Design and Synthesis of Substrate-Based Inhibitors of Botulinunm Neurotoxin Type B Metalloprotease

Biopolymers - Peptide Science Section

Volumn 71, Issue 6, 2003, Pages 602-619

  Oost, Thorsten ^a   Sukonpan, Chanokporn ^a   Brewer, Matthias ^a   Goodnough, Michael ^a   Tepp, William ^a   Johnson, Eric A ^a   Rich, Daniel H ^a,b  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b 7109 Rennebohm Hall ^*  (United States)

Author keywords

Botulinum toxin metalloproteases; Nonpeptide inhibitors; Proteases; Pseudopeptide; Toxicity; Transition state analog inhibitors

Indexed keywords

CONFORMATIONS; CRYSTAL STRUCTURE; ENZYME INHIBITION; REACTION KINETICS; SYNTHESIS (CHEMICAL); X RAY ANALYSIS;

PEPTIDES; X RAY CRYSTAL STRUCTURE;

ENZYMES;

ALPHA HYDROXYAMIDE; ALPHA THIOAMIDE; AMIDE; BOTULINUM TOXIN B; ETHYLAMINE; GLUTAMINYLPHENYLALANINE HYDROXYETHYLAMINE; METALLOPROTEINASE INHIBITOR; PEPTIDE DERIVATIVE; REDUCED AMIDE; SYNAPTOBREVIN; SYNAPTOBREVIN 2; THIOAMIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CONCENTRATION RESPONSE; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG DESIGN; DRUG SYNTHESIS; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME SUBSTRATE; INHIBITION KINETICS; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; BOTULINUM TOXINS; DRUG DESIGN; METALLOPROTEASES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEASE INHIBITORS; SUBSTRATE SPECIFICITY;

EID: 1542374135     PISSN: 00063525     EISSN: None     Source Type: Journal    
DOI: 10.1002/bip.10590     Document Type: Article

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