Comparative effects of three sites of renin-angiotensin blockade on the regression of left ventricular hypertrophy in spontaneously hypertensive rats

American Journal of Therapeutics

Volumn 4, Issue 5-6, 1997, Pages 199-202

  Zhang, Qiang ^a   Kohara, Katsuhiko ^a   Qui, Han Ying ^a   Hiwada, Kunio ^a  

^a EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Angiotensin II type 1 receptor antagonist; Angiotensin converting enzyme inhibitor; Left ventricular hypertrophy; Renin inhibitor; Renin angiotensin system; Spontaneously hypertensive rats

Indexed keywords

ANGIOTENSIN 1 RECEPTOR ANTAGONIST; DELAPRIL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HYDRALAZINE; HYDROCHLOROTHIAZIDE; RENIN INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MIXTURE; DRUG SCREENING; HEART LEFT VENTRICLE HYPERTROPHY; HYPERTENSION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SPONTANEOUSLY HYPERTENSIVE RAT;

EID: 0030979474     PISSN: 10752765     EISSN: None     Source Type: Journal    
DOI: 10.1097/00045391-199705000-00006     Document Type: Article

References (16)

1. Joint National Committee: The fifth report of the Joint National Committee on Detection, Evaluation and Treatment of High Blood Pressure. Arch Intern Med 1993;153: 154-183.
2. Guidelines Sub-Committee. 1993 Guidelines for the management of mild hypertension: Memorandum from a World Health Organization/International Society of Hypertension meeting. J Hypertens 1993;11:905-918.
3. Waeber B, Nussberger J, Brunner HR: Angiotensin-converting enzyme inhibitors in hypertension. In Hypertension: Pathophysiology, Diagnosis, and Management, 2nd ed (Edited by Laragh JH and Brenner BM), Raven Press, New York, 1995, pp. 2861-2875.
4. Dahlöf B, Pennert K, Hansson L: Reversal of left ventricular hypertrophy in hypertensive patients. A metaanalysis of 109 treatment studies. Am J Hypertens 1992;5:95-110.
5. Nelson EB, Harm SC, Goldberg M, et al.: Clinical profile of the first angiotensin II (AT-1 specific) receptor antagonists. In Hypertension: Pathophysiology, Diagnosis, and Management, 2nd ed (Edited by Laragh JH and Brenner BM), Raven Press, New York, 1995, pp. 2895-2916.
6. Bunkenburg B, Schnell C, Baum H-P, et al.: Prolonged angiotensin II antagonism in spontaneously hypertensive rats. Hemodynamic and biochemical consequences. Hypertension 1991;18:278-288.
7. Hiwada K, Kokubu T, Murakami E, et al.: A highly potent and long-acting oral inhibitor of human renin. Hypertension 1988;11:708-712.
8. Saruta T, Nishikawa K: Characteristics of a new angiotensin converting enzyme inhibitor: delapril. Am J Hypertens 1991;4:23S-28S.
9. Shibouta Y, Inada Y, Ojima M, et al.: Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-ben zimidazole-7-carboxylic acid (CV-11974), and its prodrug, (±)-1-(cyclohexyloxycarbonyloxy)-ethyl 2-ethoxy-1-[[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-ben zimidazole-7-carboxylate (TCV-116). J Pharmacol Exp Ther 1993;266:114-120.
10. Hui KY, Holtzman EJ, Quinones MA, et al.:: Design of rat renin inhibitory peptides. J Med Chem 1988;31:1679-1686.
11. Ii Y, Kitami Y, Hiwada K: Effect of a rat renin inhibitor on renal renin synthesis in spontaneously hypertensive rats. Hypertens Res 1992;15:99-104.
12. Kohara K, Mikami H, Okuda N, et al.: Angiotensin blockade and the progression of renal damage in the spontaneously hypertensive rat. Hypertension 1993;21: 975-979.
13. Devereux RB, Koren MJ, de Simone G, et al.: Left ventricular mass as a measure of preclinical hypertensive disease. Am J Hypertens 1992;5:175S-181S.
14. Frohlich E: Hemodynamics and other determinants in development of left ventricular hypertrophy. Fed Proc 1983;42:2709-2715.
15. Schelling P, Fischer H, Ganten D: Angiotensin and cell growth: a link to cardiovascular hypertrophy? J Hypertens 1991;9:3-15.
16. Schieffer B, Wirger A, Meybrunn M, et al.: Comparative effects of chronic angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade on cardiac remodeling after myocardial infarction in the rat. Circulation 1994;89:2273-2282.