Hydralazine as antihypertensive therapy in obesity-related hypertension

International Journal of Obesity

Volumn 28, Issue 3, 2004, Pages 384-390

  Carroll, J F ^a   King, J W ^a   Cohen, J S ^a  

^a UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

Author keywords

Cardiac hypertrophy; Hydralazine; Hypertension; Rabbit model of obesity; Renin angiotensin system

Indexed keywords

ADRENALIN; ALDOSTERONE; ANTIHYPERTENSIVE AGENT; ATRIAL NATRIURETIC FACTOR; HYDRALAZINE; HYDROCORTISONE; NORADRENALIN;

ALDOSTERONE BLOOD LEVEL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATTENUATION; BLOOD VOLUME; BODY FAT; BODY WATER; CONTROLLED STUDY; DISEASE EXACERBATION; FEMALE; HEART RATE; HEART VENTRICLE; HEART VENTRICLE HYPERTROPHY; HEMODYNAMICS; HYPERTENSION; LEAN BODY WEIGHT; MEAN ARTERIAL PRESSURE; NAUSEA; NONHUMAN; OBESITY; PLASMA RENIN ACTIVITY; PRIORITY JOURNAL; RABBIT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; TELEMETRY;

ANIMALS; ANTIHYPERTENSIVE AGENTS; BIOMETRY; BLOOD PRESSURE; CARDIOMEGALY; FEMALE; HEART RATE; HORMONES; HYDRALAZINE; HYPERTENSION; OBESITY; RABBITS; RENIN-ANGIOTENSIN SYSTEM;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 1542359930     PISSN: 03070565     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ijo.0802573     Document Type: Article

References (42)

1. Haapanen-Niemi N, Vuori I, Pasanen M. Public health burden of coronary heart disease risk factors among middle-aged and elderly men. Prev Med 1999; 28: 343-348.
2. Staessen J, Fagard R, Amery A. The relationship between body weight and blood pressure. J Hum Hypertens 1988; 2: 207-217.
3. Hubert HB, Feinleib M, McNamara PM, Castelli WP. Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study. Circulation 1983; 67: 968-977.
4. Messerli FH, Sundgaard-Riise K, Reisin E, Dreslinski GR, Dunn FG, Frohlich ED. Disparate cardiovascular effects of obesity and arterial hypertension. Am J Med 1983; 74: 808-812.
5. Hall JE. Renal and cardiovascular mechanisms of hypertension in obesity. Hypertension 1994; 23: 381-394.
6. Jones DW, Kim JS, Andrew ME, Kim SJ, Hong YP. Body mass index and blood pressure in Korean men and women: the Korean National Blood Pressure Survey. J Hypertens 1994; 12: 1433-1437.
7. Su HY, Sheu WH, Chin HM, Jeng CY, Chen YD, Reaven GM. Effect of weight loss on blood pressure and insulin resistance in normotensive and hypertensive obese individuals. Am J Hypertens 1995; 8: 1067-1071.
8. Mertens IL, Van Gaal LF. Overweight, obesity, and blood pressure: the effects of modest weight reduction. Obes Res 2000; 8: 270-278.
9. Carroll JF, Dwyer TM, Grady AW, Reinhart GA, Montani J-P, Cockrell K, Meydrech EF, Mizelle HL. Hypertension, cardiac hypertrophy, and neurohumoral activity in a new animal model of obesity. Am J Physiol 1996; 271: H373-H378.
10. Ikeda Y, Makamura T, Takano H, Kimura H, Obata J-E, Takeda S, Hata A, Shido K, Mochizuki S, Yoshida Y. Angiotensin II-induced cardiomyocyte hypertrophy and cardiac fibrosis in stroke-prone spontaneously hypertensive rats. J Lab Clin Med 2000; 135: 353-359.
11. Zhang Q, Kohara K, Qui H, Hiwada K. Comparative effects of three sites of renin-angiotensin blockade on the regression of left ventricular hypertrophy in spontaneously hypertensive rats. Am J Ther 1997; 4: 199-202.
12. Ideda Y, Nakamura T, Takano H, Kimura H, Obata JE, Takeda S, Hata A, Shido K, Mochizuki S, Yoshida Y. Angiotensin II-induced cardiomyocyte hypertrophy and cardiac fibrosis in stroke-prone spontaneously hypertensive rats. J Lab Clin Med 2000; 135: 353-359.
13. Kawano H, Cody RJ, Graf K, Goetze S, Kawano Y, Schnee J, Law RE, Hsueh WA. Angiotensin II enhances integrin and alpha-actinin expression in adult rat cardiac fibroblasts. Hypertension 2000; 35: 273-279.
14. Grimm D, Kromer EP, Bocker W, Bruckschlegel G, Holmer SR, Riegger GA, Schunkert H. Regulation of extracellular matrix proteins in pressure-overload cardiac hypertrophy: effects of angiotensin converting enzyme inhibition. J Hypertens 1998; 16: 1345-1355.
15. 2+ blockers prevent myocardial remodeling induced by chronic NO inhibition in rats. Hypertension 2003; 41: 963-967.
16. Kamide K, Rakugi H, Higaki J, Okamura A, Nagai M, Moriguchi K, Ohishi M, Satoh N, Tuck ML, Ogihara T. The renin-angiotensin and adrenergic nervous system in cardiac hypertrophy in fructose-fed rats. Am J Hypertens 2002; 15: 66-71.
17. Sica DA. Angiotensin-converting enzyme inhibitors. In: Izzo JL, Black HR (eds). Hypertension primer, 3rd edn. Lippincott Williams and Wilkins: Philadelphia; 2003. pp 426-429.
18. Gohlke P, Linz W, Scholkens BA, Wiemer G, Unger T. Cardiac and vascular effects of long-term losartan treatment in stroke-prone spontaneously hypertensive rats. Hypertension 1996; 28: 397-402.
19. Ram CVS, Fenves A. Direct vasodilators. In: Izzo JL, Black HR (eds). Hypertension primer, 3rd ed. Lippincott Williams and Wilkins: Philadelphia; 2003. pp 437-439.
20. Van den Buuse M. Circadian rhythms of blood pressure, heart rate, and locomotor activity in spontaneously hypertensive rats as measured with radio-telemetry. Physiol Behav 1994; 55: 783-787.
21. Janssen BJA, Tyssen CM, Struyker-Boudier HAJ. Modification of circadian blood pressure and heart rate variability by five different antihypertensive agents in spontaneously hypertensive rats. J Cardiovasc Pharmacol 1991; 17: 494-503.
22. Pitre M, Gaudreault N, Santure M, Nadeau A, Bachelard H. Isradipine and insulin sensitivity in hypertensive rats. Am J Physiol 1999; 276: E1038-E1048.
23. Carroll JF, Huang M, Hester RL, Cockrell K, Mizelle HL. Hemodynamic alterations in hypertensive obese rabbits. Hypertension 1995; 26: 465-470.
24. Carroll JF, Kyser CK. Exercise training in obesity lowers blood pressure independent of weight change. Med Sci Sports Exerc 2002; 34: 596-601.
25. Harkness JE. Rabbit husbandry and medicine. Vet Clin N Am 1987; 17: 1019-1044.
26. Carroll JF, Jones AE, Hester RL, Reinhart GA, Cockrell K, Mizelle HL. Reduced cardiac contractile responsiveness to isoprotereonol in obese rabbits. Hypertension 1997; 30: 1376-1381.
27. Carroll JF. Post β-receptor defect in isolated hearts of obese rabbits. Int J Obes Relat Metab Disord 1999; 23: 863-866.
28. Carroll JF, Summers RL, Dzielak DJ, Cockrell K, Montani J-P, Mizelle HL. Diastolic compliance is reduced in obese rabbits. Hypertension 1999; 33: 811-815.
29. Clinkingbeard C, Sessions C, Shenker Y. The physiological role of atrial natriuretic hormone in the regulation of aldosterone and salt and water metabolism. J Clin Endocrinol Metab 1990; 70: 582-589.
30. Naess PA, Christensen G, Kill F. Atrial natriuretic factor reduces renin release by opposing alpha-adrenoceptor activity. Am J Physiol 1991; 261: E240-E245.
31. Alpert MA, Alexander JK. Cardiac morphology and obesity in man. In: Alpert MA, Alexander JK (Eds). The Heart and Lung in Obesity. Futura Publishing Company, Inc.: Armonk, NY; 1998. pp 25-44.
32. Middlekauff HR, Mark AL. The treatment of heart failure: the role of neurohumoral activation. Int Med 1998; 37: 112-122.
33. Lorell BH. Left ventricular hypertrophy: the consequences for diastole. In: Gaasch WH, LeWinter MM (eds). Left ventricular diastolic dysfunction and heart failure. Lea & Febiger: Philadelphia; 1994. pp 345-353.
34. Mazzolai L, Nussberger J, Aubert JF, Brunner DB, Gabbiani G, Brunner HR, Pedrazzini T. Blood pressure-independent cardiac hypertrophy induced by locally activated renin-angiotensin system. Hypertension 1998; 31: 1324-1330.
35. Nakajima S, Suzuki H, Saito I, Saruta T. Effects of atrial natriuretic peptide, dopamine, and ouabain on aldosterone synthesis. Acta Endocrinol (Copenh) 1987; 115: 57-62.
36. Ono T, Kohya T, Tsukamoto E, Mochizuki T, Itoh K, Itoh Y, Tomita F, Tamaki N, Kitabatake A. Improvement in fatty acid utilization in relation to a change in left ventricular hypertrophy in spontaneously hypertensive rats. Jpn CircJ 2000; 64: 117-120.
37. Carroll JF, Braden DS, Cockrell K, Mizelle HL. Obese hypertensive rabbits develop concentric and eccentric hypertrophy and diastolic filling abnormalities. Am J Hypertens 1997; 10: 230-233.
38. Lipke DW, McCarthy KJ, Elton TS, Arcot SS, Oparil S, Couchman JR. Coarctation induces alterations in basement membranes in the cardiovascular system. Hypertension 1993; 22: 743-753.
39. Gorzelniak K, Engeli S, Janke J, Luft FC, Sharma AM. Hormonal regulation of the human adipose-tissue renin-angiotensin system: relationship to obesity and hypertension. J Hypertens 2002; 20: 965-973.
40. Engeli S, Schling P, Gorzelniak K, Boschmann M, Janke J, Ailhaud G, Teboul M, Massiera F, Sharma AM. The adipose-tissue renin-angiotensin- aldosterone system: role in the metabolic syndrome? Int J Biochem Cell Biol 2003; 35: 807-825.
41. Giacchetti G, Faloia E, Mariniello B, Sardu C, Gatti C, Camilloni MA, Guerrieri M, Mantero F. Overexpression of the renin-angiotensin system in human visceral adipose tissue in normal and overweight subjects. Am J Hypertens 2002; 15: 381-388.
42. Guerre-Millo M. Adipose tissue hormones. J Endocrinol Invest 2002; 25: 855-861.