ^a  

^a UNIVERSITY OF YAMANASHI   (Japan)

Author keywords

Arrhythmias; Cariporide (HOE642); Ischemia; Na+ H+ exchange; Reperfusion

Indexed keywords

ANTIARRHYTHMIC AGENT; CARIPORIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIARRHYTHMIC ACTIVITY; ARTICLE; CARDIOVASCULAR EFFECT; CONTROLLED STUDY; DOG; DOSE RESPONSE; HEART MUSCLE ISCHEMIA; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE FIBRILLATION; HEART VENTRICLE TACHYCARDIA; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTON SODIUM EXCHANGE; RAT; REPERFUSION INJURY;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; ARRHYTHMIA; GUANIDINES; HEART; HEMODYNAMIC PROCESSES; MALE; MYOCARDIAL REPERFUSION INJURY; RATS; RATS, SPRAGUE-DAWLEY; SODIUM-HYDROGEN ANTIPORTER; SULFONES; VENTRICULAR FUNCTION;

EID: 0031588370     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)01371-X     Document Type: Article

References (39)

1. Anderson S.E., Murphy E., Steenbergen C., London R.E., Cala P.M. Na-H exchange in myocardium: Effects of hypoxia and acidification on Na and Ca. Am. J. Physiol. 259:1990;C940-948.
2. Bountra C., Vaughan-Jones R.D. Effect of intracellular and extracellular pH on contraction in isolated mammalian cardiac muscle. J. Physiol. 418:1989;163-187.
3. Brooks W.W., Conrad C.H., Morgan J.P. Reperfusion induced arrhythmias following ischaemia in intact rat heart: Role of intracellular calcium. Cardiovasc. Res. 29:1995;536-542.
4. Dennis S.C., Gevers W., Opie L.H. Protons in ischemia: Where do they come from; where do they go to? J. Mol. Cell. Cardiol. 23:1991;1077-1086.
5. + exchanger in reperfusion stunning in isolated perfused rat heart. J. Cardiovasc. Pharmacol. 22:1993;877-883.
6. Dyck J.R.B., Maddaford T.G., Pierce G.N., Fliegel L. Induction of expression of the sodium-hydrogen exchanger in rat myocardium. Cardiovasc. Res. 29:1995;203-208.
7. Fliegel L., Dyck J.R.B. Molecular biology of the cardiac sodium/hydrogen exchanger. Cardiovasc. Res. 29:1995;155-159.
8. + exchanger. Mol. Cell. Biochem. 125:1993;137-143.
9. Hansen P.R. Myocardial reperfusion injury: Experimental evidence and clinical relevance. Eur. Heart. J. 16:1995;734-740.
10. + during acidosis in rat ventricular myocytes. Am. J. Physiol. 262:1992;C348-357.
11. Hearse D.J., Bolli R. Reperfusion induced injury: Manifestations, mechanisms, and clinical relevance. Cardiovasc. Res. 26:1992;101-108.
12. + exchange. Am. J. Physiol. 255:1988;H608-H615.
13. + exchanger (NHE 5/SLC9A5) to chromosome 16q22.1. Genomics. 25(3):1995;615-622.
14. Komori S., Sawanobori T., Tamura K., Kane K.A., Parratt J.R. Effects of NS-2, a new class I antiarrhythmic agent, and AFD-19, its active metabolite, on ventricular arrhythmias induced by coronary artery occlusion and reperfusion in anesthetized rats: Comparison with dysopyramide and mexilitine. Jpn. J. Pharmacol. 65:1994;193-200.
15. Lawson C.S., Coltart D.J., Hearse D.J. 'Dose'-dependency and temporal characteristics of protection by ischemic preconditioning against ischemia-induced arrhythmias in rat hearts. J. Mol. Cell. Cardiol. 25:1993;1391-1402.
16. Lazdunski M., Frelin C., Vigne P. The sodium/hydrogen exchange system in cardiac cells: Its biochemical and pharmacological properties and its role in regulating internal concentrations of sodium and internal pH. J. Mol. Cell. Cardiol. 17:1985;1029-1042.
17. + exchange inhibitor, on intracellular pH regulation in the guinea-pig ventricular myocyte. Br. J. Pharmacol. 118:1996;1905-1912.
18. Manning A.S., Hearse D.J. Reperfusion-induced arrhythmias: Mechanism and prevention. J. Mol. Cell. Cardiol. 16:1984;497-518.
19. Maxwell M.P., Hearse D.J., Yellon D.M. The coronary collateral circulation during regional myocardial ischemia: A comparative study in eight species. J. Mol. Cell. Cardiol. 16(Suppl. 2):1984;22. abstract.
20. Meng H.-P., Pierce G.N. Protective effect of 5-(N,N-dimethyl) amiloride on ischemia-reperfusion injury in hearts. Am. J. Physiol. 258:1990;H1615-H1619.
21. Meng H.-P., Maddaford T.G., Pierce G.N. Effect of amiloride and selected analogues on postischemic recovery of cardiac contractile function. Am. J. Physiol. 264:1993;H1831-H1835.
22. + exchange inhibitor, Hoe642: Difference from preconditioning in the role of protein kinase C. J. Am. Coll. Cardiol. 29:1997;693-701.
23. Moffat M.P., Karmazyn M. Protective effects of the potent Na/H exchange inhibitor methylisobutyl amiloride against post-ischemic contractile dysfunction in rat and guinea-pig hearts. J. Mol. Cell. Cardiol. 25:1993;959-971.
24. Murphy E., Perlman M., London R.E., Steenbergen C. Amiloride delays the ischemia-induced rise in cytosolic free calcium. Circ. Res. 68:1991;1250-1258.
25. Myers M. L, Mathur S., Li G.-H., Karmazyn M. Sodium-hydrogen exchange inhibitors improve postischemic recovery of function in the reperfused rabbit heart. Cardiovasc. Res. 29:1995;209-214.
26. Nayler W.G., Panagiotopoulos S., Elz J.S., Daly M.J. Calcium-mediated damage during post-ischemic reperfusion. J. Mol. Cell. Cardiol. 20(S II):1988;41-54.
27. Opie L.H. Reperfusion injury and its pharmacologic modification. Circulation. 80:1989;1049-1062.
28. Opie L.H., Coetzee W.A. Role of calcium ions in reperfusion arrhythmias: Relevance to pharmacologic intervention. Cardiovasc. Drugs Therapy. 2:1988;623-636.
29. Piwnica-Worms D., Jacob R., Horres C.R., Lieberman M. Na/H exchange in cultured chick heart cells. J. Gen. Physiol. 85:1985;43-64.
30. Rees S.A., Curtis M.J. Specific Ik1 blockade: A new antiarrhythmic mechanism? Effect of RP58866 on ventricular arrhythmias in rat, rabbit, and primate. Circulation. 87:1993;1979-1989.
31. + exchange inhibitor and its effects in cardiac ischaemia. Br. J. Pharmacol. 109:1993;562-568.
32. Scholz W., Albus U., Counillon L., Gögelein H., Lang H.J., Linz W., Weichert A., Schölkens B.A. Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischemia and reperfusion. Cardiovasc. Res. 29:1995;260-268.
33. 2 antagonists. Br. J. Pharmacol. 117:1996;817-822.
34. 2+ exchange. Circ. Res. 65:1989;1045-1056.
35. Walker M.J.A., Curtis M.J., Hearse D.J., Campbell R.W.F., Janse M.J., Yellon D.M., Cobbe S.M., Coker S.J., Harnrss J.B., Harron D.W.G., Higgins A.J., Julian D.G., Lab M.J., Manning A.S., Northover B.J., Parratt J.R., Riemersma R.A., Riva E., Russell D.C., Sheridan D.C., Winslow E., Wooward B. The Lambeth conventions: Guidelines for the study of arrhythmias in ischaemia, infarction and reperfusion. Cardiovasc. Res. 22:1988;447-455.
36. Wallenstein S., Zucker C.L., Fleiss J.L. Some statistical methods useful in circulation research. Circ. Res. 47:1980;1-9.
37. + exchange inhibitor, on ventricular arrhythmias in animal hearts. Eur. J. Pharmacol. 317:1996;309-316.
38. Yasutake M., Avkiran M. Exacerbation of reperfusion arrhythmias by α1 adrenergic stimulation: A potential role for receptor mediated activation of sarcolemmal sodium-hydrogen exchange. Cardiovasc. Res. 29:1995;222-230.
39. + exchange and reperfusion arrhythmias: Protection by intracoronary infusion of a novel inhibitor. Am. J. Physiol. 267:1994;H2430-H2440.