The putative pheromone androstadienone activates cortical fields in the human brain related to social cognition

Neurochemistry International

Volumn 44, Issue 8, 2004, Pages 595-600

  Gulyás, Balázs ^a   Kéri, Szabolcs ^a,b,c   O'Sullivan, Brandon T ^a,d   Decety, Jean ^e   Roland, Per E ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF SZEGED   (Hungary)

^c UNIVERSITY OF SZEGED   (Hungary)

^d ROYAL PRINCE ALFRED HOSPITAL   (Australia)

^e UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Human pheromones; Olfaction; PET; Prefrontal cortex; Social cognition; Superior temporal cortex

Indexed keywords

ANDROSTANE DERIVATIVE; BUTANOL; BUTYRIC ACID DERIVATIVE; DIPROPYLENE GLYCOL; GAMMA METHYLIONONE; GLYCOL; IONONE DERIVATIVE; METHYLTHIOBUTANOATE; OXYGEN 15; PHEROMONE ANDROSTADIENONE; PHEROMONE DERIVATIVE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; ATTENTION; BRAIN BLOOD FLOW; BRAIN CORTEX; BRAIN REGION; COGNITION; CONTROLLED STUDY; FEMALE; HUMAN; NERVE CELL NETWORK; NORMAL HUMAN; ODOR; POSITRON EMISSION TOMOGRAPHY; PREFRONTAL CORTEX; PRIORITY JOURNAL; SMELLING; TEMPORAL CORTEX;

ADULT; ANDROSTADIENES; BRAIN MAPPING; BUTANOLS; CEREBRAL CORTEX; CEREBROVASCULAR CIRCULATION; COGNITION; FEMALE; FUNCTIONAL LATERALITY; HUMANS; MIDDLE AGED; NEURAL PATHWAYS; ODORS; PHEROMONES; PREFRONTAL CORTEX; RADIOPHARMACEUTICALS; SMELL; SOCIAL BEHAVIOR; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 1542358095     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2003.10.003     Document Type: Article

References (31)

1. Adolphs R. Neural systems for recognizing emotion. Curr. Opin. Neurobiol. 12:2002;169-177.
2. Allman J., Hakeem A., Watson K.I. Two phylogenetic specializations in the human brain. Neuroscientist. 8:2002;335-346.
3. 15O ]butanol and positron emission tomography J. Cereb. Blood Flow Metab. 11:1991;707-715.
4. Druzgal T.J., D'Esposito M. A neural network reflecting decisions about human faces. Neuron. 32:2001;947-955.
5. Farde L., Halldin C., Stone-Elander S., Sedvall G. PET analysis of human dopamine receptor subtypes using 11C-SCH 23390 and 11C-raclopride. Psychopharmacology (Berl.). 92:1987;278-284.
6. Farde L., Ginovart N., Ito H., Lundkvist C., Pike V.W., McCarron J.A., Halldin C. PET-characterization of [carbonyl-11C]WAY-100635 binding to 5-HT1A receptors in the primate brain. Psychopharmacology (Berl.). 133:1997;196-202.
7. Friston K.J., Ashburner J., Frith C.D., Poline J.-B., Heather J.D., Frackowiack R.S.J. Spatial registration and normalization of images. Hum. Brain Mapp. 3:1995;165-189.
8. Friston K.J., Worsley K.J., Frackowiak R.S.J., Mazziotta J.C., Evans A.C. Assessing the significance of focal activations using their spatial extent. Hum. Brain Mapp. 1:1994;210-220.
9. Frith C.D., Frith U. Interacting minds - a biological basis. Science. 286:1999;1692-1694.
10. Gehlert R.D., Schober D.A., Henrick-Luecke S.K., Krushinski J., Howbert J.J., Robertson D.W., Fuller R.W., Wong D.T. Novel halogenated analogs of tomoxetine that are potent and selective inhibitors of norepinephrine uptake in the brain. Neurochem. Int. 26:1995;47-52.
11. Hadjikhani N., de Gelder B. Neural basis of prosopagnosia: an fMRI study. Hum. Brain Mapp. 16:2002;176-182.
12. Hall H., Fardel L., Halldin C., Hogberg T., Larsson S., Sedvall G. Imaging of dopamine receptors using PET and SPECT. Neurochem. Int. 20:1992;329S-333S.
13. Halldin C., Farde L., Litton J.E., Hall H., Sedvall G. [11C]Ro 15-4513, a ligand for visualization of benzodiazepine receptor binding. Preparation, autoradiography and positron emission tomography. Psychopharmacology (Berl.). 108:1992;16-22.
14. Halldin C., Gulyás B., Farde L. PET studies with Carbon-11 radioligands in neuropsychological drug development. Current Radiopharm. Design. 7:2001a;1907-1929.
15. Halldin C., Gulyás B., Langer O., Farde L. Brain radioligands - state of the art and new trends. J. Nucl. Med. Allied Sci. 45:2001b;139-152.
16. Haxby J.V., Hoffman E.A., Gobbini M.I. The distributed human neural system for face perception. Trends Cogn. Sci. 4:2000;223-233.
17. Jacob S., Kinnunen L.H., Metz J., Cooper M., McClintock M.K. Sustained human chemosignal unconsciously alters brain function. NeuroReport. 12:2001;2391-2394.
18. Jacobs B., Schall M., Prather M., Kapler E., Driscoll L., Baca S., Jacobs J., Ford K., Wainwright M., Treml M. Regional dendritic and spine variation in human cerebral cortex: a quantitative Golgi study. Cereb. Cortex. 11:2001;558-571.
19. Kanwisher N., Stanley D., Harris A. The fusiform face area is selective for faces not animals. NeuroReport. 10:1999;183-187.
20. Karlson P., Luscher M. Pheromones: a new term for a class of biologically active substances. Nature. 183:1959;55-56.
21. Keverne E.B. The vomeronasal organ. Science. 286:1999;716-720.
22. Knoop B.O., Jordan K., Spinks T., Knoop B.O., Jordan K., Spinks T. Evaluation of PET count rate performance. Eur. J. Nucl. Med. 15:1989;705-711.
23. MacLeod A.K., Buckner R.L., Miezin F.M., Petersen S.E., Raichle M.E. Right anterior prefrontal cortex activation during semantic monitoring and working memory. NeuroImage. 7:1998;41-48.
24. Nishisawa S., Mzengeza S., Diksic M. Acute effects of 3,4-methylenedioxymethamphetamine on brain serotonin synthesis in the dog studied by positron emission tomography. Neurochem. Int. 34:1999;33-40.
25. Pike V.W., Halldin C., Crouzel C., Barre L., Nutt D.J., Osman S., Shah F., Turton D.R., Waters S.L. Radioligands for PET studies of central benzodiazepine receptors and PK (peripheral benzodiazepine) binding sites-current status. Nucl. Med. Biol. 20:1993;503-525.
26. Rogers R.D., Owen A.M., Middleton H.C., Williams E.J., Pickard J.D., Sahakian B.J., Robbins T.W. Choosing between small, likely rewards and large, unlikely rewards activates inferior and orbital prefrontal cortex. J. Neurosci. 20:1999;9029-9038.
27. Savic I., Berglund H., Gulyás B., Roland P. Smelling of odorous sex hormone-like compounds causes sex-differentiated hypothalamic activations in humans. Neuron. 31:2001;661-668.
28. Sobel N., Prabhakaran V., Hartley C.A., Desmond J.E., Glover G.H., Sullivan E.V., Gabrieli J.D. Blind smell: brain activation induced by an undetected air-borne chemical. Brain. 122:1999;209-217.
29. Strange B.A., Henson R.N., Friston K.J., Dolan R.J. Anterior prefrontal cortex mediates rule learning in humans. Cereb. Cortex. 11:2001;1040-1046.
30. Talairach, J., Tournoux, P., 1988. Co-planar Stereotaxic Atlas of the Human Brain. Thieme Verlag, Stuttgart.
31. Zatorre R.J., Jones-Gotman M., Evans A.C., Meyer E. Functional localization and lateralization of human olfactory cortex. Nature. 360:1992;339-340.