Organophosphorous and organochlorine pesticides affect human placental phosphoinositides metabolism and PI-4 kinase activity

Journal of Biochemical and Molecular Toxicology

Volumn 18, Issue 1, 2004, Pages 30-36

  Souza, María S ^a   de Potas, Gladis Magnarelli ^a   Pechén de D'Angelo, Ana M ^a  

^a UNIVERSIDAD NACIONAL DEL COMAHUE   (Argentina)

Author keywords

Human placenta; Organochlorine pesticides; Organophosphorous pesticides; Phosphoinositides; PI 4 kinase

Indexed keywords

1,1,1 TRICHLORO 2 (2 CHLOROPHENYL) 2 (4 CHLOROPHENYL)ETHANE; AZINPHOS METHYL; CHLORPYRIFOS; HEPTACHLOR; ORGANOCHLORINE PESTICIDE; ORGANOPHOSPHATE PESTICIDE; PHOSMET; PHOSPHATE; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL KINASE; PHOSPHORUS 32; POLYPHOSPHOINOSITIDE; TRIPHOSPHOINOSITIDE; XENOBIOTIC AGENT;

ARTICLE; CELL FRACTIONATION; CELL FREE SYSTEM; CELL LABELING; CELL NUCLEUS MEMBRANE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DATA ANALYSIS; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; PHOSPHOINOSITIDE METABOLISM; PLACENTA; SENSITIVITY ANALYSIS; SUPERNATANT;

1-PHOSPHATIDYLINOSITOL 4-KINASE; AZINPHOSMETHYL; CELLS, CULTURED; CHLORPYRIFOS; DDT; FEMALE; HEPTACHLOR; HUMANS; INSECTICIDES; PHOSPHATIDYLINOSITOLS; PHOSPHORYLATION; PLACENTA; PREGNANCY;

EID: 1542330801     PISSN: 10956670     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbt.20003     Document Type: Article

References (36)

1. Martínez ME, Romanos LA, Praena CM, Repetto GM, Martínez RD. Compuestos organoclorados: Niveles sanguíneos en madres, recién nacidos, lactantes, en leche materna y de fórmula. Estudios en la provincia de Huelva. An Esp Pedriatr 1993;39:46-52.
2. Waliszewski SM, Aguirre A, Infanzón R, Siliceo J. Carry-over of persistent organochlorine pesticides through placenta to fetus. Salud publica. de México 2000;42:384-390.
3. Bosse U, Bannert N, Niessen K, Teufel M, Rose I. Chlorinated hydrocarbon content of fetal and pediatric organs and tissues. Zentralbl Hyg Umweltmed 1996;198:331-339.
4. Abu-Qare AW, Abou-Donia MB. Inhibition and recovery of maternal and fetal cholinesterase enzyme activity following a single cutaneous dose of methyl parathion and diazinon alone and in combination, in pregnant rats. J Appl Toxicol 2001;21:307-316.
5. Benjaminov OE, Hoffer U, Aiteman J, Urbach, Brandes JM. Parathion transfer and acetylcholinesterase activity in an in-vitro perfused term human placenta. Vet Hum Toxicol 1992;1:10-12.
6. Levario CM, Feria VA, De CL, Ramos ME, Córdova FL, Solís F. Parathion, a cholinesterase-inhibiting plaguicide induced changes in tertiary villi of placenta of women exposed: A scanning electron microscopy study. Gynecol Obstet Invest 2001;52:269-275.
7. Hatjian BA, Mutch E, Williams FM, Blain PG, Edwards JW. Cytogenetic response without changes in peripheral cholinesterase enzymes following exposure to a sheep dip containing diazinon in vivo and in vitro. Mutation Res 2000;472:85-92.
8. Brucker-Davis F. Effects of environmental synthetic chemicals on thyroid function. Thyroid 1998;9:827-850.
9. Taha TE, Gray RH. Agricultural pesticide exposure and perinatal mortality in central Sudan. Bull W H O 1993;71:317-321.
10. Nurinem T, Rantala K, Kurppa K, Holmberg PC. Agricultural work during pregnancy and selected structural malformations in Finland. Epidemiology 1995;6:23-30.
11. Flanagan L, Janmey P. Regulation of cytoskeletal proteins by inositol lipids. In: Cockroft S, editor. Biology of Phosphoinositides. Oxford: Oxford University Press; 2000. pp 166-182.
12. 2 and their regulation: PtdIns kinases and PtdInsP kinases. In: Cockroft S, editor. Biology of Phosphoinositides. Oxford: Oxford University Press; 2000. pp 109-130.
13. Stephens L, McGregor A, Hawkins P. Phosphoinositide 3 kinases: Regulation by cell surface receptors and function of 3-phosphorylated lipids. In: Cockroft S, editor. Biology of Phosphoinositides. Oxford: Oxford University Press; 2000. pp 32-108.
14. 2 and decreases the fertilization rate in Bufo arenarum oocytes. Comp Biochem Physiol 1995;112:61-67.
15. Magnarelli de Potás G, Pechen de D' Angelo AM. Phosphoinositide phosphorylation and shape changes produced by phosmet-oxon in human erythrocytes. Comp Biochem Physiol 1993;106C:561-566.
16. Moya de Juri MG, Magnarelli de Potas G, Pechen de D' Angelo AM. Alteration of thrombine-signalling mechanism produced by heptachlor in human platelets. J Biochem Mol Toxicol 2002;16:189-196.
17. Pike LJ. Phosphatidylinositol 4-kinases and the role of polyphosphoinositides in cellular regulation. J Endocr Rev 1992;13:692-706.
18. Kanaho Y, Suzuki T. Phosphoinositide kinases as enzymes that produce versatile signaling lipids, phosphoinositides. J. Biol Chem 2002;131:503-509.
19. Loewy M, Kirs V, Caravajal, Venturino A, Pechen de D' Angelo AM. Groundwater contamination by azinphos methyl in the Northern Patagonic Region (Argentina). Sci Total Environ 1999;225:211-218.
20. Rodríguez de Turco E, Spitzer J. Hepatic phosphatidylinositol kinase activity in continously endotoxemic rats. Biochim Biophys Acta 1991;1903:216-222.
21. Rouser G, Fleische S, Yamamoto A. Two-dimensional thin layer chromatographic separation of polar lipids and determination of phospholipids by phosphorus analysis spots. Lipids 1970;5:494-496.
22. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:265-275.
23. Noble A. Partition coefficients (n-octanol-water) for pesticides. J Chromatogr 1993;642:3-14.
24. Enam E, Matsumura F. Activation of c-Neu tyrosine kinase by o-p′ DDT and B-HCH in cell-free and intact cell preparations from MCF-7 human breast cancer cells. J Biochem Mol Toxicol 1998;12:83-89.
25. Gehrmann T, Heilmeyer L. Phosphatidylinositol 4-kinases. Eur J Biochem 1998;253:357-370.
26. Minogue S, Anderson JS, Waugh MG, dos Santos M, Corless S, Cramer R, Hsuan JJ. Cloning of a human, type II phosphatidylinositol 4-kinase reveals a novel lipid kinase family. J Biol Chem 2001;276:16635-16640.
27. Barylko B, Wlodarski P, Binns D, Gerber S, Earnest S, Sudhof T, Grichine N, Albanesi J. Analysis of the catalytic domain of phosphatidylinositol 4-kinase type II. J Biol Chem 2002;277:44366-44375.
28. Matsumura F. Classification of pesticides, hazards to man and domestic animals. In: Toxicology of Insecticides, 2nd edition. NY and London: Plenum Press; 1985.
29. Antunes-Madeira M, Madeira V. Partition of malathion in synthetic membranes. Biochem Biophys Acta 1987;901: 61-66.
30. Klotz DM, Ludlir BL, Vonier PM, Mc Lachlan JA, Arnold S.F. o-p′ DDT and its metabolites inhibit progesterone-dependent responses in yeast and human cells. Mol Cell Endocrinol 1997;129:63-71.
31. Manness SC, Mc Donnell DP, Gaido KW. Inhibition of androgen receptor-dependent transcriptional activity by DDT isomers and methoxychlor in HepG2 human hepatoma cells. Toxicol Appl Pharmacol 1998;151:135-142.
32. Guillette LJ, Vonier PM, Mc Lachlan JA. Affinity of the alligator estrogen receptor for serum pesticide contaminants. Toxicology 2002;27:181-184.
33. Hansen ME, Matsumura F. Effects of heptachlor epoxide on components of various signal transduction pathways important in tumor promotion in mouse hepatoma cells. Toxicology 2001;160:139-153.
34. Petit A, Guillen G, Tence M, Jard S, Gallo-Payet N, Bellabaraba D, Lehoux JG, Belisle S. Angiotensin II stimulates both inositol phosphate production and human placental lactogen release from human trophoblast cells. J Clin Endocrinol Metab 1989;69:280-286.
35. Ferriani RA, Aluned A, Sharkey A, Smith SK. Colocalization of acidic and basic fibroblast growth factor (FGF) in human placenta and the cellular effects of bFGF in trophoblast cell line JEG-3. Growth Factors 1994;10:259-268.
36. Neri LM, Borgatti P, Capitani S, Martelli A. The nuclear phosphoinositide 3-kinase/akt pathway: A new second messenger system. Biochim. Biophys Acta 2002;1584:73-80.